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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Scientific Reports

Latent profile analysis of benefit finding in maintenance hemodialysis patients and its association with treatment adherence

Xianghao Chen, Wenli Cai, Xiaodan Lin, Haidan Xie, Jialian Huang, Huifeng Song, Xiaozhou Zhou

Abstract Maintenance hemodialysis (MHD) patients experience prominent negative emotions, and dialysis outcomes/prognosis rely heavily on treatment adherence. Few studies have explored the relationship between latent Benefit Finding (BF) categories and adherence. This study aims to identify BF’s latent characteristics in MHD patients and analyze their link to adherence for targeted interventions. From Oct. 2024 to Mar. 2025, 250 MHD patients were convenience-sampled from 2 tertiary hospitals in Guangzhou. Measuremen …

02.09.2026journal-article

Clinical Journal of Sport Medicine

The Lifetime and One-Year Prevalence of Concussion in Male and Female High School Students in Alberta

Amanda M. Black, Jocelyn H. McCallum, Paul H. Eliason, Brent E. Hagel, Carolyn A. Emery

Objective: To examine the lifetime and one-year prevalence of concussion, including suspected and medically diagnosed, among high school students (ages 14-19 years) in Alberta, Canada. Design: Cross-sectional survey. Setting: High schools across Alberta, Canada. Participants: Grade 10 to 12 students from 24 schools. Independent Variables: Students completed an anonymous and validated online survey during class (October 2018-March 2019), including their sex and participation in sport and recreational activity. Main …

02.09.2026journal-article

Journal of the Heart Valve Society

Impact of Preoperative COVID-19 Infection on Myocardial Injury and Outcomes After Aortic Valve Surgery in the Pre-Vaccination Era

Mohammed Hashem, Payam Haftbaradaran Esfahan, Daniel Daher, Anders Franco-Cereceda, Magnus Bäck

Objectives To determine whether preoperative COVID-19 infection before vaccine introduction was associated with postoperative myocardial injury and long-term adverse outcomes after surgical aortic valve replacement. Methods This prospective cohort study included patients undergoing surgical aortic valve replacement between July 2020 and May 2021. Preoperative COVID-19 infection status was determined by antibody testing. Baseline data were collected, and outcomes were identified through structured medical-record rev …

02.09.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

ADAPTIVE CONTEXT-AWARE MULTIMODAL TRANSFORMER FRAMEWORK FOR ROBUST RESPIRATORY DISEASE DIAGNOSIS

R. SARADHA, M. SUNDARA RAJAN

Early detection and accurate diagnosis of respiratory diseases are remaining critical for the timely clinical interference and treatment. Many of the conventional diagnostic systems are relying on the unimodal datasets or static multimodal fusion strategies that tends in limiting the ability in capturing the respiratory diseases. Despite the success of recent multimodal learning approaches, where the practical limitations are remaining unresolved. This study proposes an Adaptive Context-Aware Multimodal Transformer …

02.09.2026journal-article

Journal of Clinical Medicine

Excessively High Maternal Total Cell-Free DNA Concentration and Fetal Growth Restriction in Singleton Pregnancies: A Retrospective Cohort Study

Lingling Xing, Xiaosha Jing, Ting Bai, Sha Liu, Jianlong Liu, Cechuan Deng, Tianyu Xia, Yunyun Liu, Xiang Wei, Yuan Luo, Quanfang Zhou, Qian Zhu, Hongqian Liu

Background/Objectives: Noninvasive prenatal screening (NIPS) fails in approximately 0.2% of cases due to high maternal plasma total cell-free DNA (t-cfDNA) concentration (≥0.6 ng/µL) confirmed after two DNA extraction attempts. The clinical implications of this quality control metric for fetal growth restriction (FGR) remain unknown. Methods: This retrospective cohort study, conducted in a major prenatal diagnosis center in China, involved pregnant women who underwent noninvasive prenatal screening (NIPS) between 2 …

02.09.2026journal-article

Journal of Medical Humanities

Virtues and Narratives in Medicine: An Analysis and Collection of Virtue-Illustrating Stories in Medical Journals

Lauris C. Kaldjian, Brittany A. Bettendorf, Fabrice Jotterand

Abstract This paper draws from a framework of virtue ethics and narrative medicine to present a content analysis and teaching resource of virtue-illustrating stories found in medical journals. As acquired dispositions, virtues are cultivated not merely by listening to lectures but through reflection, experience, role-modeling, practice, and internalization. One way to encourage such cultivation is to use narratives to illustrate moral virtues in action. With this in mind, we identified a literature-based taxonomy o …

