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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

International Journal of Clinical Oncology

Clinical outcomes of near-infrared photoimmunotherapy according to immune checkpoint inhibitor timing and treatment sequence: a multicenter retrospective study

Takuma Makino, Shohei Fujimoto, Yorihisa Orita, Tomoyasu Tachibana, Yuto Naoi, Mizuo Ando

Abstract Background Near-infrared photoimmunotherapy (NIR-PIT) is a novel local treatment for recurrent or metastatic head and neck cancer. However, the clinical significance of immune checkpoint inhibitor (ICI) timing and treatment sequencing remains unclear. This study investigated their association with clinical outcomes after NIR-PIT. Methods This multicenter retrospective study included 44 patients with 48 lesions who underwent initial NIR-PIT between January 2021 and March 2026. The primary analysis compared …

01.09.2026journal-article

Journal of Cancer Survivorship

Sustained effects of auricular point acupressure on chemotherapy-induced neuropathy: a randomized controlled trial follow-up study

Nada Lukkahatai, Yannuo Jiang, Jingyu Zhang, Jennifer Kawi, Hulin Wu, Hongyu Wang, Claudia M. Campbell, Johannes Thrul, Salahadin Abdi, Eileen D. Hacker, Constance M. Johnson, Thomas J. Smith

Abstract Purpose Chemotherapy-induced neuropathy (CIN) is a persistent condition that impairs function and quality of life. Auricular point acupressure (APA) has shown short-term benefit for CIN, but the durability of these effects after treatment completion is unknown. This study evaluated the sustainability of symptom improvements for 3 months following a 4-week APA intervention. Methods This prespecified secondary analysis of a randomized wait-list controlled trial compared mobile-supported APA (mAPA) and virtua …

01.09.2026journal-article

Cells

AI-Assisted Multimodal Transcriptomic Analysis Identifies a Senescence-Related Prognostic Signature and Characterizes ADGRF5-Associated Malignant Phenotypes in Breast Cancer

Wenhao Liu, Wenhui Wu, Shubai Chen, Kaiqiong Chen, Xin Li

Cellular senescence (CS) is increasingly recognized as an important cell-state programme involved in breast cancer progression and therapeutic response, but its context-dependent molecular heterogeneity limits its application in prognostic assessment. In this study, GeneCompass-based all-gene in silico perturbation analysis was performed to identify candidate genes predicted to induce senescence or rejuvenation, thereby expanding the known senescence-related gene set. Machine learning further established a seven-ge …

01.09.2026journal-article

Tri-Chandra Journal of Anthropology

Multitude of Suffering: From Sickness to Hospital Treatment

Dipendra Lama

This auto-ethnography examines the multiple scopes of suffering experienced from the beginning of illness throughout hospitalization and cure processes, by means of the theoretical perspectives of critical medical anthropology. It explores the psychological, material, and social, aspects of suffering correlated with illness, healthcare performs, hospital atmospheres, and the result of cure. In Nepal, healthcare arrangement and infrastructure is unequally distributed within geographic regions, with well-resourced ho …

01.09.2026journal-article

3D Printing in Medicine

3D visualization and modeling in the surgical treatment and postoperative management of hypertrophic obstructive cardiomyopathy: a case report

Uladzimir Andrushchuk, Marta Garbowska, Tomasz Chrostowski, Darya Andrushchuk, Wiktoria Dzieżyk, Dorota Sulima, Annet Litvinenko, Miłosz Nesterowicz

Abstract Background Three-dimensional (3D) visualization, modeling, and printing can enhance planning for septal myectomy in hypertrophic obstructive cardiomyopathy; however, their role in postoperative decision-making is less well defined. Case presentation A 49-year-old man underwent extended septal myectomy planned using cardiac computed tomography angiography (CTA)–based 3D modeling and virtual myectomy; patient-specific 3D-printed models processed using hydrogen peroxide plasma were used intraoperatively to gu …

01.09.2026journal-article

PLOS Global Public Health

Multimorbidity and health-related quality of life after tuberculosis treatment in Zimbabwe: A cross-sectional study with household comparators

