27.08.2026journal-article
Biomedicines
Hala Aldahshan, Abeer Al-Hubaysh, Dimah K. Alrabiah, Meshael Alturki, Reem R. Alkharji, Salwa Lin, Mohammed S. Aldughaim, Raef Albugami
Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of haematological malignancies, but conventional viral transduction results in semi-random genomic integration, contributing to heterogeneous CAR expression and potential insertional effects. Site-specific genome engineering offers an alternative by directing CAR insertion to defined genomic loci, allowing greater control over transgene expression and cellular function. This narrative review evaluates advances in site-specific CAR T-cell e …
27.08.2026journal-article
Liver International
Jian He, Jian Chen, Bohua Yu, Fuqun Wei, Weifu Liu, Peishu Huang, Songhui Wu, Xiang You, Zhisheng Chen, Ziqi Lin, Wuhua Guo, Shaowu Zhuang, Yiping Chen, Zhongwu Chen
ABSTRACT Background and Aims The optimal sequencing of programmed cell death protein 1 (PD‐1) inhibitors relative to locoregional therapy (LRT) in unresectable hepatocellular carcinoma (uHCC) remains undefined. This study evaluated the impact of PD‐1 inhibitor timing on outcomes in patients receiving hepatic arterial infusion chemotherapy (HAIC) or transarterial chemoembolisation (TACE) plus lenvatinib and PD‐1 inhibitors. Methods Patients with initially uHCC who received LRT in combination with lenvatinib and PD‐1 …
27.08.2026journal-article
Philosophical Transactions of the Royal Society B: Biological Sciences
Selene Roberts, Dave Clarke, Ioannis Galdadas, Marisa Martin-Fernandez
Abstract The epidermal growth factor receptor (EGFR) was cloned and identified as an oncogene 40 years ago, and since then has become the poster child for receptor tyrosine kinases in physiological and pathophysiological settings. Cell surface EGFRs bind growth factors secreted by adjacent cells and undergo conformational changes that transduce normal or dysregulated growth and division signals across the plasma membrane. It took more than two decades for atomic resolution of partial structures to become available, …
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27.08.2026journal-article
Pediatric Transplantation
Kevin W. O'Connor, Serena Bagnasco, Cozumel Pruette, Elizabeth Goswami, Olga Charnaya
ABSTRACT Background Acute kidney allograft rejection is a significant cause of graft dysfunction in pediatric transplant recipients. Standard of care for moderate to severe acute T‐cell‐mediated rejection among pediatric transplant recipients includes lymphocyte‐depleting agents such as rabbit anti‐thymocyte globulin (rATG). However, intolerance to or contraindications to rATG may limit its use and necessitate alternative immunosuppressive strategies. Alemtuzumab, a humanized monoclonal antibody targeting CD52, ind …
27.08.2026journal-article
International Journal of Humanities and Social Science
Siya Jain
Third spaces that sit between home (first space) and work (second space) are often described as neutral ground that is open and accessible to everyone. This study questions that assumption in the context of Delhi NCR (Delhi, Noida, Gurgaon, Ghaziabad), asking whether formal and informal (precarious) workers experience and access these spaces on equal terms. A structured questionnaire including largely quantitative questions was designed and administered to 116 workers, comprising 50 formal and 66 informal workers ( …
27.08.2026journal-article
Journal of Oral Rehabilitation
Gizem Altundal, Ceyda Deniz Özdemir, Ece Zorlu, Fatma Yüce, Sibel Biren
ABSTRACT Background Tooth wear is commonly assumed to be a marker of parafunctional load and, by extension, of mechanical stress on the temporomandibular joint (TMJ); whether greater wear accompanies greater degeneration in the same joint has rarely been tested. Objective To determine whether tooth wear severity is associated with ipsilateral CBCT‐detected TMJ degeneration in adults with TMD symptoms. Methods In this cross‐sectional study, 80 adults (160 joints; mean age 27 years; 80% female) underwent standardised …
