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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Cancers

The Impact of Molecular Characteristics on the Efficacy of Frontline Immune Checkpoint Inhibitor Therapy in Patients with Metastatic Melanoma

Seo Yoon Jang, Minsuk Kwon, Jeeyun Lee, Seung Tae Kim

Background: Metastatic melanoma in East Asian populations is enriched for acral and mucosal subtypes and harbors a distinct molecular landscape compared with Western cutaneous melanoma. However, data on the efficacy of first-line immune checkpoint inhibitor (ICI) therapy and on the impact of molecular characteristics on treatment effect in this population remain limited. We aimed to characterize the genomic landscape of an East Asian metastatic melanoma cohort and to evaluate the predictive values of molecular mark …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Effects of different rest intervals following postactivation performance enhancement on multiple components of performance-related fitness in elite athletes

Chan-Gyun Oh, Dong-Eun Kim, Tae-Beom Seo

This study aimed to investigate the effects of different rest intervals fol-lowing postactivation performance enhancement (PAPE) on upper- and lower-body skill-related physical fitness in elite athletes. Seven male elite athletes participated in a crossover design and completed four ex-perimental conditions: the control (CON), the 3-min rest (R3), the 8-min rest (R8), and the 12-min rest (R12) groups following PAPE. In the PAPE conditions, participants performed additional warm-up sets at 50% and 70% of one-repetit …

26.08.2026journal-article

Renal Replacement Therapy

Real-time microcirculatory monitoring during intradialytic exercise using an earlobe laser Doppler flowmeter: an exploratory preliminary study

Makoto Saito, Hideto Tanaka, Miki Matsui, Kazuyoshi Karasuda, Yoko Kato

Abstract Background Intradialytic exercise is recommended to improve exercise capacity, physical function, and quality of life in patients undergoing maintenance hemodialysis (HD). However, objective and practical physiological indicators for monitoring circulatory responses during intradialytic exercise remain limited in routine clinical settings. Laser Doppler flowmeter (LDF) enables noninvasive assessment of microcirculatory blood flow and may provide a useful method for monitoring peripheral circulation during …

26.08.2026journal-article

Frontiers in Rehabilitation Sciences

Handgrip strength reference values and dynapenia risk thresholds in an urban adult sample from Lima, Peru

Santos Lucio Chero-Pisfil, Aimeé Yajaira Díaz-Mau, Vanessa Elizabeth Huamanchumo-Barrientos, Rosita Maricielo Samame-Pérez, Estrella Elena Sosa-Quispe, Edgar Mario Tipula-Tipula, Ángel Eduardo Rueda-Villegas, Regina Munarriz-Medina, Antonio Esquinas

Background Handgrip strength is widely recognized as a practical biomarker of muscle function and an important screening tool for sarcopenia and functional decline. However, most di-agnostic thresholds currently used in clinical practice were developed in European or North American populations, which may limit their applicability in other ethnic groups. Evidence suggests that muscle strength varies substantially across populations, potentially leading to misclassification when universal cut-off points are applied. …

26.08.2026journal-article

Frontiers in Rehabilitation Sciences

Effectiveness of low vision rehabilitation on visual function and quality of life in Sub-Saharan Africa: a systematic review

Kwadwo Owusu Akuffo, Sylvia Agyekum, Sylvester Kyeremeh, Albert Kwadjo Amoah Andoh, Isaiah Osei Duah Junior, Josephine Ampomah Boateng, Nana Akwasi Owusu Mensah, Eldrick Adu Acquah, David Owiredu, Samson Darrah, Debora Abena Baidoo, Werner Eisenbarth

Aim This systematic review evaluates the effectiveness of low vision rehabilitation on visual outcomes and quality of life in Sub-Saharan Africa (SSA). Data sources Databases such as PubMed, Web of Science, CENTRAL, Google Scholar, and Scopus were searched from inception to May 2025. Searches were restricted to English-language publications. Review methods Titles and abstracts were screened in Covidence, with data extraction performed independently by two reviewers and disagreements resolved by consensus. Methodolo …

26.08.2026journal-article

Frontiers in Cardiovascular Medicine

Longitudinal changes in left atrial function during chronic ibrutinib therapy: a prospective observational study

Matea Kolacevic Zeljkovic, Sandra Basic-Kinda, Dubravka Čaržavec, Marijo Vodanovic, Inga Mandac Smoljanovic, Ozren Jaksic, Matea Novak, Slobodanka Ostojic-Kolonic, Dino Dujmovic, Vlatko Pejsa, Igor Aurer, Nikola Bulj

