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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Experimental & Molecular Medicine

Histone deacetylases in cancer metabolic reprogramming

Yu Hyun Jeon, Hyeyeong Seo, Ji Woo Youn, Jung Yoo, Sang Wu Lee, Soo Yeon Oh, So Hee Kwon

Abstract Cancer cells undergo extensive metabolic reprogramming to sustain rapid proliferation and adapt to heterogeneous tumour microenvironments. These metabolic alterations are tightly linked to epigenetic regulation, which reshapes gene expression and cellular signalling mechanisms. Among epigenetic regulators, histone deacetylases (HDACs) have emerged as key modulators of cancer metabolic reprogramming. Along with their canonical roles in histone deacetylation, HDACs regulate non-histone substrates, including …

02.09.2026journal-article

Pharmaceuticals

Treatment-Emergent Epiretinal Membrane in Diabetic Macular Edema: A Real-World OCT-Based Comparative Pharmacotherapy Study Across Intravitreal Agents—The TRIDENT-DME Study

Debdulal Chakraborty, Tushar Kanti Sinha, Rupak Kanti Biswas, Aniruddha Maiti, Manab Jyoti Barman, Ranabir Bhattacharya, Subhendu Kumar Boral, Arnab Das

Purpose: To evaluate the incidence, predictors, and clinical impact of treatment-emergent epiretinal membrane (ERM) in diabetic macular edema (DME) treated with dexamethasone implant, aflibercept, ranibizumab, bevacizumab, or faricimab. Methods: In this multicenter, retrospective, nonrandomized study, 501 eyes with center-involving DME were assessed and 423 eyes without ERM on pretreatment OCT and with 24-month follow-up were included. Eyes were classified by the intravitreal agent selected by the treating physicia …

02.09.2026journal-article

AGING MEDICINE

Association Between Hair Cortisol, Sarcopenia, and Sarcopenic Obesity: Results From the ELSA ‐Brasil Study

Christiano Barbosa da Silva, Isiyara Taverna Pimenta, Rosane Harter Griep, Arlinda Barbosa Moreno, Isabela Judith Martins Bensenor, Sandhi Maria Barreto, Maria Inês Schmidt, Anissa Daliry, Maria de Jesus Mendes da Fonseca

ABSTRACT Objectives Hair cortisol has been increasingly used as an important biomarker of chronic stress, as it reflects prolonged systemic exposure to cortisol over time. Such exposure has been associated with alterations in body composition; however, the associations with sarcopenia and sarcopenic obesity have still received little attention in the scientific literature on aging. The study aimed to assess the association between hair cortisol, dynapenia, sarcopenia, and sarcopenic obesity in a multicenter and mul …

02.09.2026journal-article

Sports Medicine - Open

Invisible Harms, Visible Benefits? Adverse Event Reporting in Physical Activity Interventions for Neurodevelopmental Disorders: A Meta-analysis and Critical Appraisal

Jinrong He, Changhui Peng, Lei Zhang, Dandan Wang, Xiaohuan Tan, Xili Wen, Xin Shen, Xueping Wu

Abstract Background Clinical guidelines and practice increasingly endorse physical activity interventions for individuals with neurodevelopmental disorders. However, because monitoring and reporting of potential intervention-related harms are often incomplete, the current evidence base regarding safety remains limited. Methods A systematic search of PubMed, Web of Science, Scopus, the Cochrane Library, and EBSCO was conducted on November 11, 2025, followed by three rounds of supplementary snowball searching complet …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Echinococcosis in Pregnancy: A Systematic Review on Complications, Management, and Outcomes

Kiarash Kavari, Reza Ebrahimzadeh Mirzaei, Fatemeh Khajehasani, Nasrin Asadi, Mohammad Shafiee, Majid Fasihi Harandi

ABSTRACT. Echinococcosis in pregnancy represents a complex clinical condition in terms of diagnosis and treatment with potential risk to both maternal and fetal health. There are limited clinical data on the nature and consequences of echinococcosis during pregnancy. This systematic review summarizes the current evidence on the clinical presentation, management, complications, and outcomes of echinococcosis during pregnancy. PubMed, Scopus, Web of Science, and Embase databases from 1990 to 2025 were queried. Sixty- …

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02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Social Perceptions of Konzo Disease in Nampula Province, Mozambique

Litos Raimundo, Daniela Rodrigues, Maria-Raquel G. Silva

ABSTRACT. Konzo, a neurodegenerative disease prevalent in Nampula Province, Mozambique, presents debilitating symptoms known locally as “mantakassa” (“that which breaks legs”). Although the biomedical literature attributes its cause to insufficiently processed cassava amid food insecurity, traditional narratives often cite supernatural explanations, like witchcraft. This review analyzed the existing literature to understand social perceptions of konzo, focusing on traditional leaders’ perspectives and their implica …

