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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Current Bioinformatics

Computational Tools for Identifying Cancer Driver Genes and Mutations: A Comprehensive Review

Ali F. Alsulami

Understanding the genetic basis of cancer requires the accurate identification of driver genes and driver mutations, those alterations that promote tumorigenesis, while distinguishing them from neutral, or passenger, mutations. This review provides a comprehensive overview of computational strategies developed to detect and prioritise cancer drivers at both the gene and mutation levels. The review systematically classifies and compares more than 20 widely used tools, highlighting differences in their conceptual fou …

02.09.2026journal-article

Cancer Research Communications

Antitumor Activity of Novel Transcriptional Inhibitors Ecubectedin and PM54 in Soft Tissue Sarcoma Patient-Derived Xenografts

Daniël Gorgels, Chao-Chi Wang, Lore De Cock, Luna De Sutter, Karo Wyns, Kimberly Verbeeck, Ulla Vanleeuw, Daphne Hompes, Friedl Sinnaeve, Hazem Wafa, Maria Jose Guillén, Pablo Avilés, Raf Sciot, Agnieszka Wozniak, Patrick Schöffski

Abstract Trabectedin, prototype of the ecteinascidin class of drugs, is a known second- or later-line therapeutic option for advanced soft tissue sarcoma (STS). We evaluated the antitumor activity of two novel synthetic trabectedin derivatives, ecubectedin and PM54, in selected patient-derived xenograft (PDX) STS models. In total, 364 Naval Medical Research Institutenu/nu mice were transplanted bilaterally with two leiomyosarcoma (LMS), two dedifferentiated liposarcoma (DDLPS), one synovial sarcoma (SynSa), and one …

01.09.2026journal-article

Journal of Pure and Applied Microbiology

CRISPR-Based Gene Editing in Human and Animal Health: Revolutionizing Disease Resistance and Treatment

Bandar Aloufi

CRISPR gene-editing technology has revolutionized modern genetics, offering precise and efficient modifications across multiple domains, including human medicine, agriculture, and veterinary science. This study explores the diverse applications of CRISPR, highlighting its role in treating genetic disorders such as sickle cell anemia and Duchenne muscular dystrophy, advancing cancer immunotherapies, and developing CRISPR-based antiviral therapies for HIV and COVID-19. In agriculture, CRISPR has facilitated the devel …

02.09.2026journal-article

Cancer Medicine

QRICH1 Suppresses Glioma Progression by Inducing ER Stress and Activating the PERK ‐ ATF4 ‐ CHOP Pathway

Yunjiang Wang, Min Xu, Zhenglou Chen, Xuqi Huo, Ya Xue, Xiang Ji, Yang Shen, Hongsheng Wang

ABSTRACT Background ER stress (ERS) influences tumor behavior through the unfolded protein response (UPR), yet its role in glioma is not fully defined. This study investigated the function of the ERS‐related regulator QRICH1 in glioma progression. Methods Public databases (TCGA and GTEx) were used to evaluate QRICH1 expression, survival, and prognostic significance in glioma. Lentiviral QRICH1 overexpression or knockdown was established in U87 and U251 cells, followed by functional and mechanistic assays. A subcuta …

01.09.2026journal-article

International Journal of Computer Information Systems and Industrial Management Applications

Experimental Comparison of Microwave and Conventional Heat Treatment for Improving Surface Characteristics of Copper, Titanium, and Silicon Carbide Composites

Kapil Kumar, Rojaleena Das, Nitish Kaushik Publication

Microwave heat treatment is emerging as an energy saving alternative to conventional thermal treatment owing to its fast volumetric heating, short processing time and enhancement in microstructural and mechanical properties of engineering materials. In this paper, the microwave heating efficiency of Copper (Cu), Titanium (Ti) and Silicon Carbide (SiC) composites by powder metallurgy is experimentally studied and compared with conventional heating methods. Composite samples were prepared by uniform powder mixing fol …

