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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Cell and Developmental Biology

Antibacterial polyphenols for osteomyelitis treatment: from antibacterial mechanisms to biomaterial-based delivery

Xuemei Cao, Yuanmin He, Yamin Zhu, Ping Gu, Ting Dai, Yuyu Zheng

Osteomyelitis is a refractory infection caused by bacterial invasion of bone tissue. Biofilms, small-colony variants (SCVs), and intracellular persistence enable bacteria to evade immune clearance and antibiotic killing, while sequestra and implant surfaces may act as long-term infection reservoirs. Some pathogens can also invade the osteocyte lacuno-canalicular network, further hindering complete eradication. Meanwhile, persistent inflammation, oxidative stress, and impaired local blood supply aggravate bone destr …

03.09.2026journal-article

Pediatric Blood & Cancer

A Three‐Component Immune Framework Stratifies Treatment Response and Escalation in Pediatric Hemophagocytic Lymphohistiocytosis: A Prospective Single‐Center Cohort Study

Mai Anh Thi Nguyen, Truong Nhat Trinh, Duong Ngoc Mai, Phung Nguyen The Nguyen

ABSTRACT Background Pediatric hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome that can be classified into three principal etiologies (primary HLH [pHLH], Epstein–Barr‐virus‐driven HLH [EBV‐HLH], and secondary HLH [sHLH]) and is associated with disparate outcomes. Treatment escalation decisions remain largely empirical, guided by clinical presentation and conventional laboratory results rather than by an integrated biomarker framework. Procedure We prospectively enrolled 180 consecutive pedi …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential

Qingmiao Shi, Yangni Li, Chaonan Guan

Ferroptosis, an iron-dependent form of regulated cell death, is increasingly recognized as a context-dependent therapeutic vulnerability in cancer, particularly as malignant cells adapt to oxidative, metabolic, and therapy-induced stresses. As a prevalent and reversible epitranscriptomic modification, RNA N6-methyladenosine (m6A) modification orchestrates RNA stability, translation, splicing and decay; consequently, its dysregulation contributes to cancer progression and therapeutic resistance. The intersection of …

03.09.2026journal-article

Eastern Mediterranean Health Journal

Assessing the predictors of treatment-seeking and health care access barriers among transgender individuals in Pakistan

Athar Memon, Sameena Ourangzaib, Benjamin R. Bates, Shiraz Shaikh

Background: Transgender individuals in Pakistan face barriers to health care access, increasing the risk of serious disease transmission. Aim: To identify the predictors of treatment-seeking intention and health care access delays among transgender individuals in Karachi, Pakistan. Methods: Between December 2024 and April 2025 we interviewed 360 individuals, aged ≥18 years, who identified as transgender and had accessed health care within the past 12 months. We analysed the data using SPSS version 20 and conducted …

03.09.2026journal-article

Small

NIR‐II Small‐Molecule Shuttle‐Like Nanoassemblies for Mild‐Temperature NIR‐II Photothermal Enhanced Cuproptosis/STING Activation and Cancer Immunotherapy

Xue Dong, Junfan Zhu, Ying Sun, Nianshu Li, Shipeng Dai, Weiwei Tang, Qunbo Mei, Quli Fan, Pengfei Sun

ABSTRACT The risk of tumor recurrence and insufficient immune responses are formidable challenges for cancer therapy based on mild‐temperature second near‐infrared region (NIR‐II) photothermal therapy (PTT). Herein, we report a multifunctional NIR‐II phototheranostic agent (Cu‐P/MTO@BTS) that integrates shuttle‐like NIR‐II small‐molecule nanoassemblies with copper clusters (Cu‐P) and the STING agonist mitoxantrone (MTO), enabling tumor immunotherapy via synergistic mild‐temperature NIR‐II PTT‐enhanced cuproptosis a …

03.09.2026journal-article

Frontiers in Oncology

Advanced ALK–EML4 fusion–positive non-small cell lung cancer with intraspinal metastases: a case report

Juan Lang, Baoyu Guo, Qi Han, Zhongkui Xiong

Among non-small cell lung cancer (NSCLC) cases, anaplastic lymphoma kinase (ALK)-positive disease is characterized by a chromosomal rearrangement that generates an oncogenic ALK fusion gene, occurring in approximately 2–11% of patients. ALK-positive NSCLC is associated with a high incidence of brain metastases, with at least 20% of patients presenting with brain metastases at the time of diagnosis. Conversely, intraspinal metastasis is an uncommon site of metastatic involvement in patients with NSCLC. When intraspi …

