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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Pharmaceutics

Extracellular Vesicles and Plant-Derived Vesicles in Cancer: From Mechanisms to Clinical Translation

Shery Jacob, Namitha Raichel Varkey, Sai H. S. Boddu, Jigar N. Shah, Ibrahim Mustafa Abdi, Rekha Rao

Extracellular vesicles (EVs) are naturally occurring nanoscale carriers that have gained attention as next-generation platforms for diagnostics, site-specific drug delivery, and tissue engineering owing to their high biocompatibility, minimal immunogenicity, and capacity to transport diverse bioactive cargo across biological barriers. This review discusses the classification, biogenesis, molecular constituents, and therapeutic properties of the major EV subtypes such as exosomes, microvesicles, and apoptotic bodies …

31.08.2026journal-article

Endocrinology and Metabolism

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers, Part II: Follow-up Surveillance after Initial Treatment 2026

Eun Kyung Lee, Seung Heon Kang, Bon Seok Koo, Mijin Kim, Min Joo Kim, Bo Hyun Kim, Ji Won Kim, Dong Gyu Na, Sohyun Park, Ji-In Bang, Kyorim Back, Youngduk Seo, Young-Ik Son, Young Shin Song, Dong Yeob Shin, Jong-hyuk Ahn, Hwa Young Ahn, So Won Oh, Ho-Ryun Won, Won Sang Yoo, Min Kyoung Lee, Sang-Woo Lee, Jeongmin Lee, Ji Ye Lee, Dong-Jun Lim, Ki-Wook Chung, Ari Chong, Jin Hyang Jung, Sun Wook Cho, Yoon Young Cho, Chae Moon Hong, Young Joo Park, Korean Thyroid Association Guideline Committee on the Management of Thyroid Nodule and Cancer

In patients with differentiated thyroid cancer, initial recurrence-risk stratification based on clinical, histopathological, and perioperative findings remains central to management during the first 1–2 years after initial treatment. Ongoing risk stratification (ORS) complements this initial assessment by continuously integrating longitudinal clinical data and treatment response, thereby refining long-term prognostic assessment and supporting individualized risk-adapted management. Building on the 2024 Korean Thyro …

31.08.2026journal-article

International Journal of Molecular Sciences

Monocarboxylate Transporter 2 (MCT2) Reduction Is Associated with Increased Lung Tumor Growth and Alterations in the Immune Microenvironment in a Subcutaneous Tumor Model

Yen On Chan, Zhuanhong Qiao, Trupti Joshi, David Gozal, Abdelnaby Khalyfa

Monocarboxylate transporter 2 (MCT2; SLC16A7) is a high-affinity pyruvate transporter implicated in cancer metabolism. However, its role in lung cancer progression and the tumor microenvironment remains unclear. This study examined the effects of MCT2 reduction on tumor growth and cell-type-specific transcriptional changes within the tumor microenvironment. MCT2 loxP/loxP mice were crossed with mCre-Tg mice, and MCT2 deletion was induced by tamoxifen. Control (CO) mice received vehicle treatment. TC1 cells (100,000 …

31.08.2026journal-article

Diagnostics

Post-Treatment NLR and SII Associations with Response and Progression-Free Survival After Neoadjuvant Disitamab Vedotin Plus PD-1 Blockade in Muscle-Invasive Bladder Cancer: A Real-World Cohort Study

Yongsheng Huang, Yongpeng Ji, Xiao Yang, Qiang Zhao, Yudong Cao, Jinchao Ma, Ruijian You, Yongjie Li, Yong Yang, Peng Du, Shuo Wang

Background/Objectives: This study evaluated neoadjuvant disitamab vedotin plus programmed cell death protein 1 (PD-1) blockade and associations of post-treatment neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) with response and progression-free survival (PFS) in muscle-invasive bladder cancer. Methods: This single-center retrospective cohort included 71 patients with cT2–T3N0M0, human epidermal growth factor receptor 2 (HER2)-expressing disease treated between September 2021 and Oc …

