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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Frontiers in Education

Older visitors’ acceptance of augmented-reality heritage interpretation: an extended technology acceptance model for informal cultural heritage learning

Xuejia Zhu, Suebsiri Saelee, Quan Wen

Augmented-reality (AR) interpretation is increasingly used to explain heritage buildings, yet its educational value depends on more than interface acceptance. This Hypothesis and Theory article proposes an extended technology acceptance model (TAM) for studying older visitors’ acceptance of AR heritage interpretation as an informal cultural heritage learning experience. The manuscript does not report a survey, experiment, interview, observation, usage log analysis, or any human participant dataset. Instead, it spec …

19.08.2026journal-article

International Journal For Multidisciplinary Research

The Influence of Artificial Aging on the Color Stability of Light Cure and Dual Cure Luting Cement

Ranveer Chauhan, Rajesh Kumar, Sunil MV, Manvendra Singh

Background: The long-term esthetic success of ceramic laminate veneer restorations largely depends on the color stability of the resin luting cement used for their cementation. Because ceramic veneers are thin and highly translucent, any discoloration of the underlying luting cement may become visible over time and compromise the final appearance of the restoration. Several factors, including the composition of the resin matrix, the type of polymerization, and water-related degradation, can influence the color stab …

19.08.2026journal-article

People and Nature

Spatio‐temporal patterns, associated factors and mitigation of tiger and leopard attacks on people in western Himalayas

Aman Deep Rathi, Keshab Gogoi, Rajiv Bhartari, Yadvendradev V. Jhala

Abstract Coexistence with large carnivores becomes extremely difficult in areas where there are large number of attacks on humans. An understanding of the factors that explain the spatio‐temporal context of such attacks would guide policy and management to mitigate conflict, conserve carnivores and assist coexistence. We use spatial locations of attacks by tigers ( n = 132) and leopards ( n = 1914) between 2000 and 2019 in the Himalayan state of Uttarakhand, India, to understand their seasonality, vulnerability of …

19.08.2026journal-article

Frontiers in Medicine

Comparative effectiveness of daytime versus nighttime paravertebral block analgesia on intraoperative hemodynamics in older lung cancer patients: a target trial emulation study

Qiang Wang, Lin Zhuo, Yue Zhang, Bowen Zhang, Kaibing Yang, Shijing Wei, Jingchao Yang, Xinwei Ma, Xiaolin Han, Hui Zheng, Yang Xu

Surgery remains the mainstay treatment for older patients with lung cancer, and paravertebral block (PVB) is recommended for perioperative analgesia. With the increasing surgical demand, a growing proportion of elective thoracic procedures in China are scheduled at night. Circadian variation, prolonged fasting, and resource limitations may affect intraoperative hemodynamics. However, the comparative hemodynamic safety of daytime versus nighttime PVB has not been systematically investigated. We emulated a target tri …

19.08.2026journal-article

Frontiers in Pharmacology

Multi-omics integration identifies a gut-microbiota-associated plasma metabolite signature for alzheimer disease diagnosis and metabolic pathway targeting

Jiao Chen, Xuhui Chen, Weiwei Yu, Ting Chen, Zhigang Liu, Jun Hu

Background Alzheimer’s disease (AD) is the leading cause of dementia, with early diagnosis remaining constrained by the invasiveness and limited accessibility of current biomarkers. The gut–brain axis has emerged as a critical communication network linking intestinal homeostasis with central nervous system function, yet the diagnostic utility of gut-microbiota-associated circulating metabolites in AD remains largely unexplored. Methods In this case-control study, 85 participants (37 AD patients and 48 cognitively n …

19.08.2026journal-article

Polymers

PEEK in Harsh Oil and Gas Environments: Applications and Chemical Aging Response

Wael Badeghaish, Ahmed Wagih, G. Lubineau

The oil and gas (O&G) industry is increasingly adopting non-metallic materials for pipelines and downhole components to mitigate corrosion, reduce maintenance costs, and improve performance in harsh service environments. Among high-performance polymers, polyether-ether-ketone (PEEK) has attracted significant attention owing to its excellent mechanical properties, thermal stability, and chemical resistance, making it a promising candidate for aggressive downhole applications. However, exposure to acids, hydrocarbons …

19.08.2026journal-article

Bioscience, Biotechnology, and Biochemistry

Azelaic Acid delays aging and prolongs lifespan via resisting oxidation stress mediated by IIS pathway coupling hsf-1 in C. elegans

