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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Public Health

Predicting 6-month decisional regret among family surrogate decision-makers of ICU patients: development and internal validation of prediction models

Xiaoyan Gong, Weijing Sui, Chuchu Zhang, Chaoyi Zhang, Yiyu Zhuang

Aim To develop and internally validate prediction models estimating the individual probability of high decisional regret at 6 months among family surrogate decision-makers (FSDMs) of intensive care unit (ICU) patients, and to compare regression-based and machine-learning approaches with respect to discrimination, calibration and clinical utility. Design A single-center prospective cohort study for the development and internal validation of prediction models. Methods This single-center observational prediction-model …

03.09.2026journal-article

Frontiers in Public Health

Self-care strategies and interventions to address antimicrobial resistance: evidence review and recommendations for national programs, service providers, caregivers, and self-carers

Reuben Kiggundu, J. P. Waswa, Fahad Lwigale, Herman Mwanja, Mackline Hope, Conrad Tumwine, Rodgers Rodriguez Ayebare, Andrew Kambugu, Dathan M. Byonanebye, Francis Kakooza

Background Antimicrobial resistance (AMR) poses a significant global health threat, disproportionately affecting low- and middle-income countries where fragile health systems struggle to respond effectively. Self-care strategies and interventions present a complementary approach to support antimicrobial stewardship by empowering individuals to prevent and manage infections with appropriate tools and guidance. Objective and key concepts This narrative review provides an interpretive synthesis of the role of self-car …

03.09.2026journal-article

Arteriosclerosis, Thrombosis, and Vascular Biology

Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease

Joseph H. McCarty

The blood-brain barrier (BBB) is a highly specialized interface between the central nervous system and the peripheral circulation, crucial for maintaining neuronal homeostasis and protecting the brain parenchyma from potentially harmful blood-borne substances. This review examines the molecular and cellular organization of the BBB and explores how defective cell adhesion and signaling networks lead to BBB pathologies. I discuss the intricate architecture of brain endothelial cells within the context of the larger m …

03.09.2026journal-article

Frontiers in Nutrition

Vitamin D status, metabolic determinants, and association with MASLD: retrospective health-screening cohort mediation analysis

Hui He, Yanfang Xie, Rui Peng, Xiao Pan, Han Xue, Meiyan Chen, Dong Du, Qian Ge, Yan Wu, Mingfei Wang, Yuanxiang Wang, Qingshan Geng, Weiqing Wu

Background The relationship between vitamin D and metabolic dysfunction–associated steatotic liver disease (MASLD) remains controversial due to confounding by metabolic risk factors. We aimed to evaluate the association between vitamin D status and MASLD and examine the extent to which metabolic factors statistically contribute to this association. Methods In this large retrospective cross-sectional health-screening cohort study, 35,468 adults (mean age 46.3 years [SD 11.8]) undergoing routine health examinations w …

03.09.2026journal-article

Frontiers in Psychiatry

Prevalence, role impairment, and mental health service utilization of depressive disorders among community-dwelling older adults in China

Dandan Wang, Xiaofei Hou, Zhaorui Liu, Yueqin Huang, Shuiyuan Xiao, Lingjiang Li, Tingting Zhang, Jie Yan, Yaqin Yu, Xiufeng Xu, Zhizhong Wang, Yifeng Xu, Tao Li, Xiangdong Xu, Limin Wang, Yongping Yan, Minghui Li, Guangming Xu, Huifang Yin

Background Depressive disorders pose a significant public health burden, particularly among older adults. However, their prevalence, associated factors, role impairment, and mental health service utilization patterns among community-dwelling older ay -30dults in China remain understudied. Methods The data for this study were obtained from the China Mental Health Survey (CMHS) among participants aged 60 years and older. The World Health Organization Composite International Diagnostic Interview Version 3.0 (CIDI 3.0) …

03.09.2026journal-article

Prävention und Gesundheitsförderung

Gesundheitsfachkräfte an Grundschulen in Bremen

Lisa Kühne, Pernilla Garmy, Eva Quante-Brandt

Zusammenfassung Hintergrund Der öffentliche Gesundheitsdienst (ÖGD) setzt im Sinne der kommunalen Gesundheitsförderung evidenzbasiert Interventionen um, die die Einwohner:innen in ihrem gesunden Verhalten unterstützen. Im Land Bremen werden Gesundheitsfachkräfte an Schulen eingesetzt, die nach dem Sozialmonitoring und den Erkenntnissen aus der Gesundheitsberichterstattung (GBE) priorisiert werden. Methoden Dieses Positionspapier ordnet dieses Beispiel der evidenzbasierten kommunalen Gesundheitsförderung nach der Li …

03.09.2026journal-article

Phytotherapy Research

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka

ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as valerolactones and glucuronides, which support the growth of several beneficial bacterial species including Bifidobacterium and Lactobacillus while inhibiting harmfu …

03.09.2026journal-article

European Journal of Pediatrics

Autoimmune and lymphoproliferative outcomes after Kawasaki disease: a 20-year population-based cohort study

