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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Nano LIFE

Protein Nanomedicine in Breast Cancer Therapy: Targeting Strategies, Clinical Applications and Future Perspectives

Samah Hamed Almurisi, Chua Hsuan Kai, Foo Yoong Kitt, Seow Wen En, Ngeow Qing Lun, Wee Hooi Yee, Bernice Chan Wen Jing, Annie Ling Hsiang Lan, Khater AL-Japairai, Dinesh Kumar Chellappan, Rana M. F. Sammour, Thiagarajan Madheswaran

The challenges of breast cancer treatment still exist despite significant progress. The challenges include tumor heterogeneity, drug resistance and systemic toxicity. However, the development of protein nanomedicine provides a good option to address these. The present review examines the possibilities of using protein-based nanomedicine in breast cancer treatment. It looks at targeted drug delivery, immune modulation and the mechanism of enhanced permeability and retention (EPR) for the precise targeting of the tum …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

Side effects of basic drug therapy in psychiatric practice

Vladimir Kozlovskii, Andrey Goncharenko

Adverse events that occur during basic drug therapy of patients with mental pathology are divided in accordance with the characteristics of the pharmacological action on the central and autonomic nervous regulation, as well as the sensitivity of peripheral organs to pharmacoinduced changes in metabolic processes in the body. All basic therapy agents are capable of inducing specific adverse effects associated with the pharmacodynamics of synaptotropic action on the central and autonomic nervous system and nonspecifi …

26.08.2026journal-article

Physiotherapy Research International

Intramuscular Fat Infiltration and Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Lili Yu, Cong Chen, Guancong Zhang, Qiuchen Huang, Miao Ye, Yukiko Makihara, Yusuke Nishida

ABSTRACT Background Intramuscular fat infiltration (IMFI) is considered to be closely associated with knee osteoarthritis (KOA); however, its overall association, muscle‐specific involvement, and clinical relevance remain unclear. Objective To quantify the association between IMFI and KOA, identify affected muscle groups, and evaluate prognostic value. Methods We searched PubMed, Web of Science, Scopus, and Embase up to December 2025 for observational studies. Two reviewers independently screened, extracted data, a …

26.08.2026journal-article

Endocrine Connections

Post-cycle therapy after androgen abuse: A narrative review of mechanisms, evidence, and clinical perspectives

Diederik L. Smit, Tijs Verdegaal, Peter Bond, Willem de Ronde

Abstract Post-cycle therapy (PCT) refers to the use of pharmacological agents—most commonly selective estrogen receptor modulators (SERMs), human chorionic gonadotropin (hCG), and aromatase inhibitors (AIs)—after cessation of androgen abuse to accelerate recovery of the hypothalamic–pituitary–gonadal (HPG) axis. Exogenous androgens suppress endogenous testosterone production through negative feedback, often resulting in a transient hypogonadal state that may persist for weeks to months, and occasionally longer, dep …

26.08.2026journal-article

Nutrients

Nutritional Rehabilitation and Medical Stabilization of Adolescents with Anorexia Nervosa: Length-of-Stay Predictors, Cardiovascular Recovery, Refeeding Safety, and Psychiatric Comorbidity Burden

Saba F. Elhag, Abdulla Fahmi, Abdulrahman Alansari, Sara Al-Kuwari, Amal Saleh Al-Kuwari, Amna Ahmed, Shahd Hani Jaouni, Amine Zaidi, Tasnim L. Milhem, Reem Bachir, Moayad H. Ali, Asma Ahmed, Qusi Shaban, Sheema Hashem, Madeeha Kamal

Background/Objectives: Adolescents with anorexia nervosa (AN) face substantial medical and psychiatric risk during hospitalization. We examined predictors of length of stay (LOS), cardiovascular recovery, refeeding safety, and psychiatric comorbidity in a consecutive pediatric cohort at a national tertiary center. Methods: Retrospective cohort of 68 consecutively admitted adolescents (91.2% female; mean age 14.2 ± 1.8 years, range 8–17; 85.3% restricting type) admitted between January 2017 and May 2025. A structure …

26.08.2026journal-article

Journal of Social Science and Human Research Studies

Systemic Thought in Psychology and Family Therapy: Interdisciplinary Origins, Flexibility, And African Relational Perspectives

Christian Matthew Adetunji

Objective : To reconstruct selected interdisciplinary origins of systemic thought in psychology and family therapy, clarify the movement from first- to second-order systems thinking, and examine how African relational scholarship and critiques of power revise contemporary systemic practice. Method: A critical narrative review was conducted using purposive searches of PsycINFO, Scopus, Google Scholar, Crossref, PubMed where clinically relevant, and publisher databases for foundational and interpretive literature on …