Claire Jacqueline Calderwood, Edson T. Marambire, Trevor Musunzuru, Karlos Madziva, Fungai Kavenga, Eveline Muringi, Justin Dixon, Junior Mutsvangwa, Celia L. Gregson, Rashida Abbas Ferrand, Katherine Fielding, Katharina Kranzer

Chronic conditions both drive development of and are consequences of tuberculosis (TB). While there is growing awareness of chronic lung disease, data on other health conditions post-TB are limited. In this cross-sectional study in Zimbabwe, we offered adults with pulmonary TB an integrated health check at or after treatment completion, assessing uptake and yield. Members of the same households were also offered the intervention. Selecting household members without prior or current TB as a comparator, we calculated …

01.09.2026journal-article

Cancer Reports

Paraneoplastic Myopathy as a Possible Initial Presentation of Sporadic Burkitt Lymphoma in an Immunocompetent Adult: A Case Report

Abolfazl Khalafi‐Nezhad, Dena Firouzabadi, Vahid mohammadkarimi, Amirreza Dehghanian

ABSTRACT Background Burkitt's lymphoma (BL) is a highly aggressive B‐cell non‐Hodgkin lymphoma with rapid proliferation and early systemic dissemination. Neuromuscular manifestations are rare and are typically secondary to direct infiltration or metabolic complications. Paraneoplastic myopathy as the initial presentation of BL is exceedingly uncommon, particularly in immunocompetent adults. Case Presentation We report the case of an immunocompetent adult male who presented with acute progressive proximal muscle wea …

01.09.2026journal-article

Obesity Science & Practice

Evaluating the Impact on Adult Caregivers of Family‐Based Treatment for Childhood Obesity

Paola Luca, Amy Bobyn, Grace P. S. Kwong, Alberto Nettel‐Aguirre, Ronald Sigal, Emma O. Billington, Raylene A. Reimer, Josephine Ho

ABSTRACT Background Weight management in children involves family lifestyle changes and relies on caregivers of children to implement these changes at home. Little is known about the effects of family‐based lifestyle intervention programs for children on caregivers themselves when not specifically targeted by the intervention. Objective To assess whether primary caregivers of children and adolescents with overweight or obesity experience a change in body mass index (BMI), cardiovascular risk profile and/or health b …

01.09.2026journal-article

TAJ: Journal of Teachers Association

Copy Number, mRNA Expression Analysis and Clinical Significance of p53 Gene in Bangladeshi Breast Cancer Patients

Nelofar Yasmin, Md Abdul Auwal, Rabeya Khatun, Tasnima Kamal, Md Rashel Mollah, Al-Amin Hossain, Chandan Barai, Azadur Rahman Bhuiyan, Md Ashraful Islam, Zinnat Ara Moni, Asma Ul Husna Biswas, Nousin Taslima Ferdous, Md Asadur Rahman, Md Farhadul Islam

The p53 gene also known as the tumor protein gene 53 situated on the short arm of chromosome 17. It is a tumor suppressor gene that regulates cell division and cell death and is involved in many malignancies, including breast cancers. Herein, we aim to assess the copy number and expression of the p53 gene in breast cancer patients of Bangladesh. Also, the clinical significance p53 copy number variation and mRNA expression was analyzed. The prevalence of low copy number variation of the p53 gene was 67.04% (n=59/88) …

01.09.2026journal-article

Anti-Cancer Drugs

Anlotinib inhibits glioma cell proliferation, migration, and invasion by suppressing c-MET/AKT/mTOR signaling and altering autophagy-associated protein expression

Chunmiao Bao, Xibang Liu

Glioma remains difficult to treat because malignant cells show rapid proliferation, diffuse invasion, and frequent recurrence. This study investigated the direct antitumor effects of anlotinib in human glioma cells and examined whether these effects were associated with hepatocyte growth factor receptor/protein kinase B/mechanistic target of rapamycin (c-MET/AKT/mTOR) signaling, apoptosis-associated responses, mesenchymal-transition-related proteins, and autophagy-associated proteins. U87 and U251 cells were treate …

