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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Forum

Krebsprävention in der deutschen Bevölkerung

Andrea Gaisser, Ursula Will

Zusammenfassung Hintergrund Trotz der zentralen Rolle der Krebsprävention für die Verringerung der Krebslast werden entsprechende Empfehlungen inkonsistent umgesetzt. Eine repräsentative Befragung soll Einblicke in Risikowahrnehmung, Einstellungen und Informationsbedarf in der Allgemeinbevölkerung und Hinweise für die Gestaltung von Information und Strategien zur Förderung der Prävention geben. Methoden Im November 2023 wurde eine bevölkerungsrepräsentative Befragung ( n = 1581) in Deutschland mittels persönlich-mü …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

Mechanical observables of cancer invasion: actin, adhesion, and metastatic plasticity

Subhajit Dutta, Sushree Sulava

Cancer invasion is commonly classified through epithelial-mesenchymal plasticity, yet cells with similar transcriptional states can differ substantially in force production, cytoskeletal organization and collective mobility. We critically examine whether mechanical measurements can supply information that is not already contained in molecular or histopathological classifications. The available evidence does not justify a universal five-dimensional phase space. It supports a more restrained hierarchy: primary measur …

03.09.2026journal-article

Pediatric Blood & Cancer

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich

ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA protocol for vessel thrombosis and mechanical valve obstruction in infants and children, and to characterize D‐dimer kinetics by indication. Methods This retrospecti …

03.09.2026journal-article

Cells

Context-Dependent Roles of Rnd3 in Cancer: Revisiting a Functional Paradox

Elisa Lledó, Olga Gómez, Alexandra Bizy, Amalia Solana-Orts, José Terrado, Begoña Ballester-Lurbe, Enric Poch

Rnd3 is an atypical member of the Rho GTPase family whose activity is mainly regulated by expression, localization and protein stability rather than canonical GDP/GTP cycling. In cancer, Rnd3 has been described both as a tumor suppressor and as a tumor-promoting factor, creating an apparent functional paradox. We propose that this paradox is resolved by a mechanistic invariant: Rnd3 exerts a conserved inhibition of RhoA/ROCK1-dependent actomyosin contractility, whose phenotypic output is redirected by context-speci …

03.09.2026journal-article

Current Pain and Headache Reports

Evolving Treatment Options for Spinal Pain: Balancing Innovation and Affordability in Regenerative Medicine

Annu H. Navani, Sudhir A. Diwan, Douglas P. Beall, Edward S. Rubin, Ahmed I. Anwar, Alan D. Kaye

Abstract Purpose of Review Regenerative approaches for treating spinal pain hold great clinical promise but have the potential to disrupt healthcare upending the cost paradigm of pharmacologic care or interventional procedures. Regenerative approaches have higher upfront costs but may offer long-lasting, even curative benefits. In today’s healthcare system, it is important to understand the cost-effectiveness of regenerative approaches using mesenchymal stem cells (MSC), platelet-rich plasma (PRP), and other biolog …

03.09.2026journal-article

Frontiers in Computer Science

Tri-fusion deep learning model for early breast cancer screening using multimodal biomedical data

J. Lilly Roseline Mary, R. Venkatesan, M. Mythily, D. Jasmine David

To optimize the early detection of breast cancer, a strong integration of heterogeneous biomedical signals is essential to improve diagnostic reliability and reduce false negatives. This study proposes a Tri-Fusion deep learning model for timely breast cancer screening, which integrates White Blood Cell (WBC) morphological features, mammogram image embeddings, and gene mutation signatures within a unified multimodal framework. WBC features are extracted from peripheral blood smear images using a CNN-based morpholog …

03.09.2026journal-article

Frontiers in Neuroscience

Functional recovery patterns from discharge to 12 months after endovascular treatment for aneurysmal subarachnoid hemorrhage: a multicenter cohort study

Qiao Wu, LongXiang Ma, Yang Chen, ZhenRan Zhao, JinFang Liu, Bin Zhang, HeChun Xia

Background Functional status after aneurysmal subarachnoid hemorrhage (aSAH) may improve after discharge, but paired assessments at discharge and long-term follow-up have rarely been used to distinguish delayed recovery from persistent disability. We characterized discharge-to-12-month recovery patterns after endovascular treatment and identified factors associated with persistent disability among patients with poor functional status at discharge. Methods This multicenter retrospective cohort study consecutively en …

03.09.2026journal-article

Frontiers in Psychiatry

Psychosocial recovery and nutritional rehabilitation in residential treatment for anorexia nervosa: an exploratory longitudinal multi-frequency bioelectrical impedance analysis study