31.08.2026journal-article

World Journal of Advanced Research and Reviews

GROWTH HORMONE DEFICIENCY AND CRANIOFACIAL DEVELOPMENT: IMPLICATIONS FOR ORTHODONTIC TREATMENT TIMING - A NARRATIVE REVIEW

Marilyn Margan

Background: Growth hormone deficiency (GHD) is the most common pituitary hormone deficiency in children and a principal cause of short stature. Because it manifests during the period of active craniofacial growth, it is directly relevant to orthodontic and dentofacial orthopedic decision-making. Objective: This narrative review synthesises evidence published between 2016 and 2026 on craniofacial and dental characteristics in children with GHD and evaluates the effect of recombinant human growth hormone (rhGH) repla …

31.08.2026journal-article

International Journal of Innovative Science and Research Technology

Optimizing Healthcare Waste-Treatment Asset Lifecycle Performance: From Installed Incineration Capacity to Safe, Sustainable, and Environmentally Responsible Service Delivery

Bruno Houessou, Abdel Malik Garba Gambari

Healthcare waste-treatment technologies are frequently evaluated through procurement completion, installation status, technical functionality, or nominal treatment capacity. Although useful, these indicators provide only a partial account of whether an installed asset is delivering sustained value to a health system. Incinerators illustrate this distinction particularly clearly because effective waste treatment depends not only on combustion equipment but also on waste segregation and transport, supporting infrastr …

31.08.2026journal-article

Medical Journal of Western Black Sea

Evaluating the quality, reliability and artificial intelligence involvement of online information on multiple sclerosis treatment

Cansu Sarıkaya, Hazal Ceren Manazoglu, Rana Karabudak

Aim: This study aimed to evaluate the quality, reliability and estimated artificial intelligence contribution of online information related to multiple sclerosis treatment.Material and Methods: The first 100 Google search results for "multiple sclerosis treatment" were screened. Video content, PDF documents, and inaccessible websites were excluded from the analysis. A total of 84 eligible web pages were assessed. Each page was categorized by source type (hospital, individual physician, blog, physiotherapy center, o …

31.08.2026journal-article

Frontiers in Pharmacology

A new era in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD): clinical breakthroughs and challenges

Zhifu You, Linglong Yang, Yuanhao Long, Dongye You, Qian Zhao

Metabolic dysfunction-associated steatotic liver disease (MASLD), affecting nearly one-third of adults worldwide, encompasses a spectrum from steatosis to steatohepatitis (MASH), advanced fibrosis, cirrhosis, and hepatocellular carcinoma, with fibrosis stage as the primary determinant of liver-related outcomes and cardiovascular disease as the leading cause of mortality. Despite robust evidence that lifestyle interventions achieving ≥10% weight loss induce fibrosis regression in many patients, sustained success in …

31.08.2026journal-article

The Indonesian Biomedical Journal

Prostatic Acid Phosphatase (PAP), Interleukin-8 (IL-8), and Cytotoxic T-Lymphocyte–Associated Protein 4 (CTLA-4) as Complementary Prognostic Biomarkers to Prostate-specific Antigen (PSA) in Prostate Cancer

Salahaldin Mohammed Fahad, Noor Hameed Hanoush, Ahmed Teen Ahmed

BACKGROUND: Prostate-specific antigen (PSA) is frequently used for prostate cancer screening and diagnosis, however its low specificity and incapacity to differentiate aggressive from indolent disease reduces its clinical utility. It is necessary to identify biomarkers that can complement PSA to increase the prognostic accuracy of prostate cancer. Emerging evidence suggests that androgen-related factors and immune mediators are involved in prostate cancer progression. Therefore, to identify more accurate markers of …

31.08.2026journal-article

European Heart Journal

Cardiovascular disease burden at cancer diagnosis: temporal trends in a national study from England

Ali A Alshahrani, Evangelos Kontopantelis, Catharine Morgan, Glen P Martin, Rathi Ravindrarajah, Matthew Evison, Mamas A Mamas