27.08.2026journal-article
Journal of Endovascular Therapy
Victor Bilman, Asher Rottenberg, Ilan Davidov, Sarit Malayev, Moshe Halak, Daniel Silverberg
Introduction: To evaluate outcomes of endovascular aneurysm repair (EVAR) for infective native abdominal aortic aneurysms (INAAA) and to describe microbiological, imaging, and inflammatory findings, as well as the role of prolonged antibiotic therapy and fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography ( 18 F-FDG PET-CT) in follow-up. Methods: This retrospective single-center experience included all patients diagnosed with INAAA and treated with EVAR at our institution between 2020 an …
27.08.2026journal-article
Anaesthesiology Intensive Therapy
Alicja Filipczyk, Szymon Zdanowski, Jan Kasprzyk, Karolina Niedzielska, Artur Rakhatsevich, Magdalena Anna Wujtewicz, Tomasz J. Stefaniak, Karol P. Steckiewicz
Background Thyroid hormone disturbances are a hallmark of critical illness and are commonly attributed to non-thyroidal illness syndrome. The clinical relevance of thyroid hormone supplementation in the intensive care unit (ICU) remains uncertain. This study aimed to characterize thyroid hormone concentrations in relation to disease severity in critically ill patients receiving thyroid hormone supplementation. Methods In this single-center retrospective study, data from 98 ICU patients receiving thyroid hormone sup …
27.08.2026journal-article
Clinical Psychology & Psychotherapy
Meng Liang, Gerly Tamm, Olivia De Laere, Yannick Vander Zwalmen, Ernst H. W. Koster
ABSTRACT Bullying is associated with internalizing symptoms and impaired everyday functioning. Cognitive‐behavioural therapy (CBT) and imagery interventions have been studied as treatments to improve mental health after such experiences. This meta‐analysis aimed to evaluate the effects of individual CBT and imagery interventions in targeting internalizing symptoms (negative affect, depression, anxiety and post‐traumatic stress symptoms) and improving self‐perception and coping in bullying victims. Systematic search …
27.08.2026journal-article
Frontiers in Immunology
Sheng Hou, Tianyu Gao, Yimei Wu, Hao Wang, Dapeng Zhang, Qingcheng Guo, Jin Xu, Huaizu Guo, Weizhu Qian
Introduction Osteoporosis remains a major global health challenge, and current single-pathway therapies often fail to achieve coordinated bone remodeling. Dickkopf-1 (DKK-1) is a potent inhibitor of the Wnt/β-catenin signaling pathway and plays a critical role in osteoporotic bone loss. Neutralization of DKK-1 represents a promising therapeutic strategy to promote bone formation while simultaneously inhibiting bone resorption. Methods A humanized anti-DKK-1 monoclonal antibody (IgG4) was generated via CDR grafting …
27.08.2026journal-article
Inquiry@Queen's Undergraduate Research Conference Proceedings
Jillian Morris
Introduction: Though scientific and technological advancements in perinatal and neonatal care have increased survival rates amongst preterm infants, infants born preterm remain at heightened risk of delayed speech-language development due to organs and system immaturity at birth.1-4 Speech-language impairment is the most prevalent neurodevelopmental impairment in extremely preterm (EP) infants, yet the relationship between developmental trajectory, infant morbidities, environmental factors, and language outcomes re …
27.08.2026journal-article
Neuro-Oncology
Alina Pandele, Alison Whitby, Sandra Martinez-Jarquin, Chiara Bastiancich, Donald Macarthur, Ian Kamaly-Asl, David Barrett, Richard Grundy, Dong-Hyun Kim, Ruman Rahman
Abstract Introduction Ependymoma (EPN) is the second most malignant paediatric brain tumour. The PF-A subgroup, associated with a hypoxic microenvironment, has a dismal survival rate of 50%, with clinical trials failing to demonstrate a significant survival advantage from chemotherapy to date. We present a multi-omic integration investigating whether spatially-distinct tumour microenvironments represent targetable metabolic niches in PF-A EPN. Methods Surgical sampling of spatially-distinct regions from eight PF-A …
