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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

Focus Localis

Osallisuus ja siihen yhteydessä olevat tekijät yksin asuvien ikääntyneiden kuvauksissa

Aino Asunmaa, Hanna Ristolainen, Jenni Kulmala, Elisa Tiilikainen

Strengthening social inclusion of older people has been defined as an important social policy goal, but little is known about older people's own views and experiences of inclusion. The study examines how social inclusion, and its conditions are expressed by older people living at home and which factors are related to the experience of inclusion. Data were derived from group discussions (n=4) including a total of 19 older people aged 70 and over living alone. The results show that inclusion is a multifaceted experie …

20.08.2026journal-article

international journal of advanced research in computer science

INVESTIGATING LINK-STATE ADVERTISEMENT AGING IN OSPF FOR NETWORK FAULT DIAGNOSIS

Amit Sharma

Open Shortest Path First (OSPF) utilizes Link-State Advertisements (LSAs) to keep precise information about network topology. This research empirically examines the aging behavior of LSAs and their significance in diagnosing faults within OSPF networks. In a simulated OSPF environment, different fault scenarios including link failures, adjacency instability, and inconsistencies within the database are introduced and assessed based on LSA age variations among various LSA types. The findings indicate that unusual agi …

20.08.2026journal-article

Journal of General Internal Medicine

Bridging Social Determinants of Health and Multidimensional Frailty Among Older Adults: A Domain-Specific Latent Class and Network Analysis

Ying Gao, Denise Shuk Ting Cheung, Pui Hing Chau

Abstract Background Social determinants of health (SDoH) are increasingly recognized as key contributors to frailty, yet their multidimensional associations remain underexplored. This study examined how multiple SDoH domains and specific variables relate to distinct frailty domains among Chinese community-dwelling older adults. Methods We analyzed 10,654 adults aged ≥ 60 years in the 2020 China Health and Retirement Longitudinal Study. Five SDoH domains, defined by the Healthy People 2030 framework, were assessed: …

20.08.2026journal-article

Annals of Clinical Endocrinology and Metabolism

Risk Factors and Their Impact on Diabetes Mellitus in Elderly People

Bilić-Komarica Edina

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and disrupted carbohydrate, fat, and protein metabolism, representing a growing health issue in Bosnia and Herzegovina, particularly among the elderly. This study evaluated the accumulation and distribution of identified risk factors among 108 elderly patients with type 2 diabetes (54 females and 54 males) treated at the Clinical Center University of Sarajevo. Evaluated risk factors included age, sex, hyperlipidemia, adiposity, family …

20.08.2026journal-article

Nuclear Medicine Communications

Whole body fluorine-18 fluorodeoxyglucose parametric PET/computed tomography in people with long coronavirus disease: the ERASE-LC trial protocol

Hairil Rashmizal Abdul Razak, W. David Strain, Patrick Rogers, Mark A. Faghy, Lindsay Skipper, Sascha H. Kranen, Kinan Mokbel, Tom Bewick, Ruth Ashton, Kayle-Anne Sands, Helen Neilens, Amber Lord, Helen Hambly, Jade Chynoweth, Victoria Allgar, Michelle Scott-Cleasby, Jackie Hoare, Karen M. Knapp

The ERASE-LC feasibility trial will evaluate the feasibility of using remdesivir for the treatment of long coronavirus disease (COVID) with a wide range of outcome measures. This paper focuses on the nested parametric PET/computed tomography study and outlines the novel protocol utilized. The PET/computed tomography scans will be performed at one of the sites in 20 participants with an overall recruitment target of 72 participants across both centers. The PET/computed tomography scans will be performed at day 11 fo …

20.08.2026journal-article

Tạp chí Y học Dự phòng

Tình hình và yếu tố liên quan đến tiêm ngừa vắc xin của người cao tuổi tại phường Ô Môn, thành phố Cần Thơ năm 2025

Minh Hữu Lê, Hoàng Hiếu Lê, Anh Thư Huỳnh, Thị Mỹ Như Trịnh, Hoàng Hải Lê, Uyên Nhi Đoàn Võ

