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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

The Oncologist

9 CD8+ T Cells and Clinical Outcomes from the CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition (Cyto-KIK) Trial

Karie Runcie, Calvin Park, Moshe Ornstein, Biren Saraiya, Somnath Tagore, Edridge D’Souza, Benjamin Izar, Eric Singer, Mark Stein

Abstract Background In 2020, CheckMate9ER established cabozantinib (cabo) and nivolumab (nivo) as a first-line treatment regimen for metastatic clear cell renal cell carcinoma (mccRCC). Despite recent therapeutic advancements in mccRCC, only about 10-15% of patients will achieve a complete response (CR) to current first-line therapy. Improved outcomes with neoadjuvant compared to adjuvant immune checkpoint inhibitors has been demonstrated in several tumor types including non-small cell lung cancer and melanoma. Cyt …

02.09.2026journal-article

The Oncologist

81 Tumor-Informed Circulating Tumor DNA Monitoring in Fumarate Hydratase–Deficient Renal Cell Carcinoma

Antonio Ocejo, Andrea Knezevic, Ayaa Essafi, Sahil D Doshi, Andrew Cornish, Neil J Shah, David H Aggen, Robert J Motzer, A Ari Hakimi, Darren R Feldman, Ritesh R Kotecha, Martin H Voss, Maria I Carlo

Abstract Background Fumarate hydratase (FH)–deficient renal cell carcinoma (RCC) is a rare and aggressive subtype associated with hereditary leiomyomatosis and RCC (HLRCC) syndrome. These tumors are characterized by early onset, frequent de novo metastatic presentation, and poor prognosis. Treatment standards are poorly defined, and no validated molecular biomarkers exist for real-time disease monitoring. Circulating tumor DNA (ctDNA) is showing promise as a liquid biomarker in clear cell RCC, but its feasibility a …

01.09.2026journal-article

Chemical Biology & Drug Design

Integrative Multi‐Omics Analysis Identifies Thrombosis‐Associated Molecular Features Linked to Germline Susceptibility and Immune Cell Communication in Gastric Cancer

Xiaogang Lu, Lin Sun, Fujun Jin, Biao Cheng, Ying Huang, Yuzhu Tang, Xiaolong Nie, Feng Gao

ABSTRACT Emerging evidence indicates that coagulation‐related molecular programs are associated with thrombosis, tumor progression, and molecular dysregulation in gastric cancer (GC). However, thrombosis‐associated molecular features in GC and their potential links to inherited susceptibility remain insufficiently understood. Integrated analyses of transcriptomic data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets were performed to identify thrombosis‐associated genes and establish a …

01.09.2026journal-article

Journal of the Egyptian Women's Dermatologic Society

Evaluation of the efficacy and safety of photodynamic therapy using liquid crystal-loaded methylene blue and intense pulsed light in treatment of vitiligo

Manal M. Abdel-Monem, Amany M. Abdel-Latif, Gamal M. El Maghraby, Esraa E. Elhawary

Background Depigmented macules and patches characterize vitiligo, an acquired autoimmune skin condition that has several lines of treatment. A new treatment for vitiligo, photodynamic therapy (PDT), has mixed results. Objective To evaluate the efficacy and safety of PDT using liquid crystal-loaded methylene blue and intense pulsed light in the treatment of vitiligo. Patients and methods This prospective, randomized study was conducted in 40 patients with multiple vitiligo lesions. For each patient, three vitiligo l …

01.09.2026journal-article

ACS Omega

Synthesis and Fundamental Evaluation of [67Ga]Ga-NOTA- D -KV6 as a Potential Cationic Amphiphilic Peptide Probe for Tumor Imaging

Takeshi Chiga, Takeshi Fuchigami, Akari Matsuura, Masayuki Munekane, Kenji Mishiro, Sakura Yoshida, Makoto Oba, Hiroshi Wakabayashi, Seigo Kinuya, Kazuma Ogawa

Abstract SVS-1, a cationic amphiphilic peptide (CAP), adopts a β-hairpin conformation only upon interacting with the surface of cancer cells, thereby disrupting their membrane. Previously, we developed [67Ga]Ga-NOTA-KV6, an SVS-1 derivative for tumor imaging, which demonstrated favorable early tumor uptake but poor retention. To address this limitation, we designed and evaluated a novel d-amino acid–based SVS-1 analogue, [67Ga]Ga-NOTA-d-KV6, to enhance metabolic stability and improve pharmacokinetic properties. Flu …

