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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

European Journal of Heart Failure

The C-MIC II Follow-Up Study: Safety and Efficacy Results 12 months After Deactivation of Cardiac Microcurrent Therapy

Jesus E Rame, Dragana N Kosevic, Tamara Kovacevic-Preradovic, Sasko Jovev, Marija Zdravkovic, Nermir Granov, Tanja Popov, Igor Rudez, Petar Vukovic, Velibor Ristic, Annette Holtdirk, Tim Friede, Muhammad Shahzeb Khan, Miodrag Peric, Faouzi Kallel, Marat Fudim, Stefan D Anker

Abstract Background The C-MIC II trial demonstrated benefits of 6 months of cardiac microcurrent (C-MIC) therapy in patients with non-ischemic heart failure with reduced ejection fraction (HFrEF). The prospective C-MIC II Follow-Up Study evaluates safety and efficacy outcomes post-device deactivation. Methods Primary safety-related endpoints included all-cause, cardiovascular and device-related mortality and hospitalizations and adverse events (AEs). Secondary efficacy-related endpoints included changes in left ven …

26.08.2026journal-article

Thoracic Cancer

Validity and Feasibility of the Constant‐Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy

Junghwa Do, Sungeun Park, Sei Won Lee, A. Hyun Kim, Sang Ah Kim, Seung Hak Lee, Hwayeong Cheon, Jae Yong Jeon

ABSTRACT Purpose This study evaluated the validity of the constant‐load cycle endurance test (CET), performed at 75% of maximal power output, in patients with lung cancer undergoing radiation therapy. Its feasibility, responsiveness to pulmonary rehabilitation (PR), and clinical applicability were also examined. Methods Thirty‐three patients participated in a 4‐week PR program during radiation therapy. CET time was compared with the 6‐min walk test (6MWT) to assess concurrent validity. Patients were stratified by 6 …

26.08.2026journal-article

Journal of the Pakistan Medical Association

Dual diuretic therapy for hypertension in advanced chronic kidney disease

Abdul Wahab Mirza, Zainab Jawad

Hypertension affects approximately 85% of individuals with advanced chronic kidney disease (glomerular filtration rate < 30 ml/min), primarily due to increased volume load[1]. At this stage, kidneys lose their ability to achieve the desired fractional excretion for sodium (FeNa), thus predisposing the patient to hypertension. Loop diuretics, such as furosemide, are the mainstream drugs for patients of hypertension with chronic kidney disease. They block the Na-K-Cl channels thus increasing the FeNa. However, there …

26.08.2026journal-article

Frontiers in Oncology

Comparative evaluation of TACE-RFA versus monotherapies on a background of systemic therapy for recurrent hepatocellular carcinoma: a propensity score-matched analysis

Wendi Zhang, Zuhao Ye, Jinfa Wang, Xia Ren, Liping Ying, Yifeng Wu, Zongyang Wu, Chang Xin, Jiye Feng

Background The optimal locoregional treatment for recurrent hepatocellular carcinoma (rHCC) in the era of potent systemic therapy remains undefined. This study aimed to compare the efficacy, safety, and resource consumption of transarterial chemoembolization combined with radiofrequency ablation (TACE-RFA) versus TACE or RFA monotherapy, specifically when administered on a uniform background of systemic therapy (Lenvatinib plus PD-1 inhibitors). Methods We retrospectively reviewed 243 patients with rHCC who met str …

26.08.2026journal-article

Journal of Endovascular Therapy

The Role of Intravascular Ultrasound in Aortoiliac Endovascular Interventions: International Expert-Based Delphi Consensus

Pietro Dioni, Luca Bertoglio, Filippo D’Amico, Eric A. Secemsky, Mohamad A. Hussain, Marc L. Schermerhorn, Michele Antonello, Yamume Tshomba, Stefano Gennai, Giovanni Pratesi, Mark Farber, Vincent Jongkind, Jörg Tessarek, Andrew Holden, Christopher Delaney, Kevin Mani, Erin C. Saricilar, Enrico Gallitto, Manar Khashram, Glenn Wei Leong Tan, Nuno V. Dias, Barend Mees, Ross Milner, Michele Piazza, Thomas Maldonado, Gustavo S. Oderich, Tilo Kölbel, Giovanni Tinelli, Adam W. Beck, Thodur Vasudevan, Alexander Oberhuber, Stefano Bonardelli, Sandro Lepidi, Mario D’Oria

Introduction: Intravascular ultrasound (IVUS) provides cross-sectional information on the intraluminal features of blood vessels, aiding procedural planning and postprocedural assessment of results. Although the use of IVUS in aortic procedures is increasing worldwide, consensus on best practices in aortoiliac interventions is still lacking. This study aims to obtain experts’ consensus and define recommendations regarding applications of intravascular ultrasound in aortoiliac endovascular interventions Methods: Del …

