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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

BMC Microbiology

First identification and characterization of a plasmid co-harbouring poxtA and cfr in a clinical linezolid-resistant Staphylococcus aureus isolate

Kang Xu, Kaixin Zhou, Linlin Xu, Qing Chen, Lianyan Xie, Feifei Gu, Aikuang Ma, Shuzhen Xiao, Jingyong Sun, Dongan Zhu

Abstract Background Linezolid remains an important treatment option for serious infections caused by Gram-positive pathogens; however, acquired oxazolidinone resistance genes carried by mobile genetic elements are an increasing clinical concern. In Staphylococcus aureus , cfr and poxtA have previously been reported together in the chromosomal mosaic transposon Tn 6349 , whereas complete plasmid-borne structures co-harbouring these genes remain poorly defined. Methods Isolate D2958 was identified by matrix-assisted …

03.09.2026journal-article

Japan Journal of Nursing Science

Nurses' Visual Attention During Initial Observation of Patients With Suspected Pneumonia: An Observational Pupillometry Study

Shoya Kamijo, Shinji Matsutani, Eijun Nakayama, Naoya Ohtani

ABSTRACT Aim Observation requires selective attention to visual information acquired through gaze. Measuring pupil diameter, an index of attention, we examined skilled and novice nurses during the initial assessment of a patient urgently admitted with suspected community‐acquired pneumonia. Methods This observational study was conducted in a simulated environment. Participants comprised skilled nurses with advanced practice training and novice nurses. During a 120‐s initial assessment of a mock patient with suspect …

03.09.2026journal-article

Frontiers in Pediatrics

Clinical utility of renal and urinary tract point-of-care ultrasound in the neonatal intensive care unit: insights from a case series

Gayatri Morajkar, Sujata Deshpande, Sachin Verma, Vivek Goyal, Jayanta Hazarika, Prasoon Bansal, Yogen Singh, Pradeep Suryawanshi

Background Clinical decision-making in acutely ill neonates often depends on the timely identification of the underlying pathology. Bedside point-of-care ultrasound (POCUS), performed by the treating clinician, allows immediate correlation of imaging findings with evolving clinical status. However, its role in evaluating renal and urinary tract abnormalities in neonates remains relatively underexplored and is not yet widely integrated into routine practice. Methods This multicenter case series included data from fo …

03.09.2026journal-article

Frontiers in Public Health

Fusing meteorological factors and baidu search index with an adapted deformtime model to predict influenza-like illness in Beijing

Lingling Shen, Yajun Xiong, Zhaobin Sun

Background Influenza-like illness (ILI) poses a significant burden on public health systems, particularly in densely populated megacities. Accurate and timely forecasting is crucial for early warning and resource allocation. While deep learning models have shown promise, capturing the complex, non-linear coupling between environmental drivers and human behavior remains a challenge. Methods We used weekly ILI% surveillance data from Beijing (2010–2019), complemented by 20 meteorological variables and 322 Baidu Searc …

03.09.2026journal-article

Frontiers in Public Health

Beyond visual comfort: comparing pupillometry and subjective measures of cognitive strain in workplace lighting

D-Filipa Ferreira, Ana-Carolina Fonseca, Simão Ferreira, Luís Pinto-Coelho, Matilde A. Rodrigues

Introduction This study evaluated the discriminative sensitivity of pupillometry, relative to subjective self-report measures, as an objective indicator of cognitive load during screen-based tasks performed under two workplace illuminance levels (300 and 500 lux). Inadequate workplace illuminance is associated with visual fatigue, stress, and impaired attention, yet its effect on cognitive strain during screen-based tasks remains underexplored through objective physiological indicators, particularly given the confo …

03.09.2026journal-article

Frontiers in Public Health

Safety of Sabin-derived inactivated poliovirus vaccine in adult booster recipients: a systematic review and meta-analysis

Muhammad Hussain, Muhammad Hassan, Abdul Hannan, Arham Kamil, Muhammad Tayyab Azam, Zain Ul Abideen Shahid, Hasibullah Aminpoor, Suhaylah Gore, Faizan Ahmed, Anna Guseva

Background Poliomyelitis remains a public health concern in select regions. Sabin strain-derived inactivated poliovirus vaccine (sIPV) offers a potentially safer and cost-effective alternative to conventional IPV (cIPV) for adult booster immunization. Objective To systematically review and meta-analyze evidence on the safety of sIPV in adults. Methods We searched PubMed, Embase, Cochrane, and Scopus through January 2026 for randomized controlled trials comparing sIPV with cIPV/w-IPV or placebo in adults. Safety out …

