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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Frontiers in Nutrition

Effects of peanut consumption on task-related brain activation, cognition and neuroinflammation in older adults with memory complaints: a randomized controlled trial

Gabriela Chiriac, Samuel R. Barnes, Jonathan H. Venezia, Grace J. Lee, Joan Sabate, Sujatha Rajaram

Objective Peanuts are rich in unsaturated fats, antioxidants like polyphenols, and other bioactive compounds that may reduce neuroinflammation and support cognitive health. Although limited evidence suggests potential cognitive benefits of peanut intake, none have explored these effects in older adults at risk for cognitive decline or assessed brain activity using functional magnetic resonance imaging (fMRI). This study explored the effects of daily peanut consumption on task-related brain activation, cognition, an …

21.08.2026journal-article

Epilepsia Open

Attitudes toward sodium valproate use, withdrawal, and counseling in people of reproductive potential: A scoping review

Katherine Wang, Sarah Loveday, Monica S. Cooper, Emma Macdonald‐Laurs

Abstract Regulatory restrictions and evolving clinical guidelines have aimed to reduce sodium valproate use in people of reproductive potential over the past decade due to its teratogenic risk. While clinical evidence and policy responses are well established, stakeholder perspectives remain less explored. This scoping review synthesizes the existing evidence on the attitudes of patients, caregivers and healthcare professionals regarding sodium valproate use, withdrawal and counseling in females of childbearing age …

21.08.2026journal-article

Frontiers in Nutrition

Ergothioneine, collagen peptides, and sodium hyaluronate ameliorate facial skin aging via modulating oxidative stress, inflammation, and extracellular matrix homeostasis

Zhiqing Zhou, Lingling Zhao, Lei Chen, Xuanxiang Zhao, Xinwei Li, Xuying Luo, Bin Zhang, Jianyin Miao, Feitong Liu

Background Skin aging involves intrinsic chronological aging and extrinsic photoaging, characterized by impaired barrier function, extracellular matrix (ECM) degradation, and chronic inflammation. Methods This study evaluated anti-aging efficacy and mechanisms of ergothioneine (EGT), collagen peptides (CP) and sodium hyaluronate (NaHA) using an ex vivo human skin model and a clinical trial. Results Ex vivo results showed that the EGT+CP+NaHA triple combination (TC) attenuated UV-induced epithelial thinning and coll …

21.08.2026journal-article

Journal of Psycholinguistic Research

Enhancing Pragmatic Communication in Healthy Aging: A Preliminary Investigation of the Long-Term Effects of the Advanced Cognitive Pragmatic Treatment

Ilaria Gabbatore, Giorgia Vegna, Dize Hilviu, Ariele Merlini, Francesca M. Bosco

Abstract The aging process is associated with changes in cognitive and communicative skills, including pragmatic one, the ability to appropriately use language and other expressive means in social contexts. Despite its importance for quality of life and autonomy, the decline of pragmatic ability has received little attention in aging research and intervention. This preliminary study aims to investigate the efficacy and specificity of the Advanced Cognitive Pragmatic Treatment (Advanced-CPT), a novel training progra …

1 Zitationen
21.08.2026journal-article

COVID

Relation Between Digital Literacy and Internet Use Changes in People with Physical Disabilities During COVID-19

Eun-Young Park

Since COVID-19, reliance on digital technology has surged, and digital literacy has gained attention as a key factor in explaining changes in how people use the Internet. However, most existing studies have focused on the general public, and there has been insufficient research on how digital literacy relates to changes in Internet usage among people with disabilities. This study examined the effect of digital literacy among people with physical disabilities on changes in Internet use on personal computers (PC) and …

21.08.2026journal-article

Odontology

Extended hydrothermal aging and glass infiltration on minimally processed recycled 3Y-TZP: microstructural and optical properties

Henrico B. Strazzi-Sahyon, Bruna M. Silva, Tiago M. B. Campos, Claudinei dos Santos, Mariana M. T. Piza, Edmara T. P. Bergamo, Sergio M. Tebcherani, Lukasz Witek, Paulo G. Coelho, Satoshi Yamaguchi, Estevam A. Bonfante

Abstract This study evaluated the effects of glass infiltration and hydrothermal aging on the microstructural and optical properties of minimally processed recycled 3Y-TZP. Unprocessed 3Y-TZP remnants were milled into powder, compacted into discs, and sintered. Specimens were divided into six groups according to glass infiltration and hydrothermal aging (immediate, 50 h, and 100 h at 134 °C/2.2 bar). Particle size was measured by laser diffraction. Density and optical properties (contrast ratio and translucency) we …