27.08.2026journal-article
JCI Insight
Hai Duc Nguyen, Andrew K. Ding-Su, Caroline Soulas, Tricia H. Burdo, Patrick Autissier, Pasiri Sithinamsuwan, Nitiya Chomchey, Jintanat Ananworanich, Victor Valcour, Silvia Ratto-Kim, Woong-Ki Kim, Kenneth C. Williams
Rationale: Persistent monocyte activation contributes to HIV-associated neurocognitive disorders (HAND), yet biomarkers that predict neurocognitive impairment before and after antiretroviral therapy (ART) remain incompletely defined. Objectives: We evaluated monocyte subsets and activation markers in participants from the SEARCH007 cohort prior to ART initiation and at 6 and 12 months following treatment. Methods and Results: Increased frequencies of CD14+CD16+ monocytes and elevated CD163 expression were associate …
27.08.2026journal-article
Physical and Engineering Sciences in Medicine
Young Jin Won, Jung Ju Jo, Su Ah Yu, Su Jung Shim, Kum Bae Kim, Jung Hoon Kim, Sang Hyoun Choi, Samju Cho
Abstract This study aimed to develop a customized bolus using commercially available transparent gel wax (TGW) without requiring 3D printing technology and to evaluate its applicability in radiotherapy, including its physical and dosimetric characteristics. A dental alginate impression was taken from the curved surface of a mastectomy phantom to replicate the patient’s skin contour. Based on this, a silicone mould was fabricated, into which TGW was poured to form the customized bolus. The fabricated bolus was evalu …
27.08.2026journal-article
Annals of Pharmacotherapy
Dong Wu, Xiaowu Wang, Changjing Chen, Xiaoying Wang, Hao Li, Linlin Zhao, Guangli Li, Xiaojuan Wang
Background: Laboratory-defined leukopenia/neutropenia may occur during vancomycin therapy, but mild threshold-crossing abnormalities do not necessarily establish definite drug-induced toxicity. Objective: To develop and evaluate a risk-stratification strategy based on baseline hematologic reserve and vancomycin treatment duration. Methods: This single-center retrospective cohort included adult inpatients receiving intravenous vancomycin for ≥3 days. Patients with baseline leukopenia/neutropenia, hematologic disease …
27.08.2026journal-article
Annals of the ICRP
A. Isambert, J. Vassileva, C.J. Martin
Since the 1990s, significant technological developments for the preparation and delivery of radiation treatment have resulted in the need for the use of more advanced imaging in radiotherapy. However, errors in treatment (events that can lead to unintended and accidental medical exposures and near misses) can occur while using these images. Several sources provide information feedback on events reported in the use of imaging. Events recorded in Radiation Oncology Incident Learning Systems, reports and newsletters f …
27.08.2026journal-article
Small
Sumin Kang, Yun‐Jin Jeong, Seokjae Kim, Van Du Nguyen, Songah Jeong, Juyeong Jo, Arunkumar Shanmugasundaram, Jin Uk Jeong, Dong‐Weon Lee, Eunpyo Choi, Hyungwoo Kim
ABSTRACT The clinical translation of bioresorbable polymer scaffold is limited by radiolucency, insufficient mechanical strength, and the absence of post‐implantation therapeutic control. This study introduces a multifunctional scaffold that addresses these challenges through a polymer–ceramic nanocomposite architecture and bioinspired surface modification. ZrO 2 nanoparticles are uniformly embedded into poly(ε‐caprolactone) (PCL) via solution blending and fabricated into vascular scaffold by fused deposition model …
27.08.2026journal-article
Pediatric Dermatology
Varshita Chirumamilla, Rachel E. Tao, Leah Lalor, Alexis J. Gumm
ABSTRACT This report describes a 14‐year‐old female undergoing isotretinoin therapy for severe acne who developed a persistent isolated elevation of aspartate aminotransferase (AST) with normal alanine aminotransferase (ALT), creatine kinase (CK), triglycerides, and no systemic or gastrointestinal symptoms. A focused evaluation, including medication and alcohol history review, complete blood count (CBC), and muscle and hepatic markers, showed no evidence of clinically significant hepatic, muscular, or hematologic a …
