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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
31.08.2026journal-article

Frontiers in Medicine

Performance trade-offs between dense prediction and sparse query mechanisms for brain tumor MRI detection: a comparative study of YOLOv8 and RT-DETR

Lianxin Xie, Jinghui Chen, Zhipeng Sun, Yuhan Huang, Shan Ye, Chengbin Ye

Objective This study investigates optimal training strategies for YOLOv8s in brain tumor MRI detection, systematically evaluates the effects of key hyperparameters on model performance, and compares the adaptability and trade-offs between convolution-based dense prediction and Transformer-based sparse query mechanisms in medical image detection. Methods Experiments were conducted on publicly available Kaggle MRI datasets of meningioma and glioma. YOLOv8s was adopted as the baseline model, and a systematic hyperpara …

31.08.2026journal-article

Molecular Nutrition & Food Research

Combined Docosahexaenoic Acid and Captopril Treatment Attenuates Indole Acetic Acid Induced Cardiovascular Injury in Chronic Kidney Disease

Santosh Pushpa Ramya Ranjan Nayak, Raghul Murugan, Mariadhas Valan Arasu, Ilavenil Soundharrajan, Bader O. Almutairi, Selvaraj Arokiyaraj, Jesu Arockiaraj

ABSTRACT Chronic kidney disease (CKD) is associated with the accumulation of protein‐bound uremic toxins (PBUTs), which cause cardiovascular dysfunction via oxidative stress, inflammation, and fibrosis. Indole‐3‐acetic acid (IAA), a uremic toxin generated from the gut microbiota, has been identified as a key modulator of cardiovascular injury in CKD. This study looked at the therapeutic efficacy of a 10% docosahexaenoic acid (DHA) supplemented diet paired with captopril (100 mg/kg) in CKD rats exposed to IAA (50 mg …

31.08.2026journal-article

B-ENT

Diagnosis and Surgical Treatment of a Rare Giant Osteoma of the Mastoid: A Case Report

Rocco Pio Ortore, Michele Cassano, Stefano Patruno, Christian Fiorentino, Lazzaro Cassano, Aurelio D’Ecclesia

A 43-year-old man presented with a giant retro-auricular osteoma of the right mastoid. The osteoma was removed through a retroauricular incision and removed by drilling the mastoid under continuous irrigation and using a hammer and chisel. The results from an aesthetic point of view were reported by the patient as very satisfactory. No recurrence was found in the subsequent 6-month follow-up. The experience shows that the management and surgical approach described in scientific literature can be considered effectiv …

31.08.2026journal-article

Folia Medica

Assessment of NGAL, eGFR, and tubular injury markers for early detection of chemotherapy-induced nephrotoxicity in pediatric oncology patients

Petya Markova, Antoniya Yaneva, Mariya Spasova, Stoyan Markov, Kostadin Kostadinov

Introduction : Acute kidney injury is a common complication in children with oncological diseases. Its etiology is multifactorial, with key risk factors including drug-induced nephrotoxicity, tumor lysis syndrome, and infection—including sepsis during periods of aplasia. The classical diagnostic criteria for AKI rely on monitoring serum creatinine levels and detecting oliguria. In the context of drug-induced nephrotoxicity, the predominant pathophysiological mechanism is tubular injury, which is typically non-oligu …

31.08.2026journal-article

Journal of Pediatric Endocrinology and Metabolism

A rare, invasive, and challenging cancer in childhood: diffuse sclerosing variant of papillary thyroid carcinoma

Şafak Demirtaş, Zeynep Şıklar, Elif Özsu, Zehra Aycan, Sirmen Kızılcan Çetin, Sema Nilay Abseyi, İlkyaz Türktan, Merih Berberoğlu

Abstract Objectives Pediatric thyroid cancers are rare, with papillary thyroid carcinoma (PTC) being the most common type. The diffuse sclerosing variant (DSV) is a rarer subtype associated with frequent recurrence and extensive lymphatic involvement. Among 51 pediatric patients treated for thyroid carcinoma at our tertiary center over a 20-year period, three were diagnosed with DSV-PTC. We present this retrospective case series to highlight its clinical course and diagnostic challenges. Case presentation Three pat …