21.08.2026journal-article

Annual Review of Nutrition

Ultraprocessed Foods and the Aging Brain: State of the Science

Owen T. Carmichael, Puja Agarwal, Benedict C. Albensi, Vyshnavy Balendra, Nathan M. D'Cunha, Diandra N. Denier-Fields, Naomi Vidal Ferreira, Natalia Gomes Gonçalves, Rashi Kumar, Corinne Labyak, Susanna Lopez, Mychael V. Lourenco, Ilianna Lourida, Rishav Nag, Zuzana Nedelska, Juliet Nnenda Olayinka, Jung Hyun Park, Kayalvizhi Rajendran, Ashley Shaw, Hom Lal Shrestha, Aaron N. Smith, Natalia Soldevila-Domenech, Débora G. Souza, Claudia Kimie Suemoto, Jodi R. Titiner, Rafael de la Torre, Debora Melo van Lent

Ultraprocessed foods (UPFs), which feature reductions in naturally occurring food components (fiber, phytochemicals) as well as the addition of fat, sugar, salt, and artificial food components (colorings, preservatives) are consumed in large quantities globally. Although a growing body of research has suggested that higher levels of UPF consumption are associated with poorer cardiometabolic outcomes, literature synthesizing the evidence that UPF consumption has negative effects on the aging brain has been scarce. T …

1 Zitationen
21.08.2026journal-article

Frontiers in Aging

PolyPIMuse significantly increases fall risk: comparison of three medication evaluation tools

András Érszegi, Réka Viola, Bettina Vargáné Szabó, Zsófia Engi, Mária Matuz, Ria Benkő, Zoltán Pető, Dezső Csupor

Introduction Falls are a leading cause of injury and hospitalization in older adults, with pharmacotherapy identified as a modifiable risk factor. Tools for identifying potentially inappropriate medications (PIMs), such as the EU(7)PIM, PRISCUS, and FORTA lists, differ in methodology. However, their comparative performance in predicting fall risk has not been systematically evaluated. The aim of our work was to investigate the association between PIM use and fall risk among older adults and to analyze the correlati …

21.08.2026journal-article

Frontiers in Pharmacology

Effects of premedication with atropine, penehyclidine, and glycopyrrolate on postoperative delirium in older patients undergoing endoscopic gastric or esophageal submucosal dissection: a randomized, double-blind, multicenter, controlled clinical trial

Wen Lin Xian, Jing Peng, Qinxian Wei, Na Wang, Xiao Pei Gao, Sisi Zeng, Qin Ye, Wu Chang Fu, Fang Jun Wang

Background Anticholinergic drugs are commonly used as premedication in clinical practice. The effects of premedication of atropine, penehyclidine, and glycopyrrolate on postoperative delirium in older patients remain unclear. Objective The aim of this study was to observe the effects of premedication with atropine, penehyclidine, and glycopyrrolate on postoperative delirium (POD) in older patients undergoing endoscopic gastric or esophageal submucosal dissection. Methods Older patients undergoing endoscopic gastric …

21.08.2026journal-article

Transplantation Direct

Favorable Adherence and Tolerability of Letermovir Versus Valganciclovir for Cytomegalovirus Prophylaxis in Kidney Transplant Recipients Aged 65 y or Older: Findings From a Randomized, Phase 3 Trial

Suphamai Bunnapradist, Flavio Vincenti, Oliver Witzke, Stefan Schneeberger, M. Hong Nguyen, Natalya Broyde, Christopher L. Gilbert, Barbara Haber

Background. Older patients undergoing kidney transplantation are at risk of perioperative complications, underscoring the need for optimized care. The number of kidney transplants in older adults has increased in the past decade, with greater reliance on transplants from deceased donors. Methods. The phase 3, randomized, double-blind, active-controlled P002 study evaluated 200 d of letermovir versus valganciclovir prophylaxis in cytomegalovirus-seronegative kidney transplant recipients who received kidneys from cyt …

21.08.2026journal-article

Journal of Nonformal Education

Effectiveness of Interventions to Improve Socioeconomic Participation, Access to Services, Quality of Life, and Social Inclusion Among People with Disabilities: A Systematic Review and Meta-analysis

Abdul Malik, Sunardi Sunardi, Suminah Suminah, Haryani Saptaningtyas, Ghanis Putra Widhanarto

Background – The persistent exclusion of people with disabilities from social, economic, and health systems remains a critical global issue, driven by structural barriers, stigma, and unequal access to resources. Despite a growing number of intervention studies, evidence on their comparative effectiveness across contexts remains fragmented. Research Urgency – Existing disability interventions vary widely in design, implementation, and contextual adaptability, while systematic evidence on which models are most effec …

21.08.2026journal-article

Public Health Nursing

Association Between the Dietary Inflammatory Index and Cognitive Frailty in Older Adults: A Cross Sectional Analysis of NHANES Data