03.09.2026journal-article

Frontiers in Oncology

Contrast-enhanced ultrasound features of primary renal Ewing-like undifferentiated small round cell neoplasm: a case report

Xueling Tang, Jie Xue

This article reports on the diagnosis and treatment of a patient with a renal Ewing-like undifferentiated small round cell neoplasm. The patient, a 56-year-old man, presented to our hospital on March 14, 2025, complaining of “blood clots in the urine for 2 days” and “a mass in the right kidney detected on physical examination 2 days prior.” On March 21, 2025, he underwent a “right renal mass needle biopsy” under local infiltration anesthesia. Postoperative pathology: (right renal mass) malignant tumor with necrosis …

03.09.2026journal-article

Frontiers in Oncology

Prognostic value of a modified lymph node ratio for combined colorectal cancer tumour deposits: a population-based study

Mingming Song, Feihong Wu, Yixin Heng, Tong Nie, Zhihao Liu, Jiaxin Xu, Xiaoyu Wu, Xiaoling Zhi, Wanrui Zhang, Zhixiang Yang, Menghui Dai, Jiaqi Wang, Gang Hu

Background Tumour deposits (TDs) without metastatic lymph nodes are classified as N1c in the 8th edition of the AJCC staging manual. However, the prognostic value of TDs and lymph node ratio (LNR) in stage III colorectal cancer (CRC) remains unclear. This study aimed to compare the prognostic significance of TD count and LNR with the newly developed modified lymph node ratio (mLNR), and to create a prognostic nomogram integrating mLNR for stage III CRC patients. Methods Using the SEER database, a training cohort of …

03.09.2026journal-article

Frontiers in Psychiatry

Pre-treatment serum extracellular vesicle-enriched microbiome profiles and SSRI treatment response in obsessive-compulsive disorder: a prospective naturalistic cohort study

Jee In Kang, Chun Il Park, June-Ho Seo, Chil-sung Kang, Yoon-Keun Kim, Se Joo Kim

Objective The microbiome is emerging as an important component of brain–body communication and may influence treatment outcomes in psychiatric disorders. This naturalistic cohort study prospectively evaluated whether baseline microbiome abundance and composition of circulating bacterial extracellular vesicles (EVs) are associated with subsequent response to selective serotonin reuptake inhibitors (SSRIs) in patients with obsessive-compulsive disorder (OCD). Methods Thirty-two drug-naïve or medication-free patients …

03.09.2026journal-article

Frontiers in Immunology

Overall survival with immune checkpoint inhibitors across treatment settings and clinical and PD-L1-defined subgroups in advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis of randomized trials

Bing Wang, Xiaoyu Han, Zengli Shen

Introduction To quantify overall-survival effects of immune-checkpoint-inhibitor (ICI)-containing regimens by treatment line and to evaluate whether clinical characteristics or PD-L1 definitions modify relative treatment benefit in advanced esophageal squamous cell carcinoma (ESCC). Methods PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were searched from inception through 1 August 2026. Two reviewers independently screened records, assessed full texts, extracted data, and ev …

03.09.2026journal-article

Frontiers in Immunology

Rational design of D(+)-biotin-conjugated resorcinol dibenzyl ethers as tumor-targeted PD-L1 inhibitors for precision cancer immunotherapy

Jing-Jing Du, Rongling Liu, Lei Chen, Jian Zhang

Objectives This study aims to discover and characterize novel D(+)-biotin-conjugated PD-L1 inhibitors for precision tumor-targeted cancer immunotherapy. Methods Integrated strategies, including computer-aided molecular simulation, antiproliferative activity (CCK8) assay, surface plasmon resonance (SPR), pharmacokinetic evaluation, and in vivo antitumor efficacy assessment, were performed. Results Compound SW-1 showed potent and selective inhibitory activity against PD-1/PD-L1 interaction with an IC 50 of 5.6 nM, an …

03.09.2026journal-article

Frontiers in Oncology

A case report of a composite pheochromocytoma that occurred 13 years after adrenalectomy for pheochromocytoma

Min Min, Jie Zhang, Gui-xi Liu, Jing He

Purpose To analyze the clinicopathological features, surgical management, and long-term prognosis of a composite pheochromocytoma (CP; pheochromocytoma combined with ganglioneuroma) arising 13 years after resection of a primary adrenal pheochromocytoma, with the aim of improving the clinical diagnosis and management of this rare neoplasm. Case presentation A 61-year-old Han male had undergone left adrenal pheochromocytoma resection 13 years prior to the current presentation. An asymptomatic left adrenal nodule was …