04.09.2026journal-article

Aging Cell

Tissue‐Level Transcriptomic Entropy Reveals Organ‐Specific Aging Patterns and Predicts Cancer Progression

Gabriel Arantes dos Santos, José Pedro Castro, Gabriela D. A. Guardia, Filipe F. dos Santos, Alexander Birbrair, Pedro A. F. Galante

ABSTRACT Although aging and cancer share complex molecular mechanisms, distinguishing causative factors from byproducts remains challenging. Here, we investigated the role of tissue transcriptomic entropy—a measure of transcriptional disorder—in aging and cancer processes by analyzing RNA‐sequencing data from over 25,000 samples from human and mouse tissues. We found that entropy changes during aging are highly tissue‐specific, with some tissues showing increased entropy while others exhibit decreased or stable ent …

01.09.2026journal-article

Radiology: Imaging Cancer

Spectral CT-based Nomogram for Noninvasive Assessment and Prognostic Prediction of MSI/dMMR in Esophagogastric Junction Adenocarcinoma

Yinchen Wu, Kaihe Lin, Na Lin, Yu Lin, Xinyao Huang, Mi Wang, Dejun She, Dairong Cao

A spectral CT–based nomogram predicted microsatellite instability and deficient mismatch repair status and stratified prognosis in patients with esophagogastric junction adenocarcinoma across retrospective and prospective cohorts.

01.09.2026journal-article

Annals of Clinical and Analytical Medicine

Systemic inflammation markers and axillary involvement in early breast cancer: A retrospective cross-sectional study

Burak Etemoğlu, Nuray Çolapkulu Akgül, Caner Akgül, Muhammet Yildirim, Enes Ağırman, Abdullah Güneş, Hamdi Taner Turgut

Aim This study aimed to evaluate the predictive value of preoperative systemic inflammation indices—Systemic Immune-Inflammation Index (SII), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Monocyte-to-Lymphocyte Ratio (MLR)—for axillary lymph node involvement in patients with early-stage breast cancer. Methods In this retrospective, cross-sectional study, data from 334 patients who underwent surgery for early breast cancer between January 2015 and January 2023 were analyzed. Preoperat …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

First-line Enfortumab Vedotin Plus Pembrolizumab in Platinum-ineligible Advanced Urothelial Carcinoma

GO KANEKO, DAISUKE IGARASHI, SUGURU SHIROTAKE

Background/Aim: Platinum-ineligible patients with locally advanced or metastatic urothelial carcinoma represent a clinically vulnerable population with limited treatment options and poor historical outcomes. Although first-line enfortumab vedotin plus pembrolizumab has become a new standard treatment, evidence in platinum-ineligible patients remains limited. This study described the real-world clinical course of platinum-ineligible patients treated with first-line enfortumab vedotin plus pembrolizumab within a cons …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Reduced HMGCR Expression in Clear Cell Renal Cell Carcinoma Is Associated With Poor Patient Prognosis

ETSUSHI AKITAYA, YUZUKI NAKAMURA, SHIHO KATO, HINAYO KIKUTA, TERUO ENDOH, YASUHIRO KURAMITSU, YUJI TAKAHASHI

Background/Aim: Renal cell carcinoma (RCC) is a heterogeneous malignancy, with clear cell renal cell carcinoma (KIRC) being the most common subtype, characterized by von Hippel–Lindau (VHL) tumor suppressor gene inactivation and hypoxia-inducible factor (HIF) pathway activation, leading to enhanced angiogenesis and tumor progression. Although targeted therapies are available, the prognosis remains poor. Statins targeting HMG-CoA reductase (HMGCR) may influence RCC outcomes; however, the findings are inconsistent an …

01.09.2026journal-article

Radiology: Imaging Cancer

Incremental Value of Synthetic MRI Radiomics in Predicting Neoadjuvant Response in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Siyi Chen, Yongxin Chen, Chen Jin, Bingjie Zheng, Shishen Ding, Zijin Weng, Wenjie Tang, Weifeng Liu, Yihong Lin, Qingcong Kong, Qianwei Zhou, Yuan Guo

Synthetic MRI radiomics accurately predicted pathologic complete response to neoadjuvant therapy in human epidermal growth factor receptor 2–positive breast cancer, outperformed traditional radiomics models, and was associated with immune-related pathways and recurrence-free survival.