02.09.2026journal-article

Journal of Clinical Medicine

A Comparison of Medial and Lateral Ligament Balance in Functional Versus Simulated Mechanical Alignment in Total Knee Arthroplasty Across CPAK Phenotypes: A Single-Center Study

Anne Ruth van Meijeren, Daniëlle Langeloo, Hans-Peter van Jonbergen, Martin Stevens, Marrigje Floor Meijer

Background/Objectives: Despite the excellent long-term outcomes of total knee arthroplasty (TKA), up to 10% of patients remain dissatisfied. Robotic-assisted TKA enables individualized alignment strategies, such as functional alignment (FA). Proper alignment and soft tissue balance are considered key factors for positive clinical outcomes. This study compared medial and lateral ligament balance between simulated mechanical alignment (MA) and FA across different Coronal Plane Alignment of the Knee (CPAK) types using …

02.09.2026journal-article

Frontiers in Medicine

Pharmacogenomic-guided opioid prescribing in hospice: reducing toxicity while maximizing symptom relief

Ben Thompson, Carrie Hyde, Binoy Singh

Hospice care centers on interdisciplinary-driven, patient-focused, comprehensive and individualized care at the end of life. Effective pain management has been a cornerstone of hospice care, with up to 80% of patients experiencing moderate to severe pain at the end of life. Although central to hospice care, opioid prescribing faces major challenges: wide variability in response, frequent adverse effects (sedation, constipation, respiratory depression, cognitive impairment), and high rates of uncontrolled pain (20%– …

02.09.2026journal-article

AGING MEDICINE

Shared Metabolic–Proteinopathy Axis in Alzheimer's Disease and Parkinson's Disease: Evidence for a Convergent but Not Identical Disease Spectrum

Shun‐yu Yao, Miao‐qiao Du, Lan‐xin Lin, Xu‐hui Kang, Dai‐yi Jiang, Yong Peng

ABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent neurodegenerative disorders globally and have long been classified as clinically and pathologically distinct syndromes. AD is defined by amyloid‐β (Aβ) plaques and tau‐positive neurofibrillary tangles, whereas PD is characterized by α‐synuclein aggregation and progressive degeneration of nigrostriatal dopaminergic neurons. However, mounting evidence has blurred the traditional boundaries between these disorders, revealing exte …

02.09.2026journal-article

Osteology

Does Physeal Preservation Matter? Patient-Reported Outcomes After Physeal-Sparing Versus Transphyseal Anterior Cruciate Ligament (ACL) Reconstruction in Pediatric Patients: A Systematic Review and Meta-Analysis

Mohammed Al-Rumaih, Ali Al-Ghufaily, Fares Al-Marek, Abdulrahman Al-Otaibi, Saleh Al-Saifi, Sasha Carsen, Donald Kephart, Bogdan Matache, Waleed Kishta

Background/Objectives: ACL injuries in skeletally immature patients present a unique surgical challenge, with ongoing debate regarding the optimal reconstruction technique relative to the open physis. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines, searching PubMed/MEDLINE, Cochrane Library, and Google Scholar. Twenty-two studies (n = 1036 patients; 598 physeal-sparing, 438 transphyseal) were included. The evidence base consisted predominantly of non-randomized retrospecti …

02.09.2026journal-article

Journal of Fungi

Early Bedside Risk Stratification in ICU Patients with Suspected Invasive Pulmonary Aspergillosis: A Minimalist Clinical Decision Support Model

Andrea Baldi, Giulia Capecchi, Francesca Fiani, Antonio Lesci, Dorotea Rubino, Giulia Valeria Stazi, Elena Mattiucci, Valerio Sabatini, Daniele Guerino Biasucci, Carla Fontana, Christian Napoli, Maria Grazia Bocci

Background: Early diagnosis of Invasive Pulmonary Aspergillosis (IPA) in non-neutropenic ICU patients remains challenging due to the low specificity of radiological findings and the limited reliability of individual biomarkers. This diagnostic uncertainty often delays antifungal treatment and contributes to the high mortality associated with IPA. We aimed to develop a clinically interpretable model for early bedside risk stratification. Methods: We conducted a retrospective study including 298 ICU patients. A Logis …

02.09.2026journal-article

Journal of Clinical Medicine

Is the Arterial Anastomosis Time a Key Predictor of Free Flap Failure in Oncological Head and Neck Reconstruction? A Prospective Cohort Study

Cristina Cárdenas Serres, Fernando Almeida Parra, Álvaro Ranz Colio, Ángela Bueno de Vicente, Patricia de Leyva Moreno, Verónica de Prado Mendoza, Jorge Nuñez Paredes, Manuel Picón Molina, Julio Acero Sanz