27.08.2026journal-article
International Journal of Rehabilitation Research
Thea B. Ransby, Sara J.S. Hermansen, Stina Meyer Larsen, Louise M. Nielsen
Transient ischemic attack (TIA) is traditionally regarded as a condition with full recovery. However, emerging evidence suggests that some individuals experience residual symptoms, limiting their activity and participation in everyday life. The objective was to systematically map and synthesize existing evidence on activity limitations and participation restrictions following TIA. A scoping review was conducted following the framework proposed by Arksey and O’Malley and further outlined by Levac et al . A comprehen …
27.08.2026journal-article
Scientific Reports
Martina Skapova, Pavol Partila, Jaromir Tovarek, Tereza Lubojacka, Jana Slonkova, Ondrej Hruby, Samuel Genzor, Jan Mizera, Petr Mooz
Abstract This study investigates non-invasive detection of obstructive sleep apnea (OSA) from daytime speech in a limited polysomnography-labeled clinical cohort. The objective was to evaluate whether speaker-verification-inspired representations can support robust speech-based OSA screening under constrained clinical data conditions. We compared conventional mel-frequency cepstral coefficient (MFCC)-based classifiers with i-vector systems using cosine-similarity, support vector machine (SVM), and neural-network (N …
27.08.2026journal-article
Frontiers in Cardiovascular Medicine
Jinjin Gong, Xinmei Zhang
Objective To examine the association between routine Information-Motivation-Behavioral Skills (IMB) model-based rehabilitation nursing and rehabilitation-related outcomes and self-management behaviors in patients with coronary heart disease (CHD). Methods This single-center retrospective cohort study included 150 patients with CHD admitted to Shandong Provincial Third Hospital from January 2024 to February 2025. After ethics approval, data were extracted from existing clinical and nursing records. Patients were ret …
27.08.2026journal-article
Annals of Nuclear Medicine
Domenico Albano, Chong Jiang, Francesco Bertagna
Abstract Objective End-stage renal disease (ESRD) patients undergoing renal replacement therapy (RRT) are at increased risk of infections, inflammatory disorders, and malignancies because of immune dysfunction, repeated vascular access procedures, and immunosuppressive therapy after kidney transplantation. Fever of unknown origin (FUO) is particularly challenging to investigate in this population, and evidence regarding the role of [18 F]FDG PET/CT remains limited. This study evaluated the diagnostic performance, c …
27.08.2026journal-article
Journal of Innovative Healthcare Practices
Muhammed Celal Eryılmaz
Vestibular rehabilitation therapy (VRT) is undergoing a paradigm shift toward a mechanistically informed, multisensory, and technologically integrated model. This narrative review synthesises current evidence on how this transformation is driven by advances in neurophysiology, diagnostic precision, and immersive technologies such as virtual reality (VR), which collectively enhance personalization and therapeutic efficacy. Traditional approaches that primarily targeted peripheral deficits are now complemented by str …
27.08.2026journal-article
Frontiers in Medicine
Jingyao Li, Huiyan Li, Hao Xu, Jing Dong, Tiantian Guo, Hongjiao Yao, Qi Yang
Background and aim Endoscopic therapies are important approaches for managing internal hemorrhoids. This study assessed the feasibility of endoscopic examination of the upper border of anal transitional zone (ATZ) and its clinical utility and underlying anatomical basis as a landmark for internal hemorrhoid. Methods Mucosal demarcation line (MDL) and the dentate line were identified and measured in 207 adults using white-light and narrow band imaging (NBI) endoscopy, with three biopsies for histologic confirmation. …
