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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

A ENFERMAGEM NO CUIDADO À PESSOA COM ANEMIA FALCIFORME: PRÁTICAS, DESAFIOS E EVIDÊNCIAS CIENTÍFICAS

Antonieta Benvinda Cassinda Cachipa, Kemelândua Sebastião Ngando, Maria Daniela Alves Martins, Vladson Gouveia Ferreira, Stella Maia Barbosa, Gabriela Silva Cruz, Erika Helena Salles de Brito, Ana Caroline Rocha de Melo Leite

A anemia falciforme é uma doença genética crônica de elevada morbidade, predominante na população negra, que ocasiona importantes repercussões clínicas e sociais. Nesse contexto, a enfermagem desempenha papel essencial no manejo da dor, prevenção de complicações e promoção do autocuidado. Objetivo: Sintetizar as evidências científicas sobre a atuação da enfermagem no cuidado de pacientes com anemia falciforme. Método: Revisão integrativa da literatura, baseada na estratégia PCC: População (pacientes com anemia falc …

21.08.2026journal-article

BMC Psychiatry

Encounters between people with mental health and/or substance use problems and ambulance clinicians: a qualitative interview study in Norway

Lin Eik Ulvøy, Jorun Rugkåsa, Trine Møgster Jørgensen, Solveig H. H. Kjus, Kristin Häikiö

Abstract Background Interactions between ambulance clinicians and people with mental health and/or substance use problems are frequent, and international studies show that these encounters are often shaped by stigma, power dynamics and challenges to patient autonomy. However, there is limited research exploring patients’ experiences of ambulance services in the Norwegian context. This study addresses this knowledge gap. Methods This qualitative study was based on in-depth, semi-structured interviews with 23 people …

21.08.2026journal-article

Child Development

Peer victimization, school belonging, and epigenetic aging among children of Latino immigrants

Rebeca Alvarado-Harris, Krista M Perreira

Abstract U.S.-born children of Latino immigrants often begin life with health advantages, yet the developmental conditions that ­sustain or erode these advantages remain unclear. Drawing on socioecological and sociocultural perspectives, this study examined whether peer victimization and school belonging in middle childhood predicted changes in epigenetic aging from childhood to adolescence. These associations were compared between children of immigrant and U.S.-born Latina mothers. Future of Families and Child Wel …

21.08.2026journal-article

Aging Cell

Aging Alters Hair Cell Physiological Properties in Mice With Late‐Onset Age‐Related Hearing Loss

Piece Yen, Adam J. Carlton, Andrew O'Connor, Niovi Voulgari, Stuart L. Johnson, Jing‐Yi Jeng

ABSTRACT Mammalian cochlear hair cells convert acoustic stimuli into electrical signals, which are relayed to the central auditory pathway via auditory neurons. Progressive loss of hair cells and their synapses is a characteristic of age‐related hearing loss (ARHL), but the underlying mechanisms remain poorly understood. In this study, we tested the hypothesis that hair cell physiological properties change with age in CBA/CaJ mice, a strain known for its slow ARHL progression. We found that hair cell size began to …

21.08.2026journal-article

Aging Cell

LivAge : An Online Aging Clock for Murine Transcriptomic Age Estimation

Víctor Celemín‐Capaldi, Guillermina Bea, David Roiz‐Valle, Alejandro P. Ugalde, Clea Bárcena, Pedro M. Quirós, José M. P. Freije

ABSTRACT The increase in life expectancy over the past century has been accompanied by the recognition of age as the primary risk factor for a wide range of pathologies, including cardiovascular and neurodegenerative diseases, as well as cancer. Thus, the development of interventions that slow the underlying biological processes of aging could have beneficial effects on the prevention or progression of these diseases. To evaluate such geroprotective interventions, quantifying biological damage via aging clocks—part …

21.08.2026journal-article

Administration and Policy in Mental Health and Mental Health Services Research

A Qualitative Investigation of Managers’ Experiences and Views of Early Support Hubs for Children and Young People

Kylee Trevillion, Rebecca Appleton, Gilda Spaducci, Emma Maynard, Felicity Allman, Jessica L Griffiths, Connor Clarke, Hannah K Lewis, Sadiya Begum, Anam Bhutta, Nima Cas Hunt, Eva Driskell, Lizzie Mitchell, Phoebe Barnett, Rob Saunders, Julian Edbrooke-Childs, Isabel Hanson, Polly Waite, Brynmor Lloyd-Evans, Sonia Johnson

