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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

PLOS One

Normative emotional responses to environmental sounds in middle-aged to older adults with normal hearing: Stimuli from the Marcell database

Dina Lelic, Frederic Marmel

Purpose This study aimed to provide normative affective ratings for middle-aged to older adults with normal hearing using the Marcell database. The database includes 120 diverse environmental sounds representing various real-world acoustic events, such as those produced by animals, humans, musical instruments, tools, signals, and liquids. Secondary aims were to examine the relationship between valence and arousal, and whether factors such as age, gender, hearing-related lifestyle, hearing demands, and self-reported …

21.08.2026journal-article

Geriatrics

Feasibility and Process Evaluation of a Screening Intervention for Early Detection of Malnutrition Risk Among Community-Dwelling Older Adults Receiving Home Care Services

Tine Louise Launholt, Palle Larsen, Jemma Hawkins, Hanne Kaae Kristensen

Background: Malnutrition is prevalent among older adults (OAs), ≥65 years, receiving home care services. Despite recommendations for early detection and multifactorial interventions, a gap remains between routine practice and evidence. We therefore developed a complex intervention for early detection of malnutrition risk in a Danish home care setting, comprising an implementation strategy with staff learning activities and a screening procedure with a start-up conversation and follow-up screenings. This article out …

21.08.2026journal-article

Brain Sciences

Stimulus Incongruency Effects on Visual Short-Term Memory Binding in Young and Older Adults with and Without Cognitive Impairment

Monika McAtarsney-Kovacs, Raju Sapkota, Ian van der Linde, Shahina Pardhan

Background: Literature suggests that both the Stroop task and visual short-term memory (VSTM) binding tasks can differentiate individuals with Mild Cognitive Impairment (MCI) from cognitively normal older adults. These cognitive processes have rarely been examined together. This study investigated how Stroop-like color-word incongruency and directional incongruency between arrow orientation and motion affect memory accuracy and reaction time (RT) measures during a VSTM binding task in cognitively normal adults and …

21.08.2026journal-article

Frontiers in Endocrinology

Kinesiophobia phenotypes and fall history in older adults with osteoporosis: a cross-sectional study using latent profile analysis

MengPing Tian, Ling Li, WanQiu Lv, Gang Deng, Yang Ni, Jian Xiong

Objective Falls are a leading cause of morbidity among older adults with osteoporosis. While traditional risk assessment focuses on biological factors such as bone mineral density (BMD), psychological factors—particularly kinesiophobia—have received increasing attention. However, most studies conceptualize kinesiophobia as a continuous construct, potentially overlooking clinically meaningful heterogeneity. This study aimed to identify kinesiophobia phenotypes and examine their association with fall history in older …

21.08.2026journal-article

Psychology and Psychotherapy: Theory, Research and Practice

‘I just want an explanation’: A qualitative investigation of how people with psychosis make sense of their visual hallucinations

Charlotte Aynsworth, Rob Dudley, Samuel Sargeant, Clara Humpston, Felicity Waite

Abstract Objectives Visual hallucinations (visions) in people with psychosis are common and often distressing. Cognitive theory emphasises a central role of appraisals in determining distress. We explored how people made sense of their visions to inform the development of targeted cognitive treatments for visions. Design Semi‐structured interviews were conducted with 12 participants with psychosis recently reporting visions. Methods Reflexive thematic analysis was utilised. Results There was an overarching theme th …

21.08.2026journal-article

Frontiers in Human Neuroscience

Multi-system aging vulnerability associated with prolonged violence exposure: evidence from a Colombian sample

Eduar Herrera, Alvaro Barrera-Ocampo, Willian Orlando Castillo Ordoñez

Exposure to violence is a major social determinant that can influence aging trajectories and brain health. In Colombia, a country affected by decades of armed conflict, comprehensive assessment models are needed to capture the multiple factors that shape health and may accelerate aging. This study examined whether long-term exposure to violence is associated with greater multisystem aging vulnerability across cognitive, mental health, social, and neuroendocrine domains in a Colombian cohort. Fifty participants were …

21.08.2026journal-article

Aging Cell

hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle‐Activating Capacity

Yating Chen, Wei Liu, Ying Tian, Xinyu Wang, Haonan Fan, Mingyu Yang, Feiyang Diao, Jing Li