31.08.2026journal-article

International Journal of Bioinformatics and Intelligent Computing

An Artificial Intelligence-Informed Review of the Antioxidant and Anticancer Properties of Onion (Allium cepa) and Tomato (Solanum lycopersicum) in Prostate Cancer Prevention and Management: A Contemporary Review

Alli Ayobami

Prostate Cancer (PCa) is the second most common male cancer and fifth leading cause of cancer death, with 1.4 million new cases and 375,000 deaths annually. Therapies are limited by castration-resistant prostate cancer, multidrug resistance and dose-limiting toxicities. The oxidative stress-inflammatory axis driven by ROS-induced DNA damage, NF-κB activation and dysregulated androgen receptor signaling is central to PCa initiation, progression and metastasis. Dietary phytochemicals show chemopreventive promise, but …

31.08.2026journal-article

BMC Cancer

Differential MMR protein stability and heterogeneity in bladder versus non-bladder urothelial carcinomas

Huiyu Chen, Minghui Zhong, Tingzhen Zhang, Zhang Wen, Zhangyi Zheng, Jianning Chen, Yupeng Feng, Junfeng Zhu

Abstract Background Mismatch repair deficiency (dMMR) is a predictive biomarker for immunotherapy response in various cancers, but its stability and heterogeneity across different anatomic sites in urothelial carcinoma (UC) remain poorly defined. This study aimed to evaluate dMMR status in bladder (BUC) versus non-bladder UC (upper tract [UTUC] and prostatic [PUCP]), and to assess whether it remains stable during disease progression. Methods We analyzed 249 tissue specimens from 108 UC patients (72 BUC, 35 UTUC, 1 …

31.08.2026journal-article

Molecular Nutrition & Food Research

Plant‐Based α‐Linolenic Acid as a Superior Nutraceutical to Modulates Apoptosis, Hypoxic Signaling, and Lipid Metabolic Pathway in Breast Cancer: A Comparative Preclinical Study

Anurag Kumar, Pratibha Verma, Nikam Siddhant Rahul, Gaurav Kaithwas

ABSTRACT In this study, we investigated and compared the anticarcinogenic efficacy of plant‐derived α‐linolenic acid (P‐ALA) and marine‐derived α‐linolenic acid (M‐ALA) using MCF‐7 breast cancer cell line and mammary gland carcinoma model induced by N‐methyl‐N‐nitrosourea (MNU). In vitro MTT assessment on ER+ MCF‐7 cells exhibited significant cell viability with P‐ALA (IC 50 5.57 µM) when compared with M‐ALA (IC 50 5.91 µM) and tamoxifen (TAM) (IC 50 9.16 µM). Mitochondrial‐mediated apoptosis with apoptotic changes …

31.08.2026journal-article

Journal of Cellular and Molecular Medicine

Single‐Cell Immune Profiling Suggests Non‐Classical Monocyte Is Associated Immunodepression in Tuberculosis Treatment Non‐Responders

Yiqun Xiong, Yahong Qu, Ying Wang, Dongliang Zhang, Hao Shen, Weixin Wang, Junshun Gao, ZhenBo Wang, Zhihong Shen, Yang Che

ABSTRACT Sputum culture conversion (SCC) at 2 months is an early indicator of tuberculosis (TB) treatment response, yet the associated immune alterations remain incompletely defined. We performed single‐cell RNA sequencing on peripheral blood mononuclear cells from eight TB patients, stratified by 2‐month SCC status. Non‐responders showed a relative enrichment of non‐classical monocytes and higher TB progression risk scores. CellChat analysis inferred altered IL16 and TRAIL communication involving these cells. CD4+ …

31.08.2026journal-article

Journal of Clinical Medicine

Real-World Comparative Effectiveness of First-Line Dabrafenib Plus Trametinib Versus Immunochemotherapy in Patients with Advanced BRAF V600-Mutant Non-Small-Cell Lung Cancer: A Retrospective Cohort Study