Tiêm ngừa vắc xin đóng vai trò quan trọng cho người cao tuổi. Trên thế giới và tại Việt Nam đều có khuyếnnghị tiêm ngừa vắc xin hàng năm cho tất cả những người từ 60 tuổi trở lên. Mục tiêu nghiên cứu nhằmxác định tỷ lệ tiêm ngừa và mô tả một số yếu tố liên quan đến tiêm ngừa vắc xin của người từ 60 tuổi trởlên tại phường Ô Môn, Thành phố Cần Thơ năm 2025. Nghiên cứu cắt ngang mô tả có phân tích trên 420người từ 60 tuổi trở lên tại địa bàn nghiên cứu. Các thông tin thu thập: đặc điểm dân số - xã hội, tình hìnhtiêm c …

20.08.2026journal-article

European Geriatric Medicine

Integrated rehabilitation and ambulatory recovery in older adults with hip fracture according to muscle strength and sarcopenia status: a secondary analysis of a randomized controlled trial

Seung-Kyu Lim, Jae-Young Lim

Abstract Purpose Sarcopenia and impaired muscle strength are common in older adults with hip fractures and are strongly associated with poor functional recovery. Although integrated multidisciplinary rehabilitation improves outcomes after hip fracture, whether its benefits differ according to baseline muscle strength or sarcopenia severity remains unclear. This study aimed to examine whether the functional benefits of Fragility Fracture Integrated Rehabilitation Management (FIRM) vary according to sarcopenia status …

20.08.2026journal-article

Applied Cognitive Psychology

Do Momentary Stress and Busyness Predict Naturalistic Prospective Memory Differently in Younger and Older Adults?

Nicola Ballhausen, Maximilian Haas

ABSTRACT Everyday prospective memory (PM), such as remembering medication intake or appointments, is crucial for independence and quality of life, especially in older age. However, little is known about how momentary stress and busyness as contextual factors differentially affect naturalistic PM. Forty younger (18–27 years) and 40 older adults (60–84 years) completed a 14‐day ambulatory assessment of various naturalistic PM tasks, alongside time‐contingent reports of stress and busyness. Multilevel structural equat …

20.08.2026journal-article

Frontiers in Aging Neuroscience

Layered classification in Parkinson’s disease: a content analysis of clinical, prodromal, and biological criteria evolution

Aishanjiang Yusufujiang, Shan Zeng, Hongyan Li

Background Parkinson’s disease (PD) is no longer described through a single diagnostic vocabulary. Clinical criteria, prodromal probability models, and biological research classifications now operate in parallel after the 2024 NSD-ISS and SynNeurGe proposals. Objective To clarify how major PD criteria and research frameworks have justified diagnostic change and redistributed the roles of clinical signs, biomarkers, genetics, and prodromal markers. Methods We conducted a targeted document-based qualitative content a …

20.08.2026journal-article

eLife

Multiple molecular pathways to longevity with opposing gene expression programs defining distinct aging strategies in Caenorhabditis elegans

Zenith D Rudich, Jiaxi Guan, Aura A Tamez Gonzalez, Grant F Booth, Sonja K Soo, Ulrich Anglas, Meeta Mistry, Megan M Senchuk, Jeremy M Van Raamsdonk

While aging is the greatest risk factor for the development of neurodegenerative disease, the role of aging in these diseases is poorly understood. Our previous work has shown that targeting aging pathways can be neuroprotective in animal models of neurodegenerative disease. Based on these findings, we believe that by gaining insight into the aging process that knowledge can be applied to identify novel therapeutic targets for neurodegenerative disease. To advance our understanding of aging, we used a genomics appr …

20.08.2026journal-article

npj Aging

Sex differences in aging acceleration: higher susceptibility in women, greater preventability in men

Ziye Ren, Shuiyue Quan, Fangyu Li, Longfei Jia

Abstract Aging acceleration contributes to heterogeneity of chronic disease risk and mortality; however, the sex differences of its risk factors and population attributable fractions (PAFs) remain poorly characterized. We conducted an exposure-wide association analysis (ExWAS) among 236,099 UK Biobank participants and examined sex differences in exposure factors of aging acceleration and corresponding PAFs. Our results indicated that environmental exposures, lifestyles, early-life factors, psychosocial factors, and …

20.08.2026journal-article

Frontiers in Psychiatry

Machine learning-based identification of anxiety symptoms in Chinese community-dwelling older adults: a comparative study of six algorithms with SHAP analysis and nomogram development