Yang Chen, Liangliang Wang, Zixian Zhu, Beibei Pan, Juan Bai

Abstract Azelaic acid (AzA), an antioxidant and anti-inflammatory compound from cereals used in food preservatives and cosmetics, was investigated for anti-aging effects in Caenorhabditis elegans. AzA improved locomotive activities and muscle morphology during aging, extended lifespan under both normal and oxidative stress conditions, and reduced paralysis in neurodegenerative models. It decreased reactive oxygen species levels and enhanced superoxide dismutase (SOD) activity and SOD-3 protein expression. Quantitat …

19.08.2026journal-article

International Journal of Medical Science and Clinical Research Studies

Thirty-Day Functional Ambulation After Hip Fracture Surgery in Older Adults: A Single-Centre Retrospective Cohort Study

Michele Bisaccia, Francesco Bronzini, Marco Siragusano, Giuseppe Rinonapoli

Background: Regaining walking ability is a central patient-relevant outcome after hip fracture, but early recovery estimates are difficult to interpret when death and missing functional assessments are not reported separately. Objective: To describe 30-day functional ambulation, survival, and completeness of follow-up in older adults treated surgically for hip fracture at a single trauma centre. Methods: This retrospective cohort included 96 patients aged 65 years or older who underwent surgery for an intracapsular …

19.08.2026journal-article

JMIR Aging

Effect of an Intersectoral Telemedicine Intervention on Hospitalization in Nursing Home Patients: Specification Curve Analysis of a Stepped Wedge Cluster Randomized Trial

John Grosser, Sophie Pauge, Birthe Aufenberg, Wolfgang Greiner, Miriam Hertwig, Jenny Unterkofler, David Brücken, Christian Hübel, Optimal@NRW Research Group, Jörg Christian Brokmann

Abstract Background The use of emergency medical services in Germany has significantly increased, particularly for nonemergency cases. This issue becomes especially relevant for nursing homes, where staff is confronted with resource shortages and organizational challenges, making emergency medical services involvement a common course of action. This leads to potentially avoidable hospitalizations for nursing home residents and exposes them to severe health risks, such as nosocomial infections. To address this, we d …

19.08.2026journal-article

JAMA Surgery

Clinician Considerations Regarding Surgical Decision-Making in the Context of Dementia

Rachel R. Adler, Richard E. Chunga, Joely A. Centracchio, Zeba N. Ahmad, Karen R. Sepucha, Christina Sheu, Samir K. Shah, Clancy Clark, Dae Kim, Susan L. Mitchell, Emily Finlayson, Zara Cooper, John Hsu, Kellie L. Flood, Stephen Ryan, Tamara Flys, Adolph J. Yates, Sarah A. Wingfield, Anupama Gangavati, Joel S. Weissman, Lara Traeger

Importance Clinicians, people living with dementia (PLWD), and their caregivers face clinical, ethical, and psychosocial challenges when making surgical decisions. Objective To explore clinician experiences with surgical decision-making when a patient has dementia. Design, Setting, and Participants This qualitative study uses case studies compiled from interviews, surveys, and resource review across 12 sites and 178 clinicians. Interviews were conducted between November 2021 and May 2023, while analysis of intervie …

19.08.2026journal-article

Journal of Advanced Nursing

Surrogate Medical Decision‐Making in Dementia: A Theory‐Informed Integrative Review

Claire McGowan, Rick Zoucha, Melissa Kalarchian

ABSTRACT Aim To synthesize empirical evidence on decision‐making factors and emotional outcomes among surrogate medical decision‐makers for people with dementia. Design Integrative review. Methods A comprehensive search was conducted following Whittemore and Knafl's integrative review methodology. Eligible studies were appraised using the Mixed Methods Appraisal Tool and synthesized through inductive content analysis, guided by the Transactional Model of Stress and Coping. Data Sources PubMed, CINAHL, Embase, Scopu …

19.08.2026journal-article

Healthcare

Association Between Oral Function Limitation and Frailty-Related Functional Impairment in Older Koreans: An Analysis of KNHANES 2024

Mi Ra Lee

Background/Objectives: Oral function limitation (OFL) may be associated with functional decline in older adults, but evidence from nationally representative data remains limited. This study examined the association between OFL and frailty-related functional impairment among older Korean adults using data from the 2024 Korea National Health and Nutrition Examination Survey (KNHANES). Methods: This cross-sectional study included 1247 adults aged 65 years or older with complete data on chewing discomfort, speech disco …

