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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Oncology

APIM-guided dyadic nursing after colorectal cancer surgery: a propensity score-matched cohort study

Huili Du, Jing Wang

Background Recovery after colorectal cancer surgery is influenced not only by patient symptoms but also by caregiver capacity, psychological distress, self-efficacy, and dyadic coping. However, real-world evidence on Actor–Partner Interdependence Model (APIM)-guided dyadic nursing in routine postoperative care remains limited. Objective To examine the association between documented exposure to APIM-guided dyadic nursing and 6-month postoperative outcomes among colorectal cancer patient–caregiver dyads, and to explo …

03.09.2026journal-article

Frontiers in Medicine

Redox imbalance in infertility and assisted reproduction: biomarkers, mechanisms, multi-omics integration, and personalised therapeutic strategies

Braulio Peramo, Divyesh Upadhyay, Linda Bouhafs, Habiba Alsafar

Redox biology occupies a central but paradoxical role in human reproduction. Reactive oxygen species (ROS) are indispensable mediators of sperm capacitation, oocyte activation, embryo development, and trophoblast invasion, yet excessive ROS generation causes oxidative stress that damages gametes, impairs preimplantation development, and compromises implantation. Conversely, reductive stress, an emerging but still underappreciated state in which antioxidant defences exceed physiological need, may suppress the low-le …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Long-term remission of metastatic pancreatic ductal adenocarcinoma after surgery and high-dose nicotinamide supplementation

Hubert Kolb, Werner Hartwig, Torsten Beyna, Daniela auf der Horst, Kerstin Kempf, Stephan Martin, Kerstin Struse-Soll, Markus Dommach

Background Pancreatic ductal adenocarcinoma carries a poor prognosis, with the worst outcomes observed in UICC stage IV disease characterized by hepatic—and less frequently pulmonary—metastases. Considerable genetic heterogeneity, including mutations in KRAS , BRCA1/2 , and ERBB2 , enables the development of individualized therapeutic strategies. We report here a patient with KRAS - and BRCA1/2 -wild-type but mutant TP53 and ERBB2 disease who achieved apparent remission of hepatic metastases. Case presentation A 78 …

03.09.2026journal-article

APSIPA Transactions on Signal and Information Processing

Novel PET-driven brain mapping for diagnosis of Alzheimer’s disease: integrated feature extraction and ranking capabilities

Minh Tuan Pham, Quoc Anh Le, Thanh Trung Le, Le Trong Phan, Mouloud Adel, Salah Bourennane, Eric Guedj, Ismail Burak Parlak, Guy Nagels, Nguyen Linh Trung

Early diagnosis of Alzheimer’s disease (AD) remains a significant challenge in modern healthcare. Positron emission tomography (PET) imaging combined with machine learning offers a powerful framework for this task, where brain atlases play a critical role in feature extraction. Although predefined atlases are widely used, they may provide suboptimal representations. This study introduces the novel PET-driven C-Atlas for AD diagnosis. Unlike conventional predefined brain atlases derived from healthy-control magnetic …

03.09.2026journal-article

Clinical Infectious Diseases

A Multistate Investigation of Serious Adverse Events, including Deaths, following Ceftriaxone Injections, September 2024–August 2025

Rebecca Pierce, Radhika Agarwal, Dumbani Kayira, Maribeth C Lovegrove, Nimalie D Stone, Kelly M Hatfield, Jennifer Lind Lyles, Melissa Morrison, Wes Stubblefield, Sherri L Davidson, Karen Landers, Scott Harris, Rachana Bhattarai, Theresa Dulski, Juliet Stoltey, Lauren Biehle, Josh Hoffner, Argentina Charles, JoAnna Wagner, Haley Beeman, Michael J Curran, Grace Lee, Riley Moore, Jacy Walters, Gargi Patel, Dat Tran, Jenna Sinkevitch, Marco Tori, Christopher Wilson, Simone Godwin, Shehzana Hussaini, Allison G Lafferty, Shaina Bernard, Shannon Ruelle, Catherine O Dasenbrock, Meredith Sheridan, Frank Wackes, Rachna Kapoor, Ramesh Gopalaswamy, Kiran M Perkins

