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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

International Journal of Ophthalmology

Effects of different side-cut angles on ocular surface recovery after FS-LASIK

Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China; Department of Ophthalmology, People’s Hospital of Yangzhong City, Zhenjiang 212200, Jiangsu Province, China, Zi-Chen Wang, Nan-Nan Gao, Eye Institute, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China, Xin-Liang Cheng, Ying Yu, Hai-Xia Ji

AIM: To compare the effects of different side-cut angles on postoperative ocular surface recovery after femtosecond laser-assisted in situ keratomileusis (FS-LASIK). METHODS: The prospective and randomized study enrolled 99 patients (198 eyes) with ametropia who underwent FS-LASIK in the Eye Institute at the Affiliated Hospital of Nantong University from September 2021 to December 2022. The patients were categorized into the 45°, 90°, and 135° side-cut angle groups. Preoperatively and at 10d, 1mo, and 6mo after sur …

18.08.2026journal-article

Journal of Internal Medicine

Cognitive performance and neuroimaging markers across the glycemic spectrum in multiethnic Asian older adults

Jiangbo Cui, Wei Ying Tan, Jiannan Huang, Eddie Jun Yi Chong, Chee Miao Li, Narayanaswamy Venketasubramanian, Tien Yin Wong, Ching‐Yu Cheng, Christopher Chen, Saima Hilal

Abstract Background Brain health across the glycemic spectrum in older adults remains poorly understood, particularly in prediabetes, a biologically heterogeneous condition. We aimed to explore cognitive performance and neuroimaging markers across the glycemic spectrum and to examine whether these associations vary according to cerebral microvascular dysfunction and diabetes onset. Methods We included 930 participants (mean age 65.7 years; 52% female) from a population‐based study in Singapore with a 6‐year follow‐ …

18.08.2026journal-article

Aging Clinical and Experimental Research

Sex-based differences in glycaemic variability and clinical outcomes among older inpatients with type 2 diabetes: insights from the GLIMPACT study

Nicola Confortin, Chiara Ceolin, Margherita Vergadoro, Benedetta Di Marzio, Elisabetta Ferra, Andrea Ambrosio, Filippo Catalani, Giulia Gasparini, Bruno Micael Zanforlini, Chiara Curreri, Luca Spiezia, Andrea Rossi, Giuseppe Sergi, Marina De Rui

Abstract Background Glycaemic variability (GV) has emerged as a potential marker of adverse outcomes in hospitalised patients with diabetes, yet its clinical impact in older adults and the role of sex differences remain unclear. Aims To evaluate the association between in-hospital GV and length of stay (LOS) and one- and two-year all-cause mortality in older adults with type 2 diabetes, and to explore sex-specific patterns. Methods Retrospective observational study of patients aged ≥ 65 years with type 2 diabetes a …

18.08.2026journal-article

Diagnostics

RETRACTED: Deeparani, M.; Kalamani, M. Gynecological Healthcare: Unveiling Pelvic Masses Classification Through Evolutionary Gravitational Neocognitron Neural Network Optimized with Nomadic People Optimizer. Diagnostics 2023, 13, 3131

M. Deeparani, M. Kalamani

The journal retracts the article titled, “Gynecological Healthcare: Unveiling Pelvic Masses Classification through Evolutionary Gravitational Neocognitron Neural Network Optimized with Nomadic People Optimizer” [...]

18.08.2026journal-article

Materials

Influence of Immediate Dentin Sealing on the Color Stability of Lithium Disilicate Ceramic Laminate Veneers Bonded to Sound and Eroded Dentin After Accelerated Aging

Otavio Marino dos Santos Neto, Ingrid Carneiro Cavalcante Souto, Patrícia Pauletto, Rossana Pereira Almeida

The optical stability of thin ceramic laminate veneers may be affected by both the adhesive interface and the underlying substrate. This in vitro study evaluated the influence of immediate dentin sealing (IDS) on the color stability of lithium disilicate laminate veneers bonded to sound and eroded dentin after accelerated aging. Forty bovine dentin specimens were allocated into four groups according to dentin condition and adhesive protocol: sound dentin without IDS, sound dentin with IDS, eroded dentin without IDS …

18.08.2026journal-article

Frontiers in Aging Neuroscience

Using QSM to investigate the iron deposition patterns in deep gray matter nuclei during the aging process in healthy populations

Xingyu Wang, Yiming Wang, Lin Liu, Ziqi Wang, Qingfeng Zhu, Duo Gao, Xuefang Han, Huandi Lv, Song Zhao, Hong Song, Xueshan Cao, Zuojun Geng