1 Zitationen
01.09.2026journal-article

Hypertension

Primary Aldosteronism Medical Treatment Outcomes (PAMO) Beyond 12 Months

Jun Yang, Jessica Goi, Jacopo Burrello, Martin Reincke, Christian Adolf, Denise Brüdgam, Qifu Li, Ying Song, Jinbo Hu, Shumin Yang, Fumitoshi Satoh, Yoshikiyo Ono, Renata Libianto, Michael Stowasser, Nanfang Li, Qing Zhu, Namki Hong, Drishya Nayak, Troy H. Puar, Vin-Cent Wu, Anand Vaidya, Marta Araujo-Castro, Tomaz Kocjan, Samuel Matthew O’Toole, Gregory L. Hundemer, Oskar Ragnarsson, André Lacroix, Stephanie Larose, Kazuki Nakai, Tetsuo Nishikawa, Daria Ladygina, Adina F. Turcu, Peeradon Vibhatavata, Carlos E. Fardella, Thomas Uslar, Marcus Quinkler, Paolo Mulatero, Giovanni Pintus, Gian Paolo Rossi, Stefanie Hahner

BACKGROUND: Primary aldosteronism (PA) is a common and treatable cause of hypertension, yet data on the durability of medical treatment response beyond the first year are limited. Using the PA medical treatment outcomes framework, we evaluated long-term biochemical and clinical outcomes and factors associated with treatment response. METHODS: We conducted an international, multicenter, observational cohort study across 27 centers on 4 continents. Adults with PA treated with mineralocorticoid receptor antagonists an …

01.09.2026journal-article

Disinfection affairs

Water treatment facilities and analysis of water disinfection methods at water intakes in Ufa

E.E. Zelenkovskaya, S.R. Afonkina, G.R. Allayarova, R.A. Daukaev

Presentation at the scientific-practical conference with international participation «Perspectives of disinfectology. Disinfection measures in emergency situations and in the territories of natural foci of infectious diseases» (September 22-23, 2026, Moscow)

01.09.2026journal-article

International Journal of Public Health Science (IJPHS)

Determinants of tuberculosis treatment adherence through information, motivation, and behavioural skills: a study of TB patients in Serdang Bedagai

Nixson Manurung, Sarida Surya Manurung, Rostinah Manurung

Patient non-compliance in undergoing treatment can increase the risk of therapy failure, transmission, and drug resistance. To analyse the treatment adherence strategies of tuberculosis patients through the information, motivation, behavioural skills (IMB) approach. The research uses a quantitative approach with a cross-sectional design. The research sample consists of tuberculosis patients in Serdang Bedagai Regency who were selected using the cluster random sampling technique at several community health centers. …

01.09.2026journal-article

Sustainability

Remediation of Metal-Contaminated Shallow Wetlands: Hydro-Biogeochemical Controls and Sustainable Treatment Strategies

Xian Guan, Xiaowen Liu, Yanan Shao, Hongjuan Xie, Lan Jiang

Shallow wetlands retain metals and metalloids from industrial, mining, agricultural, urban, and atmospheric sources; however, shallow water columns, active sediment–water exchange, and recurrent wetting–drying also favor remobilization. This critical narrative review evaluates physical, chemical, biological, and ecological engineering approaches for metal-contaminated shallow wetlands, focusing on the hydrological and biogeochemical conditions governing performance. Evidence was differentiated among natural or semi …

01.09.2026journal-article

Journal of Biomolecular Techniques

A National Assessment of Cancer Center Shared Resources Metrics: Results from the First NACCSR Survey