Abstract Background Reports of ceftriaxone serious adverse events (SAEs), including deaths, from multiple jurisdictions during December 2024–January 2025 prompted a nationwide investigation to evaluate product safety, characterize SAEs, and assess for changes in baseline adverse event occurrence via national databases. Methods In February 2025, CDC issued a national call for cases, defined as SAEs involving death or CPR within six hours of ceftriaxone injection, not otherwise explained and occurring in non-ICU sett …

03.09.2026journal-article

Journal of Dynamics, Monitoring and Diagnostics

Vibration-Language Model for Fault Diagnosis with Numerically Reliable Evidence

Chenyang Liu, Xiwei Li, Bin Yang, Xiang Li, Naipeng Li, Jiaqi Ye, Yaguo Lei

Fault diagnosis methods for mechanical equipment should not only identify fault categories but also provide verifiable diagnostic evidence. Existing deep learning models usually output only labels or confidence scores, making it difficult to estab-lish an interpretable diagnostic reasoning process. Large language models have strong capabilities in evidence organization and explanation generation. However, a modality gap exists between vibration signals and discrete language tokens. In addi-tion, key numerical evide …

03.09.2026journal-article

BMC Emergency Medicine

Agreement between handheld ultrasonography and computed tomography for abdominal aortic diameter measurement in unselected emergency department patients: a prospective feasibility study

Alihan Elveren, Ferhat Yildiz, Muhammed Fatih Cırıl, Mustafa Akarca, Ebru Ünal Akoğlu, Tuba Ci̇mi̇lli̇ Öztürk, Burcu Azapoğlu Kaymak

Abstract Background Abdominal aortic pathologies (aneurysm, rupture, or dissection) are among the most critical and life threatening diagnoses in patients presenting to the emergency department (ED) with abdominal or back pain. This study aimed to evaluate the agreement between bedside handheld ultrasonography (HHUS) measurements of abdominal aortic diameter performed by ED physicians and the reference standard, contrast enhanced computed tomography (CT), while also assessing inter rater reliability between clinici …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Monoclonal gammopathy associated enteropathy: a potential MGCS related phenotype with response to plasma cell directed therapy

Guo Chen, Li He, Yuan Yuan Chen, Peng Yang, Jing Tan

Background Chronic inflammatory diarrhea with preserved mucosal architecture remains diagnostically challenging when inflammatory bowel disease, autoimmune enteropathy, and infection are excluded. The potential contribution of monoclonal gammopathy in such cases remains poorly defined. Case presentation We report two patients with long-standing, treatment-refractory chronic diarrhea who underwent comprehensive clinical, histopathologic, and hematologic evaluation. Both demonstrated a consistent intestinal pattern c …

03.09.2026journal-article

The Egyptian Journal of Bronchology

Accuracy of lung ultrasonography versus plain chest X-ray in diagnosis of pneumonia

Amira Gamal Goda, Ali Mohamed Abdella, Mohammed Sayed Hantera, Mohammed Mahmoud Dawoud

Abstract Background Ultrasound interrogation of the thorax for detection of pneumonia has been explored most in critical care and emergency department settings. However, recently, the application has spread to general practice and even prehospital settings. This work aimed to evaluate the role of chest ultrasound as a diagnostic tool for pneumonia in adults compared to chest x-ray. Methods This prospective observational cross-sectional study was carried out on 30 adult patients admitted to the General Chest Departm …

03.09.2026journal-article

Frontiers in Medicine

Ultrasound-assisted modified paramedian approach vs. traditional paramedian approach for spinal anesthesia in lower limb surgery: a single-center randomized controlled trial

