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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Experimental Physiology

Tackling aging and chronic disease: How space exploration and the ‘chameleon effect’ of pharmaceuticals can lead the way

Carina Kern, Tina Woods, Keith Siew

Abstract A common misconception surrounding space exploration is that humanity's pursuit of interplanetary travel, such as missions to Mars, is an escape from Earth. In reality, this endeavour offers an invaluable opportunity to address critical biomedical challenges here at home. The extreme conditions of space, including microgravity, cosmic radiation and prolonged isolation, create a natural laboratory for studying human biology under stress, allowing us to explore the boundaries of human resilience. These expos …

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18.08.2026journal-article

Western Journal of Nursing Research

Associations Between Autonomic Nervous System Activity and Frailty in Community-Dwelling Older Women

Mikako Sakai, Junko Hoshino, Ayako Nakayama, Noriatsu Tatematsu, Rika Usami, Naomi Furukawa, Kunihiro Imai, Hideshi Sugiura

Background: The autonomic nervous system (ANS) is associated with various physical and psychological conditions. Objective: We examined the relationship between ANS activity—measured using pulse-rate variability—and physical, psychological, and social frailty in community-dwelling older women. Methods: In 2024, we conducted a cross-sectional survey in Japan with 119 community-dwelling women aged 65 years or older. The survey assessed ANS activity and physical performance and included a self-administered questionnai …

18.08.2026journal-article

Nanotechnology

Aging-induced nanocrystalline boundary coalescence in solution-process synaptic memristor

Lingyu Xie, Lehang Chu, Yanhong Zhang, Haoyu Shen, Junming Xu, Yijie Gu, Jie Jiang, Liang Chu

Abstract Aging-induced contact enhancement is a prominent natural phenomenon in materials science. However, it has often been overlooked in nanocrystalline films. Herein, we developed a NiO x /SnO 2 p–n heterojunction synaptic memristor based on NiO x and SnO 2 nanocrystals inks, where aging-driven nanocrystal boundary coalescence serves as the origin of improved memristive switching and synaptic emulation. SnO 2 nanocrystals with amorphous surfaces undergo gradually boundary coalescence after film formation to str …

18.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

A INTEGRAÇÃO DA ECOPEDAGOGIA NA EDUCAÇÃO SEXUAL DE PESSOAS COM DEFICIÊNCIA: PROMOVENDO INCLUSÃO E CONSCIÊNCIA AMBIENTAL

Aline Ribeiro Correa, Laércio de Oliveira, Elite Francisca da Silva Farias

Este artigo discute a possibilidade de integração entre a Ecopedagogia e a Educação Sexual de pessoas com deficiência, propondo um diálogo entre dois campos que, isoladamente, já apontam para a necessidade de uma escola mais inclusiva e mais consciente de sua responsabilidade socioambiental. Parte-se do pressuposto de que a Ecopedagogia e a Educação Sexual inclusiva compartilham um mesmo horizonte pedagógico: o reconhecimento do corpo, da natureza e da diversidade humana como dimensões interligadas e merecedoras de …

18.08.2026journal-article

Working with Older People

Generative AI, autonomy and healthy ageing: a reflexive thematic analysis of urban older adults through an integrated SST–SDT lens

Aniket Godse, Saikat Deb, Avishek Ghosal, Vinod Sharma

Purpose This paper aims to offer a worked methodological demonstration of an integrated socioemotional selectivity theory (SST)–self-determination theory (SDT) reflexive thematic analysis (RTA), examining how urban, community-dwelling older adults in India are illustrated as using and emotionally experiencing generative AI and how this relates to autonomy, competence, relatedness and healthy ageing. Design/methodology/approach An RTA, organised using a Gioia-style structure, was conducted on an illustrative data se …

18.08.2026journal-article

Frontiers in Public Health

Sex-specific mediating role of serum uric acid in the association between dietary diversity and muscle strength in urban community-dwelling older adults

Xixi Chu, Yuzhu Zhao, Xin Wang, Yiyao Ruan, Lulu Wang, Fang Wang, Guangyi Liu, Dayong Yu, Kaiyong Liu, Fangbiao Tao, Liang Ruan

Objectives Dietary diversity is recognized as a key strategy for healthy aging, but the underlying mechanisms linking it to muscle strength, particularly those involving systemic metabolism, remain unclear. This study aimed to examine the association between dietary diversity and muscle strength and explore the potential mediating role of metabolic indicators. Methods This cross-sectional study included 1,613 older adults (≥60 years) from the Anhui Urban Aging Cohort. Dietary diversity was assessed using a validate …