03.09.2026journal-article

Frontiers in Public Health

Association between physical fitness and myopia among school-entry students: a school-based cross-sectional study

ChengChao Duan, Yi Ba, Honglin Song, Yaqi Xue

Objective We examined whether school physical-fitness performance was associated with screening-defined current myopia in primary grade 1 and junior middle grade 1 students. We also explored item-level fitness profiles in relation to current myopia status. Methods We analyzed routine health-screening records collected in 2025 from three schools in Xicheng District, Beijing. Screening-defined current myopia required unaided visual acuity <5.0 together with a non-cycloplegic spherical equivalent ≤ −0.50 D in the same …

03.09.2026journal-article

Journal of Palliative Medicine

Liminal Personhood and Continuity of Moral Identity in Clinical Care

Harvey Max Chochinov, Marianne Sofronas, Joseph J. Fins

Capacity-based frameworks of personhood risk marginalizing individuals whose agency, cognition, or consciousness are diminished by illness, brain injury, or proximity to death. This article introduces the concept of liminal personhood , which describes the persistence of moral and relational identity even as conventional markers of personhood fade. Drawing on ethical, philosophical, and neuroethical scholarship, the paper argues that failing to recognize enduring personhood can fracture patient identity and erode c …

03.09.2026journal-article

Sustainability

Protecting Blue Skies and Health: Can “Key Controlled Areas for Air Pollution Prevention and Control” Contribute to the Sustainable Development of Residents’ Health?

Xi Gu, Sijia Qiao, Xinran Yuan

This paper examines whether the establishment of “Key Controlled Areas for Air Pollution Prevention and Control” and its associated policy package in China improved residents’ health. Based on data from the China Health and Retirement Longitudinal Study (CHARLS) 2011–2018, Our study finds that this command-and-control environmental regulation is associated with notable declines in residents’ morbidity from asthma, lung disease, and heart disease, while also producing preventive effects. Potential channel analysis i …

03.09.2026journal-article

Diabetic Medicine

A novel deep intronic EIF2AK3 variant disrupts splicing and causes Wolcott–Rallison syndrome

Alaa Al Assi, Georgia Bonfield, James Russ‐Silsby, Suhel Ahmed, Thomas W. Laver, Kadri Karaer, Bayram Özhan, Ayca Altincik, Kashyap A. Patel, Jayne A. L. Houghton, Sarah E. Flanagan, Matthew B. Johnson, Elisa De Franco

Abstract Aim Deep intronic variants can disrupt splicing and cause monogenic disease but are missed by routine genetic testing. This study assessed the contribution of deep intronic variants to Wolcott–Rallison syndrome (WRS), a recessive disorder characterized by early‐onset diabetes and progressive multisystem disease caused by loss‐of‐function EIF2AK3 variants. Methods We investigated a cohort of 116 individuals referred to the Exeter Genomics Laboratory for genetic testing who had diabetes diagnosed at ≤2 years …

03.09.2026journal-article

British Journal of Nursing

Changing a Future Nurse undergraduate nursing programme to include more mental health content: initial evaluation

Laurence Baldwin, Judith McLeod, Rachel Bage, Frances Nicol, Maya Dixon, Lyndsay Khan, Helen Alcock-Towse, Donna-Marie Gordon, Catherine Shiels

The 2018 Nursing and Midwifery Council's ‘Future Nurse’ standards introduced increased genericism to UK nursing education, prompting criticism from specialist fields concerned about diluted field-specific knowledge. This article reports on a curriculum innovation at one UK university that addressed local implementation challenges through targeted module development to include an increased number of field-specific modules alongside core content. Among others, two new modules were introduced, one on mental health for …

03.09.2026journal-article

Gastrointestinal Disorders

Public Awareness, Label Literacy, and Consumer Behavior Regarding Gluten-Free Products in Arar, Saudi Arabia: Implications for the Supportive Environment of Immune-Mediated Gastrointestinal Disorders

Anshoo Agarwal, Sadeem Fahad Alwulayi, Asayil Saleh Alanazi, Ghaliah Farraj Alanzi, Rawan Sawab Albanaqi, Danah Naif Salem Alanzi, Nada Faleh AlRuwaili, Ghala Sultan Ageel Al Enezi, Baraah Abu Alsel, Safya E. Esmaeel, Fathia Ahmed Mersal, Naglaa A. Bayomy, Manal S. Fawzy

Background/Objectives: Community-level knowledge, food-label literacy, and consumer perceptions may shape the environment in which medically indicated gluten-free diets are followed. This study assessed prior exposure to the term “gluten,” ingredient-label literacy, perceived gluten-free product (GFP) cost, and purchasing behavior and intentions among adults in Arar, Saudi Arabia. Methods: A bilingual Arabic–English online cross-sectional questionnaire was administered to adult residents of Arar using non-probabili …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