Wudong Zhuang, Xiaoyuan Li, Jianhua Wang, Ruizhao Lyu, Shan Wang, Rui Liu, Yang Bai

Study objective This randomized controlled trial aimed to determine whether an ultrasound-assisted modified paramedian approach could improve procedural outcomes compared with an ultrasound-assisted traditional paramedian approach for spinal anesthesia in patients undergoing lower limb surgery. Design Prospective, randomized, controlled clinical trial. Setting Operating rooms of Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine, China. Patients A total of 116 patients aged 18–9 …

03.09.2026journal-article

Frontiers in Surgery

Clinical outcomes of flap reconstruction following lower extremity soft tissue sarcoma resection: a single-center retrospective experience

Xinxin Guo, Jianpeng Li, Jingyu Zhang, Yongcheng Hu

Background Soft tissue sarcomas (STSs) represent a diverse category of tumors with a propensity for the lower limbs. Wide surgical resection is the primary therapeutic approach, often requiring immediate flap reconstruction with or without perioperative adjuvant therapy. This study aims to share our clinical experience and assess the efficacy of customized flap reconstruction designed according to the precise defect area after lower extremity STS resection. Methods This retrospective analysis reviewed 15 cases of l …

03.09.2026journal-article

European Journal of Trauma and Emergency Surgery

Surgical outcomes in an improvised underground operating room during missile attacks

Ilan Y. Mitchnik, Ahmad Essa, Ofer Heinig, Jonathan G. Silberzweig, Yuval Ben Sira, Oded Rabau

Abstract Purpose Armed conflict disrupts healthcare when hospital infrastructure is vulnerable to missile attacks. During a 12-day missile strike period, our hospital established an improvised operating room (OR) in an underground parking lot. This study evaluated perioperative and short-term outcomes among patients treated in the improvised OR compared with those treated in the hospital’s fortified standard OR. Methods This retrospective cohort study included patients undergoing general or orthopaedic surgery duri …

03.09.2026journal-article

Frontiers in Psychiatry

Language-informed treatment recommendations in psychiatry: bridging the gap in individual predictability

Ruyi Shui, Xu Zhang, Zheya Cai, Kangrui Zhao, Michael Siniatchkin, Jiaojiao Hou

Treatment recommendation systems in psychiatry perform suboptimally, largely due to low individual-level predictability from conventional clinical predictors. We argue that language captured through clinical interviews and electronic health records provides a rich, workflow-native substrate for estimating individualized treatment effects. We highlight opportunities for language-informed systems using modern language models and outline key challenges that must be addressed for safe and scalable deployment.

03.09.2026journal-article

Exploration of Neuroscience

Colon cancer in a patient with a mosaic monoallelic germline pathogenic NF1 gene variant

Feras Alsabagh, Karam M. Chaaban, Marlene Girardo, Ehab Harahsheh, Misha B. Asif, Dusica Babovic-Vuksanovic, Mohamad Bassam Sonbol, Mayowa A. Osundiji

Pathogenic variants in the tumor suppressor gene NF1 cause neurofibromatosis type 1 (NF1), one of the most common hereditary cancer predisposition syndromes. Pathogenic NF1 variants have been associated with an increased risk of several cancers; however, the relationship between NF1 variation and colon cancer remains underreported. We report a 41-year-old woman with a mosaic monoallelic germline pathogenic NF1 variant, NM_000267.3:c.1756_1759del (p.Thr586Valfs*18), previously detected on germline multigene panel te …

03.09.2026journal-article

Nutrition Today

Gut Microbiome Testing: From Laboratory Methods to Clinical Meaning

Lauren Cornell

As direct-to-consumer (DTC) gut microbiome testing continues to move into mainstream nutrition and medical practice, clinicians are increasingly confronted with reports built on laboratory methods that sound sophisticated but vary widely in what they can realistically deliver. This second article in a 2-part series is designed to demystify the science behind these tests by clearly explaining the primary methodologies they rely on, including 16S rRNA sequencing, quantitative polymerase chain reaction (qPCR), shotgun …

