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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

Features of coping and communication strategies in oncological medical workers

Aklima Sultanova, Sergey Bublik, Irina Kudrina

The article provides an analytical review of coping strategies and communicative competencies among medical professionals working in the field of oncology. The role of professional communication in the doctor-patient relationship as a factor affecting the psychoemotional state of both parties is examined. The main models of interaction and typical patterns of coping behavior among medical professionals under conditions of chronic stress are analyzed. The article identifies a contradiction between the need for psych …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

Differential diagnosis of premorbid and posttraumatic personality changes in patients with spinal cord injury: an interdisciplinary approach

Svetlana Samara

In modern rehabilitation, the position that the psychological status of a patient after spinal cord injury (SCI) and other neurological disorders is not just a concomitant factor, but a critical modulator of neuroplasticity, motor learning and functional outcome, is increasingly recognized. Inaccurate or delayed diagnosis of affective, cognitive, and somatoform disorders leads to the formation of a "recovery plateau," which can be mistakenly interpreted as the depletion of neurobiological reserves. This article hig …

26.08.2026journal-article

Journal of Oral Rehabilitation

Understanding Diagnostic Failure in Temporomandibular Disorders: A Narrative Synthesis of Evidence and Five‐Domain Framework for Iatrogenic Mismanagement

Bernardo Correia Lima, Rayan Eboli Fortunato, Leonardo Metello Brigido Metello, Ricardo Grillo, Mariana Aparedida Brozoski, Fernando Melhem‐Elias, Janey Prodoehl, Louis G. Mercuri

ABSTRACT Background Diagnostic errors in temporomandibular disorders (TMDs) contribute to unnecessary procedures and avoidable patient mismanagement despite advances in pain science, diagnostic classification systems, and evidence‐based care. Objective To conduct a narrative review and present a dynamic, five‐domain framework explaining how diagnostic uncertainty interacts with educational, cognitive, systemic, and ethical factors to produce iatrogenic overtreatment. Methods Searches of PubMed, Scopus, Web of Scien …

26.08.2026journal-article

Annals of Clinical and Translational Neurology

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang

ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring disease activity. Methods 111 samples from 65 AQP4 ‐ IgG + NMOSD patients were enrolled in this prospective study for serological analysis of C1q, C5a, sC5b ‐9, CH50 …

26.08.2026journal-article

Almanac of Clinical Medicine

Ethnic variability of pharmacogenetic TPMT and NUDT15 variants in Russian populations: Implications for personalized thiopurine therapy

Irina R. Gilyazova, Alexandra S. Karunas, Marina A. Bermisheva, Askar A. Akhmetshin, Alfia E. Pushkareva, Natalia V. Ekomasova, Murat A. Dzhaubermezov, Irina M. Khidiyatova, Elza K. Khusnutdinova

Background: Thiopurines, including azathioprine and 6-mercaptopurine, are widely used in the treatment of inflammatory and autoimmune diseases, as well as hematological malignancies; however, their use is limited by the risk of severe myelosuppression. Pharmacogenetic variants in the TPMT and NUDT15 genes significantly affect drug tolerability, and their frequencies vary markedly across ethnic groups, making population-based studies of these markers in different regions of Russia particularly important. Aim: To ass …

26.08.2026journal-article

Cytotherapy and Longevity

Effects of Antidiabetic Drugs on Longevity and Healthspan: Evidence and Controversies From Glucose-Lowering Therapy to Anti-Aging Intervention

Xuancheng Zhou, Xinguo Hou

Diabetes provides a clinically visible model of accelerated biological aging. Sustained hyperglycemia, insulin resistance, chronic low-grade inflammation, mitochondrial stress, and endothelial injury converge to increase the burden of cardiovascular disease, chronic kidney disease, neurodegeneration, sarcopenia, and frailty, thereby compressing both survival time and years lived with preserved function. For this reason, evaluation of glucose-lowering drugs can no longer be restricted to HbA1c reduction alone. Morta …

26.08.2026journal-article

Journal of Clinical Medicine

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

Nafay Abdul, Milan Patel, Rohit Aiyer, Manuel Lomeli, Kalvin Chen, Alan D. Kaye, Giuliano Lo Bianco, Alaa Abd-Elsayed