18 F FDG PET/CT in a Rare Case of CIC::NUTM1 Sarcoma

Yamini Dharmashaktu, Sameer Rastogi, Adarsh Barwad, Ritwik Nitin Wakankar, Shamim A Shamim

Capicua transcriptional repressor ( CIC )-rearranged sarcomas are exceedingly rare and highly aggressive malignancies affecting young individuals predominantly, and CIC::NUTM1 is thought to be a molecular variant of CIC-rearranged sarcoma. It has a poor prognosis and a rapid progression. Here, we present a case of a 3-year-old male with CIC::NUTM1 sarcoma of the pelvis who presented with complaints of constipation associated with severe pain for which 18 F fluorodeoxyglucose positron emission tomography/computed to …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Assessing the predictors of treatment-seeking and health care access barriers among transgender individuals in Pakistan

Athar Memon, Sameena Ourangzaib, Benjamin R. Bates, Shiraz Shaikh

Background: Transgender individuals in Pakistan face barriers to health care access, increasing the risk of serious disease transmission. Aim: To identify the predictors of treatment-seeking intention and health care access delays among transgender individuals in Karachi, Pakistan. Methods: Between December 2024 and April 2025 we interviewed 360 individuals, aged ≥18 years, who identified as transgender and had accessed health care within the past 12 months. We analysed the data using SPSS version 20 and conducted …

03.09.2026journal-article

World Journal of Traditional Chinese Medicine

Simultaneous Harvesting of PINK1, Parkin, and FUNDC1 Ligands from Herbal Medicines Using “Net Fishing” Strategy

Zhong-Yu Fu, Min Zhang, Fan Zhang, Cheng-Zhu Song, Yang-Yang Fu, Tao Wang, Xu-Dong He, Mei Zhang, Jie Yu, Xing-Xin Yang

Abstract Objective: Targeting mitophagy represents a promising therapeutic strategy for human diseases. This study aimed to develop an efficient approach to simultaneously identify natural ligands for PTEN-induced kinase 1 (PINK1), Parkin, and FUN14 domain containing 1 (FUNDC1) – core regulators of mitophagy – from complex herbal medicine (HM) extracts. Materials and Methods: We established a novel capture strategy where PINK1, Parkin, and FUNDC1 proteins were individually and physically adsorbed on the surface of …

03.09.2026journal-article

European Journal of Endocrinology

Adverse health outcomes across the life course in individuals with six rare bone diseases: a 10-year population-based cohort study

Pascal Gaechter, Christian Meier, Emanuel Christ, Fahim Ebrahimi, Alexander Kutz, Gabor Szinnai

Abstract Background Rare bone diseases comprise a heterogeneous group of complex and disabling conditions. Evidence on age-specific hospitalization patterns and in-hospital outcomes across multiple rare bone diseases is limited. Methods Population-based cohort study using national hospitalization data (01/2012–12/2021). Among 11,092,151 hospitalizations, 2,875 admissions of children and adults with rare bone diseases were identified via ICD-10 codes (X-linked hypophosphatemia, osteogenesis imperfecta, fibrous dyspl …

03.09.2026journal-article

International Journal of Molecular Sciences

Myeloid-Derived Suppressor Cells (MDSCs) in Cardiovascular Risk of Obesity-Associated Diabetes

Rocío Flores-Campos, Lourdes Hontecillas-Prieto, Daniel J. García-Domínguez, Antonio Fernández-Suárez, Iker Egusquiza-Lasuen, Antonio Pérez, Josep Ribalta, Juan Pedro-Botet, Víctor Sánchez-Margalet, on behalf of the Immunology Group of the Spanish Society of Laboratory Medicine (SEMEDLAB), the Cardiovascular Disease Group of the Spanish Diabetes Society (SED)

The dysregulation of immune homeostasis and the persistence of chronic, low-grade inflammation represent core pathophysiological drivers governing the onset and progression of metabolic and cardiovascular disorders. Myeloid-derived suppressor cells (MDSCs) comprise a highly heterogeneous population of immature myeloid cells that are rapidly mobilized from the bone marrow in response to biological stressors, such as sustained tissue injury and chronic inflammatory signaling. Historically evaluated within oncology an …

03.09.2026journal-article

Frontiers in Immunology

HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa

Praiscillia Kia, Edward Kankaka, Patricia Kankundiye, Marcel Tongo, Rose Nabatanzi, Tokameh Mahmoudi, Damalie Nakanjako