03.09.2026journal-article

Discover Oncology

Multi omics landscape of AGTRAP in ammonia induced cell death and cervical cancer progression

Yuanjun Li, Xiaodong Mi, Leiying Tang, Purun Zou, Dan Shu, Shilin Lv, Tong Lin

Abstract Background Cervical cancer (CESC) remains a leading cause of cancer-related mortality among women worldwide. Ammonia‑induced cell death, a recently identified metabolic cell death process, plays a significant yet incompletely understood role in tumor progression. Its regulatory mechanisms and clinical relevance in cervical carcinogenesis are poorly defined. This study aimed to elucidate the function of ammonia‑induced cell death in CESC and to identify its pivotal regulatory molecules. Methods Multi-omics …

03.09.2026journal-article

Frontiers in Pharmacology

Extracts from Eryngium heterophyllum Engelm. [Apiaceae] enhance paclitaxel cytotoxicity in A549 lung cancer cells

Blanca Elizabeth Hernandez Solano, Joel Daniel Castañeda-Espinoza, Enrique Salas-Vidal, Araceli Guerrero-Alonso, Janette Furuzawa-Carballeda, Carlos Mojica Cardoso, Abraham Noé Anzurez Jiménez, Jessica Nayelli Sánchez-Carranza, Laura Alvarez

Introduction Chemotherapy resistance is a critical bottleneck in lung cancer treatment, significantly limiting the clinical efficacy of drugs like paclitaxel. This study investigated the cytotoxic and chemosensitizing potential of hexane, acetone, and hydroalcoholic extracts from Eryngium heterophyllum Engelm. [Apiaceae] to enhance therapeutic response in A549 lung cancer cells. Methods Extracts were obtained by maceration and their antiproliferative activity was determined using crystal violet assays. Synergistic …

03.09.2026journal-article

Frontiers in Pharmacology

Sustained improvement in dark-adapted sensitivity but not BCVA after voretigene neparvovec treatment in a mainland Chinese child with biallelic RPE65-associated LCA2: a case report

Yue Ren, Shu Liu, Yanbo Liu, Di Wang, Jia Rong, Wensheng Li, Chunhui Zheng, Ling Xu, Jun Li, Zhuoshi Wang, Jijing Pang

Inherited retinal dystrophies (IRDs) represent heterogeneous genetic eye disorders frequently linked to RPE65 mutations. Voretigene neparvovec (VN, Luxturna), an AAV2-mediated gene therapy, remains the sole approved drug for biallelic RPE65 -associated IRDs. This study presents 3-, 6- and 22-month follow-up findings of the first mainland Chinese patient with compound heterozygous RPE65 -related Leber congenital amaurosis type 2 (LCA2) receiving sequential bilateral subretinal Luxturna injections. Binocular full-fie …

03.09.2026journal-article

Forum

Krebsprävention in der deutschen Bevölkerung

Andrea Gaisser, Ursula Will

Zusammenfassung Hintergrund Trotz der zentralen Rolle der Krebsprävention für die Verringerung der Krebslast werden entsprechende Empfehlungen inkonsistent umgesetzt. Eine repräsentative Befragung soll Einblicke in Risikowahrnehmung, Einstellungen und Informationsbedarf in der Allgemeinbevölkerung und Hinweise für die Gestaltung von Information und Strategien zur Förderung der Prävention geben. Methoden Im November 2023 wurde eine bevölkerungsrepräsentative Befragung ( n = 1581) in Deutschland mittels persönlich-mü …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

Mechanical observables of cancer invasion: actin, adhesion, and metastatic plasticity

Subhajit Dutta, Sushree Sulava

Cancer invasion is commonly classified through epithelial-mesenchymal plasticity, yet cells with similar transcriptional states can differ substantially in force production, cytoskeletal organization and collective mobility. We critically examine whether mechanical measurements can supply information that is not already contained in molecular or histopathological classifications. The available evidence does not justify a universal five-dimensional phase space. It supports a more restrained hierarchy: primary measur …

03.09.2026journal-article

Pediatric Blood & Cancer

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich

ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA protocol for vessel thrombosis and mechanical valve obstruction in infants and children, and to characterize D‐dimer kinetics by indication. Methods This retrospecti …