ABSTRACT Cellular senescence is a fundamental hallmark of aging and represents a major barrier to the scalable and reproducible application of mesenchymal stromal cell (MSC)‐derived small extracellular vesicles (sEVs). Senescent human umbilical cord mesenchymal stromal cells (hUCMSCs) exhibit impaired proliferative capacity, disrupted mitochondrial homeostasis, and altered secretory phenotypes, which may compromise the biological activity and therapeutic reliability of sEVs. Here, we investigated whether overexpres …

21.08.2026journal-article

Nature Medicine

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Raghav Sehgal, Daniel Borrus, Jenel F. Armstrong, John Gonzalez, Jessica Kasamoto, Yaroslav Markov, Ahana Priyanka, Ryan Smith, Natàlia Carreras-Gallo, Jessica Lasky-Su, Varun B. Dwaraka, Michael J. Corley, Albert Higgins-Chen

Abstract Aging biomarkers can potentially allow researchers to rapidly monitor the impact of an aging intervention without the need for decade-spanning trials. However, before the use of aging biomarkers, such as epigenetic clocks, as surrogate endpoints, their responsiveness to interventions that target aging must be tested. Here we curate TranslAGE, a harmonized database of 51 public and private longitudinal interventional studies, and calculate a consistent set of 16 prominent epigenetic clocks for each study, a …

21.08.2026journal-article

Journal of Functional Morphology and Kinesiology

Long-Term Flywheel Resistance Training Enhances Cognitive Flexibility in Older Women: A 36-Week Randomized Controlled Trial

Maria Luiza da Cruz Santos, Pablo Augusto Garcia Agostinho, Wanderson Matheus Lopes Machado, Thalia Miranda Rufino, Leonardo Silveira Goulart Silva, Isabella Evangelista Leite, Cláudia Eliza Patrocínio de Oliveira, Édison Andrés Pérez-Bedoya, Osvaldo Costa Moreira

Background: Executive functions (EFs) decline with aging, impacting functional independence. While resistance training (RT) is a promising non-pharmacological intervention, the optimal modality and duration for cognitive benefits remain unclear. Flywheel RT (FRT) imposes greater motor control and attentional demands than traditional RT (TRT), potentially enhancing EFs. Objective: To compare the effects of a 36-week FRT versus TRT program on executive function and serum insulin-like growth factor 1 (IGF-1) levels in …

21.08.2026journal-article

Frontiers in Public Health

Multidimensional sleep health is associated with mild cognitive impairment in older adults: a cross-sectional study

Yang Li, Xinxiu Dong, Hui Hu, Xiaotong Wang

Background Mild cognitive impairment (MCI) is a transitional stage preceding dementia and may be amenable to early intervention. Although sleep problems are common among older adults and related to cognitive function, most studies have focused on single sleep characteristics rather than multidimensional sleep health. Methods This cross-sectional study included 416 adults aged ≥ 60 years from three nursing homes and two communities in Wuhan, China. Sleep health was assessed using the Pittsburgh Sleep Quality Index ( …

21.08.2026journal-article

Frontiers in Public Health

Factors influencing self-care among older patients with heart failure and spouses in China: a mixed methods study

Xiaoyan Wu, Yiyu Zhuang, Manjun Wang, Jinhua Jin, Yuting Ke

Objective This study aimed to investigate the factors influencing self-care among older patients with heart failure (HF) and their spouses from a dyadic perspective. Methods An explanatory sequential mixed-methods design was employed. In the quantitative phase, 145 dyads of older HF patients and their spouses were recruited from a tertiary hospital in Zhejiang, China. Validated instruments were used to measure patient self-care, spouse contribution to self-care, disease-specific health literacy, mutuality, and soci …

21.08.2026journal-article

The Oncologist

IUC26682-89 Efficacy and tolerability of immune checkpoint inhibitors in older versus younger patients with metastatic renal cell carcinoma: a real-world Asian cohort

R Kanesvaran, H S Tan, J W K Chan, W C Tan, D J M Ang, J J X Tan, H X Tan, A Roy Chowdhury

Abstract Background Older adults are underrepresented in pivotal immune checkpoint inhibitor (ICI) trials for metastatic renal cell carcinoma (mRCC), resulting in uncertainty regarding treatment effectiveness and tolerability in routine clinical practice. We compared clinical outcomes and treatment-related toxicities between younger and older patients with mRCC receiving ICIs in a real-world Asian cohort. Methods We conducted a retrospective study of 171 patients with mRCC treated with ICIs at the National Cancer C …

21.08.2026journal-article

Healthcare

Perceived Barriers to Home-Based Telemedicine and Facilitators of Public Health Center-Based Telemedicine Among Digitally Capable Community-Dwelling Older Adults: A Cross-Sectional Scenario-Based Survey