Objective We utilized 3.0T quantitative susceptibility mapping (QSM) technology to simultaneously investigate (a) the relationship between susceptibility values of deep gray matter (DGM) nuclei and age in healthy populations throughout the aging process, and (b) the correlation of iron deposition among DGM nuclei and its potential clinical significance. Methods QSM images of DGM nuclei were obtained from 100 healthy participants using a 3.0T MRI scanner. Susceptibility values of corresponding DGM nuclei were acquir …

18.08.2026journal-article

BMC Geriatrics

Stakeholder perspectives informing the design and development of a digital self-help intervention for healthy aging and mental well-being among older adults in urban India: a qualitative study

Indranil Saha, Devi Das, Susmita Dutta, Suchismita Hoda, Madhurima Khasnobis, Shraddha Sharma, Jeevan J., Treasa Lisbeth Sajan, Surajit Das, Neha Dahiya, Asim Saha, Lakshmanan Sethuraman, Arun Kandasamy, Neda Agahi, Nitya Jayaram-Lindström, Martin Kraepelien, Christopher Sundström, Amit Chakrabarti

Abstract Background India’s older adult population is rapidly increasing, accompanied by a growing burden of common mental health problems such as depression, anxiety, sleep disturbances, and cognitive concerns. Promoting healthy aging and preventive mental healthcare has therefore become an important public health priority. Digital health interventions have emerged as promising approaches for improving access to preventive and supportive care among older adults. This study gathers perspectives from older adults, c …

18.08.2026journal-article

Sensors

Reliability of a Home-Based Smartphone Balance Assessment in Healthy Middle-Aged and Older Adults

Elizabeth Coker, Anat V. Lubetzky

Smartphone accelerometry could enable longitudinal home-based balance testing, yet its reliability across tasks and outcome measures must be established. We assessed the test–retest reliability and measurement precision of a custom smartphone balance application. Sixty-nine healthy, community-dwelling middle-aged and older adults (ages 41–76 years) performed a 5 s home-based balance assessment weekly for 3 weeks. The assessment was directed by the application, which generated accelerometer-based sway metrics. Parti …

18.08.2026journal-article

Journal of Enterprising Communities: People and Places in the Global Economy

Socio cultural mediation is the link between achievement motivation, risk taking, self-efficacy and employee performance in MSMES

Dorris Yadewani, Roy Matta, Sandeep Poddar

Purpose The aim of this study was conducted to determine the direct influence of the variables need for achievement, risk-taking and self-efficacy on performance, mediated by socio-cultural factors. Design/methodology/approach The study involved 60 respondents from various SMEs in West Sumatra. The modelling technique used was partial least squares structural equation modelling. Findings There is also a direct influence of the variables need for achievement, risk-taking and self-efficacy on socio-cultural factors. …

18.08.2026journal-article

British Journal of Clinical Pharmacology

Long‐acting cabotegravir and rilpivirine in people with HIV receiving chronic anticoagulation: A real‐world case series

Montserrat Laguno, Berta Torres, Maria Martínez‐Rebollar, Paula Arreba, Octavi Roman, Roger LLobet, Leire Berrocal, Alberto Foncillas, Júlia Calvo, Abiu Sempere, Ivan Chivite, Elisa de Lazzari, Josep Mallolas, Ana González‐Cordón

Background Long‐acting intramuscular cabotegravir plus rilpivirine (LA‐CAB + RPV) is an effective maintenance antiretroviral regimen for virologically suppressed people with HIV. However, its use in individuals receiving chronic anticoagulation is limited by concerns regarding intramuscular bleeding risk, and real‐world data are scarce. Methods We conducted an observational, prospective, single‐centre cohort study including all people with HIV (PVIH) who initiated LA‐CAB + RPV at Hospital Clínic of Barcelona since …

18.08.2026journal-article

Healthcare

Effects of Combined Exercise Interventions on Cognition in Older Persons: A Systematic Review and Meta-Analysis

Kaan Akalp, José Pedro Ferreira, Carlos Soares, Hicran Besikci, Ana Catarina Bizarro, Maria José Ribeiro, Ana Maria Teixeira

Background/Objectives: Combining exercise with cognitive training (Combined Intervention) is a strategy against age-related cognitive decline; however, the best exercise type to maximize the neuroprotective effects of combined intervention remains unclear. Therefore, this systematic review and meta-analysis (SRMA) aimed to compare the effects of combined interventions (exercise plus cognitive training) versus exercise-only on cognitive function and blood biomarkers in older persons across different exercise types. …

18.08.2026journal-article

Medicine & Science in Sports & Exercise

The Effects of Small Changes in Power Output Below and Above the Maximal Lactate Steady State in Performance Fatigability in Older Females and Males