02.09.2026journal-article

BMJ Open

Does stereotactic ablative body radiotherapy (SABR) added to continued systemic therapy improve time to treatment failure compared with physician’s choice of systemic therapy in oligoprogressive ER-positive, HER2-negative advanced breast cancer? Study protocol for a multicentre, randomised, open-label phase II trial in Australian tertiary cancer centres (AVATAR-II)

Emma Connolly, Michelle White, Shankar Siva, Mathias Bressel, Adrienne See, Kate Hunter, Jennifer Tan, Vanessa Panettieri, Daphne Day, Keelan Byrne, Amelia McCartney, Kate Webber, Katrina Woodford, Steven David

Introduction Oligoprogressive disease (OPD) is a clinically significant pattern of progression observed in patients with oestrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer treated with endocrine therapy (ET) and cyclin-dependent kinase (CDK) 4/6 inhibitors. Stereotactic ablative body radiotherapy (SABR) is an emerging strategy that may ablate resistant subclones and prolong the benefit of systemic therapy. The AVATAR-II trial investigates whether the ad …

04.09.2026journal-article

Journal of Obstetrics and Gynaecology Research

Intrathecal Chemotherapy Through Ommaya Reservoir in Leptomeningeal Metastasis From Cervical Cancer: A Rare Case Report and Literature Review

Chery Ahn, Haein Seo, Dongmin Jo, Byeol Han, Eunmi Choi, Sewon Kim, Seo Woo Chung, Ok‐Ju Kang

ABSTRACT Leptomeningeal metastasis (LM) is a rare complication of cervical cancer associated with a poor prognosis. We report a 61‐year‐old woman with stage IVB cervical squamous cell carcinoma who developed acute headache and diplopia during systemic chemotherapy. Brain magnetic resonance imaging suggested LM, which was confirmed by cerebrospinal fluid (CSF) cytology. An Ommaya reservoir was inserted, and intrathecal methotrexate therapy was initiated. The patient showed rapid neurological improvement, normalizati …

04.09.2026journal-article

International Journal of Urology

Distinct Prognostic Roles of Grade Group and Intraductal Carcinoma of the Prostate in Metastatic Hormone‐Sensitive Prostate Cancer Treated With Androgen Receptor Signaling Inhibitors

Junichi Ikeda, Hisanori Taniguchi, Monta Inoue, Yuki Masuo, Takahiro Nakamoto, Makoto Taguchi, Seiji Shimada, Takao Mishima, Masaaki Yanishi, Katsunori Uchida, Hidefumi Kinoshita

ABSTRACT Objectives The study aimed to evaluate the impact of grade group (GG) and intraductal carcinoma of the prostate (IDC‐P), as established prognostic factors, on clinical endpoints in metastatic hormone‐sensitive prostate cancer (mHSPC) patients treated with androgen receptor signaling inhibitors (ARSIs). Methods We retrospectively analyzed 147 patients with mHSPC treated with androgen deprivation therapy and ARSIs (abiraterone acetate, enzalutamide, or apalutamide). Associations between clinicopathological f …

31.08.2026journal-article

Annals of Hematology

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020–2022

Stefanie Forkl, Felix Freudenberger, Benedikt Jacobs, Sabine Einhell, Klaus Hirschbuehl, Rainer Claus, Dirk Hellwig, Dimitrios Mougiakakos, Martin Dreyling, Lena Illert, Simon Heidegger, Oliver Weigert, Johannes C. Hellmuth

Abstract Patients with malignant lymphomas are at increased risk for severe COVID-19. In the general population, outcomes of COVID-19 have improved dramatically over time due to increasing immunity through vaccination or infection and due to improved clinical care. It is unclear whether outcomes of COVID-19 in patients with lymphoma have improved similarly over time. We performed a multi-center retrospective study of lymphoma patients with COVID-19 at five tertiary care centers of the Bavarian Cancer Research Cente …