Abstract Background and Aims Advances in cancer care have improved survival, increasing the importance of comorbidities at diagnosis for longer-term outcomes. Pre-existing cardiovascular disease (CVD) can complicate management and prognosis, yet its long-term trends and future burden at cancer diagnosis are unclear. This study aimed to quantify temporal trends in pre-existing CVD among patients with newly diagnosed cancer and project prevalence through 2050. Methods Linked primary care, cancer registry, and hospita …

31.08.2026journal-article

PLOS One

Computational identification and evaluation of Adenium obesum phytochemicals as potential EGFR inhibitors for targeted therapy against non-small-cell lung cancer

Md. Naziur Rahman, Abu Yousuf Hossin, Shahriar Mannan Imon Talukder, Mt. Sumaiya Siddika, Md. Harun-Ur-Rashid, Shahanaz Parveen, Md. Ridwanul Islam, Md. Yeamin Hossain, Mahfuj Ahmed, Brototi Chakraborty Dyuti, Zarin Tabassum, Ajoy Kumer

Non-small-cell lung cancer (NSCLC) remains the leading cause of lung cancer–related mortality, largely driven by aberrant activation of the epidermal growth factor receptor (EGFR). Despite the clinical success of EGFR tyrosine kinase inhibitors (TKIs), intrinsic and acquired resistance, coupled with safety concerns, highlight the need for novel, safer inhibitors. Natural products represent an underexplored source of structurally diverse bioactive compounds with favorable biocompatibility. In this study, a comprehen …

31.08.2026journal-article

Clinical Case Reports

Clinical Benefit of Pembrolizumab in Lynch Syndrome‐Associated Advanced Ovarian Cancer With Germline MSH6 Variant: A Case Report

Tomomi Yokozawa, Sayako Nakagawa, Yukio Suzuki, Aya Tokinaga‐Uchiyama, Katsuyuki Konnai, Hiroto Narimatsu, Yukihiko Hiroshima, Haruya Saji

ABSTRACT This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first‐line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.

31.08.2026journal-article

JAMA Network Open

Trust in Cancer Information Sources During and After the COVID-19 Pandemic

Todd Burus, Tia N. Weber, Caree R. McAfee, Pamela C. Hull

This cross-sectional study explores changes in the level of trust in professional, governmental, and personal sources of cancer information among adults who participated in the 2018 to 2024 Health Information National Trends Survey.

1 Zitationen
31.08.2026journal-article

Translational Medical Engineering

Glycyrrhetinic Acid-Loaded Poly-γ-glutamic Acid Microneedles for Treatment of Atopic Dermatitis

Haiyang Long, Xinwei Fu, Xin Luo, Bo Wang, Bin Wang, Yuejun Kang

Background: Topical treatment of atopic dermatitis (AD) is hindered by the skin’s stratum corneum barrier. This study developed glycyrrhetinic acid (GA)-loaded poly-γ-glutamic acid (γ-PGA) dissolving microneedles (γ-PGA-GA MN) to overcome this barrier, enabling efficient transdermal delivery and enhanced anti-inflammatory efficacy. Methods: Dissolving microneedles (MNs) were fabricated via centrifugation-assisted molding. The physicochemical properties and mechanical strength of the samples were characterized using …

31.08.2026journal-article

Indian Journal of Dermatology

Real-World Efficacy and Safety of Ixekizumab in the Treatment of Psoriasis: A Case-Series from Indian Sub-Continent

Abhishek De, SK Shahriar Ahmed, Disha Chakraborty, Shrayan Pal

Abstract Psoriasis is a chronic, debilitating disease of inflammatory dermatoses. IL-17 plays a pivotal role in the pathogenesis of psoriasis. It acts as a driving force in psoriasis and has a significant role in keratinocyte proliferation, plaque progression, neutrophil recruitment, forming an amplification loop, and formation of tissue-resident memory T helper cells causing relapse. Ixekizumab is a humanized IgG4 monoclonal anti-IL-17 antibody approved for psoriasis in 2016. We are reporting a series of 22 patien …