03.09.2026journal-article

Frontiers in Oncology

Clinical trial design for primary brain tumors: a problem-based framework for neuro-oncology practice

Diego Gómez-Puerto, Jesús Yaringaño, Antonio Di Muzio, Oriol Mirallas, María Vieito

Background Primary brain tumor trials may produce an uninterpretable or non-generalizable answer when biological mismatch, inadequate intratumoral exposure, restrictive eligibility, molecular rarity, unstable controls, and disease-specific endpoint ambiguity are addressed separately. The practical problem is not the absence of modern methods, but failure to select and combine them according to the dominant threat to the development decision. Methods We performed a practice-facing narrative synthesis of methodologic …

03.09.2026journal-article

Frontiers in Medicine

Aerosolized antifungal therapy in pulmonary fungal disease: pharmacology, drug delivery and emerging clinical applications

Massimo Caracciolo, Sarah Antonella Caracciolo, Maria Francesca Stagno, Simona Pellicano, Antonino Ripepi, Nadia Pellicano, Clara Scopelliti, Angela Serranò, Antonino Loddo, Stefano La Scala

Pulmonary fungal diseases remain associated with substantial morbidity and mortality, particularly in immunocompromised individuals, transplant recipients, and critically ill patients. Although systemic antifungal therapy remains the cornerstone of treatment, its effectiveness may be limited by suboptimal penetration into selected pulmonary compartments, while systemic toxicity, drug–drug interactions, and prolonged treatment requirements may restrict therapeutic options. Aerosolized antifungal therapy provides a p …

03.09.2026journal-article

Frontiers in Psychiatry

A critical appraisal of integrating family constellation therapy with pharmacological treatment for depression

Wenhao Zhong, Mei Rao, Qian Zhou, Zeying Leng, Bing Zhang, Zhijian Lin

Depression remains a leading cause of disability worldwide, driven by a complex interplay of biological, psychological, and social factors. While pharmacotherapy, particularly selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors, provides essential symptom control, its limitations—including delayed onset, variable response, and side effects—underscore the need for complementary approaches that address systemic and relational roots of the disorder. This narrative review synthesize …

03.09.2026journal-article

Frontiers in Medicine

From benchmarking to global leadership: Singapore’s health sciences authority’s journey to WHO maturity level 4 and WHO-Listed Authority status for medicines

Dorothy Toh, Adena Lim, Agnes Chan, Alvin Chia, Pei San Ang, Annie Tan, Belinda Foo, Betty Chan, Limei Chong, Qiuyi Choo, Chih Tzer Choong, Christine Ho, Siew Wei Chua, Shin Chet Chuah, Clare Louise Rodrigues, Damian Chuah, Debbie Sun, Diana Koh, Doris Yeo, Esther Tan, Eugene Goh, Evelyn Lee, Flavian Ee, Freddie Foo, Xiao Wei Ge, Cheong Hian Goh, Phey Yen Han, Jalene Poh, Jean Low, Jessica Teo, Joyce Ng, Weng Fai Lai, Hui Keng Lee, Boon Kian Lim, Li Lian Lim, Na Lim, Sharon Lin, Boon Lee Ling, Lisa Tan, Yee Hoo Looi

This article aims to describe Singapore Health Sciences Authority’s (HSA’s) multi-year journey to attaining World Health Organisation (WHO) Maturity Level 4 (ML4) and WHO-Listed Authority (WLA) status for medicines regulatory functions, presenting HSA as a descriptive policy case study on the practical application of the WHO Global Benchmarking Tool (GBT) and WLA frameworks. It outlines the benchmarking and Performance Evaluation (PE) processes, including the scope of assessment, phased reviews, and key milestones …