Background Ibrutinib is effective for B-cell malignancies but is associated with cardiovascular adverse events, including atrial fibrillation (AF) and hypertension. Longitudinal data on left atrial (LA) remodeling during treatment are limited. We characterized serial changes in LA size and function during chronic ibrutinib therapy. Methods In this prospective observational cohort, 40 patients starting ibrutinib underwent clinical assessment, 24–72-hour Holter monitoring, and echocardiography with LA strain at basel …

26.08.2026journal-article

Langmuir

Coordination-Mediated Glucose Oxidase Functionalization Endows UiO-66 with Aqueous Monodispersity for Self-Augmented Anticancer Therapy

Yanru Yuan, Zhe Liu, Yifan Cao, Keying Lv, Zimu Li, Yanhua Wu, Shengnan Xin, Jinghan Wang, Dandan Wang, Peiwei Gong

Abstract Metal–organic frameworks show great potential for drug delivery, but issues such as poor aqueous dispersibility and structural complexity impose significant limitations on their further application. Herein, this study reports a novel surface modification strategy that utilizes the phenolic groups of the tyrosine residues on the endogenous glucose oxidase (GOx) molecule to coordinate with the zirconium elements in the UiO-66 structure. This strategy improves the dispersibility of UiO-66 in water through sur …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

Rehabilitation potential for CNS pathology in patients with musculoskeletal dysfunction using the categories of the International Classification of Functioning, Disability and Health (ICF)

Boris B. Polyaev, Mikhail B. Tsykunov, Olga V. Fuchizhi, Mariya A. Bulatova, A. Y Suvorov

Introduction.Determining the rehabilitation potential (RP) is a key stage in planning medical rehabilitation (MR). The International Classification of Functioning, Disability and Health (ICF) provides a standardized method for assessing impairments, including from the perspective of a physical therapist (PT) as a leading member of the multidisciplinary rehabilitation team (MDRT). The assessment of the musculoskeletal system in patients with CNS pathology is particularly important, as it serves as the primary effect …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

The phenomenon of survival motivation in the structure of life-meaning orientations and the Self-concept of a serviceman in combat conditions

Yuliya Grigor'eva, Dilyara Efremova

In the course of the research "The phenomenon of motivation to survive in the structure of life-meaning orientations and the Self-concept of a serviceman's personality in combat conditions", a semi-structured interview was conducted with the participation of military personnel who are on the line of combat contact. In the interview, the clinical signs of acute stress disorder and life-meaning orientations and Self-concepts of the personality of military personnel were investigated. The interview included the follow …

26.08.2026journal-article

Revista ft

Massofilaxia facial e LED vermelho associados à nanotecnologia no tratamento da flacidez tissular

Erilaine Batista Quintiliano de Lima, Daiana da Silva Granja Amorim, Juliana Barbosa de Sena Silva, Luena Maria Moraes Trindade, Luciana de Almeida Ferreira

Skin aging is a complex biological phenomenon resulting from the interaction between intrinsic factors, related to the body’s natural aging process, and extrinsic factors, such as exposure to ultraviolet radiation, environmental pollution, unhealthy lifestyle habits, and oxidative stress. These conditions promote structural changes in the skin, including the degradation of collagen and elastin fibers, reduced tissue regeneration capacity, and impairment of barrier function, resulting in wrinkles, laxity, loss of el …

26.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Recent advances in piezoelectric hydrogels for osteoarthritis therapy: material design, signal transduction, and clinical translation

Senbo Zhu, Yu Tong

With no disease-modifying therapy available, osteoarthritis (OA) remains a primary cause of disability worldwide. However, between 2023 and 2026, rapid advances have been made in the development of piezoelectric hydrogels, a technology that transduces joint motion into endogenous electrical signals, thereby restoring the electromechanical microenvironment of degenerated cartilage. This short review provides a critical synthesis of these developments through a four-dimensional framework encompassing material design, …

26.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Hearing Aid Benefit in Auditory Neuropathy Due to Friedreich Ataxia: A Case Report

I. Zay Melville, Alice H. Smith, Gavin B. Coad, Peter R. Thorne, Richard H. Roxburgh, Rachael L. Taylor

Purpose: Friedreich ataxia is one of the most common recessively inherited ataxias, with hearing loss due to auditory neuropathy being a recognized complication. However, there are limited data on the best interventions for hearing loss in these patients. We report the significant behavioral and subjective benefits of binaural amplification in a patient with auditory neuropathy due to Friedreich ataxia. Method: Auditory function was assessed in a 44-year-old woman with genetically confirmed Friedreich ataxia using …

26.08.2026journal-article

Southern African Journal of HIV Medicine

Early outcomes of South African children with persistent viral non-suppression following switch to dolutegravir-based antiretroviral therapy