Seung-Kwon Ji, Wonseuk Jang

Background/Objectives: Home-based telemedicine requires patients to perform technical tasks independently, whereas assisted public health center (PHC)-based telemedicine transfers some of these tasks to on-site personnel. This study describes model-specific perceptions and estimates the difference in intention to use between the two scenarios among relatively digitally capable, community-dwelling older adults. Methods: A cross-sectional, fixed-order, scenario-based online survey was completed by 300 adults aged 65 …

21.08.2026journal-article

Aging Cell

RICTOR Prevents Decidualization Disorder in Women With Advanced Maternal Age via Regulating FoxO1 Nuclear Export

Yifeng Lin, Jiwei Sun, Yue Ying, Dan Li, Yuewen Ying, Xilin Shen, Xiao Sun, Dan Zhang, Yiqing Wu, Runju Zhang

ABSTRACT Miscarriage and abnormal embryonic development in women of advanced maternal age (AMA) are often associated with impaired decidualization. mTORC2 is an evolutionarily conserved protein kinase. As a core component of mTORC2, RICTOR has been implicated in nutrient sensing and is closely linked to implantation disorders; however, its role in regulating age‐related decidualization disorders remains unreported. In this study, we identified pronounced decidualization defects in AMA foster mice, accompanied by a …

21.08.2026journal-article

Frontiers in Medicine

Declining yet persistent asthma mortality among U.S. adults aged 65 years and older (1999–2020)

Tong Feng, Pengcheng Zheng, Yue Cao, Ding Han, Ran Duan

Background Asthma in older adults (≥65 years) represents a growing yet understudied public health burden. Comprehensive spatiotemporal trends and future projections of asthma mortality in this population remain incompletely characterized. This study aimed to characterize the temporal, demographic, and geographic patterns of asthma mortality among U.S. adults aged ≥65 years, project future mortality trends through 2030, and evaluate state-level disparities relative to an empirical mortality frontier. Methods Using t …

21.08.2026journal-article

Healthcare

Effects of Traditional Chinese Mind–Body Exercise on Physical Function in Older Adults with Sarcopenia and Frailty: A Meta-Analysis of Randomized Controlled Trials

Jingtao Zhou, Wi-Young So, Minhye Shin

Background and Objectives: Sarcopenia and frailty are associated with falls, disability, and functional decline in older adults. This review evaluated traditional Chinese mind–body exercise (TCMBE), including Tai Chi and Health Qigong, in adults aged 60 years or older with clinically defined sarcopenia or frailty. Materials and Methods: Randomized controlled trials identified through December 2024 from six English- and Chinese-language databases were synthesized. The analyses included physical performance and secon …

21.08.2026journal-article

Applied Sciences

Effects of an Eight-Week Combined Isometric and Elastic-Resistance Training Program on Body Composition and Functional Fitness in Older Women

Sanghyun Lee, Byungkwan Kim

This exploratory randomized trial evaluated an eight-week combined isometric and elastic-resistance program in community-dwelling women aged 70 years or older. Forty-nine participants were randomized to exercise (EG; n = 24) or control (CG; n = 25). Twenty-two EG participants completed the intervention and follow-up; two had no post-intervention measurements because of scheduling conflicts. All randomized participants were included in the intention-to-treat analysis using 50 data sets generated by predictive mean m …

21.08.2026journal-article

Perspectiva XXI

Autoestima, depresión y preocupación sexual y su relación con las actitudes hacia el uso del condón en personas que viven con VIH en Villavicencio, Colombia

Diego Alejandro Garcés Rojas, David Mauricio Rodríguez Machado

Las personas que viven con VIH pueden experimentar dificultades emocionales e interpersonales vinculadas con su sexualidad, las cuales podrían estar asociadas con sus actitudes hacia las prácticas preventivas. El objetivo de este estudio fue analizar la relación entre las dimensiones de la sexualidad y las actitudes hacia el uso del condón en personas que viven con VIH en Villavicencio, Colombia. Se desarrolló una investigación cuantitativa, no experimental, transversal, descriptiva y correlacional. Participaron 15 …

21.08.2026journal-article

PLOS One

Integrated liver transcriptomic data reveal differences in aging-associated regulation between metabolic dysfunction-associated steatotic liver disease and normal liver aging