31.08.2026journal-article

IoT

Design and Experimental Validation of a LoRa-Based IoT Architecture for Real-Time Monitoring of a Coupled Constructed Wetland Wastewater Treatment System

Jesús Mendoza Padilla, Eugenio Escalante Otero, Ximena Vargas-Ramirez, Lina Esquea Arroyo, Daniel Fernando Forero Meriño

Continuous monitoring of water quality is essential for supporting environmental management and enabling timely decision-making in wastewater treatment facilities. Although numerous Internet of Things (IoT) solutions have been proposed for environmental monitoring, many rely on proprietary cloud platforms or commercial gateways that limit flexibility, scalability, and integration with customized applications. This paper presents the design, implementation, and field validation of a modular IoT architecture for real …

31.08.2026journal-article

Seed Science and Technology

Plasma treatment alleviates seed dormancy and enhances early seedling growth in Albizia julibrissin

Jana Jirešová, Christopher William Heinz, Božena Šerá, Alexandra Angelovičová, Mustafa Ghulam, Michal Šerý, Vladimír Scholtz

Seed dormancy caused by a water-impermeable seed coat limits the germination of Albizia julibrissin , an important agroforestry species. This study tested non-thermal plasma (NTP) as an eco-friendly method to break physical dormancy and improve early growth. Seeds were treated with corona-discharge NTP for 1.25–40 minutes and evaluated for surface changes, wettability, water uptake, germination and seedling performance. Scanning electron microscopy (SEM) showed progressive surface cleaning and microstructural modif …

31.08.2026journal-article

Frontiers in Oncology

Efficacy and safety of chemotherapy plus immunotherapy in unresectable stage III–IV non-small cell lung cancer, with analysis of the additional role of anti-angiogenic agents

Xifen Qin, Zhiguo Wang, Hongbin Zhu

Purpose Chemo-immunotherapy has demonstrated significant survival benefits in non-small cell lung cancer. However, real-world data on its effectiveness and safety in patients with unresectable stage III–IV disease remain insufficient. Furthermore, whether the addition of anti-angiogenic agents provides additional benefit beyond chemo-immunotherapy remains unclear. This study aimed to evaluate the real-world effectiveness and safety of adding immune checkpoint inhibitors to chemotherapy, and to further explore the a …

31.08.2026journal-article

The Journal of International Advanced Otology

A Study to Test the Effectiveness of Intratympanic Dexamethasone Injections as a Treatment for Severe Disabling Tinnitus

Asma Mohd Shoukat, Jyothi A. Chavadaki, Ayesha Nazneen, Mohammed Soharwardi

BACKGROUND: Tinnitus is the perception of sound without an external source and is frequently linked with hearing impairment. Subjective tinnitus affects approximately 10% of the population, and in many cases, no cause is identified, classified as idiopathic. Intratympanic corticosteroids have gained attention for their targeted therapeutic effects. This study explores intratympanic dexamethasone in managing idiopathic cochlear tinnitus.To evaluate the effectiveness of intratympanic dexamethasone injections in patie …

31.08.2026journal-article

Sağlık Bilimleri ve Klinik Araştırmaları Dergisi

A Comparison of Risk Factors in Women with and without a Diagnosis of Breast Cancer: A Cross-Sectional Analysis from the West of Turkey

Berna Dizer, Arzu Tuna, Ayvaz Ulaş Urgancı, Nilüfer Özgürbüz

Introduction: To compare breast cancer (BC) risk factors in women with a BC diagnosis and in socio-demographically similar women without malignancy in western Turkey. Methods: Descriptive, retrospective, cross-sectional study in a private hospital’s surgical outpatient clinic. Cases were women diagnosed between 1 January–31 December 2020 (n=58); controls were age- and socio-demographically matched clinic attendees without malignancy (n=58) chosen by simple random sampling. Data were abstracted from records and comp …