Mila Guerrini, Minette Maré, Claire Hulsman, Leonore Greybe, Juanita Lishman, Clair Edson, Thania Hisham, Lisa Frigati, Helena Rabie

Background: Since 2019 dolutegravir-based antiretroviral therapy (ART) has been introduced for South African children and adolescents living with HIV (CALHIV), including those with persistent viral non-suppression. Current guidelines recommend the reuse of abacavir when switching CALHIV weighing < 30 kg with persistent viral non-suppression to dolutegravir-based ART. Objectives: We aimed to describe the viral suppression rates, clinical outcomes and risk factors for non-suppression in CALHIV switching to dolutegrav …

26.08.2026journal-article

International Medical Education

Academic Performance, Admission Pathways, and Educational Disruption as Predictors of Professional Licensure Success: Evidence from Physical Therapy Education

Onchuma Mueangson, Parinya Vongvaivanichakul, Nantanatch Chaiyamaneerat, Haswanee Purong, Amissaanis Doloh, Nusree Hayisa-I

This study investigated academic and environmental predictors of national licensing examination success among physical therapy graduates in Thailand, examining overall academic achievement, domain-specific competencies (Code 01: Law/Ethics/Administration; Code 02: Techniques; Code 03: Clinical), admission pathway, and COVID-19-related online-learning disruption. This retrospective cohort study analyzed 342 graduates (2020–2023) using multivariable logistic regression and Pearson correlation, with GPA-based predicto …

26.08.2026journal-article

Advanced Healthcare Materials

Spatiotemporally Controlled Prodrug Release From Light‐Triggered Azo‐Bond‐Cleaved BODIPY Nanoplatform for Trimodal Synergistic Ovarian Cancer Therapy

Jiaqi Wang, Jie Zhang, Dongping Xu, Yiming Zhang, Xueqing Xia, Shuo Li, Xin‐Dong Jiang, Jiangli Fan, Xiaojun Peng, Gaowu Qin

ABSTRACT Chemotherapy (CT) suffers from poor selectivity and systemic toxicity, while photodynamic therapy (PDT) and photothermal therapy (PTT) are inherently limited by tumor hypoxia and thermoresistance. Herein, we develop a trimodal synergistic nanoplatform ( PDM‐BDP NPs) for ovarian cancer treatment by integrating PDT, mild PTT (mPTT), and CT into a single azo‐bond‐linked prodrug system. Upon 808 nm laser irradiation , PDM‐BDP NPs generate reactive oxygen species and mild hyperthermia, while simultaneously trig …

26.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

AFFECT AS AN ACTIVE METHODOLOGY IN MUSIC THERAPY FOR PEOPLE WITH AUTISM SPECTRUM DISORDER

Vilton Zimmermann de Souza, Nórton Zimmermann de Souza, Gabriel Baldissera de Souza, Rafael Manfro, Elizabeth Ferreira Martinez

Autism Spectrum Disorder (ASD) is characterized by persistent differences in social communication and interaction, associated with restricted or repetitive patterns of behavior and sensory particularities. In this context, music therapy provides relational, expressive, and participatory resources that may foster engagement and communication. This article aims to analyze the role of affect as a structuring element of active methodologies applied to music therapy for people with ASD. A qualitative literature review w …

26.08.2026journal-article

Malque Health

Age of identification of speech and communication disorders in children and the functioning of the referral system in Elbasan, Albania

Gjergji Doka, Venemin Gega, Ylli Alicka, Enea Belicari, Julis Saraci, Ardit Berdufi

Early recognition and referral of speech and communication problems are important for timely access to assessment and intervention, yet referral pathways remain insufficiently described in Albania. This retrospective, descriptive cross-sectional study examined the age and source of first recognition of warning signs and how families reached rehabilitation services in Elbasan. The study used a clinical convenience sample of children already receiving services in one public and one private rehabilitation center and i …

26.08.2026journal-article

Echocardiography

Six‐Week Changes in Global Longitudinal Strain and Rehabilitation Outcomes After Enhanced External Counterpulsation Following PCI for Myocardial Infarction: An Analysis of a Pre‐Existing Matched Cohort

Juan Su, Li Zhang, Cuihuan Xie

ABSTRACT Background Left ventricular pressure–strain loop (LV‐PSL) analysis provides non‐invasive myocardial‐work indices by integrating strain with contemporaneous brachial systolic blood pressure. Follow‐up myocardial‐work assessment requires blood pressure measured at the same assessment. Objective To describe baseline myocardial mechanical abnormalities after percutaneous coronary intervention (PCI) for myocardial infarction and to explore associations between a 6‐week enhanced external counterpulsation (EECP) …

26.08.2026journal-article

Nano LIFE

Protein Nanomedicine in Breast Cancer Therapy: Targeting Strategies, Clinical Applications and Future Perspectives