26.08.2026journal-article

Haemophilia

Effects of Manual Therapy and Structured Exercises on Postural Balance and Walking Capacity in Adults With Haemophilia

Ayşe Merve Tat, Necati Muhammed Tat, Pervin Yeşiloğlu Kılıçlar, Ali Doğan

ABSTRACT Introduction Haemophilic arthropathy (HA) impairs joint health, walking capacity, and postural balance in adults with haemophilia (AwH). Evidence regarding the combined effects of manual therapy and structured exercise on postural balance remains limited. Aim To investigate the effects of manual therapy combined with structured exercise on joint health, activity‐related pain, walking capacity, and static and dynamic balance in AwH. Methods This randomized controlled trial included 35 AwH (control group [CG …

26.08.2026journal-article

Medical Sciences

Extracellular Vesicles at the Interface of Cancer Therapy and Regenerative Medicine: Biology, Bidirectional Roles, and Engineered Therapeutics

Jun-Hyeog Jang

Extracellular vesicles (EVs), including exosomes and microvesicles, are nanoscale membrane-enclosed particles that transfer proteins, lipids, mRNAs, and microRNAs between cells. The same communication system is now being developed in two apparently opposing settings: mesenchymal stem/stromal cell (MSC)-derived EVs are explored as cell-free regenerative therapeutics, whereas tumor-derived EVs can promote metastasis, immune evasion, and treatment resistance while also serving as liquid-biopsy biomarkers. Rather than …

26.08.2026journal-article

DEN Open

Apparent Endoscopic Decrease in the Size of a Large Ulcerated Gastric Schwannoma After Helicobacter pylori Eradication Therapy: A Case Report

Takahito Awatsu, Daisuke Asaoka, Hirofumi Fukushima, Daishi Kabemura, Yusuke Nomoto, Osamu Nomura, Kazunori Kajino, Mariko Hojo, Akihito Nagahara

ABSTRACT Gastric subepithelial lesions (SELs) comprise a heterogeneous group of tumors, among which gastric schwannomas are rare and generally benign. We report a case of a large gastric schwannoma with ulceration and symptomatic anemia that showed an apparent endoscopic decrease in size following Helicobacter pylori eradication. An 85‐year‐old man presented with iron deficiency anemia. Esophagogastroduodenoscopy revealed a large ulcerated SEL in the lower body of the stomach, along with multiple gastric ulcers. En …

26.08.2026journal-article

Applied Sciences

Biomechanical Responses to a Six-Week Sport-Specific Physiotherapy Programme in Elite Male Flatwater Kayakers: A Prospective Controlled Cohort Study

Zoltán Bejek, Eszter Kővári, Mónika Horváth, Ágnes Mayer, Erzsébet Tóth-Jova, Bernadett Kertész

Background: Biomechanical evidence concerning sport-specific physiotherapy in elite kayaking remains limited. Objective: This study aimed to evaluate joint range of motion (ROM), muscle activation, and bilateral footrest force before and after a six-week physiotherapy programme. Methods: Twenty-two elite male kayakers participated in a non-randomised prospective controlled cohort study (study group, n = 11; control group, n = 11). Three-dimensional motion analysis, surface electromyography, and footrest-force measu …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

The mosaic of older mental disorders

Nataliya Petrova

The review provides statistical data on the prevalence of psychiatric disorders of various etiologies in elderly patients. The variants of clinical comorbidity are described and recommendations for safe pharmacotherapy are given. Special attention is paid to the original antipsychotic tiaprid (Tiapridal®, Sotex), which is used to correct behavioral disorders in mental disorders and organic lesions of the central nervous system. Clinical targets for tiaprid are aggression, irritability, and psychomotor agitation. Th …

26.08.2026journal-article

European Journal of Endocrinology

Sustained shrinkage of bilateral adrenal adenomas during long-term osilodrostat therapy

Erika Messina, Martina Romanisio, Antonio Gigante, Cinzia Parola, Lorenzo Cantore, Soraya Puglisi, Federica Solitro, Maurizio Balbi, Andrea Veltri, Massimo Terzolo, Giuseppe Reimondo

Abstract Introduction Surgery remains the first-line therapy for all forms of Cushing’s syndrome; medical therapy may be appropriate when surgery is not feasible or as adjunctive therapy in severe hypercortisolism. Case presentation A 70-year-old woman was hospitalized for hemorrhagic shock due to massive abdominal bleeding. Abdominal computed tomography (CT) scan detected bilateral adrenal masses. Hormonal evaluation revealed adrenocorticotropic hormone-independent hypercortisolism. Given her frail condition, medi …