Zihan Yi, Na Zhou, Zikejimu Sun, Xiaochu Liu, Chengchuan Chen

ABSTRACT Background Cognitive frailty (CF) is a prevalent geriatric syndrome associated with increased risks of falls, hospitalization, disability, and all‐cause mortality among older adults. Emerging evidence suggests that chronic inflammation may contribute to the pathophysiology of CF, while dietary patterns can modulate inflammatory responses. The Dietary Inflammatory Index (DII) is a validated tool for quantifying the inflammatory potential of diet. Although higher DII scores have been associated with physical …

21.08.2026journal-article

Biopsychosocial Science and Medicine

Social Network Density and Healthcare Access and Utilization Among Racially and Ethnically Diverse Older Adults

Melissa Flores, Savannah M. Boyd, Riley M. O’Neill, Amelia Ibarra-Mevans, Hatty Lara, Kelly N. B. Palmer

Objective: Previous literature emphasizes the benefits of social integration for accessing and utilizing healthcare. However, many studies overlook the role of social network infrastructure, specifically the degree to which a network is interconnected (social network density). Social network density has been associated physiological benefits for ethnic minority older adults; however, little is known about whether a densely connected social network facilitates healthcare access and utilization. The current study exa …

21.08.2026journal-article

Medical Sciences

Five-Year Cardiorenal Outcomes and Longitudinal Chronic Kidney Disease Screening in People with Type 2 Diabetes Managed by Endocrinologists: A Nationwide Retrospective Cohort Study

José Ignacio Martínez-Montoro, José Juan Aparicio-Sánchez, Belén Pimentel, Mónica Juárez-Campo, Maria Luisa Alamillo, Yesika Díaz, José Carlos Fernández-García

Background/Objectives: Type 2 diabetes (T2D) is a major risk factor for cardiovascular disease and chronic kidney disease (CKD), yet the extent of longitudinal CKD screening in routine clinical practice remains unclear. This study aimed to assess long-term cardiorenal outcomes and CKD screening practices in patients with T2D managed across primary care and endocrinology settings, evaluating the feasibility of risk stratification in real-world practice. Methods: We conducted a retrospective cohort study using anonym …

21.08.2026journal-article

Düzce Tıp Fakültesi Dergisi

Evaluation of Hepatitis B Vaccination Coverage and Serological Response in People Living with HIV

Sengül Üçer, Pınar Gürkaynak, Uğur Emre Gümüş, Melek Sena Altun, Şerife Altun Demircan, Esra Kaya Kılıç, Cigdem Ataman Hatipoglu, Gunay Tuncer Ertem, Salih Cesur, Sami Kınıklı

Aim: People living with HIV (PLWH) face a heightened risk of acquiring hepatitis B virus (HBV) infection because these two viruses share common transmission pathways. HIV/HBV coinfection is associated with accelerated liver disease progression. Consequently, hepatitis B vaccination is a critical preventive measure for PLWH. This study was designed to assess the serological response to hepatitis B vaccination in PLWH.Material and Methods: PLWH followed at the Infectious Diseases and Clinical Microbiology Clinic who …

21.08.2026journal-article

Science Advances

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hiroshi Kobayashi, Shintaro Watanuki, Yusuke Shiozawa, Motohiko Oshima, Shuhei Koide, Naoya Takayama, Takayuki Morikawa, Miho Haraguchi, Shinpei Tamaki, Takayoshi Asakura, Toshio Miyata, Atsushi Iwama, Seishi Ogawa, Keiyo Takubo

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used single-cell RNA sequencing data to show that old HSCs contain two distinct transcriptional programs: one shared with megakaryocytes and the other reflecting the most primitive HSC state. Developmental time-series profiling further suggests that …

21.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

INFLUÊNCIA DO SEXO NA MORTALIDADE HOSPITALAR POR DOENÇA DE ALZHEIMER NO BRASIL

Juliene Amanda Salvador, Gustavo Almiron Lopes, Rafaela Meneguetti, Victor Hugo Lemos Miguel, Lisa Schultz, Amábile Vittoria Miliorini, Maria Luísa de Oliveira Santos, Maria Fernanda Americo de Oliveira, Andressa Beatriz Weyer Zanato, Amanda Moliterno, Laura Parpineli Ardenghi, Nayla Caroline de Moraes Pinelli, Ana Júlia Paglia

Introdução: A doença de Alzheimer é a principal causa de demência e representa um importante problema de saúde pública. Objetivo: Analisar a taxa de mortalidade hospitalar por doença de Alzheimer no Brasil, segundo o sexo, entre 2020 e 2025. Métodos: Estudo ecológico, retrospectivo e descritivo, realizado com dados secundários do Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS), disponíveis no DATASUS. Foram analisadas as taxas de mortalidade hospitalar por sexo e ano de processamento. Result …