Abstract Early Support Hubs are an emerging model of youth mental health provision, designed to offer holistic, open-access support for young people whose needs often fall below the threshold for specialist services. Despite increased expansion in many countries, little is known about how these Hubs are implemented in practice or the challenges faced by those responsible for delivering them. This paper presents a qualitative interview study with 19 managers of Early Support Hubs in England. A codebook thematic anal …

21.08.2026journal-article

Alzheimer's & Dementia: Behavior & Socioeconomics of Aging

Social frailty as a predictor of new onset dementia in older adults

Claire Wang, Sofia Liu, Rendong He, Katherine Ornstein, Anna Beeber, Thomas K. M. Cudjoe, Subhash Aryal, Yunxiang Sun, Junxin Li

Abstract Introduction Social frailty, defined as the loss of essential social resources, has been linked to cognitive impairment. Yet, few studies have examined whether changes in social frailty influence dementia risk or transitions along the cognitive decline continuum. Methods We included 13,207 community‐dwelling adults aged ≥ 65 from the National Health and Aging Trends Study (2011–2024), a nationally representative sample of US Medicare beneficiaries. Social frailty was measured using a 5‐item index (social f …

21.08.2026journal-article

Dietetics

Perceived Genetic Risk and Dietary Prevention Beliefs Among Offspring of People Living with Dementia: A Mixed-Methods Study Guided by the Health Belief Model

Vaios Svolos, Dimitra Eleftheria Strongylou, Elli Zoupa, Anastasia Triantafyllou, Maria Katsama, Konstantinos Michas, Rena Kosti, Olympia Bogiatzidou, Vasileios Siokas, Ioannis Liampas, Efthimios Dardiotis, Odysseas Androutsos

Background: Given the rising global prevalence of dementia and its complex etiology, involving genetic and environmental risk factors, the aim of the present exploratory study was to investigate how offspring of individuals with dementia perceive genetic risk and the role of diet in dementia prevention. Methods: A mixed-methods study was conducted in Greece. Overall, 118 offspring completed an online questionnaire assessing demographics, risk perceptions, and dietary beliefs and practices in dementia risk reduction …

21.08.2026journal-article

Medicine

Linking probable respiratory sarcopenia to frailty in older adults

Mingqi Wu, Feiyan Cao, Yidan Huang, Kangkang Chen, Pingfei Ding

Frailty is a common geriatric syndrome linked to disability and mortality. Respiratory sarcopenia (RS), recently conceptualized as concurrent decline in muscle and respiratory function, may contribute to frailty, but evidence is scarce. We analyzed data from the nationally representative China Health and Retirement Longitudinal Study. Probable RS was defined, following the 2023 consensus, as low peak expiratory flow rate (PEFR) plus low appendicular skeletal muscle (ASM) mass. Frailty was assessed using the Fried f …

21.08.2026journal-article

Journal of Dementia and Alzheimer's Disease

A Systematic Review on the Effects of Speech and Language Therapy in Patients with Dementia

Ioanna Rodaki, Despina Moraitou, Theodora Papamitsou, Effrosyni Koutsouraki

Background/Objectives: Dementia is a progressive neurocognitive disorder characterized by decline in cognitive, communicative, and functional abilities. Speech and language therapists (SLTs) play a role in managing communication and cognitive–linguistic impairments while supporting families and caregivers. However, evidence regarding the effectiveness of speech and language therapy interventions remains heterogeneous, and evidence has not integrated cognitive–linguistic and caregiver-related outcomes. This systemat …

21.08.2026journal-article

Frontiers in Public Health

Latent profile analysis and determinants of social isolation among older adults in China

Xiaoxing Lai, Zhiyuan Zhang, Yonghua Cai, Yang Li, Rui Sun, Shuai Zhang, Kexin Zhang, Hongdi Du, Shuxian Li, Jingwei Hao, Xiaopeng Huo

Objective This study aimed to identify social isolation profiles among older adults in China using latent profile analysis and to explore their associations with demographic and health factors. Methods A cross-sectional study was conducted between July and December 2023 in the Chaoyang and Dongcheng districts of Beijing, China. Participants aged 60 years or older were recruited through convenience sampling from six communities. Latent profile analysis was used to classify social isolation patterns, and multivariate …