18.08.2026journal-article

Journal of Medical Internet Research

“Like Taking Part in Star Wars”: Qualitative Study Using Thematic Analysis to Explore the Acceptability and Experiences of Older Adults Participating in Remote Longitudinal Sleep and Dementia Research

Bijetri Biswas, Victoria Grace Gabb, Jonathan Blackman, Hamish Morrison, Elizabeth Coulthard, Anne Roudaut

Abstract Background Sleep disturbance is a common symptom of and potential risk factor for neurodegeneration and dementia. Remote monitoring technologies and increasing digital literacy offer promise for monitoring symptoms and treatment responses via sleep and cognitive assessments from patients’ homes. However, the acceptability of remote sleep and circadian research in older adults with and without cognitive impairment is not known. Objective This study aimed to explore and describe the barriers, facilitators, a …

18.08.2026journal-article

Revista Brasileira em Promoção da Saúde

Fatores Associados à Autopercepção Negativa de Saúde em Pessoas Idosas: Diferenças entre Idosos Jovens e Longevos

Nathalia Ayumi Nagai, Talita Müller Gonçalves de Melo, Larissa Helena Sacheto Abdo, Gabriel da Silva Nascimento, Mariana Lima de Moura, Isabella Felisberto Cândido, Kaio Henrique Correa Massa

Objetivo: Analisar as diferenças na autopercepção de saúde entre idosos jovens (60–79 anos) e idosos longevos (≥ 80 anos), bem como identificar fatores sociodemográficos e de saúde associados à autopercepção negativa. Métodos: Estudo transversal com dados da Pesquisa Nacional de Saúde de 2019, representativa da população idosa brasileira. A variável dependente foi a autopercepção de saúde, dicotomizada em positiva ou negativa. As variáveis independentes incluíram sexo, faixa etária, raça/cor de pele, escolaridade, …

18.08.2026journal-article

PLOS Global Public Health

Acceptability of advanced Controlled Human Infection Models: The case of a pneumococcal challenge in people living with HIV and mycobacterial challenge with Bacillus Calmette Guerin in Malawi

Anthony E. Chirwa, Charity Gunda, Shalom Songolo, Edna Nsomba, Neema Toto, Lumbani Makhaza, Mphatso Mailboy, Clara Ngoliwa, Linda Chamtunga, Modesta Reuben, Chikondi Chakwiya, Pemphero Liwonde, Andrew Sigoloti, Evaristar Kudowa, Godwin Tembo, Ben Morton, Bridgette Galafa, Faith Thole, Lorensio Chimgoneko, Brenald Dzonzi, Vitumbiko Nkhoma, Edward Mangani, Mphatso Mayuni, Alfred Muyaya, Fanny Kapakasa, Morrison P. Kamanga, Tiyamika Nthandira, Diana Mwaipaya, Nengie Chirwa, Ndaziona P. K. Banda, Marc Y. R. Henrion, Tarsizio Chikaonda, Kondwani C. Jambo, Blessings Kapumba, Stephen B. Gordon, Anna C. T. Gordon, Deborah Nyirenda, on behalf of the Malawi Accelerated Research in Vaccines by Experimental and Laboratory Systems (MARVELS) consortium

Controlled Human Infection Models (CHIM) in which volunteers are experimentally exposed to pathogens are used to study pathogenesis and down select among treatment and vaccine candidates. Scientifically, CHIM studies are best conducted among at-risk populations in which the infection is endemic, and who are likely to benefit from new interventions tested. Ethically, the perspectives of these communities should be carefully considered in designing such research. CHIM studies are often conducted among healthy adults, …

18.08.2026journal-article

Revista de la Facultad de Ciencias de la Salud Universidad del Cauca

La nueva Política Pública Nacional de Discapacidad, una necesidad para la defensa de sus derechos

Liset Viviana Campos-Bermúdez

Colombia ha trazado y ajustado su horizonte de trabajo en materia de discapacidad con la política pública nacional para los próximos diez años hasta el 2035. Este trabajo se ha plasmado progresivamente desde mediados de los años noventa del siglo XX en documentos de política pública, los cuales han sido derrotero para el accionar articulado entre las organizaciones de personas con discapacidad, el Estado, organismos multilaterales y la sociedad civil.