Francesco Monaco, Annarita Vignapiano, Stefania Landi, Rossella Bonifacio, Daniela Falchetta, Emanuela Ferrara, Ernesta Panarello, Bruno Attianese, Annaluce Caputo, Luca Steardo, Gennaro Sosto, Giulio Corrivetti

Background Nutritional rehabilitation is widely considered a prerequisite for recovery in anorexia nervosa (AN), given the profound effects of malnutrition on cognitive, emotional, and behavioral functioning. However, whether psychiatric improvement during residential treatment is directly coupled with the degree of nutritional restoration remains insufficiently understood. This study investigated longitudinal changes in body composition and psychosocial outcomes during residential psychiatric rehabilitation for AN …

03.09.2026journal-article

Frontiers in Environmental Engineering

Non-target analysis for wastewater treatment evaluation: strategies, applications, and future directions

Isra Koko, Fares AlMomani, Muhammad Zia UR Rahman Hashmi, Sophia Ghanimeh

Non-target analysis (NTA), based on high-resolution mass spectrometry (HRMS), is increasingly used to characterize the complex chemical composition of wastewater and evaluate the fate of emerging contaminants (EC) during treatment. However, despite its growing application, the use of NTA for wastewater treatment evaluation remains fragmented across the literature, with existing reviews focusing primarily on analytical workflows, contaminant identification, or environmental monitoring rather than treatment performan …

03.09.2026journal-article

Frontiers in Public Health

Knowledge, attitudes, and practices of gynecologic oncology nurses toward patient decision aids for fertility preservation: a cross-sectional study in Zhengzhou, China

Xiaoyu Han, Xiaoxue Li, Manman Li, Tian Tian, Kaige Shi, Yun Shi, Fengzhi Zhang

Introduction To investigate nurses’ knowledge, attitudes, and practices regarding patient decision aids for fertility preservation in gynecologic oncology departments and to evaluate the associated factors. Methods This cross-sectional study used a questionnaire survey and convenience sampling. A total of 201 nurses working in gynecologic oncology-related departments of tertiary first-class hospitals in Zhengzhou, China, were recruited. The questionnaire covered demographic information, knowledge of patient decisio …

03.09.2026journal-article

Frontiers in Oncology

Clinicopathological and preoperative biomarkers associated with recurrence after primary surgical treatment for endometrial cancer

Yi-Hua Liu, Bing Wei

Background Postoperative recurrence remains a major concern in endometrial cancer (EC), and routinely available preoperative biomarkers may complement established clinicopathological factors. This study aimed to evaluate the associations of preoperative neutrophil-to-lymphocyte ratio (NLR), fibrinogen (FIB), and serum cancer antigen 125 (CA125) with recurrence after primary surgical treatment for EC. Methods This single-center retrospective cohort included 368 patients treated between January 2019 and December 2024 …

03.09.2026journal-article

Frontiers in Oncology

Development and validation of a novel nomogram integrating visceral-to-subcutaneous fat ratio and neutrophil-percentage-to-albumin ratio for overall survival in locally advanced rectal cancer undergoing neoadjuvant radiotherapy

Xueqing Zhang, Jianjian Qiu, Shiji Wu, Xingte Chen, Junxin Wu

Background Emerging evidence suggests that neutrophils are preferentially recruited to visceral adipose tissue, connecting adipose distribution to systemic inflammation. Visceral fat accumulation and systemic inflammation-nutrition status are known to affect cancer prognosis, yet no existing prognostic model integrates visceral-to-subcutaneous fat ratio (VSR) and neutrophil-percentage-to-albumin ratio (NPAR). This study aimed to develop and validate a cost-effective nomogram incorporating VSR and NPAR to predict ov …

03.09.2026journal-article

Current Anesthesiology Reports

Preoperative Clinics: Do We Still Need Them? Reframing the Preoperative Period as a Treatment Window

Victor R. Davila

Abstract Purpose of Review This review examines whether the traditional preoperative assessment clinic, designed primarily to reduce perioperative complications, improve patient safety, and prevent day-of-surgery cancellations, remains the appropriate model for perioperative care, and evaluates the evidence for a shift from preoperative evaluation to preoperative optimization. Recent Findings Virtual preoperative evaluation is non-inferior to in-person evaluation for cancellation prevention and patient satisfaction …

03.09.2026journal-article

Frontiers in Oncology

Loss of RanBP9 cooperates with p53 deficiency to promote sarcomagenesis

Brianna C. Gonga-Cavé, Gabriel Onea, Xu Wang, Sean P. Cregan, Michael B. Boffa, Patti K. Kiser, Caroline Schild-Poulter