Rafael de Almeida Azevedo, Guillaume Y. Millet, Juan M. Murias

Purpose: In young adults, performance fatigability is affected by sex even with minor power output (PO) changes around the maximal lactate steady-state (MLSS). This study investigated whether these sex- and intensity-dependent effects persisted in older adults. Methods: 9 females (65±5 yrs) and 10 males (67±4 yrs) performed three 30-min constant-PO exercise bouts at MLSS, 10 W below (MLSS−10), and 10 W above (MLSS+10), each followed by a time to task failure (TTF) test at 80% peak-PO. Performance fatigability was a …

18.08.2026journal-article

Genes

Genetic Architecture of Synaptic Failure in Dementia with Lewy Bodies: From α-Synuclein Proteoforms to GBA1-Mediated Plasticity Deficits

Anastasia Bougea

Dementia with Lewy bodies (DLB) is increasingly conceptualised not merely as a disorder of neuronal death but as a primary synaptopathy in which the functional collapse of synaptic transmission and plasticity precedes, and predicts, neurodegeneration and clinical decline. Two genetic determinants dominate the heritable risk architecture of DLB: the α-synuclein gene SNCA, in which both copy-number variation and missense mutations exert dose- and conformation-dependent effects, and GBA1, encoding the lysosomal hydrol …

18.08.2026journal-article

Scientific Data

Dataset of lipidome and transcriptome of Gentiana crassicaulis seeds during artificial aging

Yingsi Gao, Xiaoye Zhang, Fangtao Huang, Furui Sang, Xiheng Wan, Jia Chen, Guowei Zheng

Abstract Gentiana crassicaulis is a significant traditional medicinal plant in China. Currently, seed reproduction is the predominant method for large-scale seedling cultivation. However, the seeds of Gentiana are typically susceptible to aging and deterioration, which severely impacts seedling production and germplasm preservation. Research on the seed aging process of G. crassicaulis is still relatively limited, particularly in terms of systematic multi-omics data support. In this study, transcriptomic and lipido …

18.08.2026journal-article

Revista edUCA - Revista Multidisciplinar da Faculdade Católica Paulista

Processos organizacionais, People Analytics e Síndrome de Boreout: evidências sobre absenteísmo, presenteísmo e bem-estar no trabalho

Miriam dos Santos Lopes, Luciano Silva Figueiredo, Thiago Assunção de Moraes, Luiz Daniel Albuquerque Dias, Rogério Agenor de Sousa Severino, Caio José de Sousa Silva, Roselis Ribeiro Barbosa Machado, Luiz Felipe Sousa Dias, Samuel Serafim Moraes, Francisco Antônio Gonçalves de Carvalho

Este estudo aborda a relação entre os processos organizacionais, o uso de People Analytics, o absenteísmo, o presenteísmo e a Síndrome de Boreout no contexto das organizações. O objetivo consistiu em analisar como a eficiência dos processos organizacionais e a utilização de práticas de People Analytics influenciam o absenteísmo e a manifestação da Síndrome de Boreout, considerando seus impactos sobre o desempenho e o bem-estar dos trabalhadores. Trata-se de uma pesquisa quantitativa, descritiva e correlacional, des …

18.08.2026journal-article

Journal of the American Heart Association

Interactive Effects of Plasma Alzheimer Disease Biomarkers and White Matter Hyperintensities on Cognitive Decline and Clinical Progression in Nondemented Adults

Jing Yang, Xinyuan Zhao, Yidan Liu, Yangwei Cai, Yuhua Fan, and the Alzheimer's Disease Neuroimaging Initiative

Background Alzheimer disease pathology and cerebral small‐vessel disease frequently coexist in older adults, yet how their interaction influences early clinical progression remains poorly understood, particularly in individuals without dementia. We aimed to investigate how plasma Alzheimer disease biomarkers and white matter hyperintensities (WMHs) interact to influence cognitive trajectories and the risk of progression to cognitive impairment and dementia. Methods We studied 463 nondemented participants from the A …

18.08.2026journal-article

European Geriatric Medicine

Nonspecific symptoms explain functional limitations in older adults better than disease-specific symptoms

Sandra L. Wezeman, René J. F. Melis, Cillian Hourican, Rick Quax, Thomas M. Gill, Marcel G. M. Olde Rikkert, Geeske Peeters

Abstract Purpose Older adults often have multiple diseases and age-related physiologic changes that may present with nonspecific symptoms such as fatigue or dizziness. Identifying symptoms that are most strongly associated with functioning may guide symptom management. This study examined the association of nonspecific and disease-specific symptoms with functional limitations in community-dwelling older adults over a 23-year period. Methods Data were from the Precipitating Events Project, a longitudinal cohort stud …

18.08.2026journal-article

Military Medicine

Potential Marker of Accelerated Aging: Worsening of Gait Speed in Post-9/11 Veterans in the TRACTS Longitudinal Cohort

Elisa F Ogawa, James W Whitworth, Michelle M Pebole, Anna Etchin, Dylan Katz, Madeleine K Nowak, William P Milberg, Catherine B Fortier