21.08.2026journal-article

Innovation in Aging

The National Archive of Computerized Data on Aging (NACDA) Portal: Variable-level discovery and custom metadata and data extraction for aging research

Seoyoun Kim, Kathryn Lavender, Sanda Ionescu, Jennifer Zeiger

Abstract Background and Objectives Population aging has intensified demand for data infrastructure that supports life-course, cohort, and within-person research using longitudinal surveys. However, traditional file-centric dissemination and the growing number and diversity of aging data collections have complicated secondary analysis, limiting researchers’ ability to locate comparable measures, evaluate cross-wave continuity, and assemble cross-study analytic datasets. To address these challenges, we introduced the …

21.08.2026journal-article

JMIR Research Protocols

Effect of Remote Vital Signs Monitoring in People Receiving Long-Term Oxygen Therapy: Protocol for a Randomized Controlled Trial

Elinny Raissa Moreira dos Reis, Gabriela Martins Alencar, Amanda Maria Schneider, Mari Claussen Tani Fernandes, Juliana de Melo Batista dos Santos, Celso Ricardo Fernandes Carvalho

Background Individuals receiving long-term oxygen therapy (LTOT) are often confined to their homes and have impaired health-related quality of life (HRQoL). Despite technological advances, monitoring these individuals remains a challenge. Objective This study aims to evaluate the impact of remote monitoring on HRQoL, dyspnea, health status, symptoms of anxiety and depression, and adherence to data entry via a mobile app in individuals receiving LTOT. Methods This randomized controlled trial will recruit 60 particip …

21.08.2026journal-article

Nutrients

Prevalence of Sarcopenia and Its Association with Nutrition Risk in Community-Dwelling Older Adults with Subjective Cognitive Impairment or Living in Retirement Homes

Raksha Aravind, Heather H. Keller

Background: Sarcopenia is an age-related condition characterized by declines in muscle strength and muscle mass associated with adverse health outcomes in older adults. Nutrition risk may contribute to sarcopenia development; however, its relationship with sarcopenia among community-dwelling older adults, especially those living in retirement homes or with subjective cognitive impairment, remains unclear. This study aimed to determine the prevalence of sarcopenia and its indicators using the EWGSOP2 criteria in com …

21.08.2026journal-article

Research on Aging

The Weight of Care: Examining the Relationship Between Grandchild Caregiving and Adiposity in Later Life

Ting-Syuan Lin, Wen-Hua Lai, Seung-won Emily Choi

Grandchild caregiving is an increasingly common later-life family role, yet its association with older adults’ adiposity remains unclear. Using five waves of the Health and Retirement Study (2010–2018), this study examines associations between grandchild caregiving arrangements and four adiposity indicators: BMI based on self-reported height and weight, physically measured BMI, waist circumference, and relative fat mass. Linear panel models, including random-effects and fixed-effects models, assess whether adiposit …

21.08.2026journal-article

Obstetric Anesthesia Digest

Time-restricted Eating and Exercise Training Before and During Pregnancy for People With Increased Risk of Gestational Diabetes: Single Center Randomized Controlled Trial (Before the Beginning)

MJ Sujan, HM Skarstad, G Rosvold, SL Fougner, T Follestad, KA Salvesen, T Moholdt

( BMJ 2025;390:e083398. doi: 10.1136/bmj-2024-083398) Gestational diabetes mellitus (GDM) is a condition that affects about 1 of 7 live births globally and is characterized by hyperglycemia during pregnancy. There are several risk factors for GDM, including older age, a high body mass index, gaining excessive weight while pregnant, having a prior history of GDM or diabetes, and non-European ethnicity. Studies show that hyperglycemia typically resolves after delivery, and GDM is linked to many negative outcomes in l …

21.08.2026journal-article

Frontiers in Nutrition

Associations of dietary diversity trajectories with depressive symptoms among Chinese older adults: a 10-year longitudinal study

Jiafa Yang, Yuxia Xie, Fengting Hu, Jin Peng, Weiran Wang, Lin Shen

Background Depression is one of the most prevalent mental health conditions among older adults in China, profoundly impairing quality of life and impeding healthy aging. Dietary diversity, as a comprehensive indicator of overall diet quality, has been associated with various chronic diseases and mental health outcomes. However, the association between longitudinal trajectories of the Dietary Diversity Score (DDS) and depressive symptoms among older adults remains poorly understood. Methods Using four waves of longi …

