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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Trends in Eligibility Criteria in Solid Tumor Systemic Therapy Trials Over Time

Jenny Han

Background: Cancer clinical trials have used restrictive eligibility criteria, limiting patient access and the generalizability of findings. In response, FRIENDS and ASCO issued recommendations to modernize eligibility criteria in 2017 and 2021. We evaluated whether these recommendations led to measurable changes in eligibility criteria in systemic therapy trials for solid tumours by comparing trial protocols at two points across a 10-year period. Methods: We reviewed randomized clinical trial protocols evaluating …

27.08.2026journal-article

Dentistry Journal

Baseline Prediabetes, Hyperglycemia, and Incident Dental Outcomes Among Peruvian Formal-Sector Workers: A Retrospective Occupational Cohort Study

Víctor Juan Vera-Ponce, Jhosmer Ballena-Caicedo, Nelly Del Carmen Villegas Ampuero, Julio David Sagastegui Jauregui, Fiorella E. Zuzunaga-Montoya

Background/Objectives: Early glycemic abnormalities may identify adults at increased oral health risk, but longitudinal evidence from Latin American occupational populations is limited. We evaluated whether screening-based baseline prediabetes and hyperglycemia were associated with recorded incident dental outcomes among Peruvian formal-sector workers. Methods: We conducted a retrospective cohort study using occupational health records from 2013–2021. The primary outcome was a composite incident dental outcome, def …

27.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Clinical and Electrophysiological Effects of Downhill Treadmill Walking in Patients With Ischemic Stroke

Burak Yıldız, İpek Midi, Evrim Karadağ-Sayg, Özge Keniş-Coşkun

Objective: To evaluate the clinical and electrophysiological effects of downhill treadmill walking performed at different inclines in patients with stroke. Design: Thirty-five patients with stroke were randomized to level treadmill walking (control), −7.5% downhill walking, or −15% downhill walking. In this assessor-blinded trial, the intervention consisted of five sessions delivered over 5 consecutive days. Clinical outcomes assessed before and after the intervention were the Modified Ashworth Scale, Fugl-Meyer Lo …

27.08.2026journal-article

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Tubercular paraplegia in pregnancy with complete neurological recovery following antitubercular therapy: a case report

Firdaus Fathima, Ambika Patil, Santosh Rathod

Spinal tuberculosis with paraplegia during pregnancy is rare and is a diagnostic and therapeutic challenge. Pregnancy, being a relatively immunocompromised state, may prompt rapid destruction of the vertebral body, resulting in an acute and profound neurological deficit. A 23-year-old G2P1L1 woman at 19+5 weeks presented with progressive bilateral lower-limb weakness; MRI showed D2 collapse with epidural collection and cord compression. Sputum Ziehl-Neelsen staining confirmed acid-fast bacilli, and first-line HRZE …

27.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Development of the Mandarin Version of the Hearing and Functioning in Everyday Life Questionnaire

Shangqiguo Wang, Zhihong Zheng, Liping Zhang, Carol Pang, Hang Zhao, Wen Jiang, Qinglin Meng, Yuan Chen, Lena L. N. Wong, Elin Karlsson

Purpose: This study aimed to translate, culturally adapt, and preliminarily evaluate the Mandarin version of the Hearing and Functioning in Everyday Life Questionnaire (HFEQ-Mandarin) for older adults with hearing loss. Method: The study involved a systematic translation and cultural adaptation process following international guidelines, including forward and back translation, expert committee review, and field testing with 15 participants. A total of 227 older adults completed the HFEQ-Mandarin. In the non–hearing …

27.08.2026journal-article

PLOS Digital Health

To learn or not to learn? Model-based estimation of motor learning in a large, “in the wild”, home rehabilitation database

Yan Wen, Dongze Ye, Rukshana Poudel, Dan Zondervan, David Reinkensmeyer, Nicolas Schweighofer

Motor learning, defined as practice-related processes leading to relatively permanent changes in response capability, is critical for regaining motor function following brain injury. However, quantifying learning in real-world, unsupervised settings remains challenging. Here, we present a model-based framework for estimating the presence and extent of motor learning across multiple tasks and users from a large “in-the-wild” rehabilitation dataset collected via the FitMi sensor system. We analyzed 4,661 episodes fro …

27.08.2026journal-article

Scientific and Technical Journal of Information Technologies, Mechanics and Optics

Karelian speech recognition system with support for Karelian-Russian code-switching