Background Clinical and biological consequences of accelerated immune aging are substantial, with growing evidence of increased risk of non-communicable diseases (NCD) among people living with HIV (PLHIV). However, there is limited understanding of reliable biomarkers of immune aging, singly or in combination, that can be used for monitoring HIV treatment in large longitudinal cohorts in sub-Saharan Africa (SSA). This review describes candidate biomarkers of immune aging during HIV treatment and their potential cli …

03.09.2026journal-article

Frontiers in Medicine

AI-enabled language technologies for language-mediated learning and clinical communication in international undergraduate dental education: a scoping review

Wenjuan Qiang, Xiaohong Deng, Tiezhou Hou, Le Qiang

Background International undergraduate dental students often learn and communicate in a language other than their first language, affecting terminology acquisition, clinical reasoning, patient explanations, informed consent, clinical communication, and patient safety. AI-enabled language technologies—including generative artificial intelligence (GenAI), large language models (LLMs), and neural machine translation (NMT)—may support these tasks, but their use in this population has not been systematically mapped. Met …

03.09.2026journal-article

Frontiers in Medicine

Fulminant group A streptococcal necrotizing fasciitis presenting as severe calf pain after pharyngitis in an adolescent: a case report

Lisa Roncoroni, Jan Kühle, Lampros Kousoulas, Katharina Müller-Peltzer, Dawid L. Staudacher

Background Invasive Group A Streptococcus (GAS) infection can rapidly progress to life-threatening conditions, including necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS). While typically associated with cutaneous breaches or underlying comorbidities, hematogenous seeding following primary pharyngeal infection is a rare but documented phenomenon. Early diagnosis is often complicated by subtle skin changes and the rarity of the disease. Case A previously healthy 17-year-old female presented wi …

03.09.2026journal-article

Journal of Intensive Care Medicine

Incidence and Risk Factors for Invasive Mechanical Ventilation Dependency in Japan: A Nationwide Retrospective Cohort Study

Hiroyuki Ohbe, Monique Daniels, Daisuke Kudo, Hiroki Matsui, Stef Groenewoud, Werner Brouwer, Hideo Yasunaga

Objectives To describe the incidence and risk factors for becoming dependent on invasive mechanical ventilation (IMV) in Japan. Design Retrospective cohort study using a nationwide inpatient database from April 1, 2014, to March 31, 2020. Setting More than 1500 acute care hospitals participating in the Diagnosis Procedure Combination Study Group Database, covering approximately 50% of all hospitalizations in acute care hospitals in Japan. Patients Adults (≥18 years), in whom IMV was initiated during hospitalization …

03.09.2026journal-article

European Journal of General Dentistry

Conservative Esthetic Approach for Crown Fracture with Pulp Exposure in a Young Male Patient: A Case Report with Mini-review

Naif N. Abogazalah

Abstract Traumatic dental injuries may hurt the social and psychological well-being of a young patient. Maxillary anterior teeth are the most affected teeth. In permanent dentition, the most common trauma involves clinical crown fractures, with or without pulp exposure. This article describes a case report of a 12-year-old male patient who exhibited dental trauma, which resulted in a complicated crown fracture with pulp exposure of tooth #11 (maxillary right central incisor). A partial pulpotomy was performed to pr …

03.09.2026journal-article

Journal of Imaging Informatics in Medicine

A Clinically Grounded Review of Medical Image Classification: Quantitative Insights into CNNs, Vision Transformers, and Hybrid CNN-ViT Models

Hamza Hussaini, Shahana Bano, Eyad Elyan, Carlos Francisco Moreno-Garcia

Abstract Medical image classification has advanced substantially with convolutional neural networks (CNNs), Vision Transformers (ViTs), and hybrid CNN–ViT architectures, yet clinical translation remains limited by dataset dependency, inconsistent evaluation practices, and insufficient external validation. This review provides a clinically grounded comparative synthesis of these model families across diverse medical imaging modalities. A structured literature review was conducted across PubMed, IEEE Xplore, Scopus, …

03.09.2026journal-article

Transplantologiya. The Russian Journal of Transplantation

A rare complication in a patient undergoing continuous ambulatory peritoneal dialysis

A. G. Yankovoy, V. A. Stepanov

Introduction. Continuous ambulatory peritoneal dialysis (PD) is one of the methods of treating patients in the structure of renal replacement therapy (RRT). The most common complications directly related to the peritoneal catheter usually occur during the first weeks and range from catheter dysfunction to dialysis peritonitis. Delayed intestinal perforation with a peritoneal catheter upon termination of peritoneal dialysis (PD) is extremely rare. Objective. The article describes a rare clinical case and successful …