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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Healthcare

Self-Reported Knowledge and Awareness of Musician-Related Disorders Among Music Educators and Pre-Service Music Teachers in Higher Education Institutions in Türkiye: An Occupational Health Literacy Perspective

Rıza Akyürek, Ayşe Şevval Dinçer

Background/Objectives: Musicians face occupational health risks from repetitive movement, sustained posture, and intensive practice. This study examined self-reported knowledge of musician-related disorders, physical complaints, and selected health practices among music educators and pre-service music teachers, using occupational health literacy (OHL) as an interpretive framework. Methods: A cross-sectional survey included 432 participants from public higher education institutions in Türkiye (83 educators; 349 pre- …

02.09.2026journal-article

Blood Advances

Teclistamab and Daratumumab Immune-Based Doublet Therapy for Relapsed/Refractory Multiple Myeloma: the TRIMM-2 Study

Paula Rodriguez-Otero, Daniel Morillo, Anita D'Souza, Donna Reece, Niels van de Donk, Ajai Chari, Bhagirathbhai Dholaria, K. Martin Kortüm, Maria-Victoria Mateos, John T. Mckay, Laura Rosiñol, Anna Sureda, Ralph Wäsch, Manisha Bhutani, Katja C Weisel, Nizar J Bahlis, Deeksha Vishwamitra, Sheri Skerget, Kalpana K Bakshi, Yue Guo, Weili Sun, Jenna D. Goldberg, Tara Stephenson, Thomas J Prior, Lien Vandenberk, Sangmin Lee, M. Damiette Smit, Raluca I. Verona, Albert Oriol, Amrita Krishnan

Teclistamab is the first approved B-cell maturation antigen×CD3 bispecific antibody with weight-based dosing for triple-class-exposed relapsed/refractory multiple myeloma (RRMM). We evaluated the safety and efficacy of teclistamab combined with the anti-CD38 monoclonal antibody daratumumab in the phase 1b TRIMM-2 study. Eligible patients had RRMM (≥3 prior lines of therapy [LOT] or were double-refractory to a proteasome inhibitor and immunomodulatory drug); prior anti-CD38 exposure was permitted. Patients received …

02.09.2026journal-article

Current Opinion in Critical Care

Managing fluid status in patients receiving renal replacement therapy

Matthieu Chivot, Jean-Christophe Richard, Laurent Bitker

Purpose of review Net ultrafiltration (UF NET ) may help correct fluid overload in patients receiving renal replacement therapy (RRT). Yet, how to set it safely at the bedside remains unsettled. This review addresses the hemodynamic aspects of UF NET setting, its time-dependent adjustments in relation phase-dependent balance target, and the contribution of fluid inputs to fluid balance control. Recent findings Hemodynamic instability associated with RRT, the principal obstacle to active fluid removal, arises from v …

02.09.2026journal-article

The Journal of ECT

Association of Pre-ECT Anxiety Symptoms With Electroconvulsive Therapy Treatment Efficacy in Schizophrenia

Birong Chen, Hasvinjit Kaur D/O Gulwant Singh, Nisha Chandwani, Jonathan Jie Lee, Shih Ee Goh, Xiao Wei Tan

Objectives: Pre-ECT anxiety symptoms are common among patients undergoing Electroconvulsive Therapy (ECT). In this retrospective observational cohort study, we aim to explore the association between pre-ECT anxiety symptoms and ECT treatment outcomes in patients with schizophrenia. Methods: We conducted a retrospective analysis of 979 patients with schizophrenia or schizoaffective disorder who received ECT at a tertiary public psychiatric hospital in Singapore. Patients were categorized into two groups based on the …

02.09.2026journal-article

Physics in Medicine & Biology

Dynamic proton arc therapy sequencing optimization algorithm for brain stereotactic radiosurgery

Peilin Liu, Lewei Zhao, Gang Liu, Xiaoda Cong, Zerun Zhang, Xiaoqiang Li, Xuanfeng Ding

Abstract Objective: Proton arc (PAT) therapy combines the dosimetric advantages of protons with the efficiency of arc delivery, but current planning algorithms are based on a static delivery sequence. The discrepancy between the static plan and the actual delivery can result in dosimetric deviations during stereotactic radiosurgery (SRS), where precision is critical.