Background/Objectives: Free flap microsurgical reconstruction is the gold standard for complex oncological head and neck defects. Despite high success rates, flap failure carries significant morbidity and oncological implications. This study aimed to identify preoperative, analytical, and intraoperative predictors of free flap non-viability in a prospective series of head and neck oncological reconstructions. Methods: A prospective observational cohort study included 98 consecutive patients undergoing microsurgical …

02.09.2026journal-article

Clinical EEG and Neuroscience

Neurophysiological Evidence of Enhanced Cognitive Control Following Auditory Control Enhancement (ACE) Therapy: A Pilot RCT in Schizophrenia-Spectrum Disorders with Persistent Auditory Hallucinations

Brian A. Coffman, Dylan Seebold, Jenay Kocsis, Brianna Lepore, Lauren Fowler, Hayley Rhorer, Jack Kavanagh, Fran Lopez-Caballero, Alfredo Sklar, Dean F. Salisbury

Schizophrenia (Sz) involves positive symptoms such as auditory hallucinations, paranoia, and delusions, and are commonly linked to deficits in cognitive control. These deficits appear in tasks like the A-X version of the continuous performance test (AX-CPT), which reflects reduced proactive control, and in diminished auditory steady-state responses (ASSR) during selective attention. Notably, in Sz, ASSR to sounds presented during diverted attention increases with hallucination severity. We report results from a sin …

02.09.2026journal-article

Applied Sciences Research Periodicals

The Impact of Menopausal Status on Body Composition Following Roux-en-Y Gastric Bypass Surgery

Covarrubias F. Isabel, Mary Ann Mosti, Carla-Isabel Gomez-Fernandez, Karla-Carolina Flores-Maciel, Hugo Sánchez-Aguilar, Jose-Maria Arteaga-Rojas, Miguel F Herrera

Introduction: Menopausal women are prone to muscle loss due to reduced anabolic signaling and decreased physical activity associated with declining estrogen levels. These changes impair muscle protein synthesis. Following Roux-en-Y gastric bypass (RYGB), calorie restriction, impaired protein absorption, and vitamin deficiencies may further exacerbate muscle loss. This study aimed to evaluate whether menopausal status has an additive effect on body composition, particularly fat-free mass (FFM) loss, at 12 months fol …

02.09.2026journal-article

Haemophilia

Real‐World Experience With Emicizumab for Haemophilia A From the Physician Perspective in a Real‐World Clinical Setting

Michael Recht, Chris Blazos, Sophie Lai, Nathan Ball, Ella Morton, Lucy Lee, Juliana M. L. Biondo, Janet S. Lee

ABSTRACT Introduction Emicizumab is a bispecific antibody approved for prophylaxis in people with haemophilia A (PwHA). Aim To describe from the physician perspective the characteristics and treatment experiences of PwHA receiving emicizumab. Methods The Adelphi Real World Haemophilia Disease Specific Programme is a cross‐sectional, retrospective data collection from US haematology and haematology‐oncology specialists between July 2023 and April 2024. Male PwHA with or without inhibitors were included if they had b …

02.09.2026journal-article

Measurement Science and Technology

Physics-informed multimodal front-end enhancement for robust incipient encoder fault diagnosis in PMSMs under extreme noise

Kunxing Feng, Bitao Zhang, Zhipeng Lai

Abstract Reliable condition monitoring of permanent magnet synchronous motor (PMSM) encoders under extreme industrial noise remains a persistent challenge due to severe feature corruption. To address this, this paper proposes a Physics-Informed Multimodal Front-end Enhancement (PI-MFE) framework. The framework systematically internalizes physical priors as inductive biases into the feature extraction hierarchy to actively disentangle nonlinear noise distortions. For the electromagnetic modality, a Physics-Constrain …

02.09.2026journal-article

Brain Pathology

Clinical evaluation of the CrossNN DNA methylation classifier for central nervous system tumors

Jonas Dahnoun, Léon C. van Kempen, Senada Koljenović, Ken Op de Beeck, Tomas Menovsky, Bart Feyen, Melek Ahmed, Anne Sieben, Karen Zwaenepoel

Abstract DNA methylation profiling is an integral diagnostic tool in the classification of central nervous system (CNS) tumors. While the Heidelberg CNS Tumor Methylation Classifier is widely used to support CNS tumor diagnostics, new classifiers such as CrossNN are emerging. However, their clinical performance and added value within routine diagnostic workflows remain insufficiently explored. In this study, we evaluated the diagnostic performance of the CrossNN classifier in a real‐world CNS tumor cohort and compa …