Chronic pain continues to be a major global health burden and is frequently refractory to conventional pharmacologic and conservative therapies. Spinal cord stimulation (SCS) has emerged as an important neuromodulatory treatment for selected patients with chronic neuropathic and mixed pain syndromes. Since its introduction in the 1960s, SCS has evolved from paresthesia-based tonic stimulation into more adaptive and personalized neuromodulation. This review summarizes the current evidence regarding the mechanisms, c …

26.08.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

Mechanical Reliability of Hospital Oxygen Supply Systems and Its Impact on Respiratory Therapy

Saeed Mubarak Almatir, Abdulaziz Mohammed Alghamdi, Abdulrahman Marzaq Alotaibi, Omar Hassan Harisi, Awadh Ali Alshehri, Mohammed Yousef Alhazmi, Mohammed Alasmari, Ahmed Saeed Abdullah Alqahtani

Hospital oxygen supply systems are critical components of healthcare infrastructure, particularly in intensive care units (ICUs), emergency departments, operating rooms, neonatal units, and respiratory therapy services. The reliability of these systems depends on the coordinated performance of oxygen sources, storage facilities, pressure regulation devices, pipeline networks, valves, alarms, terminal units, and backup systems. Mechanical failures at any point in the oxygen delivery chain may result in pressure inst …

26.08.2026journal-article

Canadian Diabetes & Endocrinology Today

Losing Weight, Losing Muscle? Muscle Health During GLP-1-Based Obesity Therapy

Michael Tsoukas

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and related nutrient-stimulated hormone (NuSH) therapies have transformed obesity pharmacotherapy, delivering weight loss approaching that seen with bariatric surgery. However, concerns have emerged regarding loss of fat‑free mass, skeletal muscle mass, and possible sarcopenia. Reductions in lean mass occur during treatment with semaglutide and tirzepatide, but these changes are generally proportional to total weight loss and occur alongside greater reductions in …

26.08.2026journal-article

Frontiers in Psychiatry

Advancing equity in perinatal PTSD: a systemic trauma framework for written exposure therapy

Tiffany R. Williams, Joanne K. Daggy, David M. Haas

This article applies a systemic trauma framework to perinatal PTSD and advances Written Exposure Therapy as a scalable, equity-aligned intervention that can be integrated into routine perinatal care pathways, addressing critical gaps in current obstetric and mental health systems. Perinatal posttraumatic stress disorder (PTSD) affects ~9% of pregnant and postpartum individuals in the United States, with another 18% at elevated risk, yet it remains inconsistently identified in clinic care. From a systemic trauma per …

26.08.2026journal-article

Annals of Hematology

Comparison of time to therapy initiation, therapeutic strategies and survival in patients with MDS IB1, IB2 and AML-MR using data of the duesseldorf registries

Felicitas Schulz, Catharina Mundt, Annika Kasprzak, Paul Jaeger, Andrea Kuendgen, Corinna Strupp, Norbert Gattermann, Kathrin Nachtkamp, Sascha Dietrich, Guido Kobbe, Ulrich Germing

Abstract In 2022, the ICC redefined AML by lowering marrow blast count to 10% herewith integrating former MDS IB2 into AML. To evaluate the clinical implications of this reclassification, we analyzed data of our Duesseldorf registries regarding different aspects in patients with MDS IB1, IB2 or AML-MR and included 928 patients suffering from IB1 (213 patients), IB2 (279 patients) and AML-MR (436 patients). We analyzed time to initiation of treatment as well as treatment strategies and survival times. Time to initia …

26.08.2026journal-article

Alimentary Pharmacology & Therapeutics

Clinical Trial: Intensive Supervised Nutritional Therapy Versus Guideline‐Based Nutritional Advice for Sarcopenia in Decompensated Cirrhosis—A Randomised Controlled Trial

Gireesh Kumar Dhaked, Prabhat Narain Sharma, Kamlesh Kumar Sharma, Sudhir Maharshi, Shubham Agrawal, Rupesh Pokharna, Sandeep Nijhawan, Shyam Sunder Sharma

ABSTRACT Background Sarcopenia is highly prevalent in decompensated cirrhosis and independently predicts adverse outcomes. Although nutritional therapy is guideline‐recommended, evidence comparing specialist dietitian‐supervised nutritional care with routine physician‐delivered dietary advice remains limited. Aim To compare the efficacy of dietitian‐supervised intensive nutritional therapy with physician‐led guideline‐based dietary advice for improving skeletal muscle mass, strength and physical performance in pati …