19.08.2026journal-article

Environmental Toxicology

Comparing the Effects of Microplastics From Conventional Cigarette Butts and Heated Tobacco Device: The Role of UV ‐Induced Aging

Andraž Dolar, Veno Kononenko, Valentina Perc, Damjana Drobne, Gabriela Kalčíková, Jernej Imperl, Tina Skalar, Ula Rozman, Branka Mušič, Anita Jemec Kokalj

ABSTRACT Despite the widespread presence of cigarette butts in the environment, the potential toxicological effects posed by microplastics (MPs) derived from them remain poorly understood. In this study, we compared the effects of MPs from conventional cigarette butts (cellulose acetate) and heated tobacco devices (cellulose acetate and polylactic acid film), the latter being under‐investigated. We also compared their effects before and after UV‐accelerated aging. The most notable change in chemical properties of M …

19.08.2026journal-article

Drug and Alcohol Review

The Hidden Epidemic: Epidemiology of Acute Infections in People Who Inject Drugs in Fiji

Manisha Naidu, Yogeshni Chandra

ABSTRACT Introduction Injection drug use is an emerging challenge in Fiji and the Pacific region, where injection‐related infections may contribute substantially to morbidity, mortality and healthcare burden. However, data on the epidemiology and outcomes of these infections remain limited. Methods We conducted an observational cross‐sectional study among people who inject drugs admitted to hospital with infections over a 6‐month period. Data on infection type, injecting practices, substance use history, and releva …

19.08.2026journal-article

Endocrinology, Diabetes & Metabolism

Qualitative and Quantitative Health‐Related Quality‐of‐Life Outcomes From an 8‐year Follow‐Up After Gastric Bypass Surgery in People With Type 2 Diabetes

Giovanni Fanni, Petros Katsogiannos, Magnus Sundbom, Janeth Leksell, Eva Randell

ABSTRACT Background Obesity and Type 2 diabetes (T2D) impair health‐related quality of life (HRQoL) across metabolic, mechanical and mental domains. Gastric bypass surgery improves HRQoL in the short term, but long‐term trajectories remain insufficiently understood. This study evaluated HRQoL 8 years after gastric bypass in a cohort with T2D, integrating quantitative assessments with qualitative exploration of lived experiences. Methods Eleven individuals with obesity and T2D who underwent gastric bypass participat …

19.08.2026journal-article

Vaccines

Cost-Effectiveness Analysis of Older Adult Vaccination with the Bivalent Respiratory Syncytial Virus Prefusion F (RSVpreF) Vaccine in Mexico

Veronica Guajardo, Ali Shajarizadeh, Nishu Gaind, Luka Ivkovic, Rengina Kefalogianni, Diana Mendes

Background/Objectives: Respiratory syncytial virus (RSV) causes substantial morbidity and mortality in older adults, and in Mexico’s rapidly growing older-adult population it may place increasing pressure on hospital-based care; however, Mexico-specific evidence to inform adult RSV immunization policy remains limited. This study estimated the long-term clinical and economic burden of medically attended RSV among adults aged 60–99 years in Mexico and evaluated the health impact and cost-effectiveness of a year-round …

19.08.2026journal-article

Life

Integrative GWAS Catalog Analysis of Proxy-Trait Intersection in Sarcopenia-Related Musculoskeletal Aging with Multi-Criteria Evidence Integration

Hung-Wen Chen, Chen-Long Chen, Yao-Jen Liang, Yen-Lin Chen

Background: Sarcopenia is a multidimensional musculoskeletal-aging phenotype defined by reduced muscle quantity together with weakness and impaired performance, but public genetic resources rarely capture sarcopenia as a single uniformly labeled phenotype. Methods: Official National Human Genome Research Institute-European Bioinformatics Institute (NHGRI-EBI) genome-wide association studies (GWAS) Catalog association files archived locally on 15 April 2026 were grouped into muscle-quantity and function-frailty doma …

19.08.2026journal-article

Journal of the Chinese Medical Association

Urban–rural differences in health behaviors and cognition: Two Taiwanese older cohorts