Approach: A dynamic arc delivery sequencing optimization framework was developed, consisting of three steps: (1) static irradiation and dynam …

02.09.2026journal-article

Journal of Rehabilitation Medicine

Identifying classes with different disability profiles amongst patients with persistent neck pain

Konsta Koivunen, Mikhail Saltychev, Juhani Juhola

Objective: To identify latent classes with distinct disability profiles among patients with persistent neck pain using item-level responses from the Neck Disability Index, and to examine demographic, clinical, and lifestyle factors associated with class membership. Design: Cross-sectional survey-based study. Patients: 962 patients with persistent neck pain. Methods: This survey-based study included 962 patients with persistent neck pain. Latent class analysis was performed using the 10 dichotomized items of the Nec …

02.09.2026journal-article

British Journal of Occupational Therapy

A grounded theory of practice learning: What, and how, do students learn during practice placements and how can this learning be maximised?

Terri Grant, Yvonne Thomas

Introduction: With ever increasing pressures on healthcare services and a rising demand for placement opportunities to enable the education and registration of greater numbers of healthcare professionals, it is vital that students gain maximum learning during placement opportunities. A grounded theory approach was used to explore what was learned and how the learning occurred during pre-registration occupational therapy programmes at one university in the UK’s West Midlands. This article presents and discusses a th …

02.09.2026journal-article

Pharmaceuticals

Quality by Design-Guided Development of Ketoprofen-Cationic Aspasomes Unlocks the Antifungal Potential of Repurposed Ketoprofen for Topical Therapy

Moaz A Eltabeeb, Rofida Albash, Mariam Hassan, Sadek Ahmed, Ahmed M. Agiba, Azza A. K. El-Sheikh, Diana E. Aziz

Background/Objectives: Cutaneous fungal infections remain a major therapeutic challenge due to poor skin penetration and emerging antifungal resistance of current treatments. Drug repurposing offers a promising strategy to expand antifungal therapy, with ketoprofen (KPN) recently demonstrating antifungal activity. Methods: In this study, KPN-cationic aspasomes (Ca-ASPMs) were developed using a Quality by Design (QbD) approach to enhance topical delivery and maximize the therapeutic potential of repurposed KPN. A D- …

02.09.2026journal-article

PLOS One

Virtual reality-based emotion-to-emotion therapy for post-traumatic stress disorder: Protocol for a randomized controlled trial of efficacy, safety, and cost-effectiveness

Do-Eun Lee, Namju Lee, Nam-Kwen Kim, Joohee Seo, Jaeuk U. Kim, In Chul Jung, Moon Joo Cheong, Hyung Won Kang

Background Trauma-focused psychotherapies are recommended first-line treatments for post-traumatic stress disorder (PTSD). Emotion-to-Emotion Therapy (ETE) is a psychotherapy derived from traditional Korean medicine that regulates excessive emotional responses using theoretically opposing emotions. Virtual reality (VR) may support standardized and immersive delivery of the meditation component of ETE. This trial will evaluate the efficacy, safety, and cost-effectiveness of VR-based ETE for PTSD. Methods This multic …

02.09.2026journal-article

Zeitschrift für Naturforschung C

Investigating the phytochemical composition of Curcuma longa , Azadirachta indica , and Asparagus racemosus using network pharmacology and molecular docking approaches for ovarian cancer therapy

Seneha Santoshi, Aastha Tanwar, Riddhi Bahri, Navya Aggrawal, Deepak Ganjewala, Hina Bansal

Abstract Given that ovarian cancer is a major health concern for women worldwide, we explored the potential of Indian medicinal plants, namely Curcuma longa (Turmeric), Azadirachta indica (Neem), and Asparagus racemosus (Shatavari) via a combined approach of network pharmacology and molecular docking. Initially, bioactive phytochemicals of these plants were sourced from the IMPPAT and SwissTargetPrediction databases, resulting in the identification of 202 compounds along with 1,124 corresponding protein targets. Th …

