Frontiers in Endocrinology
Weekly long-acting growth hormone versus daily growth hormone therapy on quality of life, efficacy, and safety in children with short stature: a systematic review and meta-analysis
Background This meta-analysis aims to compare the QoL, efficacy, and safety of once-weekly LAGH versus daily GH in children with short stature. Methods We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science from inception to June 30, 2026, for studies comparing LAGH with daily GH in children with short stature. Outcomes of interest encompassed QoL, efficacy, and safety. Pooled analyses were conducted using a random-effects model. Treatment effects for continuous and dichotomous variable …