26.08.2026journal-article

Drug and Alcohol Review

Implementing Prolonged Exposure Therapy in a Community Substance Use Treatment Program: A Qualitative Study

Steven Curto, Tasha Bulgin, Jordan A. Gette, Margaret Swarbrick, Angela Gonnella, Denise Hien, Sonya B. Norman, Shannon M. Kehle‐Forbes

ABSTRACT Introduction Post‐traumatic stress disorder (PTSD) commonly co‐occurs with substance use disorders (SUD), yet few community‐based SUD programs incorporate evidence‐based trauma‐focused. Prolonged exposure (PE), including its massed format (M‐PE) with session frequency of 3–4 times per week, is a gold standard intervention for PTSD; however, concerns about client readiness, logistical demands and relapse risk have limited its adoption within SUD settings. This study examined staff perspectives on the feasib …

26.08.2026journal-article

Physics in Medicine & Biology

Laser-driven particle accelerators for cancer therapy: a review of state-of-the-art techniques, challenges and opportunities

Roumani Alabd, Daniel R Franklin

Abstract Charged particle radiation therapy (such as electron, proton and heavy ion therapies) is presently delivered via large linear or circular electromagnetic particle accelerators. There is growing interest in laser plasma accelerators as an alternative source for therapeutic charged particle radiation, including protons, carbon ions, and very high energy electrons. Laser plasma accelerators offer the potential for extremely high dose rates in a very compact physical footprint. While these radiation sources ad …

26.08.2026journal-article

Seminars in Speech and Language

Group Education for Future Healthcare Professionals on Aphasia and Communication Partner Strategies

Corri Newman, Erin L. O'Bryan, Imran Musaji, Douglas F. Parham, Jamie Harrington

Abstract Many healthcare professionals receive little to no training in communicating with individuals with aphasia, which can negatively affect patient participation and quality of care. Communication partner training (CPT), including Supported Conversation for Adults with Aphasia (SCA), has demonstrated benefits, but many established training models rely on multi-component or resource-intensive formats. This study examined whether future healthcare professionals could acquire knowledge of aphasia and supported co …

26.08.2026journal-article

Journal of Oral Rehabilitation

Association Between Oral Function and Obstructive Sleep Apnea in Elderly Patients: A Cross‐Sectional Study Using Home Sleep Apnea Testing

Yuki Sakamoto, Shunsuke Sawada, Yuka Kojima

ABSTRACT Objective Obstructive sleep apnea (OSA) is common among elderly individuals and is associated with various systemic diseases. While obesity and craniofacial morphology are established risk factors, age‐related decline in oral and pharyngeal muscle function may also contribute to OSA development in older adults. However, the relationship between OSA and oral function in elderly patients remains insufficiently investigated. Methods This cross‐sectional study enrolled 40 patients aged ≥ 65 years who visited t …

26.08.2026journal-article

Current Oncology

DNA Damage Response Alterations Stratify Response to ICI-Based Therapy in Advanced NSCLC with High PD-L1 Expression

Fang Hao, Linlin Zhang, Diansheng Zhong

Background: Although high PD-L1 expression correlates with improved outcomes to immune checkpoint inhibitor (ICI), it remains an imperfect predictive biomarker. DNA damage response (DDR) pathway alterations are closely associated with antitumor immunity, shaping tumor immunogenicity and the immune microenvironment. This study evaluates the distribution and clinical impact of DDR alterations in advanced Non-small cell lung cancer (NSCLC) with Programmed death-ligand 1 (PD-L1) ≥ 50%, providing insights for personaliz …

26.08.2026journal-article

Canadian Diabetes & Endocrinology Today

Cardiovascular Risk with Gender‑Affirming Hormone Therapy

Irena Druce

Gender incongruence refers to a persistent mismatch between an individual’s experienced gender and the sex assigned at birth. While modern terminology is recent, descriptions of gender variance date back to antiquity, including writings attributed to Hippocrates. By the 7th century, Paul of Aegina, in his Medical Compendium, described surgical procedures aimed at modifying sex characteristics. While these early interventions were not grounded in a modern understanding of gender identity, they reflect attempts to ad …

26.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Artificial intelligence responses to toilet training questions: A reliability and readability analysis of ChatGPT and gemini applications