Jerry Edward Chipuk, Fei Ye, Jai N. Patel, Steven J. Madore, Crystal F. Kline, Matthew Nowacki, Andrés Chousal Cantú, David S. Goerlitz, Kevin K.C. Lloyd, Jay W. Fox, George S. Grills

Tracking core metrics is a critical component of centralized core facility management and is essential for ensuring that individual cores are efficiently operated, effectively evaluated, and optimally catalyze research. The National Alliance of Cancer Center Shared Resources (NACCSR) is a consortium of shared resource leaders from the National Institutes of Health (NIH) National Cancer Institute (NCI) designated Cancer Centers. The NACCSR Core Metrics Committee (CMC) includes shared resource leaders from a dozen NC …

01.09.2026journal-article

Clinical Kidney Journal

Targeting calciphylaxis: the emergence of vitamin K as a potential treatment

Maria Fusaro, Smeetha Sinha, Antonio Bellasi, Markus Ketteler, Carlo Alfieri, Martin H de Borst, Ditte Hansen, Pietro Manuel Ferraro, Juan Miguel Díaz-Tocados, Mathias Haarhaus, Mehmet Kanbay, Maurizio Gallieni, Paolo Simioni, Sandro Giannini, Sharon Huish, Althea Cossettini

Abstract Calciphylaxis, or calcific uraemic arteriolopathy (CUA), is a rare, life-threatening vascular disorder predominantly affecting patients with advanced chronic kidney disease (CKD), especially those on dialysis. It is characterized by arteriolar calcification, thrombosis, and painful ischemic skin lesions that frequently ulcerate, contributing to high morbidity and mortality. Calciphylaxis arises from medial arterial calcification, endothelial injury, and a pro-inflammatory, pro-thrombotic milieu. Disruption …

01.09.2026journal-article

Cancers

Multicenter Validation of Foundation Model Adaptation for Automated Pancreatic Tumor Delineation on CT Scans

Halil Ertugrul Aktas, Eminenur Sen Tasci, Linkai Peng, Muhammed Enes Tasci, Yavuz B. Taktak, Sitki Safa Taflan, Baver Tutun, Fergan Bol, Murat Iren, Mucahit Ekici, Andrea Mia Bejar, Elif Keles, Hongyi Pan, Wanying Dou, Burak Gultekin, Alper Akin, Oyku Ikizgul, Okan Cetin, Emre Uysal, Maide Mureva, Mustafa Orhan Nalbant, Nurullah Kaya, Alpay Medetalibeyoglu, Kadir Atakir, Berna Akkus Yildirim, Gulbiz Dagoglu Kartal, Zongwei Zhou, Sukru Mehmet Erturk, Frank H. Miller, Gorkem Durak, Ulas Bagci

Background: Accurate pancreatic tumor segmentation on contrast-enhanced computed tomography (CECT) is important for staging, treatment planning, and response assessment in pancreatic ductal adenocarcinoma (PDAC). Although foundation models have shown promise for medical image segmentation, their effectiveness for disease-specific tumor delineation remains uncertain. This study evaluated whether fine-tuning a Segment Anything Model (SAM)-based framework on the target cohorts improves pancreatic tumor segmentation co …

01.09.2026journal-article

Immunology

Elevations of Th17.1 Cells ( CXCR3 + CCR6 + T Cells With IL ‐ 17A and IFN ‐γ Production) in Peripheral Blood of Patients With Lung Cancer

Jiaoyun Lv, Wencheng Yin, Xialin Nie, Siyuan Chen, Yuqi Zhong, Shufa Yang, Ziyi He, Yanhong Yao, Qiqi Wang, Yang Zhao, Hui Dai

ABSTRACT Peripheral T cell profiles reflect antitumour immunity, yet systemic immune shifts often remain confounded by demographic factors. This study aimed to delineate true tumour‐driven T cell alterations in lung cancer. We analysed peripheral blood from 121 lung cancer patients and strictly age‐ and sex‐matched healthy controls using multiparametric flow cytometry, corroborated by human lung cancer spatial transcriptomics (ST). Following demographic standardisation, patients exhibited a systemic T cell priming …