02.09.2026journal-article

Annals of Surgery

Multidisciplinary Rehabilitation Following Upper Gastrointestinal Cancer Surgery (RESTORE II)

Linda M. O’Neill, Emily Smyth, Neil Kearney, Grainne Sheill, Louise Brennan, Sophie Grehan, Sanela Begic, Fiona Murphy, Ciara Tansey, Niamh Flanagan, Mikel Egaña, Ricardo Segurado, Marie Galligan, Jinbo Zhao, Ciaran M. Fairman, Claire M. Timon, Suzanne L. Doyle, Deirdre Connolly, Jacintha O’Sullivan, John V. Reynolds, Juliette Hussey, Emer M. Guinan

Objective: RESTORE II compared in an RCT the impact of a 12-week multidisciplinary rehabilitation program versus standard care (SC) on cardiorespiratory fitness and physical function in patients postupper gastrointestinal (UGI) oncologic surgery. Summary of Background Data: The value of multidisciplinary cancer rehabilitation in UGI cancer survivorship is unclear, with limited high-quality data. Methods: Disease-free patients, ≥3 months post-UGI cancer resection were randomized to SC or RESTORE (physiotherapy-led a …

02.09.2026journal-article

Advances in Social Behavior Research

A review of research on culturally adapted cognitive behavioral therapy (CA-CBT)

Yizhou Zhang

Cognitive behavioral therapy (CBT) is a short-term, highly effective, evidence-based treatment recommended by numerous national organizations; however, because it is rooted in Western cultural values, its direct application to non-Western cultural groups may result in reduced efficacy and high dropout rates. Consequently, culturally adapted cognitive behavioral therapy (CA-CBT) has emerged. This paper conducted a systematic review of empirical studies, randomized controlled trials, and meta-analyses on CA-CBT publi …

02.09.2026journal-article

Frontiers in Medicine

Toward nursing-integrated biomarker surveillance for immune-related adverse events during immune checkpoint inhibitor therapy

Jiafeng Jin, Liwen Zheng, Yali Tian, Minjuan Chu, Beinuo Cao

Immune checkpoint inhibitors (ICIs) have transformed cancer care but can cause immune-related adverse events (irAEs) involving almost any organ system. Delayed recognition may permit reversible inflammation to progress to organ dysfunction, treatment interruption, prolonged immunosuppression, or death. Biomarker surveillance offers an objective complement to symptom assessment, yet no single marker is sufficiently accurate for universal prediction. This Mini Review examines the mechanistic basis and clinical eviden …

02.09.2026journal-article

Progress in Biomedical Engineering

Wearable hand exoskeletons for motor rehabilitation: a scoping review

Lluis Bernat, Cristina Romero, Anahis Casanova, Carlos A Jara, Andres Ubeda

Abstract This scoping review maps the current development landscape of wearable hand exoskeletons for motor rehabilitation, covering publications from 2010 to October 2025 across four major databases. A total of 134 articles were included, identifying 116 unique devices validated with human subjects. The results show a clear predominance of soft structures over rigid or hybrid ones, with electric motors and tendon-driven mechanisms being the most frequent actuation and transmission choices. However, there is a lack …

02.09.2026journal-article

Physics in Medicine & Biology

Assessment of elemental decomposition algorithms for particle therapy dose monitoring using positron emission tomography and prompt-gamma imaging

Yan Li, Weiguang Li, Xinyu Hu, Yuying Yin, Xueying Yang, Shutong Yu, Chao Yang, Cheng Chang, Mingqing Wang, Kai-Wen Li, Lisheng Geng, Yibao Zhang

Abstract Objective: Accurate dose verification remains a major challenge in particle therapy. Dose monitoring methods such as positron emission tomography (PET) and prompt-gamma (PG) imaging are highly sensitive to uncertainties in tissue composition derived from CT, which can be improved by dual-energy CT (DECT)-based material decomposition. This study systematically assessed the accuracy of four DECT elemental decomposition algorithms in predicting physical dose, annihilation-photon, and PG reference distribution …

02.09.2026journal-article

Child's Nervous System

Laser interstitial thermal therapy in pediatric neurosurgery: a prospective nationwide study on indications, safety, and early outcomes