21.08.2026journal-article

Psychogeriatrics

From Overload to Understanding: How Caregivers Experience and Use Information in Dementia Counselling

Esther Yin Hui Chew, Wen An Matilda Heng, Ee‐Yuee Chan

ABSTRACT Background Caregiver education is fundamental to dementia care, yet novice caregivers often receive large amounts of information immediately following diagnosis, when emotional adjustment and learning readiness may influence engagement. Less is known about how caregivers engage with, understand and apply dementia‐related information in this period. This study explored caregivers' experiences of receiving and applying information during nurse‐led dementia counselling, using Cognitive Load Theory as one inte …

25.08.2026journal-article

Journal of Physics: Condensed Matter

Recent progress in the free energy landscape theory and its application to aging and slow Arrhenius process

Takashi Odagaki

Abstract The Helmholtz free energy landscape (FEL) picture is known to provide a theoretical framework which can explain various aspects of non-equilibrium systems. I first show that the landscape for various thermodynamic potentials including enthalpy and Gibbs free energy can be properly defined. In order to find physics behind two complex phenomena observed in non-equilibrium systems, protocol-dependent aging and the slow Arrhenius process (SAP), I introduce phenomenologically a delayed response of the FEL to a …

21.08.2026journal-article

Frontiers in Medicine

Number of natural teeth and intrinsic capacity among hospitalized older adults in China: a cross-sectional study on the role of social support

Xiaoming Zhang, Xinjuan Wu

Background Tooth loss is common in older adults and has been associated with adverse health outcomes, but its relationship with intrinsic capacity (IC), a multidimensional indicator of healthy aging, remains insufficiently understood. Whether social support is involved in this association is also unclear. Methods This cross-sectional study included 421 hospitalized adults aged 60 years or older who were recruited from Peking Union Medical College Hospital, Beijing, between February and May 2022. The number of natur …

21.08.2026journal-article

Nursing Ethics

From autonomy to well-being: Reimagining ethics consultation in dementia

Optimus Hurtig

Respect for patient autonomy is a cornerstone of modern bioethics, yet the gap between ethical ideals and clinical practice remains pronounced. To bridge this divide, Björk and Hirsch have proposed the introduction of a new professional role: autonomy consultants. This essay critically examines the applicability of such a role within dementia care, a context characterized by progressive cognitive decline and irreversible alterations of personal identity. Using a philosophical and theoretical analysis, illustrated t …

21.08.2026journal-article

Frontiers in Psychiatry

Exploratory prescribing risk profiles and drug drug interaction burden in older adults with depressive episodes

Florina-Diana Goldiş, Sebastian-Mihai Ardelean, Lucreţia Udrescu

Introduction Older adults with depressive episodes are frequently treated in the context of psychiatric multimorbidity, somatic co-treatment, and polypharmacy, increasing their vulnerability to drug-drug interactions (DDIs) and cumulative medication-related risk. This study characterized DDI burden and exploratory prescribing risk profiles among psychogeriatric outpatients, focusing on patients with depressive episodes. Methods We conducted a retrospective observational study of psychiatric outpatient visits in 202 …

21.08.2026journal-article

Postgraduate Medical Journal

Association between ischemic stroke and herpes zoster in older people: a propensity-matched cohort study

Shih-Wei Lai, Kuan-Fu Liao

Abstract Objective Ischemic stroke is known to cause immune dysregulation, yet its potential impact on subsequent herpes zoster risk remains unclear. This study aimed to evaluate whether ischemic stroke was associated with incident herpes zoster among patients aged 65–84 years. Methods This retrospective cohort study utilized electronic medical records from 2006 to 2024, obtained through the TriNetX Collaborative Network. Two study groups were identified: patients aged 65–84 years with a diagnosis of ischemic strok …

21.08.2026journal-article

Journal of Transcultural Nursing

Culturally Relevant Heart Health Program for Older African American Women of Rural Areas

Mudasir Andrabi, Betty Key, Kelvin Ovabor, Chen Lin, Mercy Mumba, Avani Shah, Karlene Ball

Introduction: Cardiovascular disease (CVD) remains a major public health issue, with the highest rates in the United States found among African Americans (AA) in rural areas like Alabama’s Black Belt. In this pilot study, we evaluated the feasibility and preliminary efficacy of a culturally relevant heart health program for older AA women in rural Alabama. Methods: We recruited 30 AA women aged 65 years and older from Alabama’s rural Black Belt with CVD or multiple risk factors. Feasibility was assessed via recruit …