02.09.2026journal-article

GLOBAL JOURNAL OF PHARMACEUTICAL AND SCIENTIFIC RESEARCH

CLINICAL SIGNIFICANCE OF NUTRACEUTICALS IN HYPERTENSION: PERSPECTIVES FROM INDIAN RESEARCH

Hardik Agrahari, Vimal Kumar Yadav, Akanksha Singh

Hypertension is a major global health challenge and a leading risk factor for cardiovascular disease, stroke, and renal complications. Despite effective pharmacological treatment, inadequate blood-pressure control and treatment-related limitations have increased interest in complementary approaches. Nutraceuticals, including medicinal plants, vitamins, minerals, fatty acids, polyphenols, probiotics, and functional foods, have demonstrated potential antihypertensive effects through modulation of nitric oxide availab …

02.09.2026journal-article

Journal of Pediatric Orthopaedics

Cell Saver Use is Not Associated With Increased Morbidity But Reflects Transfusion Burden in Pediatric Spinal Deformity Surgery: A Retrospective Cohort Study

Daniel A. Ortega, Yaxel Levin-Carrion, Justin L. Reyes, Elisabeth Geraghty, Ted Shi, Hannah Peterson, Takera Purdie, Daysha Fliginger, Lawrence G. Lenke, Joseph M. Lombardi, Lisa Eisler, Zeeshan M. Sardar

Study Design: Retrospective cohort study. Introduction: Cell saver (CS) is widely used in spinal fusion to reduce exposure to allogeneic transfusion, which carries risks such as infection and prolonged hospitalization. Pediatric spinal fusion is frequently associated with significant intraoperative blood loss. Concerns persist that reinfused blood could increase morbidity. We therefore evaluated the association between CS exposure and postoperative outcomes after pediatric spinal fusion using the American College o …

02.09.2026journal-article

American Journal of Surgical Pathology

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Michelle R. Downes, Sara E. Wobker, Steven C. Smith, Markus Eckstein, Mahmut Akgul, Dilek E. Baydar, Fadi Brimo, Eva Compérat, Arndt Hartmann, Ashish M. Kamat, Anandi Lobo, Maria R. Raspollini, Ankur R. Sangoi, Shahrokh F. Shariat, Toyonori Tsuzuki, Bas W. G. van Rhijn, Sean R. Williamson, Geert J. L. H. van Leenders, Liang Cheng, Antonio Lopez-Beltran, the Members of ISUP GU Cancer Treatment Effects Consensus Panel

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025, focused on the evaluation of treatment effects in both the prostate and bladder. Working Group 2 was assigned the topic of the urinary bladder, and a group of pathologists and clinicians was convened. They worked cooperatively to develop …

02.09.2026journal-article

Advances in Skin & Wound Care

Implementing a Nurse-driven Quality Improvement System for Incontinence-associated Dermatitis Prevention in a General Surgery Ward

Hongxia Xu, Yanping Huang, Lili Cheng, Huiyan Wei, Liping Zhu, Liuqun Feng, Ying Wang, Jinli Mao, Hongyang Hu, Hongying Pan

OBJECTIVE: This quality improvement (QI) project evaluated the effectiveness of a structured, nurse-driven incontinence-associated dermatitis (IAD) prevention system in reducing IAD incidence and severity and improving nursing staff knowledge and caregiver adherence in a general surgery ward. METHODS: A pre-post QI project was conducted in the general surgery ward of a tertiary hospital. The intervention included systematic identification of high-risk patients, standardized preventive nursing protocols, nurse train …

02.09.2026journal-article

Biomedicines

Stem Cell-Derived Extracellular Vesicles for the Treatment of Osteoporosis: A Systematic Review of Preclinical Evidence

Yi Yang, Lifen Qiao, Yan Huang, Qin Xia, Hui Xie

Background: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mass and microarchitectural deterioration, resulting in an increased risk of fractures. Stem cell-derived extracellular vesicles (EVs) have emerged as a promising cell-free therapeutic strategy owing to their inherent advantages, including excellent biocompatibility, low immunogenicity, diverse biological activities, and engineering potential. Despite growing interest in this field, the existing preclinical evidence remains high …

02.09.2026journal-article

The Journal of Applied Engineering and Technologies

Propagation-Aware Sensor Evidence Mapping for Aircraft Engine Health Diagnosis

Camille Laurent, Antoine Moreau, Claire Dubois

Aircraft engines generate continuous multivariate sensor time series from exhaust gas temperature, fuel flow, vibration, rotor speed, oil pressure, compressor pressure ratio, turbine temperature, and control actuator signals. These variables are tightly coupled through thermodynamic, mechanical, and control feedback relationships. A local abnormal change in one component may propagate to multiple downstream sensors, making it difficult to distinguish the initiating fault from secondary responses. This study propose …