Peiyue Li, Chunxiao Yan, Jianbo Li, Qimi Zheng, Huiqi Zhang

Background Anxiety disorders are common among older adults but remain underrecognized in community settings, particularly in China where mental health resources are scarce. This study aimed to develop and compare multiple machine learning models for identifying anxiety symptoms in Chinese community-dwelling older adults and to construct a practical clinical tool. Methods A cross-sectional study included 5,331 community-dwelling older adults (aged ≥65 years) from Shenzhen, China. Anxiety symptoms were assessed using …

20.08.2026journal-article

Frontiers in Public Health

Effects of qigong and resistance exercise on improving balance and cognitive ability of community-dwelling older adults

Wen Fu, Li Zhang, Yu Liao, Qi Zheng, Xiaolei Peng, Jiayu Zou, Tingjin Duan, Xiaochun Chen

Background To address the challenges posed by an aging society and reduce the incidence of falls and cognitive decline, there is a need for scientifically validated training methods that enhance both balance and cognitive function in older adults. Objective To evaluate and compare the effects of Baduanjin and Resistance Band training on improving balance and cognitive function in community-dwelling older adults. Methods A total of 93 community-dwelling older adults (mean age: 64.86 ± 3.13 years) were assigned accor …

20.08.2026journal-article

Frontiers in Public Health

Effects of Tai Chi-based combined interventions on muscle function, muscle mass, and physical performance in older adults with sarcopenia, frailty, or risk of functional decline: a systematic review and meta-analysis

Xudong Jin, Enliang Hu, Caiduo Shi

Background and objective Sarcopenia and frailty involve declines in muscle strength, muscle mass, and physical performance, and single Tai Chi may be insufficient to cover all functional needs. Tai Chi-based combined interventions have emerged, but their overall effects remain unclear. This study evaluated their effects in older adults with sarcopenia, frailty, or risk of functional decline. Methods We systematically searched PubMed, Embase, CENTRAL, Web of Science, Scopus, CINAHL, ClinicalTrials.gov , CNKI, Wanfan …

20.08.2026journal-article

Zoo Biology

The Responsibility of Zoos to Advance the Rights and Interests of Indigenous People

Jack Pascoe, Sally Sherwen

ABSTRACT The Earth is in its 6th mass extinction event, in 2022, in response to this crisis, 196 countries adopted the Kunming–Montreal Global Biodiversity Framework (GBF), a legally binding international agreement that aims to halt and reverse the trajectory of biodiversity loss by 2030. It is clear that Zoos have a role to play in this conservation effort; however, there has been less guidance for zoo and regarding how they can support the rights of Indigenous Peoples within this movement. In this paper, we explo …

20.08.2026journal-article

AGING MEDICINE

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

Xiaoming Wang, Cuntai Zhang

ABSTRACT Dysregulation of the renin‐angiotensin‐aldosterone system (RAAS) constitutes a pivotal factor in the onset and progression of various geriatric diseases, including cardiovascular diseases, diabetes, and chronic kidney disease (CKD), all closely linked to adverse cardiorenal outcomes in older patients. Excessive activation of the mineralocorticoid receptor (MR) drives inflammation, fibrosis, and oxidative stress across tissues and organs, representing a fundamental mechanism underlying systemic metabolic di …

20.08.2026journal-article

BMC Urology

Preoperative frailty and multidimensional concurrent correlates among older adults scheduled for radical cystectomy: a social ecological model-informed cross-sectional study

Yanhong Yan, Lina Wang, Yuehong Zhou, Xuejing Wang, Qiaoling Jiang, Ting Lu, Haiyan Ma, Jian Qian

Abstract Background Frailty is common in older adults considered for radical cystectomy (RC), but the nutritional, muscular, functional, psychological, behavioral, and social features that accompany frailty before surgery remain incompletely characterized. Using the Social Ecological Model as an organizational framework, we estimated frailty prevalence and examined concurrent correlates among older adults scheduled for RC. Methods This single-center cross-sectional study consecutively screened 151 adults aged 65 ye …

20.08.2026journal-article

Journal of Leukocyte Biology

Circulating platelet-natural killer cell complexes are elevated in people living with human immunodeficiency virus on antiretroviral therapy

Brita Ostermeier, Amber Douglass, Tomas Raul Wiche Salinas, Sanchita Pandey, Cheryl Clarkson-Paredes, Gregory M Cresswell, Anastas Propratiloff, Marc Siegel, Conrad Russell Y Cruz, Mirko Paiardini, Sanjay B Maggirwar