Yu-Ruei Lin, Li-Ning Peng, Wei-Ju Lee, Liang-Kung Chen, Chih-Ping Chung

Background: Although urban–rural differences in dementia prevalence have been widely reported, little is known about whether vascular risk factors and health behaviors relate differently to cognitive function across urban and rural populations. This study investigated urban–rural differences in these factors and their associations with cognition. Methods: We analyzed data on demographics, vascular risk factors, lifestyle factors, laboratory measures, and comprehensive neuropsychological assessments. Suboptimal cogn …

19.08.2026journal-article

Hypertension

Blood Pressure Variability and Alzheimer Disease Biomarkers

Trevor Lohman, Isabel Sible, Yuan Ma, Niema M. Pahlevan, Daniel A. Nation

Increased blood pressure variability (BPV) is associated with increased risk for dementia, independent of hypertension. The increased risk for dementia associated with high BPV includes probable Alzheimer disease (AD) dementia, but high BPV is also associated with increased risk of stroke and cerebral small vessel disease, which are commonly comorbid with AD. This raises the question of whether high BPV is independently predictive of AD-specific pathophysiology and neurodegeneration, which could have significant cl …

19.08.2026journal-article

Current Alzheimer Research

The Relationship Between Biomarkers in Blood and Urine and Alzheimer's Disease and Sleep Disorders (Long Sleep): A Mendelian Randomization Study

Jianran Ma, Zhen Wei, Chunshu Rong, Wei He, Xu Wang, Dexi Zhao

Introduction: Alzheimer's Disease (AD) is a neurological condition that increases in severity from a gradual start. Previous studies have found an association between long sleep (LS) and AD. To slow its progression, it is important to recognize biomarkers associated with the early stages of both AD and LS. Methods: This study aimed to use two-sample Mendelian Randomization (MR) to identify blood and urine biomarkers associated with AD and LS. Thirty-five biomarkers from blood and urine were included as exposures in …

19.08.2026journal-article

Behavioral Sciences

A “Lightweight” Support Circle: How Urban Chinese Older Adults Reconfigure Online Peripheral Ties Through Low-Cost Digital Practices

Huijun Wu, Yan Ge

Although peripheral ties are essential for social integration, traditional aging theories suggest that they naturally atrophy as older adults withdraw from physical social settings and prioritize intimate relationships. Digital technologies, however, offer new affordances that enable older adults to actively sustain such ties. Through six online focus groups with 32 older Chinese WeChat users (aged 55–74), this study examines how older adults manage their peripheral networks in the digital environment. Three findin …

19.08.2026journal-article

Nutrients

Vitamin C as a Potential Geroprotector: Interactions with Aging Hallmarks and Implications for Healthy Longevity

Diána Bodó, Ferenc Jójárt, Rebeka Jójárt, Dezső Csupor, Barbara Tóth

Vitamin C (L-ascorbic acid) is an essential micronutrient with established roles in antioxidant defense, epigenetic regulation, collagen synthesis, redox signaling, immune modulation, and cellular stress responses. This narrative review critically evaluates the potential role of vitamin C as a modulator of the hallmarks of aging. Although mechanistic studies suggest that vitamin C influences gene expression, inflammatory regulation, mitochondrial function, and cellular stress adaptation, the available evidence rema …

19.08.2026journal-article

Psychology and Education: A Multidisciplinary Journal

Challenges Experienced by Indigenous People (IP) Learners and Their School Performance

Cherielyn Rabong, Edna Curayag

This study was conducted to find the extent of poverty experienced by Indigenous people in Pinamula Integrated School and learners' school performance. It followed the descriptive-correlational research design. It was conducted in Pinamula Integrated School, Kibawe East District, Division of Bukidnon, SY 2023-2024. The respondents were the indigenous people learners studying in the said locale who were selected through Purposive Sampling. This study used a researcher-made survey questionnaire as the instrument to g …

19.08.2026journal-article

Общество: политика, экономика, право

Key Models of Political Communication among Young People in the Context of Digitalization

Konstantin P. Kurylev, Marina N. Moseykina, Sergey A. Stepanov, Zhibek S. Syzdykova

The article formulates the main factors determining the construction of political communication among young people today. In this regard, some modern conditions, in which the formation of a civic position and political socialization of the younger generation takes place, are identified as well. First, these are the processes of in-formatization, digitalization, psychological destructurization, and manipulation that explane certain problems and potential conflicts, additionally determine the ideological, value, and …