Haizhou Yue, Qianxin Zhou, Suyu Wang, Shuangyi Li, Junyi Li, Huanzhi La, Shuyan Meng

Background: The optimal first-line treatment for advanced BRAF V600-mutant non-small cell lung cancer (NSCLC) remains uncertain. We compared the real-world effectiveness of first-line Dabrafenib plus trametinib (Dab+Tram) with immunochemotherapy (ICT) and other systemic regimens. Methods: This single-centre retrospective cohort study included 142 patients with unresectable stage III/IV BRAF-mutant NSCLC treated between April 2017 and May 2024. Patients were grouped by first-line regimen Dab+Tram, ICT, chemotherapy …

31.08.2026journal-article

Headache: The Journal of Head and Face Pain

Systematic Review of Pharmacologic Treatment for Migraine Prevention in Adults

Tamara Pringsheim, Don B. Smith, Sarah Tanveer, Werner J. Becker, Rebecca Burch, Lara J. Cooke, Todd Fenton, Jeff J. Fletcher, Gillian L. Gordon Perue, Andrew D. Hershey, Jeffrey L. Jackson, Shirley Kessel, Elizabeth W. Loder, Mia T. Minen, Maryam Oskoui, Vijay K. Ramanan, Michelle Murren, Todd J. Schwedt, Stephen D. Silberstein, Kylie A. Botchway‐Doe, Heather M. Silsbee, Sonja Potrebic

Abstract Background and Objectives This systematic review (SR) provides updated evidence‐based conclusions regarding the use of pharmacologic migraine prevention in adults to inform a new joint American Academy of Neurology (AAN) and American Headache Society practice guideline. Methods A multidisciplinary panel conducted an SR following the 2017 AAN Clinical Practice Guideline Process Manual. Randomized controlled trials evaluating pharmacologic preventive treatments for adults with episodic or chronic migraine we …

31.08.2026journal-article

International Journal Of Community Medicine And Public Health

A study using patient feedback to predict the effects of quality improvement initiatives in a tertiary care cancer hospital of India

Mohd Anwar Ul Khaliq, Seema Khan, Sumit Yadav

Background: Patient feedback is increasingly recognized as an important indicator of healthcare quality and quality improvement (QI), but evidence from tertiary cancer hospitals in India remains limited. Aim was to assess whether patient feedback predicts perceived QI effectiveness and identify key influencing factors. Methods: A descriptive cross-sectional study was conducted among 872 patients at a tertiary care cancer hospital (March-August 2023). Data were collected using a standardised 21-item questionnaire an …

31.08.2026journal-article

Biomedicines

Predictive Value of Histopathological Variables and Peripheral Immune-Inflammatory Markers in De Novo Metastatic Breast Cancer: Development and Clinical Utility of the Novel KiTNASP Score

Serkan Yilmaz, Mesut Yur, Erhan Aygen, Yavuz Selim İlhan, Ahmet Akbaş, Şafak Özer Balin, Ali Rıza Avul

Background and Aim: Approximately 10% of breast cancer patients present with distant organ metastases at initial diagnosis. This study aimed to evaluate the efficacy of immune-inflammatory markers and histopathological variables in identifying de novo metastatic breast cancer. Methods: Patients with breast cancer referred to a tertiary surgical oncology clinic between January 2020 and December 2022 were retrospectively screened. A total of 412 patients met the strict inclusion criteria. Laboratory parameters and ra …

31.08.2026journal-article

HCA Healthcare Journal of Medicine

Coping Beyond Cancer: Exploring Fear of Recurrence in Colorectal Cancer Survivors—A Pilot Investigation

Emily M Su, Steve Paciorek, Erica L Laipply, Anuja L Sarode

Background Evidence is limited on the fear of cancer recurrence (FCR) among colorectal cancer (CRC) survivors in the US, especially regarding patterns and trends of post-recovery coping mechanisms. This pilot mixed-methods study quantified FCR, examined its associations with Brief COPE domains, and contextualized coping through qualitative analysis. Methods Twenty-three patients who successfully underwent CRC surgery were included in this pilot study. Fear of cancer recurrence was measured using the FCR Inventory ( …