Ayşegül Sarıkaya, Ayşe Alptekin

Background Toilet training is a critical developmental milestone that may have long-term implications for children's psychosocial development if improperly guided. With the increasing use of artificial intelligence (AI) chatbot applications for health-related information, evaluating the reliability and readability of AI-generated guidance on sensitive developmental topics has become essential. Objective This study aimed to evaluate the reliability and readability of responses provided by AI chatbot applications reg …

26.08.2026journal-article

Russian Bulletin of Obstetrician-Gynecologist

The influence of socio-psychological factors, adverse effects of hormone therapy on the refusal of patients from its implementation or interruption of therapy after surgical treatment of ovarian endometriosis

E.Yu. Zhilnio, I.A. Salov, V.M. Kuleshov, Yu.V. Naumova

Objective. To analyze the role of socio-psychological factors and undesirable effects of hormone therapy on the patient’s refusal to undergo it or discontinue therapy after surgical treatment for ovarian endometriosis. Materials and methods. A prospective study is presented in which the frequency of refusals of patients and the frequency of interruption of anti-relapse hormone therapy after surgical treatment for ovarian endometriosis in the gynecological department of Saratov City Clinical Hospital No. 8 during th …

26.08.2026journal-article

Eurasian Journal of Medicine and Oncology

Сirculating DNA markers for assessing antitumor therapy efficacy and monitoring metastatic colorectal cancer

Anastasia Ponomaryova, Dmitry Kostromitsky, Anna Tarasova, Elena Rykova, Alexey Dobrodeev, Ulyana Zhilenkova, Sergey Afanasiev, Nadezhda Cherdyntseva

Introduction: Colorectal cancer remains one of the leading causes of oncological morbidity and mortality. Aberrant methylation patterns of tumor-suppressor genes and oncogenes have been detected in circulating DNA isolated from the blood of cancer patients, suggesting their potential utility as diagnostic and prognostic markers. Objective: To evaluate changes in the methylation levels of VIM, SEPTIN9, and DCC genes in cell-surface-bound cell-free DNA (csb-cfDNA) from the blood of metastatic colorectal cancer (mCRC) …

26.08.2026journal-article

Journal of Advances in Medical and Pharmaceutical Sciences

Osteogenesis Imperfecta from Historical Nosology to Gene-directed Therapy: A Critical Narrative Review of Mechanism, Evidence and Translational Uncertainty

Stefan Bittmann, Elisabeth Luchter, Elena Moschüring-Alieva

Osteogenesis imperfecta is the prototypical heritable disorder of bone fragility, and the last three decades have transformed it from a clinically defined syndrome into a molecularly stratified group of conditions involving more than twenty genes. That transformation has not been matched by comparable progress in classification, outcome measurement or therapeutic evidence, and the resulting mismatch is the central concern of this review. The purpose of the article is to evaluate critically how historical nosology, …

26.08.2026journal-article

Biologics

Longitudinal FIB-4 and APRI Monitoring in Psoriatic Arthritis: Associations with Cumulative Methotrexate Exposure and Biologic Therapy Class

Mehmet Serkan Kılıçoğlu, Safa El Mardi Alaoui, Ozan Volkan Yurdakul, Ayşegül Yabacı Tak, Teoman Aydın

Background: Psoriatic arthritis (PsA) is associated with hepatic risk, but longitudinal data during methotrexate (MTX) and biologic therapy are limited. We evaluated two-year changes in age-fixed FIB-4 and APRI and their associations with cumulative MTX exposure and biologic class. Methods: This retrospective cohort included 74 patients receiving continuous biologic therapy for 24 months. Baseline age was used to calculate FIB-4 at both time points. Logistic regression assessed factors associated with FIB-4 ≥ 1.3 a …

26.08.2026journal-article

Pedagogy. Theory & Practice

Historical and pedagogical analysis of value and goal orientations in speech therapist training in the context of the development of Russian special education

Elena Valeryevna Koryakova, Elena Valentinovna Kondratenko

The purpose of the study is to identify, through an analysis of historical trends, the value and goal orientations in the development of the Russian system of professional training for speech therapists aimed at providing psychological and pedagogical support to students with disabilities. The article presents a historical periodization of the genesis of value and goal orientations in speech therapist training in Russia (10th century – early 21st century): 1) the religious and charitable stage (10th-17th centuries) …