Abstract Natural killer (NK) cells stand as a critical pillar in the innate immune defense against viral infections, particularly human immunodeficiency virus (HIV). However, during HIV infection, NK cells demonstrate profound dysfunction, undermining effective immune control and accelerating disease progression along with viral persistence. Understanding the mechanisms driving NK cell dysfunction is essential for the development of innovative therapeutic strategies. This study reveals a significant increase in cir …

20.08.2026journal-article

BMC Infectious Diseases

People living with HIV and proportion diagnosed in Aotearoa New Zealand: first published national estimates from two modelling approaches

Julia Scott, Andrew Anglemyer, Susan McAllister, Jason J. Ong, Peter Saxton

Abstract Background Aotearoa New Zealand (NZ) is a country of low HIV incidence and prevalence where men who have sex with men (MSM) are most affected, and indigenous Māori inequitably affected by late diagnosis. NZ aims for 95% of people living with HIV (PLWH) diagnosed. We estimated PLWH and proportion (%) diagnosed in 2024 using two mathematical models; the first estimate by local researchers. Methods We used the European Centre for Disease Prevention and Control (ECDC) HIV Modelling tool and Spectrum Case Surve …

20.08.2026journal-article

Addiction

Prescribed alternative stimulants among people who use unregulated stimulants: Examining the association between maximum dose reached and medication discontinuation in the first 3 years of implementation in British Columbia, Canada

Bin Zhao, Kevin Hu, Roshni Desai, Shania Au, Kali‐olt Sedgemore, Vitor Tardelli, Addie Carter, Paxton Bach, Christian Schutz, Amanda Slaunwhite, Alexis Crabtree, Heather Palis

Abstract Background and aims In 2020, British Columbia (BC), Canada, introduced ‘Prescribed Alternatives’ (PA) as an approach to offering regulated substances to people accessing the unregulated supply. This study aimed to estimate and compare prescribing characteristics of dextroamphetamine and methylphenidate stimulant PAs in BC, to estimate medication discontinuation probabilities for each PA type by episode order, and to estimate the hazard ratio for medication discontinuation comparing episodes that reached a …

20.08.2026journal-article

Reviews in Cardiovascular Medicine

Procedural Management of Atrial Fibrillation in Older Patients

Francis Jonathan Ha, Yan Zhao, Hui-Chen Han, Adam J Brown, Nitesh Nerlekar, Emily Kotschet

Atrial fibrillation (AF) is becoming increasingly prevalent worldwide because of population aging and the widespread availability of continuous rhythm monitoring. While medical therapy remains central to management, several procedural strategies are being considered for older patients, including catheter ablation with pulsed field ablation (PFA), atrioventricular node ablation with conduction system pacing (CSP), leadless pacemaker (LPM) implantation, and percutaneous left atrial appendage occlusion (LAAO). Cathete …

20.08.2026journal-article

Arthritis Care & Research

Factors Associated With Fibromyalgia Diagnosis Among People Meeting Criteria: Results From UK Biobank

Sung‐A Kim, Gary J. Macfarlane, Marcus J. Beasley

Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification. This study aimed to identify factors associated with receiving an FM diagnosis among individuals who met 2016 criteria and explore potential barriers to diagnosis. Methods Usi …

20.08.2026journal-article

Journal of Proteome Research

Integrated Hepatic Lipidome Analysis in Aging Mice

Punyatoya Panda, Christina R. Ferreira, Allison J. Schaser, Uma K. Aryal

Abstract The liver is a metabolically active organ vital for carbohydrate, protein, and lipid metabolism as well as detoxification of harmful substances. Here, we integrated multiple reaction monitoring (MRM) profiling, untargeted lipidomics, and desorption electrospray ionization-mass spectrometry imaging (DESI-MSI) to identify age-associated changes in lipid profiles in the liver of adult mice across three age groups: adult (3–4 months), midaged (10 months), and old (19–21 months). Comparative lipidomic analysis …

20.08.2026journal-article

Frontiers in Public Health

Construction strategies and implementation pathways of resilience governance system for care risks in older adult care institutions from a social-ecological perspective

Chunyan Li, Yang Xie, Weiping Liu

Against the backdrop of population ageing, the governance of care risks in older adult care institutions has become a global challenge. This paper aims to construct a resilience governance system for care risks in older adult care institutions based on social-ecological systems theory, exploring its construction strategies and implementation pathways. The article first reviews the development trajectory of resilience governance theory in social sciences, then introduces social-ecological systems theory into the res …