01.09.2026journal-article

Pharmaceuticals

Comparative Physicochemical Characterization and Biological Effects of Magnetite- and Maghemite-Based Magnetic Colloidal Suspensions in A704 Renal Cancer Cells

Mihai Cristian Neagu, Diana Haj Ali, Emil Radu Iacob, Andreea Smeu, Roxana Stoicescu, Călin Marius Popoiu, Georgiana Boştinaru, Ştefan Marcu, Robert Ianoş, Vlad Socoliuc, Lucian Barbu Tudoran, Elena-Alina Moacă

Background/Objectives: Magnetic iron oxide nanoparticles are investigated in cancer research; however, the direct biological effects of unloaded magnetic colloidal suspensions in renal cancer remain insufficiently characterized. This study compared two double-oleic-acid-coated formulations prepared from precursors: magnetite-based MCS 1 and maghemite-based MCS 2. Methods: The suspensions were characterized by vibrating-sample magnetometry, dynamic light scattering, bright-field scanning transmission electron micros …

04.09.2026journal-article

Obstetrical & Gynecological Survey

Comment on “De-escalation in Definitive Surgical Management for Cervical Cancer”

Linda Van Le

Traditionally, early-stage cervical cancer has been treated with radical hysterectomy and lymphadenectomy.Recently, this approach has changed due to advances in understanding the disease, surgical approaches and the adoption of the idea that radical procedures are not necessary for all patients. The concept of surgical de-escalation in cervical cancer is increasing in traction. Examples of de-escalation include sentinel lymph node mapping, simple hysterectomy, fertility-sparing surgery, intraoperative assessment to …

03.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Spatial habitat radiomics predicts tertiary lymphoid structure status and identifies an IDO1 + migratory dendritic cell axis in breast cancer

Yushuai Yu, Qing Wang, Yidan Lin, Kaiyan Huang, Ruijuan Wang, Junxiao Wang, Xiewei Huang, Jie Zhang, Weiwei Chen, Ruiliang Chen, Xuejun Chen, Fan Meng, Hengyu Zhang, Junhui Yuan, Jianqing Lin, Chuangui Song

Background Tertiary lymphoid structures (TLS) are spatially organized immune niches associated with therapeutic response and favorable outcomes in breast cancer (BC). However, TLS assessment currently relies on invasive tissue-based analyses, and the biological mechanisms underlying imaging-based TLS prediction remain poorly understood. Methods We developed and validated a spatial heterogeneity-based radiomic TLS signature (shTLS) using dynamic contrast-enhanced MRI to non-invasively predict TLS status across multi …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Two Cases of Uterine Small-cell Neuroendocrine Carcinoma With Somatostatin-receptor-type-2 (SSTR2) Expression and Minor Components of Endocervical Adenocarcinoma

MASAMICHI BAMBA, TOMO NAMURA, TOSHIKAZU KATO, MASANORI SHIOHARA, KENJI ISOGAWA, MAO UEMURA, SHIRO WAKINOUE, HIROKO YOMO, TETSUYA NAKAGAWA, TETSUYA KATSUMORI, RYOJI KUSHIMA, SUZUKO MORITANI

Background/Aim: Uterine small cell neuroendocrine carcinoma (SCNEC) is a highly malignant and aggressive neoplasm. When chemotherapy is necessary, a platinum-based regimen similar to that used for pulmonary SCNEC is recommended. We encountered two cases of uterine SCNEC expressing somatostatin receptor type 2 (SSTR2), both with minor components of endocervical adenocarcinoma (ECAC). This study aimed to clarify the histogenesis and progression of these carcinomas through detailed histopathological, immunohistochemic …

01.09.2026journal-article

Eurasian Clinical and Analytical Medicine

A rare case of thyroid metastasis occurring 27 years after initial diagnosis of breast cancer: A Case Report

Ayten Eraydin, Semin Melahat Fenkci, Gozde Topel, Ibrahim Celik, Asude Fenkci

Introduction Breast cancer (BC) most frequently metastasizes to bone, lung, and brain, whereas thyroid involvement is rare. We report a rare case of thyroid metastasis detected 27 years after the initial diagnosis of BC with subsequent pulmonary, cervical lymph node, and skeletal metastases. Case Presentation A 72-year-old woman diagnosed in 1997 with stage IIA, ER-positive, PR-positive, HER2-negative invasive ductal carcinoma underwent modified radical mastectomy followed by adjuvant therapy. After 27 disease-free …

01.09.2026journal-article

International Journal of Informatics and Communication Technology (IJ-ICT)