31.08.2026journal-article

Frontiers in Oncology

ADC-based radiomics for risk stratification in prostate cancer: a clinical decision support study

Kun Zhang, Jiajun Zhang, Yangguang Yuan, Zhijing Chen, Yifeng Du, Hanlin Liu

Introduction Reliable differentiation between malignant and benign prostate lesions remains a critical challenge in clinical practice, particularly in settings with limited access to expert interpretation of multiparametric MRI (mpMRI). We investigated whether a streamlined radiomics framework based solely on apparent diffusion coefficient (ADC) imaging could provide accurate, reproducible, and interpretable diagnostic support for prostate cancer detection. Methods We retrospectively analyzed ADC images from 198 me …

31.08.2026journal-article

Frontiers in Public Health

Navigating tradition and treatment: cultural identity, social expectations, and type 1 diabetes self-management among young Saudi adults–a qualitative narrative inquiry

Abdulaziz M. Alodhailah, Mohammed Almutairi, Ahmed Alsadoun, Raeed Alanazi, Zainab Alfar, Thurayya Eid, Waleed M. Alshehri

Background Type 1 diabetes (T1D) requires lifelong, intensive self-management that intersects with cultural practice in collectivistic societies, where communal food traditions, religious observance, and family expectations shape daily routines. Despite an estimated incidence of 18–20 per 100,000 annually in Saudi Arabia, qualitative evidence examining how young adults navigate disease management alongside cultural identity remains limited. Objective This study explored how young Saudi adults with T1D experience an …

31.08.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Tobacco and opium use and risk of liver and colorectal cancer mortality: Analysis of the Golestan Cohort Study (GCS)

Hao Larissa. Wang, Monireh Sadat Seyyedsalehi, Hossein Poustchi, Mahdi Sheikh, Akram Pourshams, Farin Kamangar, Christian C. Abnet, Arash Etemadi, Reza Malekzadeh, Paolo Boffetta

Abstract Background: Tobacco and opium consumption are prevalent in Iran and have been linked to increased risk of upper GI cancers. To investigate their role in lower GI cancers, the associations of tobacco and opium use with liver and colorectal cancer mortality were examined in this study. Methods: From 2004-2008, participants aged 40 to 75 years were recruited through random systematic cluster sampling and primary healthcare worker contact in Golestan, Iran. Baseline assessment of tobacco and opium use, demogra …

31.08.2026journal-article

The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Gallbladder Polyps: Benign Bystanders or Malignant Precursors? Defining the Path from Detection to Treatment

Darius Hartanto, Bradley Jimmy Waleleng, Luciana Rotty, Fandy Gosal, Jeanne Winarta, Andrew Waleleng

Gallbladder polyps (GP) are defined as elevations of gallbladder wall that protrude into the lumen. These elevations are commonly detected incidentally during abdominal ultrasonography and predominantly asymptomatic. Based on malignant potential, gallbladder polyps are broadly classified into neoplastic and non-neoplastic types. Although most cases remain clinically silent, some patients may present with right upper quadrant pain, localized tenderness, and, in certain instances, a palpable mass in the upper abdomen …

31.08.2026journal-article

Brazilian Journal of Health Review

Metastasis in oral cavity. Report in Chile of a metastatic breast cancer

Carlos Humeres Sigala, Anggie Véliz Amigo, Fatima Mota Arteaga, Sergio Vidal Gill

Metastasis in the oral cavity is a rare event, constituting approximately 1% of all malignant pathologies located in this area. Breast cancer is a common type of cancer in women, but strangely it can produce metastases in the oral cavity. We present the case of a 77-year-old female patient, with a previous history of breast cancer and metastases in lung and brain, who came to the Regional Hospital of Antofagasta in 2020 to be evaluated in Oral Pathology for an ulcerated lesion with pain that did not heal. On clinic …