26.08.2026journal-article

Frontiers in Surgery

Morphometric and immunohistochemical reorganisation of the palatine tonsil in chronic tonsillitis and its response to combined ozone-ultrasound therapy

Nigina Alimova, Dilnoza Khasanova, Nigora Dustova, Nigora Asadova

Background Chronic tonsillitis is a common upper respiratory tract disease for which there is no objective tissue-level basis for judging conservative treatment. We characterised the morphometric and immunohistochemical reorganisation of the palatine tonsil in chronic tonsillitis and its response to a combined ozone-ultrasound protocol. Methods In a single-centre observational study with a pre-post design and no randomised comparator group, we examined 480 palatine tonsil specimens: histologically normal controls ( …

26.08.2026journal-article

Frontiers in Oncology

Immune checkpoint inhibitor–based combination therapy for platinum-resistant or platinum-refractory recurrent ovarian cancer: a systematic review and meta-analysis of prospective trials

Jing Xu, Lin Zhang, Wen-Ying Yang, Xiao-Jing Cai, Xiong Xiao

Background The clinical value of immune checkpoint inhibitor (ICI)-based combinations in platinum-resistant or platinum-refractory recurrent ovarian cancer remains regimen-dependent and uncertain. We updated the evidence base and separated nonrandomized response evidence from randomized comparative evidence. Methods PubMed/MEDLINE, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception to 23 July 2026, supplemented by reference and citation searching. E …

26.08.2026journal-article

Electronics

FPGA Chip-Based Mobile Sensor Design for Speech Emotions Recognition

Shing-Tai Pan, Han-Jui Wu

This paper presents a speech emotion recognition approach and its implementation on a field-programmable gate array (FPGA) with efficient neural network inference. The proposed approach employs a hybrid neural network architecture that integrates convolutional neural networks (CNNs), long short-term memory (LSTM) networks, and fully connected neural networks (FCNNs) to effectively capture both local and temporal features from speech signals. This architecture is well suited for modeling time-series data and is appl …

26.08.2026journal-article

Advances in Research

Current Evidence and Clinical Outcomes of Neuro-oncology Rehabilitation: A Systematic Review

Jagmohan Lal Meena, Madho Singh Mehra, Prakash Kumar, Arun Balaji, Bhumika Rathod, Nandinee P. Jena

Background: Adults with brain tumours can experience motor, cognitive, psychological and participation limitations across surgery, active treatment and survivorship, but rehabilitation evidence is heterogeneous. Objective: To synthesise clinical outcomes, harms and implementation results of structured adult neuro-oncology rehabilitation without statistical meta-analysis. Methods: Openly accessible PubMed/PMC record pages, ClinicalTrials.gov records, backward citations and related reports were searched through 30 Ju …

26.08.2026journal-article

Journal of Occupational & Environmental Medicine

Development and Validation of an Organizational Well-being Scale for Workers Across Diverse Industries

Watcharakorn Chuthong, Wiroj Jiamjarasrangsi, Jate Ratanachina

Objectives: To develop an instrument for assessing organizational well-being and examine its construct validity and cross-sample stability among Thai workers. Methods: This sequential validation study generated a 45-item pool across five domains. Survey 1 (telecommunications; n = 655) refined the scale using first- and second-order confirmatory factor analyses (CFA). Survey 2 (multi-sector; n = 511) evaluated cross-sample validation, model fit, and structural stability. Results: CFA condensed the instrument into a …

26.08.2026journal-article

Clinical nutrition and metabolism

Efficiency of a semi-elemental mixture as part of complex therapy for chronic diarrhea in patients with gastric cancer after completion of treatment

Olga A. Obukhova, Ildar A. Kurmukov

BACKGROUND: Radical antitumor treatment for gastric cancer (GC) can lead to chronic diarrhea. Therefore, the choice of enteral formula for nutritional support becomes important. AIM: To compare the effectiveness of using semi-elemental and standard polymer mixtures in the post discharge period in patients after gastrectomy. METHODS: A retrospective, non-randomized, single-center study included patients with gastric cancer over 18 years old after gastrectomy, completed anticancer treatment, had no progression of the …

26.08.2026journal-article

Health Science Reports

Comparison of Therapist‐Guided Versus Self‐Guided Internet‐Based Stress Inoculation Therapy (ISIT) on Psychological Distress Symptoms in Women After Miscarriage in Iran: A Study Protocol of a Randomized Clinical Trial