18.08.2026journal-article

International Journal of Business, Humanities, Education and Social Sciences (IJBHES)

Exploring the Dynamics of Happiness Among People Living with HIV/AIDS (PLWHA): A Case Study of Residents at Kebaya Shelter House, Yogyakarta

Ikhlas Hariadi, Ayu Rezki Utari

Previous studies have shown that happiness is closely related to health conditions, particularly among individuals with chronic illnesses who often experience psychological distress and unhappiness. HIV/AIDS is one of the chronic diseases, and previous research indicates that some people living with HIV/AIDS (PLWHA) fail to reconstruct their happiness. However, limited studies have explored the dynamics of happiness among PLWHA, especially within shelter-based settings. This study aims to understand the dynamics of …

18.08.2026journal-article

Kera yvoty

Características sociohistóricas del pueblo indígena maká

Ada Cristina Matto Rios

Este estudio se desprende del marco histórico de la tesis doctoral titulada Experiencias pedagógicas en una institución educativa del pueblo indígena maká de Mariano Roque Alonso y tiene como objetivo conocer las características sociohistóricas del pueblo indígena maká. Se trata de una revisión bibliográfica a partir de escritos publicados en revistas científicas del Centro de Estudios Antropológicos de la Universidad Católica, específicamente de publicaciones realizadas por el Dr. José Zanardini y de algunas obras …

18.08.2026journal-article

BMC Geriatrics

Triglyceride-total cholesterol-body weight index is associated with mortality in Chinese community-dwelling older adults

Hao Yu, Xuerong Ye, Wenhua Yu, Wenli Xie, Zhenxia Zhu, Hongying Chen, Ye Guo, Lina Ma

Abstract Background With the progression of population aging and the growing demands for health management among older adults, identifying factors influencing mortality risk is of great significance. In particular, parameters related to blood lipids and body composition warrant in-depth investigation. This study aims to examine the association between the triglyceride-total cholesterol-body weight index (TCBI) and mortality among Chinese older adults. Methods Data were obtained from the China Health and Retirement …

18.08.2026journal-article

Journal of Medical Internet Research

Digital Physical Exercise Interventions for Cognitive Functions in Older Adults: Systematic Review and Bayesian Network Meta-Analysis of Randomized Controlled Trials

Qing Hu, Siyi Sun, Jingru Zhu, Xiaoke Zhong, Shengyu Dai, Changhao Jiang

Abstract Background Cognitive decline in older adults imposes a major global burden, with physical inactivity a leading modifiable risk factor for dementia. Digital physical exercise interventions offer scalable alternatives to traditional programs, but comparative effectiveness across cognitive domains remains unclear. Objective The aim of the study is to compare and rank 4 digital physical exercise interventions—immersive virtual reality exercise (IVR_E), nonimmersive exergame (NI_ExG), remote exercise (RE), and …

18.08.2026journal-article

Transport of the Urals

Исследование старения изоляции ТЭД локомотивов

М.А. Шрайбер

В статье представлены результаты комплексных лабораторных исследований, направленных на изучение процесса старения изоляции обмоток тяговых электродвигателей (ТЭД) локомотивов. Объект исследования — изоляция обмоток, подверженная циклическим термомеханическим нагрузкам, обусловленным колебаниями температуры медного проводника в ходе эксплуатации. Цель — всестороннее изучение влияния циклических термомеханических напряжений на процесс деградации изоляции ТЭД локомотивов. Для достижения этой цели разработана и реализ …

18.08.2026journal-article

Highlights in Business, Economics and Management

Spatial Interventions and Humanistic Care in Biophilic Design within the Context of an Aging Society

Jiaxin Ye

The accelerating global trend of population aging, combined with changes in family structures that have weakened traditional eldercare functions, has transformed loneliness and caregiving pressures faced by older adults into a pressing public challenge. In this context, the living and care environments of the elderly have become critically important for their physical and mental well-being. Biophilic design theory provides an interdisciplinary framework for improving eldercare settings; however, its application in …

18.08.2026journal-article

Asian Journal of Physical and Chemical Sciences

Metaheuristic Optimization of an Empirical Lithium-Ion Battery Aging Model for Mobile-Device Operating Conditions

Ngoidita Natebaye, Mawilina Jonas, M. Madjiko Luc, Ndouwe Salvador, Ahmat I. Gogo

Lithium-ion battery degradation is influenced by operating temperature, electrical current, depth of discharge (DoD), and charge–discharge cycling. This study presents a computational framework for identifying operating conditions associated with a reduced value of an empirical battery-ageing objective function. Unlike an initial monotonic formulation, the objective function used here combines deviation-based penalty terms for temperature and current, reproducing the experimentally reported U-shaped ageing response …

18.08.2026journal-article

BMC Psychology

Apathy in older adults is associated with selective overweighting of effort during decisions between everyday activities

Seokhwan Kim, Xu Yan, Azara Lalla, Sean Devine, Signy Sheldon, A. Ross Otto, Akram Bakkour, Karin Foerde, Madeleine Sharp