I. S. Kipyatkova, M. D. Dolgushin, K. O. Kiseleva, I. A. Kagirov

This paper focuses on the development of an automatic speech recognition system for the Livvi-Karelian variety of the Karelian language, as it is spoken under conditions of code-switching between Karelian and Russian. The study of bilingual speech recognition methods is carried out. In order to improve the quality of speech recognition, a methodology for training text data augmentation via partial translation and intra-word code-switched wordforms artificial synthesis was developed. Acoustic modeling was performed …

27.08.2026journal-article

European Heart Journal - Case Reports

Severe neonatal long QT syndrome type 3 treated with genotype-directed therapy and early left cardiac sympathetic denervation: a case report

Andrea Greco, Estefania Martinez-Barrios, Agustin Lujan, Oscar Campuzano Larrea, Georgia Sarquella-Brugada

Abstract Background Long QT syndrome type 3 may present in fetal or neonatal life with QT prolongation, functional 2:1 atrioventricular block, and life-threatening ventricular arrhythmias. Early recognition and individualized genotype-directed management may be lifesaving. Case summary A neonate delivered after fetal bradycardia and intermittent 2:1 atrioventricular block presented with severe QT prolongation and recurrent torsades de pointes. The functional 2:1 atrioventricular block persisted despite beta blockad …

27.08.2026journal-article

Journal of Genetic Medicine and Gene Therapy

Traffic-informed Pavement Performance Prediction and Maintenance Prioritization Using the Pavement Condition Index: A Case Study from Afghanistan

Pouya­ Abdul Karim, Ahmadi Abdul Wahed

Road infrastructure serves as the primary medium of economic and agricultural transportation in developing countries. Afghanistan’s district roads play a critical role in connecting rural production centers to markets; however, systematic maintenance is often hindered by inadequate funding, lack of structural monitoring, and climatic deterioration. This research develops pavement condition assessment and deterioration prediction models using Pavement Condition Index (PCI), pavement age, characteristic rebound defle …

27.08.2026journal-article

Bioelectricity

Natural Compounds and Electroporation in Oncology: Synergistic Approaches for Enhanced Cancer Therapy

Dilek Yonar, Burcu Baba, Çağla Zübeyde Köprü, Urszula Ciesielska, Julita Kulbacka, Anna Choromańska

This review explores the emerging integration of natural agents with electroporation (EP) techniques in oncology. Natural compounds derived from plants, microbes, and marine organisms hold promise for cancer treatment due to their multifaceted mechanisms of action, including apoptosis induction and inhibition of tumor progression. EP, a method that enhances cell membrane permeability, facilitates the efficient intracellular delivery of these bioactive compounds. This synergistic approach has demonstrated significan …

27.08.2026journal-article

Nursing in Critical Care

Analysis of Factors Influencing Downtime During Continuous Renal Replacement Therapy in Critically Ill Patients and Construction of a Prediction Model

Bingbing Pang, Jie Zhang, Yanshuo Wu, Qiaoju Kang, Kaihua Dong, Suzhi Guo, Yanling Yin

ABSTRACT Background Prolonged CRRT downtime compromises treatment efficacy and worsens outcomes. Daily downtime > 20% exacerbates acidosis and is associated with 28‐day mortality. Aims This study aimed to develop and validate a bedside‐accessible nomogram for early identification of treatment days at risk of suboptimal CRRT downtime control in critically ill patients. Study Design This retrospective cohort study was conducted in one Chinese ICU (January 2019–December 2023). The binary outcome was cumulative downtim …

27.08.2026journal-article

American Journal of Speech-Language Pathology

Functional Reading Activities to Motivate and Empower: Maintenance of Reading Outcomes for Young Adults With Intellectual and Developmental Disabilities Following a Randomized Controlled Trial

Alison Prahl, Kaitlynn Fraze, Anupama Kannan, Jeffrey Grauzer, Rodney X. Sturdivant

Purpose: This study examined whether the effects of Functional Reading Activities to Motivate and Empower (FRAME), a functional, strategy-based reading comprehension intervention for young adults with intellectual and developmental disabilities (IDDs), were maintained 6 months following the completion of the intervention and explored participants' perceptions of the intervention's feasibility, relevance, and perceived impact. Method: Participants were 44 young adults with IDDs (ages 18–26 years) who participated in …

27.08.2026journal-article

Proceedings of the Human Factors and Ergonomics Society Annual Meeting

Real-Time Smartphone Camera–Based Hand Tracking for Controller-Free XR Exposure Therapy

Alex C. Lim, Trang Nguyen, Byeol Kim

Exposure therapy is an effective treatment for anxiety-related disorders, but conventional in vivo approaches are often limited by logistical and accessibility barriers. Extended reality (XR) addresses many of these limitations by providing controlled, repeatable exposure in virtual environments. Smartphone-based XR further improves accessibility through a portable, low-cost platform, although many systems rely on low-fidelity interactions that may reduce immersion. This study presents a stereoscopic smartphone-bas …

27.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Does Race Influence Velopharyngeal Structure Size and Velar Stretch During Sustained Phoneme Production in Children?