02.09.2026journal-article

Medicina

Anterior Cruciate Ligament Reconstruction: Clinical Outcomes and Biomechanical Considerations of Graft Selection—A Narrative Review

Bogdan Huzum, Dan Viorel Cionca, Daniel Ciupilan, Cǎtǎlina Ionescu, Mihnea-Theodor Sîrbu, Malina Visternicu, Alin Ciobica, Oana Badulescu, Paul-Dan Sîrbu

Anterior cruciate ligament (ACL) reconstruction represents the current gold standard for restoring knee stability following ligament rupture, particularly in young and physically active individuals. The aim of this narrative review is to provide an updated overview of the biomechanical, biological, and clinical considerations underlying graft selection in ACL reconstruction, with particular emphasis on graft incorporation, fixation strategies, and postoperative outcomes. While surgical techniques and fixation devic …

02.09.2026journal-article

World Journal of Surgery

Extended D3 Mesenterectomy in Small Bowel Cancer Treatment: Feasibility and Importance for Staging. First Results of a Prospective Clinical Trial

Erik Kjæstad, Espen Thiis‐Evensen, Bjørn Edwin, Arne Olav Bakka, Anne Helene Lilleaas, Yngve Thorsen, Johannes Kurt Schultz

ABSTRACT Background There is no consensus on surgical techniques in small bowel cancer, particularly regarding the extent of lymph node dissection and strategic choices according to tumor localization and histological type. Clearance of central lymph node metastases can be challenging, especially when small intestinal neuroendocrine tumor (siNET) metastases give rise to fibrosis and desmoplasia around the cranial parts of the superior mesenteric vessels. The aim of this study was to assess the feasibility and stagi …

02.09.2026journal-article

Surgery Today

The impact of intraoperative small intestine arrangement on postoperative intestinal function recovery in patients with laparoscopic colectomy: A single-center, double-blinded, randomized controlled trial

Shengzhe Ma, Xiaoming Zhu, Zheng Lou, Zijian Zhou, Haifeng Gong, Yonggang Hong, Liqiang Hao, Guanyu Yu, Wei Zhang

Abstract Background This study aimed to evaluate the effect of small intestine arrangement on the bowel function after laparoscopic colectomy. Methods A total of 160 patients were randomly divided into two groups. The control group received conventional treatment, while the experimental group underwent small intestine arrangement. The primary outcome was the time to initial postoperative gas discharge. Results The experimental group showed a significant difference in the time of initial postoperative gas discharge …

02.09.2026journal-article

Journal of Pediatric Intensive Care

Multicenter Quality Improvement Project to Prevent Acute Kidney Injury after Pediatric Cardiac Surgery

Jamie S. Penk, Tara C. Cosgrove, Katja M. Gist, Mathew G. Clark, Samir Q. Latifi, Caroline A. Rodeman, Angela M. Jarden, Matt Barhight, Christina Laternser, Rajit K. Basu, David S. Cooper, Santiago Borasino, Catherine D. Krawczeski, Bradley S. Marino

Objective: Acute kidney injury (AKI) is common after pediatric cardiac surgery and is associated with morbidity. We hypothesized that the incidence and severity of AKI could be decreased by a bundle of preventative interventions. Our aim was to decrease the incidence of post-operative AKI from a baseline of 41% to

02.09.2026journal-article

Developmental Medicine & Child Neurology

Maternal depression as a mediator of preterm birth and child development

Ashish KC, Miriam Sophia Meier, Jaya Chandna, Lea Kreyenbaum, Carin Andrews, Omkar Basnet

Abstract Aim To assess the causal pathway between preterm birth and infant neurodevelopmental delay, with maternal depression as the mediator using a counterfactual mediation framework. Method A prospective cohort of 1253 mother–infant pairs were enrolled and followed up until 6 months in Nepal. Preterm birth was assessed using medical birth register; maternal depression and infant neurodevelopmental delay were assessed using maternal interview. Causal mediation analysis was performed using logistic regression mode …

02.09.2026journal-article

The Brown University Psychopharmacology Update

Therapeutic drug monitoring of sertraline and clinical response

Y. W. Francis Lam

Variability in drug exposure and response among individual patients can occur because of numerous factors, including age, sex, metabolic capacity, medication adherence, and the presence and magnitude of interactions with concurrently administered drugs. For decades, therapeutic drug monitoring with drug concentration determinations has been used to evaluate whether variability in drug exposure might be related to significant differences in therapeutic response to psychotropics (Hart et al., 2024; Kang & Lee, 2009).