Introduction Ubiquitination is a major regulatory process that is often dysregulated in carcinogenesis. The C-terminal to LisH (CTLH) complex is a multi-subunit E3 ubiquitin ligase that has been shown to exert tumor-promoting and tumor-suppressing functions. Its core scaffolding subunit, RanBP9, has been implicated in regulating oncogenic signaling, but it remains unclear whether RanBP9 loss promotes tumorigenesis in vivo . Objectives This study aimed to evaluate the functional consequence of RanBP9 loss, alone or …

03.09.2026journal-article

International Journal of Molecular Sciences

Association Between Biopsy PD-L1 Combined Positive Score and Pathological Upgrading at Radical Prostatectomy in Grade Group 1 Prostate Cancer: A Retrospective Study

Ludovica Pepe, Valeria Zuccalà, Ida Rizzuto, Walter Giuseppe Giordano, Mariagiovanna Ballato, Pietro Tralongo, Gabriele Ricciardi, Vincenzo Cianci, Marta Rossanese, Giuseppe Iatì, Silvana Parisi, Francesco Pierconti, Antonio Ieni, Guido Fadda, Pietro Pepe, Maurizio Martini, Vincenzo Fiorentino

Programmed death-ligand 1 (PD-L1) expression in Grade Group 1 (GG1) prostate carcinoma biopsies has not been established as a marker of pathological upgrading at radical prostatectomy (RP). This two-center retrospective case–control study included 172 men with GG1 carcinoma in the biopsy closest to RP: all 86 patients upgraded to GG2 and 86 randomly selected non-upgraded controls from 126 eligible GG1 patients. PD-L1 was assessed with the SP263 clone using the combined positive score (CPS), with CPS ≥ 1 predefined …

03.09.2026journal-article

Medical Review

Structure-guided targeting of the LAT1-4F2hc amino acid transporter in cancer and brain disorders

Ziwei Hu, Stefan Bröer, Renhong Yan

Abstract The heterodimeric amino acid transporter L-type amino acid transporter 1 (LAT1)-4F2hc (SLC7A5-SLC3A2) is a key regulator of large neutral amino acid exchange, linking extracellular nutrient availability to intracellular growth signaling. It is physiologically enriched at the blood-brain barrier (BBB) and in proliferative tissues but is broadly upregulated in cancer, where it supports metabolic reprogramming and mechanistic target of rapamycin complex 1 (mTORC1)-driven oncogenic growth. These properties mak …

03.09.2026journal-article

Parasitology Research

Persistence of Theileria orientalis Chitose genotype on a closed dairy farm: possible vertical transmission and limited clearance after buparvaquone treatment

Mengyang Li, Tian Xie, Huan Liu, Li Tian, Jingjiao Yan, Chunlei Du, Chuanwen Wang, Haiyong Hui, Junlong Liu

Abstract Theileria orientalis comprises tick‑borne protozoan parasites that can cause substantial economic losses in cattle. We previously reported an outbreak of oriental theileriosis associated with mixed T. orientalis Ikeda and Chitose infection on a closed dairy farm. However, the predominant genotype and the mechanisms underlying long-term persistence under closed-herd management remain unclear. In December 2024, conventional PCR detected T. orientalis in 41 of 147 periparturient cows; sequencing of MPSP ampli …

03.09.2026journal-article

Clinical and Translational Imaging

Dynamic PSMA total-body PET/CT in prostate cancer: technical principles and clinical potential

Yongkang Shuai, Irene Brusa, Riccardo Mei, Stefano Fanti

Abstract Background The incidence of prostate cancer continues to rise worldwide. While conventional static PET/CT provides semi-quantitative metrics, total-body PET/CT enables voxel-level dynamic imaging and parametric imaging, demonstrating great potential for clinical applications in prostate cancer. Therefore, this review synthesizes the technical principles of dynamic PSMA total-body PET/CT and its emerging clinical applications in prostate cancer, providing a novel clinical insight for individualized patient …

03.09.2026journal-article

Gastric Cancer

Clinical impact of CT-defined sarcopenia on long-term oncological outcomes in gastric cancer: validation of muscle mass cut-offs established according to EWGSOP recommendations

Jasmin Hasanovic, Paul Friedrich Esslinger, Veronika Lummer, Heiner Nebelung, Leo Misera, Ralf-Thorsten Hoffmann, Johanna Kirchberg, Marius Distler, Jürgen Weitz, Daniel E. Stange, Felix Merboth

Abstract Background Sarcopenia is an important prognostic factor in gastrointestinal malignancies, but CT-based definitions vary. This study evaluated recently published computed tomography (CT)-based cut-offs for skeletal muscle index (SMI) and psoas muscle thickness normalized to height (PMTH), derived from a young, presumably healthy reference population according to recommendations of the European Working Group on Sarcopenia in Older People (EWGSOP), in patients undergoing surgery for gastric cancer. Methods Th …