Abstract Apathy, characterized by reduced motivation and goal-directed behavior, is common in normal aging and may arise from biased cost–benefit evaluation during decision making. While prior research has focused on simple choices involving the trade-off between motor or cognitive effort and monetary reward, real-life decisions of people with apathy likely reflect biases affecting many other dimensions of value. Additionally, the extent to which mood symptoms that frequently co-occur with apathy also contribute to …

18.08.2026journal-article

Drug and Alcohol Review

People Seeking Treatment for Meth/Amphetamine Use Are Getting Older and Treatment Services Need to Adapt

Liam S. Acheson, Krista J. Siefried, Brendan Clifford, Maureen Steele, Kathryn Fletcher, Nadine Ezard

ABSTRACT Introduction Harms associated with meth/amphetamine use increase with cumulative exposure and overlap with age‐related health conditions. Understanding demographic shifts in drug treatment populations is required to ensure services meet evolving needs. Methods We analysed data from the Australian Institute of Health and Welfare's Alcohol and Other Drug Treatment Services National Minimum Data Set, including all treatment episodes where meth/amphetamine was the primary drug of concern from 2003–04 (first da …

18.08.2026journal-article

Frontiers in Molecular Neuroscience

Diet–gut microbiota–immune–brain interactions in aging: mechanistic pathways and clinical implications

Maha A. Jarfan, Karani Santhanakrishnan Vimaleswaran, Anisha Wijeyesekera

With rising life expectancy and global population aging, cognitive decline has become a major and growing public health challenge. Advances in nutritional neuroscience highlight the gut microbiota–immune–brain axis as a key biological pathway through which diet may influence cognitive function during aging. The gut microbiota, a metabolically active ecosystem, responds dynamically to habitual dietary patterns and produces bioactive metabolites capable of modulating immune signaling, neuroinflammation, and neuronal …

18.08.2026journal-article

Occupational and Environmental Medicine

Sleep disturbances and sleep duration as predictors of working life expectancy among adults aged 50 years and older in Finland

Saana Myllyntausta, Katriina Heikkilä, Jaana Pentti, Holendro Singh Chungkham, Sakari Suominen, Mika Kivimaki, Jussi Vahtera, Paola Zaninotto, Jenni Ervasti, Sari Stenholm

Objectives To examine the associations of sleep disturbances and sleep duration with working life expectancy (WLE; the estimated number of years an individual is expected to be in the workforce) from age 50 to 68. Methods Data of individuals ≥50 years were drawn from two cohort studies: the Finnish Public Sector (FPS) study involving public sector employees in 2000–2016 (n=70 339, 80% women) and the Health and Social Support (HeSSup) study in 1998–2013 initially representing the general working age population in Fi …

18.08.2026journal-article

British Journal of Occupational Therapy

Effects of a short-term, low-frequency occupational participation programme on health-related quality of life in community-dwelling older adults: A multicentre quasi-experimental study

Shota Aoyagi, Ryota Izumi, Yohei Kurita, Tetsuya Sano, Kosuke Suzuki, Yuki Satake

Introduction: Promoting health-related quality of life in community-dwelling older adults is central to occupational therapy practice in super-ageing societies. However, evidence for short-term, low-frequency occupational participation programmes remains limited. Methods: A multicentre, non-randomised within-subject longitudinal study was conducted in Japanese community groups. Participants served as their own controls during a usual activity period, followed by a 3-month intervention comprising three monthly sessi …

18.08.2026journal-article

Journal of the Medical Association of Thailand

Geriatric Trauma Outcome Score and Mortality in Elderly Trauma Patients: A Retrospective Cohort Study

Kamtone Chandacham, Pornsinn Koonsinn, Supaporn Rattanasiri, Wilaiwan Chongruksut, Wasana Ko-iam, Narain Chotirosniramit

Background: The aging population in Thailand is rapidly increasing, leading to a rise in elderly trauma cases. Understanding the epidemiology, causes, complications, and outcomes of geriatric trauma is crucial for improving care and developing preventive strategies. Objective: To analyze the epidemiological patterns, causes, complications, and outcomes of elderly trauma patients, and to assess the relationship between the Geriatric Trauma Outcome Score (GT OS) and mortality. Materials and Methods: This retrospectiv …

18.08.2026journal-article

International Journal of Gynecology & Obstetrics

Hormone therapy ( HT ) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay

Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and psychological morbidity, and sexual health concerns. Therefore, interventions in POI/EM represent some of the most actionable opportunities to reduce long‐term disability an …