Silas Haahr Nielsen, Jon Foss-Skiftesvik, Torstein Ragnar Meling, Astrid Marie Sehested, Christina Engel Høi-Hansen, Michael Thude Callesen, Gorm von Oettingen, Adam Espe Hansen, Jane Skjøth-Rasmussen, Rune Rasmussen

Abstract Purpose To evaluate indications, safety, and early outcomes of MRI-guided laser interstitial thermal therapy (LITT) in a nationwide prospective pediatric cohort and to assess the feasibility of same-session stereotactic biopsy. Methods All consecutive pediatric patients (≤ 18 years) who underwent LITT at the Danish National Referral Center between June 2021 and October 2025 were prospectively enrolled. Demographic, clinical, radiological, and surgical variables were recorded. Safety outcomes included compl …

02.09.2026journal-article

Journal of Intensive Care Medicine

Comparison of Midline Venous Catheters Versus Peripherally Inserted Central Catheters for Intravenous Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Kumail Mustafa Ali, Hafsa Ahmed, Syeda Fatima Mustafa Zaidi, Talha Khalid, Ahmed Hasan, Urooba Mughal, Ibrahim Zulfiqar Ali, Farida Khan Kakar, Muhammad Hamza, Samina FNU, Rohin Kumar, Suraksha Rani, Tayyaba Uzair, Ahmed Mustafa Rashid

Background Midline venous catheters (MVCs) have been encouraged as alternatives to peripherally inserted central catheters (PICCs) for intermediate to long-term intravenous therapy. However, randomized controlled trials (RCTs) have reported contradictory findings regarding their comparative safety and resilience. We aim to compare MVCs and PICCs in patients receiving intravenous therapy. Methods PubMed/MEDLINE, Embase, Scopus, and the Cochrane Central databases were searched from inception through March 2025. RCTs …

02.09.2026journal-article

International Journal of Sports Physical Therapy

Patients’ Mental Barriers in Rehabilitation after ACL Reconstruction: A Qualitative Interview Study

Ingunn Fleten Mo, Nicky van Melick, Trine Hysing-Dahl, Liv H Magnussen, Per H Randsborg, Rob Bogie, Anne Gro H Faleide, Eivind Inderhaug

Background Recovery after anterior cruciate ligament reconstruction (ACLR) involves both physical and psychological challenges. Although psychological readiness for return to sport (RTS) is increasingly recognized as important, less is known about how patients experience psychological barriers during rehabilitation and how interactions with physiotherapists (PTs) may shape this process. Purpose To explore how patients recovering from ACLR navigate potential psychological barriers, what helps them overcome these bar …

02.09.2026journal-article

Sports

From Static Stability to Dynamic Gait Governance: Differential Effects of Adapted Physical Activity and Tango-Based Therapy on Walking Distance and Plantar Load Redistribution in Parkinson’s Disease

Raffaella R. R. Marzovillo, Gabriella D’Orsi, Paride Vasco, Giuseppe Cartagena, Donato Melchionda, Natalia Forte, Giuseppe Cibelli, Anna A. Valenzano

Gait and balance impairments in Parkinson’s disease (PD) severely compromise mobility and independence. This exploratory randomized pilot study evaluated a multimodal Adapted Physical Activity (APA) protocol, a tango-based program (Riabilitango®, RT), and standard care regarding walking distance, static postural stability, joint range of motion, and plantar-load redistribution. Twenty-seven participants with PD (Hoehn and Yahr 1–3) were allocated to APA (n = 10), RT (n = 10), or Control (n = 7). The active groups c …

02.09.2026journal-article

Otology & Neurotology

Twelve-Month Outcomes After Hearing Rehabilitation With an Active Middle Ear Implant and Latest Generation Vibroplasty Couplers in Adults And Children: A Prospective Multicenter Study