21.08.2026journal-article

Asia-Pacific Journal of Business Administration

The role of technology in facilitating accessible tourism: a systematic literature review of service access for people with disabilities

Giannis Theofanous, Alkis Thrassou, Yioula Melanthiou

Purpose Accessible tourism has become increasingly identified as a right, aligned with the global commitment for inclusion outlined in the 2030 Sustainable Development Goals. However, there are still significant barriers preventing people with disabilities from having smooth and inclusive tourism experiences. While technology has much potential to bridge these barriers, there is still a limited understanding of how technology currently develops access to services in accessible tourism. This study aims to conduct a …

20.08.2026journal-article

International Journal of Disaster Risk Science

Unequal Access to Emergency Facilities for Older Adults: A Spatial Analysis in Shanghai, China

Xi Chen, Xiaogang Zhu, Wuxiao Teng

Abstract Increasingly frequent disasters and the heightened vulnerability of older adults highlight the need for equitable access to lifesaving resources such as evacuation shelters and emergency supply storage. This study evaluates whether the spatial accessibility of these facilities aligns with the distribution of older residents in core and non-core areas of Pudong New Area, Shanghai Municipality. We develop a spatial equity framework employing bivariate local Moran’s I, Lorenz curves, and Gini coefficients to …

20.08.2026journal-article

ACS Applied Materials & Interfaces

An Adiponectin Receptor Agonist Dispersed via Nonencapsulative Exosomes Alleviates Aging-Associated Cardiac Dysfunction

Yin Zhou, Xue Li, Lilei Wang, Penghui Zeng, Yuxiao Zhang, Qi Zhu, Rui Wang, Cong Wang, Xifei Yang, Qi Zhao, Yushuo Feng, Ming Dong

Abstract Aging-related cardiac dysfunction constitutes a major and growing global health challenge with limited effective treatment options. While adiponectin receptor activation has demonstrated cardioprotective potential, its translation into a viable therapy for the senescent heart remains unrealized. In this study, we developed CardiAdip (CAD), an agonist with improved predicted binding affinity for adiponectin receptors. In d-galactose (d-gal)-induced senescent H9c2 cardiomyocytes, CAD attenuated senescence-as …

20.08.2026journal-article

The Singapore Economic Review

Advances in Medical Technology, Population Aging, and Healthcare Expenditure in Japan

Takeyuki Hirai, Hisashi Okamoto

Using annual data from 1960 to 2023, we estimate autoregressive distributed lag models to examine the effects of population aging and technological advances in high-cost areas of medical care, such as cancer treatment, on Japan’s public healthcare insurance finances in the long-run. Results show that while population aging and technological advances increase healthcare expenditure and public burden, their effects on insurance premiums and out-of-pocket payments differ. An increase in public burden will further dete …

20.08.2026journal-article

Aging Cell

The Thymic Microenvironment Shapes Age‐Related Qualitative Changes in the TCR Repertoire

Jasmine Rowell, Diana C. Yanez, Susan Ross, Ching‐In Lau, Eden Zhang, Amir Monfared, Oscar A. Peña, Benny Chain, Tessa Crompton

ABSTRACT Ageing impairs immune function, increasing susceptibility to infection, autoimmunity and inflammation. The thymus undergoes involution during childhood, and thymocyte and thymic epithelial cell (TEC) numbers decline. Given that adaptive immunity depends on T‐cells recognising diverse antigens via their unique T‐cell receptor (TCR), the precise age‐related changes in TCR repertoire composition are key to understand immunity. To investigate the influence of age on the thymic TCR repertoire we sequenced TCRα …

20.08.2026journal-article

JDR Clinical & Translational Research

Nonlinear Association between Density of Dental Clinics and Dental Visits among Older Japanese

K. Honda, S. Kiuchi, K. Takeuchi, T. Kusama, K. Osaka, J. Aida

Objectives: Correcting clinic maldistribution is key to universal health care. The imbalance in dental clinic supply, characterized by both oversupply and undersupply, remains underexplored, and few studies link geographic distribution with patient utilization patterns. This study examined the association between the density of dental clinics and dental visits among the older Japanese population. Method: This repeated cross-sectional study used data from 3 waves (2016, 2019, and 2022) of the Japan Gerontological Ev …