Abstract Introduction Veterans may experience negative changes in gait at younger ages because of military-related exposures and prevalent health conditions, such as traumatic brain injury (TBI), posttraumatic stress disorder (PTSD), depression, and metabolic syndrome (MetS). This study aimed to evaluate gait speed by age and examine factors associated with gait speed among veterans. Materials and Methods Post-9/11 U.S. veterans were included in this study (n = 100, mean 42 ± 11 years). Gait speed was assessed unde …

18.08.2026journal-article

JMIR Formative Research

Gerontechnology Acceptance in Thai Older Adult Care Facilities—Sensor Network and Machine Learning Adoption: Mixed Methods Study

Metta Ongkasuwan, Uree Cheasakul, Akechai Judkrue, Pair Sajampun

Abstract Background Thailand is undergoing a rapid demographic transition, with an estimated 28% of the population expected to be aged 60 years or older by 2030. This shift creates an urgent demand for technology-enhanced solutions for older adults. Despite growing interest in Internet of Things (IoT) sensor networks and machine learning applications for older adult care, the patterns of technology acceptance and implementation readiness in Thai older adult care facilities remain underexplored. Objective This study …

18.08.2026journal-article

Frontiers in Aging Neuroscience

Trajectories of chronic disease burden, depressive symptoms, and functional limitations related to falls in middle-aged and older adults: a matched longitudinal study

Mengmeng Wang, Yaohui Cui, Lincheng Duan, Xiaowei Qin

Background Falls are often treated as isolated events, but the physiological, psychological, and functional trajectories surrounding a first fall remain poorly understood. We examined chronic disease burden, depressive symptoms, and activities of daily living (ADL) limitations before and after first fall reports in England and the United States. Methods We conducted a matched longitudinal analysis of adults aged ≥50 years in the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS). …

18.08.2026journal-article

Frontiers in Immunology

Exercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer

Wen Fang, Yihan Wang, Zhenyu Yang, Hongyun Zheng, Yang Wu, Ruogu Chen, Ruilong Wang, Huayu Tang, Menghao Tang, Xinming Ye

Cancer in older adults has become a significant public health challenge, with increasing incidence and limited efficacy of conventional treatments due to aging-related biological changes, such as chronic inflammation, immune decline, metabolic dysfunction, and cellular senescence. These alterations create a pro-tumor environment, weakening antitumor capacity and reducing treatment sensitivity. Exercise medicine has emerged as a promising systemic intervention, regulating multiple physiological systems, including me …

18.08.2026journal-article

Diabetology

Association Between Glycemic Burden, Diabetes Duration, and MMSE-Defined Cognitive Impairment in Middle-Aged and Older Adults: A Comparative Cross-Sectional Study

Rachid Aithammou, Mohamed Ben-El-Caid

Background/Objectives: Diabetes mellitus is associated with cognitive impairment, but evidence from southern Morocco remains limited. This study examined the associations of diabetes status, HbA1c, and diabetes duration with Mini-Mental State Examination (MMSE) performance among adults aged 45 years or older in Dakhla. Methods: This hospital-based comparative cross-sectional study included 100 participants (50 with diabetes and 50 without diabetes). Data were collected through a structured bilingual questionnaire a …

18.08.2026journal-article

Sports Medicine

The Optimal Exercise Modality and Dose for Blood Pressure Management in Middle-Aged and Older Adults: A Systematic Review with Bayesian Model-Based, and Dose–Response Network Meta-Analysis of RCTs

Zhongxu Hu, Matthew Weston, Samuhaer Azhati, Xianyang Xin, Xingyi Niu, Jinfa Gu

Abstract Background Exercise is an established non-pharmacological strategy for lowering blood pressure (BP), but the comparative effectiveness and optimal dose of different exercise modalities in middle-aged and older adults remain unclear. Objective This study aimed to systematically compare the effects of different exercise modalities and doses on resting systolic and diastolic BP (SBP/DBP) in middle-aged and older adults (≥ 45 years). Methods Randomized controlled trials (RCTs) were identified from six electron …

18.08.2026journal-article

Australasian Psychiatry

Benzodiazepine prescribing at discharge from adult and older persons psychiatric inpatient units: A systematic review and meta-analysis

Justin McMahon, John McMaster, David Maletsky, Hesitha Abeysundera

Objective Psychiatric inpatient discharge is a prescribing transition at which benzodiazepines initiated for short-term symptom control may unintentionally continue beyond discharge. Existing guidance is limited for prescribing decisions. We aimed to estimate benzodiazepine discharge prevalence from adult and older persons psychiatric inpatient units and examine between-study heterogeneity. Methods We searched five databases from inception to 31 December 2022, updated the search on 27 November 2025 (PROSPERO: CRD42 …