26.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Digital Aids for Social Media in Adults With Traumatic Brain Injury: Longitudinal Evaluation Study

Dakota Sullivan, Nirav N Patel, Lisa Kakonge, Callie Y Kim, Yaxin Hu, Hailey L Johnson, Catalina L Toma, Melissa Duff, Lyn Turkstra, Bilge Mutlu

Background Digital social media aids are features that enhance accessibility to social media for users with disabilities. One group of adults with disabilities who have reported barriers to social media access is adults with traumatic brain injury (TBI). Results of previous studies showed that adults with TBI want to engage in social media but encounter significant barriers to doing so, due in large part to TBI-related cognitive and communication challenges. We previously collaborated with adults with TBI to develo …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Habitual elbow joint use time is associated with pain adaptation but not strength performance in young adults: a cross-sectional multithreshold classification study

Dong Hyun Yoo, Yong-Seok Jee

This study investigated the differences between weekly elbow joint use time, pain level, and isokinetic moment in young adults using multiple exposure classification strategies. A total of 67 participants were cate-gorized using three grouping approaches: median-based (

26.08.2026journal-article

Journal of Mid-life Health

Sleep Deprivation, Occupational Stress, and Work-related Determinants of Sleep Disturbance Among Practicing Physicians: A Cross-sectional Study

Prabhat Kumar Agrawal, Shambo Samrat Samajdar, Ruchika Garg, Shatavisa Mukherjee, Prashant Kumar Gupta, Shashank R. Joshi, J Aravinda

A BSTRACT Background: Sleep deprivation and occupational stress are increasingly recognized as critical determinants of physician well-being, with potential implications for healthcare quality and patient safety. However, data on sleep patterns and their determinants among heterogeneous groups of practicing physicians remain limited. Objective: To assess sleep patterns, lifestyle characteristics, and work-related stressors among practicing physicians and to examine their interrelationships. Methods: This cross-sect …

26.08.2026journal-article

Cancers

The Impact of Molecular Characteristics on the Efficacy of Frontline Immune Checkpoint Inhibitor Therapy in Patients with Metastatic Melanoma

Seo Yoon Jang, Minsuk Kwon, Jeeyun Lee, Seung Tae Kim

Background: Metastatic melanoma in East Asian populations is enriched for acral and mucosal subtypes and harbors a distinct molecular landscape compared with Western cutaneous melanoma. However, data on the efficacy of first-line immune checkpoint inhibitor (ICI) therapy and on the impact of molecular characteristics on treatment effect in this population remain limited. We aimed to characterize the genomic landscape of an East Asian metastatic melanoma cohort and to evaluate the predictive values of molecular mark …

26.08.2026journal-article

Nutrition in Clinical Practice

Parents'/Caregivers' perspectives on weight management in children with cystic fibrosis receiving modulator therapy: A cross‐sectional survey

Sarah Gunnell Bellini, Kayla Keiser, Makenzie Christenson, TrudyAnne Coe, Catherine M. McDonald, Madison McRoberts, Jenna Stoker

Abstract Background Modulator therapy in children with cystic fibrosis (cwCF) has improved lung function and digestive health, prompting changes in nutrition management strategies for many cwCF. The purpose of this study is to describe parents'/caregivers' perspectives on weight management in cwCF with the introduction of cystic fibrosis transmembrane conductance regulator modulator therapies (CFTRm). Methods Researchers developed a cross‐sectional survey regarding parents'/caregivers' perceptions of weight managem …

26.08.2026journal-article

Cancer Research Communications

A Phase 1b/2 Study of Atezolizumab in Combination with Thiopurine Therapy in Patients with Metastatic Solid Tumors and Intermediate Tumor Mutational Burden

Christine Federspiel. Secher, Martin Højgaard, Iben Spanggaard, Ane Yde. Schmidt, Yuliu Guo, Luca Robinson, Daniela De Zio, Linea N. Toksvang, Frederik Otzen. Bagger, Kjeld Schmiegelow, Kristoffer S. Rohrberg

Abstract Purpose: The TEMPLE study was a phase 1b/2 trial evaluating the safety, tolerability, and efficacy of atezolizumab combined with thiopurine therapy in patients with metastatic solid tumors, aim-ing to increase tumor mutational burden (TMB) through single-nucleotide mismatching and neoepitope generation. Patients and Methods: Phase 1b was an open-label, single-arm dose de-escalation trial conducted to determine the recommended phase 2 dose (RP2D) of 6-mercaptopurine and 6-thioguanine combined with atezolizu …