Taylor D. Snodgrass, Thomas J. Sitzman, Xiangming Fang, Patrick M. Briley, Bradley P. Sutton, Jamie L. Perry

Purpose: Differences in the size of velopharyngeal structures across racial groups at rest have been described in the literature, with race influencing adenoid thickness, pharyngeal depth, effective velar length, and velar length. The purpose of this study was to examine differences in velopharyngeal anatomy and velar stretch during sustained phoneme production in two racial groups. Method: A cross-sectional design was utilized for the study. Five- and 6-year-old children who were either Black or White completed st …

27.08.2026journal-article

Journal of Neuromuscular Diseases

Delphi consensus on gene therapy of spinal muscular atrophy with onasemnogene abeparvovec in Germany, Austria and Switzerland – part II – expert based recommendations for surveillance and management of side-effects

Andreas Ziegler, Claudia Weiß, Katharina Vill, Matthias Baumann, Günther Bernert, Astrid Blaschek, Astrid Eisenkölbl, Marina Flotats-Bastardas, Johannes Friese, Dorothea Holzwarth, Claudia Ganter, Klaus Goldhahn, Andreas Hahn, Maja von der Hagen, Hans Hartmann, Oswald Hasselmann, Veronka Horber, Ralf A Husain, Sabine Illsinger, David Jacquier, Jessika Johannsen, Cornelia Köhler, Heike Kölbel, Michael Kolodzig, Andrea Klein, Astrid Pechmann, Arpad von Moers, Wolfgang Müller-Felber, Christian Rauscher, Gudrun Schreiber, Oliver Schwartz, Joachim Sproß, Georg M Stettner, Corinna Stoltenburg, Eva Stumpe, Regina Trollmann, Gerd Wiegand, Ekkehard Wilichowski, Ulrike Schara, Janbernd Kirschner

Background: Systematic protocols for long-term surveillance of children with spinal muscular atrophy treated with onasemnogene abeparvovec are lacking. Together with best practice recommendations for safety monitoring and management, such recommendations should increase patient safety and confidence levels of healthcare providers. Objective: Based on systematic literature review and evidence grading from part 1, this initiative aims to develop a structured treatment plan applicable across all treatment centers in G …

27.08.2026journal-article

ACS Applied Nano Materials

Metabolic-Modulating and Antibacterial Nanoplatforms Improve Immunosuppression via Downregulating Glycolysis Pathway in Fusobacterium nucleatum -Infected Colorectal Cancer Therapy

Jingwen Ma, Yun Zeng, Xiaoye Wang, Yuan Liu, Dan Xiao, Bowei Zhou, Na Cai, Rong Qiang

Abstract Fusobacterium nucleatum (F.n.) infection is closely related to poor prognosis and high mortality in colorectal cancer (CRC) patients, promotes the proliferation and migration of CRC cells, induces inflammation, and creates an immunosuppressive tumor microenvironment. Compared with CRC cells not infected with F.n., F.n.-infected CRC cells exhibit greater glycolytic activity, considered as a beneficial metabolic change for establishing a symbiotic relationship between CRC cells and F.n. In this study, the cl …

27.08.2026journal-article

Clinical Journal of Health Sciences

Treatment of Borderline Personality Disorder in Cognitive Behavioral Therapy: A Case Report

Berk İşlek, Meryem Karaaziz

Borderline Personality Disorder (BPD) is a personality structure characterized by significant instability in affect regulation, interpersonal relationships, and self-concept, leading to substantial impairment in functioning. This case report presents the Cognitive Behavioral Therapy (CBT) process applied to a 26-year-old female client for whom a clinical diagnosis of BPD was considered. Clinical interviews conducted in accordance with DSM-5 diagnostic criteria, together with findings obtained from the Minnesota Mul …