03.09.2026journal-article

Frontiers in Public Health

The mediating role of psychological capital between work stress and compassion fatigue among clinical nurses: a cross-sectional study

Chengxi Huang, Dengbin Liao, Yunting Luo, Yiran Xu, Haoyang Luo, Lingxiao He

Objective To explore the parallel multiple mediating effects of the sub-dimensions of psychological capital (self-efficacy, hope, resilience, and optimism) between work stress and compassion fatigue among clinical nurses. Methods A cross-sectional study was conducted using convenience sampling. Clinical nurses from a tertiary hospital were recruited. Data were collected using a general demographic questionnaire, the Nurse Work Stress Scale (NWSS), the Psychological Capital Questionnaire-revised (PCQ-R), and the Pro …

03.09.2026journal-article

International Journal of Laboratory Hematology

Clinical and Laboratory Associations of JAK2 V617F Variant Allele Frequency in Patients With JAK2 V617F ‐Positive Erythrocytosis: A Single‐Centre Retrospective Analysis

Tahir Alper Cinli, Çisem Çınar

ABSTRACT Background JAK2 V617F variant allele frequency (VAF) reflects clonal burden in myeloproliferative neoplasms, but the clinical associations of low‐level VAF in patients with erythrocytosis remain uncertain. Objective The objective of this study is to examine associations between diagnostic JAK2 V617F VAF categories and clinical, laboratory, bone marrow and thrombotic outcomes in patients with JAK2 V617F‐positive erythrocytosis. Patients and Methods This single‐centre retrospective cohort included 174 adults …

03.09.2026journal-article

Journal of Hepato-Biliary-Pancreatic Sciences

Pretreatment Contrast‐Enhanced Harmonic EUS Predicts Pathological Response and Recurrence‐Free Survival After Multimodal Treatment in Resectable Pancreatic Cancer

Yuichi Kano, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Yoshihisa Takada, Ryohei Kumano, Takeshi Yamamura, Kazuhiro Furukawa, Hiroki Kawashima

ABSTRACT Objectives Recurrence remains common in resectable pancreatic cancer (PC) despite multimodal treatment. We evaluated whether pretreatment contrast‐enhanced harmonic endoscopic ultrasonography (CH‐EUS) predicts pathological response and recurrence‐free survival (RFS). Methods We retrospectively analyzed 52 patients with resectable PC who underwent CH‐EUS before standardized multimodal treatment (neoadjuvant chemotherapy, surgery, and adjuvant chemotherapy). Associations between CH‐EUS enhancement patterns ( …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Care Services for Patients with Noncancer Diseases in Outpatient Clinics Across Canada: A National Survey Study

Asia Estis-Deaton, Daphna Grossman, Tania Johannsen, Kathleen Milne, Leah Salvage, Michael Bonares

Background: The palliative care needs of patients with noncancer diseases are increasingly recognized, yet the prevalence, models, and delivery of outpatient specialist palliative care for these populations remain understudied. Objective: To describe outpatient palliative care clinics for noncancer diseases across Canada, including clinic prevalence and models of care. Methods: Cross-sectional survey study of practicing Canadian palliative care physicians recruited nationally. Quantitative data were analyzed descri …

03.09.2026journal-article

Pathogens

Clinical Characteristics and Antimicrobial Resistance Profiles of Pediatric Enterococcal Infections: A Comparison Between Enterococcus faecium and Enterococcus faecalis

Zixuan Wang, Chenchen Li, Yuanjie Zhou, Xiang Deng, Weichun Huang, Qing Cao

Objective: To compare the clinical characteristics, healthcare exposures, and antimicrobial susceptibility profiles of pediatric Enterococcus faecium and Enterococcus faecalis infections. Methods: This retrospective study included hospitalized children with E. faecium or E. faecalis isolated from sterile specimens between August 2018 and June 2025. Clinical characteristics and antimicrobial susceptibility were compared. Logistic regression identified factors associated with pathogen species, while negative binomial …