26.08.2026journal-article

Modern Therapy in Psychiatry and Neurology Journal

A clinical case of chronic migraine complex therapy

Marina Belous, Irina Volgina, Anastasiya Pavlova

Migraine is a chronic disease with a genetic predisposition, the main symptom of which is an intense headache. Diagnosis and therapy of migraine has some difficulties, so results of it is a late detection of the disease at the stage of its chronic form, which is difficult to treat with standard treatment. The clinical case in question clearly demonstrates the difficulties of diagnosing and treating chronic migraine, the need for an integrated approach in the management of such patients, need to raise awareness of t …

26.08.2026journal-article

Journal of Exercise Rehabilitation

Effects of different rest intervals following postactivation performance enhancement on multiple components of performance-related fitness in elite athletes

Chan-Gyun Oh, Dong-Eun Kim, Tae-Beom Seo

This study aimed to investigate the effects of different rest intervals fol-lowing postactivation performance enhancement (PAPE) on upper- and lower-body skill-related physical fitness in elite athletes. Seven male elite athletes participated in a crossover design and completed four ex-perimental conditions: the control (CON), the 3-min rest (R3), the 8-min rest (R8), and the 12-min rest (R12) groups following PAPE. In the PAPE conditions, participants performed additional warm-up sets at 50% and 70% of one-repetit …

26.08.2026journal-article

Renal Replacement Therapy

Real-time microcirculatory monitoring during intradialytic exercise using an earlobe laser Doppler flowmeter: an exploratory preliminary study

Makoto Saito, Hideto Tanaka, Miki Matsui, Kazuyoshi Karasuda, Yoko Kato

Abstract Background Intradialytic exercise is recommended to improve exercise capacity, physical function, and quality of life in patients undergoing maintenance hemodialysis (HD). However, objective and practical physiological indicators for monitoring circulatory responses during intradialytic exercise remain limited in routine clinical settings. Laser Doppler flowmeter (LDF) enables noninvasive assessment of microcirculatory blood flow and may provide a useful method for monitoring peripheral circulation during …

26.08.2026journal-article

Frontiers in Rehabilitation Sciences

Handgrip strength reference values and dynapenia risk thresholds in an urban adult sample from Lima, Peru

Santos Lucio Chero-Pisfil, Aimeé Yajaira Díaz-Mau, Vanessa Elizabeth Huamanchumo-Barrientos, Rosita Maricielo Samame-Pérez, Estrella Elena Sosa-Quispe, Edgar Mario Tipula-Tipula, Ángel Eduardo Rueda-Villegas, Regina Munarriz-Medina, Antonio Esquinas

Background Handgrip strength is widely recognized as a practical biomarker of muscle function and an important screening tool for sarcopenia and functional decline. However, most di-agnostic thresholds currently used in clinical practice were developed in European or North American populations, which may limit their applicability in other ethnic groups. Evidence suggests that muscle strength varies substantially across populations, potentially leading to misclassification when universal cut-off points are applied. …

26.08.2026journal-article

Frontiers in Rehabilitation Sciences

Effectiveness of low vision rehabilitation on visual function and quality of life in Sub-Saharan Africa: a systematic review

Kwadwo Owusu Akuffo, Sylvia Agyekum, Sylvester Kyeremeh, Albert Kwadjo Amoah Andoh, Isaiah Osei Duah Junior, Josephine Ampomah Boateng, Nana Akwasi Owusu Mensah, Eldrick Adu Acquah, David Owiredu, Samson Darrah, Debora Abena Baidoo, Werner Eisenbarth

Aim This systematic review evaluates the effectiveness of low vision rehabilitation on visual outcomes and quality of life in Sub-Saharan Africa (SSA). Data sources Databases such as PubMed, Web of Science, CENTRAL, Google Scholar, and Scopus were searched from inception to May 2025. Searches were restricted to English-language publications. Review methods Titles and abstracts were screened in Covidence, with data extraction performed independently by two reviewers and disagreements resolved by consensus. Methodolo …

26.08.2026journal-article

Frontiers in Cardiovascular Medicine

Longitudinal changes in left atrial function during chronic ibrutinib therapy: a prospective observational study

Matea Kolacevic Zeljkovic, Sandra Basic-Kinda, Dubravka Čaržavec, Marijo Vodanovic, Inga Mandac Smoljanovic, Ozren Jaksic, Matea Novak, Slobodanka Ostojic-Kolonic, Dino Dujmovic, Vlatko Pejsa, Igor Aurer, Nikola Bulj

Background Ibrutinib is effective for B-cell malignancies but is associated with cardiovascular adverse events, including atrial fibrillation (AF) and hypertension. Longitudinal data on left atrial (LA) remodeling during treatment are limited. We characterized serial changes in LA size and function during chronic ibrutinib therapy. Methods In this prospective observational cohort, 40 patients starting ibrutinib underwent clinical assessment, 24–72-hour Holter monitoring, and echocardiography with LA strain at basel …