31.08.2026journal-article

Future Pharmacology

Gamma-Hydroxybutyrate Toxicokinetics and Toxicodynamics Are Influenced by Sex and Cross-Sex Estrogen/Progesterone Treatment

Hao Wei, Annie Lee, Qing Zhang, Melanie A. Felmlee

Background/Objectives: Non-medical use of GHB poses a public health risk due to the risk of overdose. GHB exhibits nonlinear toxicokinetics mediated by monocarboxylate transporters (MCTs), and previous studies have demonstrated sex-related differences in transporter regulation and GHB toxicokinetics. This study investigated the impact of exogenous estrogen and progesterone on GHB toxicokinetics and toxicodynamics, and evaluated the efficacy of AR-C155858 (an MCT1 inhibitor) to treat GHB overdose. Methods: Ovariecto …

31.08.2026journal-article

Caucasian Medical Journal

Pancreatic cancer and chronic pancreatitis differential diagnosis by multidetector computed tomography results postprocessing: a novel approach presentation

Dmitry Bordin, Konstantin Lesko, Julia Kuleznewa, Elena Dubtsova, Ludmila Vinokurova

Background/Aim: Differential diagnosis of pancreatic cancer (PC) and chronic pancreatitis (CP) remains challenging question in radiology and pancreatology. A potential key to resolve this problem is postprocessing of multidetector computed tomography (CT) results. Our aim was to assess the diagnostic potential of contrast enhancement dynamics analysis using CT in the differential diagnosis of PC and CP.Methods: This study analyzed contrast-enhanced abdominal CT images from 135 patients with CP and suspected PC. The …

31.08.2026journal-article

Cancer Immunology Research

CD266+ myofibroblasts mediate resistance to immunochemotherapy through ECM stiffness in head and neck squamous cell carcinoma

Houyu Ju, Yusheng Lu, Chaoji Shi, Zhiwei Zheng, Yun Bi, Wenyi Yang, Zhaoyang Guo, Mahdi D. Dashti, Ming Yan, Guoxin Ren, Jingzhou Hu

Abstract The efficacy of immunotherapy in unresectable/recurrent/metastatic head and neck squamous cell carcinoma (U/R/M HNSCC) remains suboptimal compared to primary untreated resectable HNSCC. The immunological and stromal landscape during immunotherapy in U/R/M HNSCC is crucial for understanding drug resistance mechanisms. In this study, single-cell RNA sequencing was performed on 42 samples pre- and post-treatment from patients in our prospective trial (NCT05156970) who received immunochemotherapy. A subset of …

31.08.2026journal-article

Probecell Science

CD44-Targeted Hyaluronic Acid Nanoparticles for Triple-Negative Breast Cancer: Recent Advances and Clinical Perspectives

Sirajunisa Talath

Triple-negative breast cancer (TNBC) is a tough, heterogeneous subtype of breast cancer characterised by the absence of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 expression, which results in limited therapeutic options and bad clinical outcomes. Several nanomedicine strategies based on the use of hyaluronic acid (HA)-based nanoparticles have attracted a great deal of attention due to their biocompatibility, biodegradability and the intrinsic affinity toward the CD44 rece …

31.08.2026journal-article

Bioinformation

Oral health and treatment needs across tribal and non-tribal groups: A tertiary care cross-sectional study

Sonal Saigal

Comparative oral health data for tribal and non-tribal populations in India remain limited, particularly regarding whether disparities reflect disease burden or healthcare access. This cross-sectional study assessed 343 participants (169 non-tribal, 174 tribal) at a tertiary care institution using WHO Basic Oral Health Survey (2013) criteria across three age strata. Overall caries experience differed statistically between the groups, although the absolute difference in mean affected surfaces was small (3.54 versus …

31.08.2026journal-article

ChemistrySelect

Sustainable Plant‐Derived Polymeric Materials‐Based Nanocarriers for Targeted Drug Delivery of Breast Cancer Therapeutics: State‐of‐the‐Art Review