31.08.2026journal-article

Pharmaceuticals

Anticancer Effects of Fluphenazine Alone and in Combination with Cisplatin in Gastric Cancer Cells and a Mouse Xenograft Model

Seung-Hyeon Ahn, Jihyun Shin, Hwayoung Na, Hong Kyu Lee, Kyung-Chul Choi

Background/Objectives: Gastric cancer remains a leading cause of cancer-related mortality worldwide, highlighting the need for novel therapeutic strategies. Drug repositioning offers a cost-effective approach by identifying new therapeutic applications for clinically approved drugs. Fluphenazine (FPZ), a dopamine receptor D2 antagonist used as an antipsychotic drug, has demonstrated anticancer activity; however, its effects on gastric cancer remain unclear. Methods: This study investigated the anticancer effects of …

31.08.2026journal-article

Korean Journal of Clinical Oncology

Nipple adenoma mimicking Paget’s disease: a case report

Younjung Cha, Eunhwa Park, Meesook Roh

Nipple adenoma is a rare benign tumor arising from the lactiferous ducts of the nipple and may clinically mimic malignant breast conditions such as Paget’s disease. Accurate diagnosis is often challenging, and histopathological confirmation is essential. A 37-year-old woman presented with a 10-month history of a red tumor on the right nipple accompanied by erosion and bloody nipple discharge. Imaging studies revealed no definite causative lesion; however, a subtle hypoechoic lesion within the nipple was noted on ul …

31.08.2026journal-article

Research Journal of Chemistry and Environment

In silico exploration of anti-lung cancer activity of selected steroidal saponins via anti-apoptotic pathway

Hung Duc Nguyen

Lung cancer is the leading cause of cancer death in the world. Inhibition of apoptosis involves blocking the cell’s natural process of self-destruction. This can occur through various mechanisms including the action of proteins like Bcl-2 family members and apoptosis inhibitors and growth factor upregulation. This study performed molecular docking, molecular dynamics simulation and ADMET prediction on eleven steroidal saponins isolated from Paris rugosa as potential apoptosis inhibitors for lung cancer treatment. T …

31.08.2026journal-article

Journal of Korean Biological Nursing Science

Development of a predictive model for high-flow nasal cannula treatment failure in emergency department patients with acute heart failure: a retrospective secondary data analysis

Sun-Ja Kim, Sun Hyoung Bae

Purpose: This study developed and internally validated a model integrating oxygenation, acid-base, and severity variables for high-flow nasal cannula (HFNC) failure in emergency department (ED) patients with acute heart failure (AHF).Methods: This retrospective secondary analysis included adults with AHF who received HFNC therapy in a tertiary ED between January 2021 and August 2025. Five prespecified predictors—follow-up saturation-to-fraction of inspired oxygen (S/F) ratio, follow-up respiratory rate-oxygenation …

31.08.2026journal-article

Exploration of Neuroscience

Haematological indices as markers of neuropathic pain in Nigerian cancer patients: a cross-sectional study

Ogochukwu Izuegbuna, Saburi Oyewale, Chijioke Chidindu Adindu, Saliu Oguntola, Tiwalade Woods-Ali, Israel Kolawole

Aim: Neuropathic pain (NP) is common in cancer patients, but its relationship with haematological inflammatory markers remains poorly understood. This study explored the association between NP and haematological parameters in Nigerian cancer patients. Methods: This cross-sectional study enrolled 90 patients with solid tumours from the University of Ilorin Teaching Hospital. Pain severity was assessed using the Numerical Rating Scale, while NP was evaluated with the painDETECT questionnaire. Complete blood count par …

31.08.2026journal-article

Diagnostics

AnemiaScore: An Investigator-Developed Rule-Based Clinical Decision-Support Framework for Cancer-Related Anemia—A Single-Center Retrospective Proof-of-Concept Concordance Study