02.09.2026journal-article

Journal of Emergency and Disaster Medicine

Unmanned systems in large-scale combat operations: a scoping review of their impact and integration in prolonged casualty care

Chloé Waters, Attila J. Hertelendy, Fadi Issa, Williams Lopez Vidal, Amalia Voskanyan, Gregory Ciottone

Abstract Background Large-scale combat operations (LSCO) have disrupted prior battlefield healthcare models reliant on rapid evacuation and the “Golden Hour.” In contemporary conflicts, including Ukraine, Gaza, Sudan, and Iran, care is often delivered in highly contested environments with degraded infrastructure and persistent surveillance, where evacuation is frequently delayed or denied. This has necessitated a shift toward prolonged casualty care (PCC). Although unmanned systems (UxS) demonstrate utility in civi …

02.09.2026journal-article

Annals of Surgery

Integrative Muscle-Adipose Score (IMAS)

Frederik Schliephake, Isabella Lurje, Jan Bednarsch, Katharina Dreher, Jude Bitar, Carolin V. Schneider, Deniz Uluk, Zoltan Czigany, Pavel Strnad, Cornelius Engelmann, Ulf P. Neumann, Florian W. Vondran, Johann Pratschke, Robert Öllinger, Frank Tacke, Georg Lurje

Objective: To investigate the potential of integrating muscle and fat compartments into a novel and unified score for outcome prediction in a bicentric European cohort of LT recipients. Background: Body composition (BC) reflects nutritional status and metabolic reserves and influences outcomes after orthotopic liver transplantation (LT). Validated tools for predicting long-term survival after LT remain scarce. Increasing evidence highlights sex-specific disparities in post-transplant outcomes. Study Design: A total …

02.09.2026journal-article

Ophthalmic Plastic & Reconstructive Surgery

Occult Lacrimal Pathology in Young Versus Older Patients With Presumed Primary Acquired Nasolacrimal Duct Obstruction: Implications for Preoperative Imaging

Steffie Arès, Charlotte Lussier, Olivia Serhan, Myriam Belaiche, Evan Kalin-Hajdu

Purpose: Approximately 50% of ASOPRS surgeons consider young age to be an indication for imaging in patients with nasolacrimal duct obstruction. This practice is rooted in the assumption that young age confers a higher risk of clinically occult disease. This study examines whether young age is, in fact, associated with clinically occult lacrimal pathology. Methods: A retrospective multicenter chart review was conducted at the Université de Montréal on consecutive patients with clinically presumed primary acquired n …

02.09.2026journal-article

Academy for Practical Oncology

Comparative analysis of clinical and functional results of one-stage and two-stage breast reconstruction after mastectomy in patients with large mammary glands

S. V. Kozlov, O. I. Kaganov, M. V. Tkachev, A. V. Bukin

BACKGROUND : The advancement and refinement of surgical treatment approaches for breast carcinoma facilitate the preservation of a high quality of life in patients following reconstructive procedures, particularly in cases of substantial breast volume and pronounced ptosis. AIM : To compare the immediate and long-term outcomes and quality of life in patients undergoing two-stage versus one-stage reconstruction after skin-sparing mastectomy in breasts exceeding 150 mL in volume. METHODS : A retrospective analysis of …

02.09.2026journal-article

World Journal of Surgery

Perioperative Hemoglobin Trajectory and Hemoglobin Decrease in Major Abdominal Surgery

Javier Ripollés‐Melchor, Ane Abad‐Motos, Carlos Jericó, Toby Richards, Ángel Espinosa, Gianluca Pellino, Diana Fernández‐García, Rosalía Navarro‐Pérez, Rachel Budithi, Kenneth J. Macpherson, José A. García‐Erce, POSTVenTT Group

ABSTRACT Background Most studies evaluate perioperative hemoglobin at a single time point despite substantial changes across the perioperative period. We examined whether perioperative hemoglobin trajectory and perioperative hemoglobin decrease were associated with postoperative outcomes after major abdominal surgery. Methods We performed a secondary analysis of the international POSTVenTT cohort, a prospective multicentre observational study of adults undergoing major abdominal surgery. Hemoglobin trajectory was d …

02.09.2026journal-article

Journal of Tropical Medicine and Public Health Solutions

Haematological Responses to Ethanol Extracts of Chia Seed and Tiger Nut in Alloxan-Induced Diabetic Rats