Nazanin Karimihamzekolaee, Hajar Adib‐Rad, Hajar Pasha, Mahbobeh Faramarzi, Hossein‐Ali Nikbakht, Melika MashaghiTabari, Maryam Ghaemi‐Amiri, Farideh Mohsenzadeh–Ledari

ABSTRACT Background and Aims Miscarriage can lead to various psychological consequences such as grief, anxiety, depression, and psychological distress. Although women who experience a miscarriage may not have formed a bond with their unborn child, the intensity of grief following an abortion does not significantly differ from the loss of other first‐degree relatives. The present study will be conducted to compare therapist‐guided versus self‐guided internet‐based stress inoculation therapy (ISIT) on psychological d …

26.08.2026journal-article

Cells

Liposomal Drug Delivery in Ocular Therapy: Strategies for Enhancing Corneal Penetration and Bioavailability

Palak Mehta, Erik Moore, Alekha Dash, Surabhi Shukla

Vision impairment affects approximately 2.2 billion people worldwide, with glaucoma, age-related macular degeneration, fungal keratitis, and diabetic retinopathy among the leading causes of preventable blindness. Effective pharmacotherapy remains severely constrained by the eye’s multilayered barrier architecture. Tear film, the corneal epithelium, the blood–aqueous barrier, and the blood–retinal barrier collectively restrict conventional topical drug bioavailability to less than 5% of the administered dose. Liposo …

26.08.2026journal-article

International Journal of Nusantara Islam

Differentiated Learning Management in Improving Elementary School Students' Speech Text Writing Skills

Santi Susilawati Suherman, Eva Dianawati Wasliman

This qualitative study examines how the management of differentiated instruction enhances speech-writing skills among elementary school students at SD Negeri Lemburtengah and SD Negeri Sriwidari 1. Guided by George R. Terry’s POAC (Planning, Organizing, Actuating, Controlling) framework, data were collected through observation, interviews, and documentation, and subsequently analyzed using the Miles and Huberman model. The findings indicate that systematic management of differentiation—encompassing content, process …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Influence of sarcopenia on functional independence and depression in older adults: a cross-sectional study

Tae-Hyun Yoon, Yong-Seok Jee

Differences in physical function, encompassing activities of daily living (ADL) and instrumental activities of daily living (IADL), and depression were evaluated across degrees of sarcopenic severity in older adults. A total of 236 participants (78.72±6.92 years), comprising 101 men and 135 women, were classified into four groups: no sarcopenia (23.7%), possible sarcopenia (26.3%), sarcopenia (28.0%), and severe sarcope-nia (22.0%). Sarcopenic measures included calf girth, grip strength, 5-time chair stand test, an …

27.08.2026journal-article

Annals of Work Exposures and Health

The occupational exposome and new-onset COPD: longitudinal analyses of two European cohorts

Theresa Kynde, Wenxin Wan, Anne Mette Lund Würtz, Lützen Portengen, Jorunn Kirkeleit, Sheikh M Alif, Andrei Malinovschi, Benedicte Leynaert, Caroline Jane Lodge, Cecilie Svanes, Chantal Raherison, Emeline Lequy, Geza Benke, Hanifa Bouziri, Hans Kromhout, Hans Orru, Hayat Bentouhami, Ioannis Basinas, Isabel Urrutia Landa, Jan-Paul Zock, Jenny Selander, Jesús Martínez-Moratalla Rovira, Judith Garcia-Aymerich, Katarina Kjellberg, Lars Modig, Leopoldo Palacios Gómez, Lidia Casas Ruiz, Maria Albin, Mathias Holm, Nicole Le Moual, Orianne Dumas, Pascal Demoly, Pernilla Wiebert, Rachel Nadif, Susan Peters, Theodore Lytras, Thorarinn Gislason, Valerie Siroux, Victoria Alcaraz-Serrano, Henrik Albert Kolstad

Abstract Objectives Occupational exposures may contribute to the development of COPD, a leading cause of morbidity and mortality globally. Using an exposome approach in a follow-up design, we aimed to examine the association between the occupational exposome and new-onset COPD in 2 population-based cohorts: the European Community Respiratory Health Survey (ECRHS) with 2 follow-ups (n = 4,087; observations = 6,224) and the CONSTANCES cohort with 1 follow-up (n = 8,255). Methods COPD was defined by respiratory sympto …

26.08.2026journal-article

Archives of Anesthesia and Critical Care

Extracorporeal Hemoperfusion as an Adjunctive Therapy in Neurotoxic Snakebite Envenomation: A Case Report