Samah Hamed Almurisi, Chua Hsuan Kai, Foo Yoong Kitt, Seow Wen En, Ngeow Qing Lun, Wee Hooi Yee, Bernice Chan Wen Jing, Annie Ling Hsiang Lan, Khater AL-Japairai, Dinesh Kumar Chellappan, Rana M. F. Sammour, Thiagarajan Madheswaran

The challenges of breast cancer treatment still exist despite significant progress. The challenges include tumor heterogeneity, drug resistance and systemic toxicity. However, the development of protein nanomedicine provides a good option to address these. The present review examines the possibilities of using protein-based nanomedicine in breast cancer treatment. It looks at targeted drug delivery, immune modulation and the mechanism of enhanced permeability and retention (EPR) for the precise targeting of the tum …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

Side effects of basic drug therapy in psychiatric practice

Vladimir Kozlovskii, Andrey Goncharenko

Adverse events that occur during basic drug therapy of patients with mental pathology are divided in accordance with the characteristics of the pharmacological action on the central and autonomic nervous regulation, as well as the sensitivity of peripheral organs to pharmacoinduced changes in metabolic processes in the body. All basic therapy agents are capable of inducing specific adverse effects associated with the pharmacodynamics of synaptotropic action on the central and autonomic nervous system and nonspecifi …

26.08.2026journal-article

Physiotherapy Research International

Intramuscular Fat Infiltration and Knee Osteoarthritis: A Systematic Review and Meta‐Analysis

Lili Yu, Cong Chen, Guancong Zhang, Qiuchen Huang, Miao Ye, Yukiko Makihara, Yusuke Nishida

ABSTRACT Background Intramuscular fat infiltration (IMFI) is considered to be closely associated with knee osteoarthritis (KOA); however, its overall association, muscle‐specific involvement, and clinical relevance remain unclear. Objective To quantify the association between IMFI and KOA, identify affected muscle groups, and evaluate prognostic value. Methods We searched PubMed, Web of Science, Scopus, and Embase up to December 2025 for observational studies. Two reviewers independently screened, extracted data, a …

26.08.2026journal-article

Endocrine Connections

Post-cycle therapy after androgen abuse: A narrative review of mechanisms, evidence, and clinical perspectives

Diederik L. Smit, Tijs Verdegaal, Peter Bond, Willem de Ronde

Abstract Post-cycle therapy (PCT) refers to the use of pharmacological agents—most commonly selective estrogen receptor modulators (SERMs), human chorionic gonadotropin (hCG), and aromatase inhibitors (AIs)—after cessation of androgen abuse to accelerate recovery of the hypothalamic–pituitary–gonadal (HPG) axis. Exogenous androgens suppress endogenous testosterone production through negative feedback, often resulting in a transient hypogonadal state that may persist for weeks to months, and occasionally longer, dep …

26.08.2026journal-article

Nutrients

Nutritional Rehabilitation and Medical Stabilization of Adolescents with Anorexia Nervosa: Length-of-Stay Predictors, Cardiovascular Recovery, Refeeding Safety, and Psychiatric Comorbidity Burden

Saba F. Elhag, Abdulla Fahmi, Abdulrahman Alansari, Sara Al-Kuwari, Amal Saleh Al-Kuwari, Amna Ahmed, Shahd Hani Jaouni, Amine Zaidi, Tasnim L. Milhem, Reem Bachir, Moayad H. Ali, Asma Ahmed, Qusi Shaban, Sheema Hashem, Madeeha Kamal

Background/Objectives: Adolescents with anorexia nervosa (AN) face substantial medical and psychiatric risk during hospitalization. We examined predictors of length of stay (LOS), cardiovascular recovery, refeeding safety, and psychiatric comorbidity in a consecutive pediatric cohort at a national tertiary center. Methods: Retrospective cohort of 68 consecutively admitted adolescents (91.2% female; mean age 14.2 ± 1.8 years, range 8–17; 85.3% restricting type) admitted between January 2017 and May 2025. A structure …

26.08.2026journal-article

Journal of Social Science and Human Research Studies

Systemic Thought in Psychology and Family Therapy: Interdisciplinary Origins, Flexibility, And African Relational Perspectives

Christian Matthew Adetunji

Objective : To reconstruct selected interdisciplinary origins of systemic thought in psychology and family therapy, clarify the movement from first- to second-order systems thinking, and examine how African relational scholarship and critiques of power revise contemporary systemic practice. Method: A critical narrative review was conducted using purposive searches of PsycINFO, Scopus, Google Scholar, Crossref, PubMed where clinically relevant, and publisher databases for foundational and interpretive literature on …