03.09.2026journal-article

Cells

Context-Dependent Roles of Rnd3 in Cancer: Revisiting a Functional Paradox

Elisa Lledó, Olga Gómez, Alexandra Bizy, Amalia Solana-Orts, José Terrado, Begoña Ballester-Lurbe, Enric Poch

Rnd3 is an atypical member of the Rho GTPase family whose activity is mainly regulated by expression, localization and protein stability rather than canonical GDP/GTP cycling. In cancer, Rnd3 has been described both as a tumor suppressor and as a tumor-promoting factor, creating an apparent functional paradox. We propose that this paradox is resolved by a mechanistic invariant: Rnd3 exerts a conserved inhibition of RhoA/ROCK1-dependent actomyosin contractility, whose phenotypic output is redirected by context-speci …

03.09.2026journal-article

Current Pain and Headache Reports

Evolving Treatment Options for Spinal Pain: Balancing Innovation and Affordability in Regenerative Medicine

Annu H. Navani, Sudhir A. Diwan, Douglas P. Beall, Edward S. Rubin, Ahmed I. Anwar, Alan D. Kaye

Abstract Purpose of Review Regenerative approaches for treating spinal pain hold great clinical promise but have the potential to disrupt healthcare upending the cost paradigm of pharmacologic care or interventional procedures. Regenerative approaches have higher upfront costs but may offer long-lasting, even curative benefits. In today’s healthcare system, it is important to understand the cost-effectiveness of regenerative approaches using mesenchymal stem cells (MSC), platelet-rich plasma (PRP), and other biolog …

03.09.2026journal-article

Frontiers in Computer Science

Tri-fusion deep learning model for early breast cancer screening using multimodal biomedical data

J. Lilly Roseline Mary, R. Venkatesan, M. Mythily, D. Jasmine David

To optimize the early detection of breast cancer, a strong integration of heterogeneous biomedical signals is essential to improve diagnostic reliability and reduce false negatives. This study proposes a Tri-Fusion deep learning model for timely breast cancer screening, which integrates White Blood Cell (WBC) morphological features, mammogram image embeddings, and gene mutation signatures within a unified multimodal framework. WBC features are extracted from peripheral blood smear images using a CNN-based morpholog …

03.09.2026journal-article

Frontiers in Neuroscience

Functional recovery patterns from discharge to 12 months after endovascular treatment for aneurysmal subarachnoid hemorrhage: a multicenter cohort study

Qiao Wu, LongXiang Ma, Yang Chen, ZhenRan Zhao, JinFang Liu, Bin Zhang, HeChun Xia

Background Functional status after aneurysmal subarachnoid hemorrhage (aSAH) may improve after discharge, but paired assessments at discharge and long-term follow-up have rarely been used to distinguish delayed recovery from persistent disability. We characterized discharge-to-12-month recovery patterns after endovascular treatment and identified factors associated with persistent disability among patients with poor functional status at discharge. Methods This multicenter retrospective cohort study consecutively en …

03.09.2026journal-article

Frontiers in Psychiatry

Psychosocial recovery and nutritional rehabilitation in residential treatment for anorexia nervosa: an exploratory longitudinal multi-frequency bioelectrical impedance analysis study

Francesco Monaco, Annarita Vignapiano, Stefania Landi, Rossella Bonifacio, Daniela Falchetta, Emanuela Ferrara, Ernesta Panarello, Bruno Attianese, Annaluce Caputo, Luca Steardo, Gennaro Sosto, Giulio Corrivetti

Background Nutritional rehabilitation is widely considered a prerequisite for recovery in anorexia nervosa (AN), given the profound effects of malnutrition on cognitive, emotional, and behavioral functioning. However, whether psychiatric improvement during residential treatment is directly coupled with the degree of nutritional restoration remains insufficiently understood. This study investigated longitudinal changes in body composition and psychosocial outcomes during residential psychiatric rehabilitation for AN …

03.09.2026journal-article

Frontiers in Environmental Engineering

Non-target analysis for wastewater treatment evaluation: strategies, applications, and future directions

Isra Koko, Fares AlMomani, Muhammad Zia UR Rahman Hashmi, Sophia Ghanimeh

Non-target analysis (NTA), based on high-resolution mass spectrometry (HRMS), is increasingly used to characterize the complex chemical composition of wastewater and evaluate the fate of emerging contaminants (EC) during treatment. However, despite its growing application, the use of NTA for wastewater treatment evaluation remains fragmented across the literature, with existing reviews focusing primarily on analytical workflows, contaminant identification, or environmental monitoring rather than treatment performan …