Selvaraj Kunjiappan, Parasuraman Pavadai, Devika Muraleedharan, Basavana Gowda Hosur Dinesh, Murugesan Sankaranarayanan

ABSTRACT Globally, breast cancer is the most common cause of cancer‐related deaths in women. Despite considerable scientific advancements in drug design and discovery, the mortality rate has increased. However, finding precision breast cancer therapy and high‐efficiency anticancer drug delivery is still a considerable difficulty. A major challenge in cancer therapy is the lack of a highly selective drug‐delivery system that targets malignant cells without damaging healthy cells, thereby minimizing off‐target effect …

31.08.2026journal-article

Läkartidningen

Handläggningen av urotelial cancer i övre urinvägarna varierar i Sverige

Johannes Bobjer, Firas Aljabery, Victor Falini, Truls Gårdmark, Tomas Jerlström, Henrik Kjölhede, Karin Söderkvist, Anders Ullén, Fredrik Liedberg

Urotelial cancer i övre urinvägarna är en ovanlig och diversifierad sjukdomsentitet där det föreligger regionala skillnader för de flesta kvalitetsindikatorer för handläggning och behandling. Målnivåer för de uppsatta kvalitetsindikatorerna nås bara i ett fåtal regioner, och oftare vid sjukhus med större behandlingsvolymer (>10 patienter per år). Förbättringsmöjligheter föreligger, och regionaliserade multidisciplinära tumörkonferenser skulle kunna vara en katalysator i ett sådant förändringsarbete. Ökad täckningsg …

31.08.2026journal-article

Vessel Plus

Case Report: Sequential transcatheter treatment of coronary artery fistula, aneurysmal atrial septal artery and mitral regurgitation

Yiyuan Huang, Zewei Chen, Zhaowei Zhu, Jianjun Tang, Zhenfei Fang

Coronary artery fistulas are rare vascular anomalies that may cause chronic left-to-right shunting, cardiac chamber remodeling, and heart failure. We report a 72-year-old woman with a left main coronary artery-to-right atrium fistula draining through a giant aneurysmal atrial septal artery and accompanied by severe secondary mitral regurgitation. Echocardiography and cardiac computed tomography showed a 19 mm fistulous tract, a 31 × 30 mm aneurysmal vascular structure with a 5 mm outlet to the right atrium, and sev …

31.08.2026journal-article

Advanced Science

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang

ABSTRACT Doxorubicin remains an important component of chemotherapy for triple‐negative breast cancer (TNBC), yet chemoresistance severely limits its clinical efficacy. Here, we identify Tumor necrosis factor receptor superfamily member 19 (TNFRSF19) as an epigenetically silenced gene that critically regulates doxorubicin response. Integrative analyses of The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and clinical cohorts reveal that high TNFRSF19 expression predicts superior pathological complete r …

31.08.2026journal-article

BMC Cancer

Exercise and Cardiorespiratory fitness Improvement through supervised TraINinG in patients undergoing surgery for Upper GastroIntestinal cancer (EXCITING-UGI): study protocol for a randomized controlled trial

Takuya Fukushima, Makoto Yamasaki, Nobuyuki Yamamoto, Eisuke Ochi, Shuntaro Sato, Yuta Yamada, Nao Murai, Hanako Koda, Satoshi Toshiyama, Takashi Harino, Yuki Hashimoto, Masaya Kotsuka, Takuji Sato, Yoshiki Yasukochi, Kentaro Inoue, Koichiro Higasa, Yutaka Kimura, Jiro Nakano

Abstract Background Upper gastrointestinal cancers, including esophageal and gastric cancers, are associated with substantial postoperative functional decline despite curative surgery. Particularly, cardiorespiratory fitness decreases markedly after surgery, and such decrease is associated with poor clinical outcomes. Thus, it serves as a surrogate marker of prognosis. Exercise has been shown to improve cardiorespiratory fitness in patients with cancer; however, the optimal exercise intensity in the early postopera …