Mohammad Arief Kurniawan, Riyadh Firdaus, Sidharta Kusuma Manggala

Snakebite envenomation is a medical emergency with potentially fatal systemic complications. We report a case of a 32-year-old male patient who presented to the Emergency Department with a complaint of a snakebite on his right ear. On arrival, he didn’t have signs of bleeding, fever, or swelling. Two hours after admission, the patient developed cardiac arrest and required mechanical ventilation. Although resuscitation was successful, the patient’s condition deteriorated, with progressive neurological and motor defi …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

The room is the whole world. The movie "The Room": comment by a practicing psychiatrist

Aleksandr Artem'ev

The film "The Room", the script of which is based on real events, reliably shows the mechanisms of adaptation of mother and child in conditions of prolonged isolation, psychological pressure and physical suffering. In harsh conditions, all the hidden resources of the body are activated to ensure survival. But as soon as the tension subsides, the symptoms of post-traumatic stress disorder increase. The flexibility of the child's psyche allows for faster adaptation to a new reality, and an adult needs support and pro …

26.08.2026journal-article

American Journal of Speech-Language Pathology

Impact of Respiratory Muscle Strength Training Program on Hospital Readmissions in Patients With Chronic Obstructive Pulmonary Disease: A Retrospective Pilot Study

Juhi Vora, Sarah Morey

Purpose: Chronic obstructive pulmonary disease (COPD) is associated with high 30-day hospital readmission rates and significant health care costs. Respiratory muscle weakness and dysphagia are common in this population and may contribute to adverse outcomes. Respiratory muscle strength training (RMST) has demonstrated benefits in outpatient settings; however, evidence supporting its initiation during acute hospitalization is limited. The purpose of this study was to evaluate the impact and feasibility of a speech-l …

26.08.2026journal-article

Cahiers Africains de rhétorique

La diplomatie par la parole : tradition mbochi et doctrine de Sassou N'Guesso au Congo (1979-2026)

Gomas Aimée Noelle

Publié en 1997, à la charnière du retour au pouvoir de son auteur à l'issue d'une guerre civile, Le manguier, le fleuve et la souris est à la fois un récit de vie et un exposé de politique étrangère, rédigé par un chef d'État congolais qui dirige son pays depuis près d'un demi-siècle. Cet article reconstitue, à partir du texte lui-même, la doctrine diplomatique que Denis Sassou N'Guesso y revendique. Aussi, il la confronte à l'historiographie indépendante des épisodes qu'il relate et à la diplomatie conduite par la …

26.08.2026journal-article

Frontiers in Endocrinology

Effect of magnetic thermal vibration therapy combined with Femoston on endometrial repair in postoperative patients with moderate to severe intrauterine adhesions: a randomized controlled trial

Aiping Wu, Qun Huang, Jing Zhang, Liping Chen

Background Moderate to severe intrauterine adhesions (IUA) remain clinically challenging after hysteroscopic adhesiolysis because endometrial repair may be incomplete, and uterine perfusion may remain suboptimal. This study evaluated whether magnetic thermal vibration therapy (MTVT) combined with Femoston improves postoperative recovery compared with Femoston alone. Methods This single-center, parallel-group, randomized controlled superiority trial enrolled 200 postoperative women aged 18–40 years with moderate to …

26.08.2026journal-article

Heart Failure Reviews

The long road to recognition: a historical review of amyloidosis from early pathology to disease-modifying therapy

Lauren N. Halverson, Brett W. Sperry

Abstract Within the last several decades, great strides are being made in both the diagnosis and treatment of cardiac amyloidosis, yet the condition itself has been a severely under-recognized cause of heart failure for centuries. For much of medical history, the accumulation of these insoluble fibril deposits was an enigmatic finding, observed primarily post-mortem in patients suffering from chronic inflammatory conditions. This review traces the fascinating evolution of amyloidosis: from its origins as a botanica …

26.08.2026journal-article

Frontiers in Oncology

Circulating tumor DNA in neoadjuvant therapy for solid tumors

Xueqin Huang, Yu Deng, Yi Shen

Circulating tumor DNA (ctDNA), a core component of liquid biopsy, demonstrates significant potential in the field of neoadjuvant therapy for solid tumors. This review systematically examines the role of ctDNA across the pre-, intra-, and post-neoadjuvant treatment phases, with a focus on its value in predicting therapeutic efficacy, assessing early treatment response, detecting minimal residual disease (MRD), and monitoring for recurrence. By synthesizing the latest clinical research data and advancements in molecu …