Antonio Macciò, Gianuario Sanna, Manuela Neri, Paolo Albino Ferrari

Background/Objectives: AnemiaScore is an investigator-developed, deterministic, rule-based clinical decision-support framework for cancer-related anemia. This initial proof-of-concept study evaluated agreement with recorded local oncologist decisions, used as a clinical reference comparator rather than an independent standard. Methods: This single-center retrospective study analyzed 180 directly comparable A–C cases in the primary three-category analysis. An exploratory full-cohort analysis included 188 eligible ca …

31.08.2026journal-article

Endocrinology and Metabolism

Korean Thyroid Association Guidelines on the Management of Differentiated Thyroid Cancers, Part II: Follow-up Surveillance after Initial Treatment 2026

Eun Kyung Lee, Seung Heon Kang, Bon Seok Koo, Mijin Kim, Min Joo Kim, Bo Hyun Kim, Ji Won Kim, Dong Gyu Na, Sohyun Park, Ji-In Bang, Kyorim Back, Youngduk Seo, Young-Ik Son, Young Shin Song, Dong Yeob Shin, Jong-hyuk Ahn, Hwa Young Ahn, So Won Oh, Ho-Ryun Won, Won Sang Yoo, Min Kyoung Lee, Sang-Woo Lee, Jeongmin Lee, Ji Ye Lee, Dong-Jun Lim, Ki-Wook Chung, Ari Chong, Jin Hyang Jung, Sun Wook Cho, Yoon Young Cho, Chae Moon Hong, Young Joo Park, Korean Thyroid Association Guideline Committee on the Management of Thyroid Nodule and Cancer

In patients with differentiated thyroid cancer, initial recurrence-risk stratification based on clinical, histopathological, and perioperative findings remains central to management during the first 1–2 years after initial treatment. Ongoing risk stratification (ORS) complements this initial assessment by continuously integrating longitudinal clinical data and treatment response, thereby refining long-term prognostic assessment and supporting individualized risk-adapted management. Building on the 2024 Korean Thyro …

31.08.2026journal-article

Bioinformation

Quality of life among breast cancer survivors in India

Vishal Chaudhary

Significant progress in the early detection and treatment of breast cancer has greatly improved survival rates, enabling numerous patients to enjoy longer and healthier lives. Nevertheless, even with these medical advancements, survivors frequently face physical issues like fatigue, pain and cognitive difficulties that can affect their everyday activities. Moreover, they often deal with psychosocial problems such as anxiety, depression, concerns about body image and feelings of social isolation, which may continue …

31.08.2026journal-article

PLOS One

CT radiomics-histopathological correlation for mediastinal lymph node staging in non-small cell lung cancer

Judith Legrand, Antoine Decoux, Loïc Duron, Cécile Di-Rocco, Manuel Gargiulo, Pascal Thomas, Armelle Arnoux, Kathia Chaumoitre, Jean-Yves Gaubert, Laure Fournier, Paul Habert

Background Non-small cell lung cancer (NSCLC) staging relies on accurate assessment of mediastinal lymph nodes. This study investigates the utility of radiomic features derived from contrast-enhanced thoracic CT scans in predicting malignancy in clinically positive (cN+) mediastinal lymph nodes. Methods A retrospective cohort of 110 NSCLC patients with cN + who underwent surgical resection was analyzed. 3D segmentations of up to three lymph nodes per patient were performed. Radiomic features, encompassing heterogen …

01.09.2026journal-article

Journal of Surgical Case Reports

Early-onset colorectal cancer in patients under 30: a case series from Tanzania highlighting an emerging epidemiological shift

Mujaheed Suleman, Jay Lodhia, Evance Salvatory Rwomurushaka, Felister Uisso, Alex Mremi

Abstract Early-onset colorectal cancer (EOCRC) is increasingly recognized, particularly in low- and middle-income countries where patients often present with advanced disease. We describe a case series of three patients under 30 years managed at a tertiary referral centre in northern Tanzania. All presented after prolonged symptoms, including rectal bleeding, altered bowel habits, abdominal pain, and weight loss. Two patients had rectosigmoid tumors, while one had a right-sided lesion. Histopathology demonstrated m …