27.08.2026journal-article

Current Stem Cell Research & Therapy

Targeting Abdominal Aortic Aneurysms with Multipotent Mesenchymal Stromal/Stem Cells: Insights into Immunological Effects

Seyed Mohammad Sajjadi, Fahimeh Lavi Arab

Abstract: An abdominal aortic aneurysm (AAA) is a serious vascular disease characterized by progressive dilation of the abdominal aorta, resulting in an increased risk of rupture. AAA develops through multiple pathogenic mechanisms, including chronic inflammation, extracellular matrix (ECM) degradation, oxidative stress, and vascular smooth muscle cell (VSMC) apoptosis. Surgical intervention is the primary treatment for AAA; however, no effective pharmacological therapies are currently available to halt or reverse …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Pelvic floor rehabilitation improves anorectal function after sphincter-preserving surgery for low rectal cancer

Xiao-Jun Liu, Ming-Li Wei, Li-Li Liu, Jing-Jing Qin

BACKGROUND Sphincter-preserving surgery with prophylactic colostomy is the benchmark treatment for low rectal cancer, although postoperative anorectal dysfunction significantly reduces quality of life. Although pelvic floor muscle training seems effective in functional recovery, there is currently little systematic evidence regarding the efficacy of this therapy in this specific population. AIM To investigate whether structured pelvic floor muscle rehabilitation training provides better anorectal functioning than s …

27.08.2026journal-article

Advanced Healthcare Materials

Injectable Modular Cellularized Blocks via Dual‐Photocrosslinking for Enhanced Cell Therapy

Jiajia Wang, Junyi Wang, Shuhan Duan, Huijing Ma, Wentao Jiang, Rongpu Liu, Huijiao Yan, Licheng Wan, Shaoyi Wang, Rong Yang, Wenjie Zhang

ABSTRACT Cell‐based regenerative medicine is limited by poor survival of transplanted cells and the lack of scalable, ready‐to‐use delivery platforms. Here, we developed an injectable dual‐photocrosslinking microsphere (DP‐MS) bioink composed of Ru/SPS, o‐nitrobenzyl‐modified hyaluronic acid (HANB), and gelatin methacryloyl (GelMA). Orthogonal green (525 nm) and UV (365 nm) light enable sequential crosslinking: first to generate cell‐laden microspheres, and the second step requires only 10 s to induce inter‐microsp …

27.08.2026journal-article

Current Oncology

Return to Intended Oncologic Therapy After Brain Metastasis Surgery: Mapping the Early Postoperative Pathway

Alexis Hadjiathanasiou, Martin Liebisch, Johanna Dahn, Johannes Lemcke, Patrick Schuss

Surgery for brain metastases (BM) is embedded in a multidisciplinary oncologic pathway. This study evaluated oncologic readiness and return to intended oncologic therapy (RIOT) after surgery for BM. Patients undergoing surgery for histologically confirmed BM were retrospectively identified. Oncologic readiness was defined as sufficient postoperative clinical and neurological recovery to allow the next indicated oncologic treatment. RIOT was defined as postoperative radiotherapy and/or systemic treatment within 30 d …

27.08.2026journal-article

International Accounting

Internal control and audit in the public sector: The need to synchronize occupational standards in the digital economy

Natal'ya E. SPIRIDONOVA

Subject. This article analyzes the content of occupational standards in the field of internal control and internal auditing, which set qualification requirements for specialists and provide guidelines for developing educational programmes. Objectives. The article aims to systematize the requirements for the qualifications and digital skills of specialists performing control functions within an economic entity, identify areas of concern in the current system distinguishing the profession lines of Internal Controller …

27.08.2026journal-article

Current Neuropharmacology

Association of Androgen Deprivation Therapy with Cerebral Small Vessel Disease Burden in Prostate Cancer

Longhai Zeng, Rentang Bi, Zijun Yang, Qian Liu, Yanmei Qiu, Yanhao Wei, Haokun Peng, Wenbin Xiong, Bo Hu, Ya'nan Li

Introduction: Androgen Deprivation Therapy (ADT) is essential for advanced Prostate Cancer (PCa) but may increase cardiovascular and cerebrovascular risks. Its adverse effects on cerebral small vessels remain unclear. Leukoaraiosis (LA) and Lacunar Infarction (LI) are neuroimaging markers of Cerebral Small Vessel Disease (CSVD) associated with cognitive decline and stroke. materials and methods: Study Population This study utilized data from the SMART cohort, which includes patients at 13 public tertiary hospitals …