Tanchun Wang, Qin Huang, Yan Wang, Cong Li, Juan Ni, Fang Xie

Background Age-related molecular trajectories of metabolic dysfunction-associated steatotic liver disease (MASLD) remain insufficiently characterized, limiting age-stratified risk assessment and intervention. Objective To test whether MASLD-related molecular changes with age merely reflect accelerated physiological aging or represent a disease-specific divergence. Methods We utilized public transcriptomic data from normal liver and MASLD samples to identify differential transcriptomic signals. We employed Spearman …

21.08.2026journal-article

The Oncologist

IUC26589-95 First-Line or Maintenance Immune Checkpoint Inhibitors in Older Patients with Advanced Urothelial Carcinoma: A Systematic Review and Meta-Analysis

D Incognito, A D'arienzo, C Barraco, A Nicastro, S Facchini, G Facchini

Abstract Background Evidence on immune-based treatment in older patients with advanced urothelial carcinoma are limited because age-specific outcomes are usually exploratory. We assessed the efficacy of first-line and maintenance immune-based strategies in patients aged ≥65 years. Methods PubMed/MEDLINE, Embase, Cochrane and major oncology congresses were searched from Jan 2015 to May 2026 for randomized trials reporting age-specific hazard ratios (HRs) for overall survival (OS) or progression-free survival (PFS). …

21.08.2026journal-article

Frontiers in Public Health

Models for identifying cognitive frailty in hospitalized older adults with chronic heart failure in China: a systematic review

Yue Mou, Longyun Li, Qian Geng, Yao Li, Tingjia Zhang, Fang Cao, Yuanyuan Li, Ting Zhang

Objective To systematically evaluate models for identifying cognitive frailty (CF) among hospitalized older adults with chronic heart failure (CHF) in China and assess their intended use, performance, and methodological quality. Methods A systematic search was conducted in PubMed, Web of Science Core Collection, Embase, the Cochrane Library, China National Knowledge Infrastructure, Wanfang, VIP, and the Chinese Biomedical Literature Database from inception to March 31, 2026. Two reviewers independently screened the …

21.08.2026journal-article

Acta Odontologica Scandinavica

Bioinformatics analysis reveals shared gene signatures and molecular mechanisms between periodontitis and rheumatoid arthritis in the context of aging

Hanlu Xiao, Yajun Zhao, Yishu Wang, Yuhan Wang, Dingxin Zhang, Rongzeng Huang, Chengwu Song, Shan Cao, Shuna Jin

Objective: The interplay between periodontitis (PD) and rheumatoid arthritis (RA) is well recognized, with aging being a central risk factor for both. However, the shared aging-related molecular mechanisms remain unclear. We aimed to identify common aging-related hub genes linking PD and RA and elucidate their underlying functional mechanisms. Material and methods: PD and RA gene expression profiles were obtained from Gene Expression Omnibus database. Crosstalk genes were identified via differential expression anal …

21.08.2026journal-article

RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218

A ENFERMAGEM NO CUIDADO À PESSOA COM ANEMIA FALCIFORME: PRÁTICAS, DESAFIOS E EVIDÊNCIAS CIENTÍFICAS

Antonieta Benvinda Cassinda Cachipa, Kemelândua Sebastião Ngando, Maria Daniela Alves Martins, Vladson Gouveia Ferreira, Stella Maia Barbosa, Gabriela Silva Cruz, Erika Helena Salles de Brito, Ana Caroline Rocha de Melo Leite

A anemia falciforme é uma doença genética crônica de elevada morbidade, predominante na população negra, que ocasiona importantes repercussões clínicas e sociais. Nesse contexto, a enfermagem desempenha papel essencial no manejo da dor, prevenção de complicações e promoção do autocuidado. Objetivo: Sintetizar as evidências científicas sobre a atuação da enfermagem no cuidado de pacientes com anemia falciforme. Método: Revisão integrativa da literatura, baseada na estratégia PCC: População (pacientes com anemia falc …

21.08.2026journal-article

BMC Psychiatry

Encounters between people with mental health and/or substance use problems and ambulance clinicians: a qualitative interview study in Norway

Lin Eik Ulvøy, Jorun Rugkåsa, Trine Møgster Jørgensen, Solveig H. H. Kjus, Kristin Häikiö

Abstract Background Interactions between ambulance clinicians and people with mental health and/or substance use problems are frequent, and international studies show that these encounters are often shaped by stigma, power dynamics and challenges to patient autonomy. However, there is limited research exploring patients’ experiences of ambulance services in the Norwegian context. This study addresses this knowledge gap. Methods This qualitative study was based on in-depth, semi-structured interviews with 23 people …