A multi-cancer detection framework using deep learning and hybrid machine learning approaches

Karan Singh, Amruta Pawar, Drishya Tomar, Amrita Yadav, Aditi Chhabria, Vaibhav Narawade

The diagnostic solutions offered by the present artificial intelligence (AI) solutions suffer from non-generalizability and heavy reliance on complex models. In an attempt to solve these issues, we propose a lightweight yet versatile method consisting of a combination of ResNet50 transfer learning and hybrid machine learning. Image features are extracted using dermoscopy, magnetic resonance imaging (MRI), and histopathological images. These are subjected to principal component analysis (PCA) dimensionality reductio …

01.09.2026journal-article

Radiology: Artificial Intelligence

A Deep Learning Model Incorporating Spatiotemporal Asymmetries on Longitudinal Mammograms to Predict Breast Cancer Risk

Zhengbo Zhou, Dooman Arefan, Margarita L. Zuley, Jules H. Sumkin, Shandong Wu

A deep learning risk model that explicitly captures bilateral and longitudinal asymmetries detected on sequential mammograms outperformed existing models for breast cancer risk prediction.

01.09.2026journal-article

Anti-Cancer Drugs

Anlotinib inhibits glioma cell proliferation, migration, and invasion by suppressing c-MET/AKT/mTOR signaling and altering autophagy-associated protein expression

Chunmiao Bao, Xibang Liu

Glioma remains difficult to treat because malignant cells show rapid proliferation, diffuse invasion, and frequent recurrence. This study investigated the direct antitumor effects of anlotinib in human glioma cells and examined whether these effects were associated with hepatocyte growth factor receptor/protein kinase B/mechanistic target of rapamycin (c-MET/AKT/mTOR) signaling, apoptosis-associated responses, mesenchymal-transition-related proteins, and autophagy-associated proteins. U87 and U251 cells were treate …

01.09.2026journal-article

Clinical and Translational Imaging

Comparison between 18 F-FDG PET/MRI and CT for distant metastases detection in restaging of locally advanced rectal cancer after neoadjuvant chemoradiotherapy

Sebastiano Milite, Francesco Vendemiati, Francesca Serani, Chiara Zanon, Quoc Riccardo Bao, Amalia Lupi, Alessandra Pulvirenti, Gaya Spolverato, Diego Cecchin, Emilio Quaia, Giulio Cabrelle, Filippo Crimì

Abstract Purpose To evaluate the diagnostic accuracy of total-body 18 F-FDG PET/MRI compared with contrast-enhanced CT in detecting distant metastases in patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (pCRT). Methods This retrospective study included patients with LARC treated with pCRT between 2016 and 2019. Both contrast-enhanced CT and 18 F-FDG PET/MRI were performed within 6–8 weeks after completion of pCRT. Two independent expert teams assessed the presence of hepatic, …

01.09.2026journal-article

Cancer Epidemiology, Biomarkers & Prevention

Sarcomas: Research on Ultrarare Subtypes Gains Ground

Peter Hohenberger

Abstract Rare cancers account for almost one fourth of all cancers. Sarcomas belong to the group of cancerous diseases with an incidence of less than 6 cases per 100,000 inhabitants. Over the past decade, activities were launched worldwide to elucidate the peculiarities of many of the more than 100 sarcoma subtypes described in the World Health Organization handbook. The major contributor to exact diagnosis is molecular pathology. The subgroup of ultrarare sarcomas (URS) poses a significant problem as each URS type …

01.09.2026journal-article

Cancer Reports

Paraneoplastic Myopathy as a Possible Initial Presentation of Sporadic Burkitt Lymphoma in an Immunocompetent Adult: A Case Report

Abolfazl Khalafi‐Nezhad, Dena Firouzabadi, Vahid mohammadkarimi, Amirreza Dehghanian

ABSTRACT Background Burkitt's lymphoma (BL) is a highly aggressive B‐cell non‐Hodgkin lymphoma with rapid proliferation and early systemic dissemination. Neuromuscular manifestations are rare and are typically secondary to direct infiltration or metabolic complications. Paraneoplastic myopathy as the initial presentation of BL is exceedingly uncommon, particularly in immunocompetent adults. Case Presentation We report the case of an immunocompetent adult male who presented with acute progressive proximal muscle wea …

01.09.2026journal-article

Obesity Science & Practice

Evaluating the Impact on Adult Caregivers of Family‐Based Treatment for Childhood Obesity