31.08.2026journal-article

Cancer Medicine

Evaluation of the Expression and Prognosis of Neural‐Related Products Expressed by Cancer‐Derived Mesenchymal Stem Cells With the Characteristics of Neural Stem Cells

Liu Yongjun, Pan Zhiwen, Fu Shangui, Zhai Jinjie, Ying Rongbiao, Chen Zhongjian, Chen Wanyuan, Ju Haixing, Ma Dening, Long Dan, Luo Cong, Fu Zhixuan

ABSTRACT Studies have demonstrated that the nervous system plays an important role in cancer progression. Nevertheless, the effect of mesenchymal stem cells (MSCs) on cancer has yielded conflicting results. In this study, we discovered that cancer‐derived MSCs (CA‐MSCs) not only exhibit the properties of neural stem cells (NSCs) but also express a significant amount of neural‐related products. These products include neurotrophic factors, neuropeptides, synapse‐related products, and axon guidance factors. These iden …

31.08.2026journal-article

Gema Lingkungan Kesehatan

From Knowledge to Treatment Adherence: A Pre-Post Questionnaire-Based Study among Tuberculosis Patients in Primary Healthcrae Centers

La Ode Asrianto, Teti Susliyanti Hasiu, Sarifudin Andi Latif, Budi Prasetyo

Tuberculosis remains a major public health problem that requires serious attention, particularly with regard to treatment success, which is highly dependent on patient adherence. Low levels of treatment adherence are frequently associated with limited patient knowledge about the disease, the therapeutic process, and the potential risks of incomplete treatment. This study aims to analyze changes in patients’ knowledge levels following an educational intervention and to examine the influence of knowledge on treatment …

31.08.2026journal-article

Headache: The Journal of Head and Face Pain

Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations

Sonja Potrebic, Sarah Tanveer, Werner J. Becker, Rebecca Burch, Lara J. Cooke, Todd Fenton, Jeff J. Fletcher, Gillian L. Gordon Perue, Andrew D. Hershey, Jeffrey L. Jackson, Shirley Kessel, Elizabeth W. Loder, Mia T. Minen, Maryam Oskoui, Vijay K. Ramanan, Michelle Murren, Todd J. Schwedt, Stephen D. Silberstein, Don B. Smith, Kylie A. Botchway‐Doe, Heather M. Silsbee, Tamara Pringsheim

Abstract This practice guideline provides updated evidence‐based recommendations regarding the use of pharmacologic migraine prevention in adults. A multidisciplinary panel conducted a systematic review and developed practice recommendations following the process outlined in the 2017 edition of the American Academy of Neurology Clinical Practice Guideline Process Manual. The systematic review includes studies published through June 6, 2024, and is available in a companion publication. Recommendations are supported …

31.08.2026journal-article

International Journal of Urology

Comparative Prognostic Impact of Two‐Dimensional and Three‐Dimensional Computed Tomography‐Based Sarcopenia Indices in Metastatic Castration‐Sensitive Prostate Cancer

Tomohiro Hori, Hiroaki Iwamoto, Takahiro Inaba, Ryunosuke Nakagawa, Taiki Kamijima, Hiroshi Kano, Tomoyuki Makino, Renato Naito, Suguru Kadomoto, Hiroshi Yaegashi, Kazuyoshi Shigehara, Takahiro Nohara, Kouji Izumi, Atsushi Mizokami

ABSTRACT Objectives This study evaluated and compared the prognostic significance of three different computed tomography (CT)‐based radiological indices of sarcopenia—skeletal muscle index (SMI), psoas muscle index (PMI), and three‐dimensional (3D) psoas muscle volume index (PVI)—in patients with metastatic castration‐sensitive prostate cancer (mCSPC). Methods We retrospectively reviewed 120 patients diagnosed with mCSPC (2003–2022). Baseline muscle parameters were calculated from diagnostic CT scans. Sarcopenia wa …