Kristen Rak, Stefan K. Plontke, Thomas Lenarz, Daniela Hollfelder, Piotr H. Skarzynski, Georg M. Sprinzl, Marcus Neudert, John-Martin Hempel, Wafaa Shehata-Dieler, Rudolf Hagen, Torsten Rahne, Anke Lesinski-Schiedat, Nicole Knölke, Susan Busch, Karl-Ludwig Bruchhage, Astrid Magele, Philipp Schörg, Marlene Pollotzek, Wilma Großmann, Nora M. Weiss, Carmen Giefing-Kröll, Gabriella Bock, Robert Mlynski

Objective: To evaluate the audiological efficacy, patient-reported outcomes, and safety of an active middle ear implant (AMEI) in children and adults with distinct coupling options. Study design: Prospective, longitudinal, multicenter, noninterventional observational study with repeated within-subject measures and a 12-month follow-up. Setting: Nine tertiary referral centers in Germany, Austria, and Poland. Patients: Adults and children with sensorineural, conductive, or mixed hearing loss. Adults were grouped by c …

02.09.2026journal-article

Bioinformatics

Identifying expanding TCR clonotypes with a longitudinal Bayesian mixture model and their associations with cancer patient prognosis, metastasis-directed therapy, and VJ gene enrichment

David Swanson, Alexander Sherry, Cara Haymaker, Alexandre Reuben, Chad Tang

Abstract Motivation Examination of T cell receptor (TCR) clonality has become a way of understanding immunologic response to cancer and its interventions in recent years. An aspect of these analyses is determining which receptors expand or contract statistically significantly as a function of an exogenous perturbation such as therapeutic intervention. Results We characterize the commonly used Fisher’s exact test approach for such analyses and propose an alternative formulation that does not necessitate pairwise, wi …

02.09.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Biomechanical and neuromuscular correlates of DaeDo output during successful dominant- and non-dominant-leg taekwondo side kicks: a repeated-measures study

Yijun Liu, Mengyao Jia

Abstract Objective This study aimed to compare temporal, kinematic, kinetic, and support-side neuromuscular characteristics between dominant- and non-dominant-leg Taekwondo side kicks and to examine their associations with DaeDo output during successful scoring trials. Methods Twelve high-level male Taekwondo athletes, all right-leg dominant, performed side kicks with both legs. Three-dimensional kinematics, force-platform data, support-side surface electromyography (EMG), and DaeDo output were recorded simultaneou …

02.09.2026journal-article

Angewandte Chemie

Raising the Mayan Pyramids: Construction of Polyoxothiomolybdates via In Situ Sulfurization for Enhanced Antitumor Therapy

Zi‐Yu Xu, Dao‐Jing Yuan, Lin‐Jie Lan, Yue Zhao, Ke‐Wei Tong, Chao‐Qin Chen, Pan‐Chao Yin, Jing Du, Teng Gong, Peng Yang

ABSTRACT The advancement of atomic‐level sulfurization technology is ushering materials engineering from coarse regulation toward precise editing. As represented by polyoxothiometalates (POTMs), the available sulfurization methods remain limited and nongreen, imposing severe constraints on their structural diversity and functional applications. In this study, an in situ sulfurization approach was developed to construct the Mo‐based POTMs (POTMos) in a distinct and eco‐friendly manner. The emergence of unprecedented …

02.09.2026journal-article

Angewandte Chemie

Self‐Amplifying AIE Probe for HClO‐Activatable Imaging and Antioxidative/Anti‐Inflammatory Therapy of Thoracic Aortic Dissection

Yanzi Xu, Yunpeng Luo, Jiale Shen, Zihao Deng, Anran Gao, Shengyi Yang, Jacky W. Y. Lam, Ryan T. K. Kwok, Changhuo Xu, Lingjie Meng, Weixun Duan, Dongfeng Dang, Ben Zhong Tang

ABSTRACT Thoracic aortic dissection (TAD) is a highly lethal cardiovascular disease, yet its accurate diagnosis and effective treatment remain challenging due to poor imaging contrast and insufficient specificity. Leveraging the overexpressed reactive oxygen species (ROS) in TAD, we reported a hypochlorous acid (HClO)‐activatable molecular probe DT‐PZ. It enables two‐stage self‐amplifying fluorescence imaging (chemical activation and then physical aggregation) and light‐independent therapy on a single chemical enti …