Paola Luca, Amy Bobyn, Grace P. S. Kwong, Alberto Nettel‐Aguirre, Ronald Sigal, Emma O. Billington, Raylene A. Reimer, Josephine Ho

ABSTRACT Background Weight management in children involves family lifestyle changes and relies on caregivers of children to implement these changes at home. Little is known about the effects of family‐based lifestyle intervention programs for children on caregivers themselves when not specifically targeted by the intervention. Objective To assess whether primary caregivers of children and adolescents with overweight or obesity experience a change in body mass index (BMI), cardiovascular risk profile and/or health b …

01.09.2026journal-article

PLOS Global Public Health

Multimorbidity and health-related quality of life after tuberculosis treatment in Zimbabwe: A cross-sectional study with household comparators

Claire Jacqueline Calderwood, Edson T. Marambire, Trevor Musunzuru, Karlos Madziva, Fungai Kavenga, Eveline Muringi, Justin Dixon, Junior Mutsvangwa, Celia L. Gregson, Rashida Abbas Ferrand, Katherine Fielding, Katharina Kranzer

Chronic conditions both drive development of and are consequences of tuberculosis (TB). While there is growing awareness of chronic lung disease, data on other health conditions post-TB are limited. In this cross-sectional study in Zimbabwe, we offered adults with pulmonary TB an integrated health check at or after treatment completion, assessing uptake and yield. Members of the same households were also offered the intervention. Selecting household members without prior or current TB as a comparator, we calculated …

01.09.2026journal-article

International Journal of Clinical Oncology

Clinical outcomes of near-infrared photoimmunotherapy according to immune checkpoint inhibitor timing and treatment sequence: a multicenter retrospective study

Takuma Makino, Shohei Fujimoto, Yorihisa Orita, Tomoyasu Tachibana, Yuto Naoi, Mizuo Ando

Abstract Background Near-infrared photoimmunotherapy (NIR-PIT) is a novel local treatment for recurrent or metastatic head and neck cancer. However, the clinical significance of immune checkpoint inhibitor (ICI) timing and treatment sequencing remains unclear. This study investigated their association with clinical outcomes after NIR-PIT. Methods This multicenter retrospective study included 44 patients with 48 lesions who underwent initial NIR-PIT between January 2021 and March 2026. The primary analysis compared …

01.09.2026journal-article

Prostate Cancer and Prostatic Diseases

Oncological and functional outcomes of focal irreversible electroporation for localised prostate cancer: a single institution series of 171 cases

Z. Mian, T. Gianduzzo, B. Kua, J. Yaxley

Abstract Background Focal irreversible electroporation (IRE) is an attractive choice for patients aiming to obtain local control of prostate cancer, while decreasing the postoperative risk of impotence and incontinence compared to whole-gland treatments. Methods Retrospective review of a single centre prospective database of 171 consecutive primary IRE procedures for localised prostate cancer. Primary outcomes include oncological infield and out-of-field progression. Secondary objectives include post-IRE continence …

01.09.2026journal-article

Exploration of Neuroscience

The emerging role of nanobiomaterials in the early detection and treatment of Alzheimer’s disease

Abraham Olufemi Asuku, Peace Ayo Olaoluwa

The neurodegenerative condition known as Alzheimer’s disease (AD) is defined chiefly by intraneuronal tangles, large-scale neuronal death, and dementia. Although much progress has been made in Alzheimer’s research, early diagnosis of the disease and effective treatment are difficult; conventional diagnostic tests fail to detect the pathology until there is significant neurodegeneration, and many treatments do not penetrate the blood-brain barrier and have poor target specificity. Nanotechnology has the ability to c …

01.09.2026journal-article

Journal of Cancer Survivorship

Sustained effects of auricular point acupressure on chemotherapy-induced neuropathy: a randomized controlled trial follow-up study

Nada Lukkahatai, Yannuo Jiang, Jingyu Zhang, Jennifer Kawi, Hulin Wu, Hongyu Wang, Claudia M. Campbell, Johannes Thrul, Salahadin Abdi, Eileen D. Hacker, Constance M. Johnson, Thomas J. Smith

Abstract Purpose Chemotherapy-induced neuropathy (CIN) is a persistent condition that impairs function and quality of life. Auricular point acupressure (APA) has shown short-term benefit for CIN, but the durability of these effects after treatment completion is unknown. This study evaluated the sustainability of symptom improvements for 3 months following a 4-week APA intervention. Methods This prespecified secondary analysis of a randomized wait-list controlled trial compared mobile-supported APA (mAPA) and virtua …