03.09.2026journal-article

Clinical and Translational Oncology

Prognostic modeling of overall survival in metastatic pancreatic cancer: an inflammation-based tool validated in PANTHEIA-SEOM cohort

Vilma Pacheco-Barcia, Axel Mariño-Mendez, María Ángeles Vicente Conesa, María de Toro Carmena, Paula Cerdà Serdà, Carmen Guillen-Ponce, Mónica Benavente Lucas, Raquel Hernández San Gil, Ángela Lamarca, Javier Gallego, Maria Luisa Soriano Tabares de Nava, Jorge Hernando, Elena Brozos-Vazquez, Ana López-Alfonso, Jorge Adeva, Ismael Ghanem, Sandra Soriano, Javier Soto-Alsar, Andrés Muñoz, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas

Abstract Purpose To develop and internally validate the PANTHEIA-SIRI prognostic model, which integrates log-transformed systemic inflammation response index (SIRI) with clinical predictors, to estimate overall survival (OS) in metastatic pancreatic ductal adenocarcinoma (mPDAC) treated with first-line chemotherapy. Methods We used data from the multicenter PANTHEIA-SEOM registry. OS was defined from chemotherapy start. The model was fitted as a Weibull accelerated failure time model in the survival-analysis popula …

03.09.2026journal-article

Frontiers in Oncology

Type I collagen promotes triple-negative breast cancer progression through a UBE2V1–ACSL5 regulatory axis

Lu Liu, Yida Wang, Haiyue You, Cenzhu Wang, Xinfeng Yang, Feng Zhang, Danping Wu, Xin Ning, Zhiwen Qian, Ying Jiang, Yan Zhang, Xiaoqian Zhao, Tingting Han

Introduction Triple-negative breast cancer (TNBC) is characterized by aggressive behavior and extensive extracellular-matrix remodeling. Type I collagen (COL I), a major stromal component, promotes tumor progression, but the downstream tumor-cell mechanisms remain incompletely defined. We investigated whether COL I regulates acyl-CoA synthetase long-chain family member 5 (ACSL5) through ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) and whether this relationship contributes to malignant behavior. Methods We int …

03.09.2026journal-article

BMC Cancer

Study protocol of a multicenter prospective [¹⁸F]F-FAPI PET-CT imaging study in patients with cancer of unknown primary

Esther Droogers, Mathijs P. Hendriks, Warnyta Minnaard, Walter Kool, Leo J. Schouten, Caroline Loef, Frederik. A. Verburg, Debbie G.J. Robbrecht, Sophie E.M. Veldhuijzen van Zanten

Abstract Background Cancer of unknown primary (CUP) is defined by the presence of metastatic disease without an identified primary tumor despite comprehensive diagnostics. The absence of a known primary tumor creates substantial diagnostic uncertainty for patients and caregivers, and precludes site-specific, evidence-based treatments. Fibroblast activation protein inhibitor (FAPI) PET tracers have recently gained attention as promising alternatives to [ 18 F]fluoro-2-deoxy-d-glucose ([ 18 F]FDG), as they selectivel …

03.09.2026journal-article

Frontiers in Oncology

Changes in life expectancy due to trends in cancer mortality rates, Spain 1980 – 2024

Javier Llorca, Inés Gómez-Acebo, Jessica Alonso-Molero, Sara Valero-Domínguez, Trinidad Dierssen-Sotos

Background Cancer is a leading cause of death worldwide. Although cancer mortality has declined in recent decades, its contribution to gains in life expectancy and to female-male life expectancy gap has not been fully quantified in Spain. This study assessed trends in age-adjusted cancer mortality in Spain from 1980 to 2024 and quantified their contribution to overall life expectancy and by cancer type (lung, colorectal, stomach, breast, and prostate). Methods Mortality data and life tables for the Spanish populati …

03.09.2026journal-article

Frontiers in Oncology

Bibliometric and clinical trial landscape of hepatoblastoma (2000–2024): a multi-database analysis of global research

Xu Li, Junyi Lou, Xiaoyu Li, Shibo Tang, Shuang Li, Zining Luo, Jiebin Xie

Background Hepatoblastoma (HB) is the most common childhood liver malignancy, yet its research trajectory and trial landscape remain uncharacterized. Methods We analyzed 219 trials from 16 international registries and 2,635 PubMed publications (2005–2024) using joinpoint regression, Gini coefficient, and diversity indices. Results Trial activity peaked in 2013 and 2016, driven by risk-stratified protocols and the emergence of targeted therapies. Phase III/IV trials were scarce. Cisplatin dominated drug utilization, …