Chinyere S. Nwaka, Andrew C. Nwaka

Diabetes mellitus is often accompanied by disturbances in haematological indices, reflecting the broader metabolic stress of chronic hyperglycaemia. This study evaluated the effect of ethanol extracts of chia seed (Salvia hispanica) and tiger nut (Cyperus esculentus), administered separately and in combination, on haemoglobin (Hb), packed cell volume (PCV), red blood cell (RBC) count, white blood cell (WBC) count, lymphocyte, and neutrophil levels in alloxan-induced diabetic Wistar rats. Sixty-three male rats were …

02.09.2026journal-article

Neuroradiology

Clinical outcome after rescue intracranial stenting: a comparison of the ACCLINO flex and the CREDO heal stenting platforms after failed mechanical thrombectomy

Christoph M. Mooshage, Niclas Schmitt, Fabian Preisner, Tim Hilgenfeld, Kianush Karimian-Jazi, Michael O. Breckwoldt, Daniel Schwarz, Alexander Hubert, Sophia Hohenstatt, Julius M Kernbach, Alexandra Filipov, Damjan Mirkov, Peter A Ringleb, Christian Herweh, Martin Bendszus, Dominik F. Vollherbst, Markus A. Möhlenbruch

Abstract Purpose Mechanical thrombectomy (MT) is the first-line therapy for patients with acute ischemic stroke due to large vessel occlusion; however, despite substantial advances in MT techniques and devices, mechanical recanalization remains unsuccessful in up to 15% of patients. Intracranial rescue stenting represents a promising option to achieve successful recanalization and good clinical outcomes in patients with failed MT. Methods In this retrospective, observational single-center analysis 77 consecutive pa …

02.09.2026journal-article

Review of Communication Research

Application of Computer-Simulation-Based Clinical Case Training for General Practice Clinical Reasoning in Standardized Residency Training: A Digital Health Communication Perspective

Huan Yu, Zhen Qiao, Lina Ma, Peng Li

Clinical reasoning is a core competency in standardized residency training for general practitioners, yet conventional case-based instruction is often constrained by limited clinical exposure, inconsistent case complexity, and insufficient opportunities for repeated decision-making practice. This study explores the application of computer-simulation-based clinical case training to improve clinical reasoning among general practice residents from a digital health communication perspective. A digital simulation enviro …

02.09.2026journal-article

Iranian Journal of Allergy, Asthma and Immunology

Clinical and Inflammatory Benefits of Nebulized Furosemide with Salbutamol–ipratropium in COPD Exacerbations: A Randomized Controlled Trial

Mahdi Behi, Babak Gholamine, Mohammad Reza Masjedi, Alireza Eslaminejad, Esmaeil Idani, Mohsen Sadeghi, Akram Qanavati, Sayed Mehran Marashian, Esmaeil Mortaz, Atefeh Abedini, Mihan Pourabdollah, Bita Pakshad, Saeid Mahmoodian

Exacerbations of chronic obstructive pulmonary disease (COPD) are a leading cause of morbidity, mortality, and healthcare burden. While standard bronchodilator therapy alleviates airway obstruction, its efficacy is often limited. This study evaluated nebulized furosemide, which has bronchodilatory and anti-inflammatory effects, as an adjunct to salbutamol–ipratropium in hospitalized COPD patients. Ninety‑two patients with exacerbated COPD were randomly assigned to two equal groups (46 each). The intervention group …

02.09.2026journal-article

Artefactum - revista de estudos interdisciplinares

COMPATIBILITY OF RICE HUSK AS A CARRIER MEDIUM FOR BACILLUS SP. IN AN ACTIVATED SLUDGE PROTOTYPE FOR DOMESTIC SEWAGE TREATMENT

Carlos Eduardo Saraiva Mauer

Sanitation in Brazil still shows significant gaps in coverage and operational efficiency, which encourages the search for inputs capable of enhancing the performance of wastewater treatment plants. Among these inputs are granular bioremediators, whose formulation relies on food-grade cereals – mainly wheat bran – as the carrier medium for microorganisms, accounting for roughly 70% of the product cost. This article assesses the compatibility of rice husk, an abundant and low-cost agro-industrial residue, as a carrie …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Building Research Leadership for Global Health Impact

Anna Kalbarczyk, Meagan Harrison, Yukari C. Manabe, Benjamin H. Chi, Bhakti Hansoti

ABSTRACT. Global health research training programs have traditionally emphasized methodological competencies, yet technical skills alone cannot ensure equitable partnerships, effective crosscultural collaboration, or durable and locally relevant research impact in international settings. The Research Leadership Academy (RLA) was developed to fill this gap. The RLA is a structured leadership curriculum embedded within the NIH Fogarty-funded UJMT LAUNCH global health research fellowship grounded in experiential learn …