Rim Kasem Ali Sliman, Nadin Shalaby, Hilla Cohen, Dana Hadar, Inbal Halabi, Mohamad Hamad Saied

Abstract Kawasaki disease (KD) is an acute systemic vasculitis of childhood associated with profound immune dysregulation that may persist beyond the acute inflammatory phase. The long-term risks of autoimmune diseases and lymphoproliferative malignancies in children with KD remain incompletely defined. To determine whether children with KD carry increased 20-year risks of autoimmune and lymphoproliferative outcomes compared with matched controls. We conducted a retrospective matched cohort study using the Clalit H …

03.09.2026journal-article

Scientific Journal of Pediatrics

Procalcitonin Read Outside Its Derivation Population and an Antibiotic Course Ended by the Calendar: A Late Preterm Neonate with Transient Tachypnoea of the Newborn Managed as Probable Early-Onset Sepsis

Deril Ridwan, Eny Yantri, Benny Sana Putra

Background: Respiratory distress in a late preterm neonate forces an early choice between transient tachypnoea of the newborn and pneumonia with early-onset sepsis, usually before any confirmatory result exists. Objective: To audit how biomarkers and an antibiotic stop rule were interpreted in a late preterm neonate managed as probable early-onset sepsis. Methods: This CARE-guided case report reviewed the de-identified clinical record, re-read each test against its derivation population, and recomputed clinical, re …

03.09.2026journal-article

Frontiers in Education

Qualitative and probability-based analysis of student open-ended responses on academic stress and mental health

Jyoti Badge, Krishna Thakkar

Likert-scale instruments capture how much stress students report, but not what shape that stress takes. We present a thematic and probability-based analysis of open-ended survey responses from 217 graduate students at a private university in central India, collected in July 2025. Students described how academic stress had affected their mental health and proposed institutional changes they considered necessary. Seven stressor themes were extracted through inductive coding following the Braun and Clarke framework. A …

03.09.2026journal-article

Frontiers in Pediatrics

Comparing Chinese-language large language models for caregiver questions about developmental dysplasia of the hip

Fangyuan Wang, Xianhong Li, Yinghui Guan, Jiaqi Tian, Le Xu, Bing Huang, Jianhui Xie

Background Large language models (LLMs) are increasingly used for caregiver-facing health information, but their reliability in Chinese-language pediatric orthopaedics remains uncertain. This study evaluated whether responses to developmental dysplasia of the hip (DDH) questions were clinically accurate, aligned with Chinese guidance, and educationally usable. Methods We compared ChatGPT-4o and DeepSeek-R1 using 53 Chinese-language DDH questions, including 31 caregiver-oriented frequently asked questions and 22 gui …

03.09.2026journal-article

Frontiers in Digital Health

Objective quantification of suckling biomechanics in infants with and without tongue-tie using hydraulic differential-pressure recording and machine learning

Lene Dahl Siggaard, Serguei Chiriaev, Anders Kramer Knudsen, Torben Lildholdt

Introduction Objective assessment of infant suckling biomechanics remains limited despite decades of pressure-based measurement research, and tongue-tie (ankyloglossia) is still largely evaluated using semi-quantitative anatomical scoring. We developed a hydraulic differential-pressure device — the electronic baby bottle (EBB) — designed to record real-time net intraoral mechanical load during nutritive suckling through a fluid-filled sensing cavity with a controlled air inclusion coupled to a differential pressure …

03.09.2026journal-article

Frontiers in Pediatrics

Characteristics of gut microbiota in children with language developmental delay

Yawen Li, Shouyi Wang, Huiping Xu, Xuan Nie, Dongchi Zhao, Wenkai Zhu, Rui Zhu

Objective To explore the characteristics of gut microbiota in children with Language Developmental Delay (LDD). Methods Children aged 0–6 years diagnosed with LDD at the Pediatric Outpatient Department of Zhongnan Hospital of Wuhan University, and healthy children undergoing physical examinations during the same period (June 2023 to June 2024) were enrolled as study subjects. Fecal samples were collected, and the characteristics of gut microbiota were assessed using 16S rDNA high-throughput sequencing. Results A to …

03.09.2026journal-article

Frontiers in Public Health

Exploring the factors associated with diabetes and hypertension complications among refugees living in Egypt

Noura Seada, Sungsoo Chun

Introduction Non-communicable diseases (NCDs) account for 74% of global deaths, with high global prevalence of diabetes and hypertension. Egypt hosts over 1 million refugees and asylum seekers, with systematic difficulties in the access to healthcare services. This study assessed factors associated with Type 2 Diabetes (T2D) and Hypertension (HTN) complications among Syrian and Sudanese refugees in Egypt, focusing on healthcare access, sociodemographic characteristics, lifestyle, and health behaviors. Methods This …

03.09.2026journal-article

Frontiers in Public Health

Online-dominant self-management is associated with lower, while hybrid mode is associated with higher, quality of life: a community-based cross-sectional study

Xuanyu Wang, Fan He, Qinli Zhang, Yang Meng, Ting Chen, Ye Zhu

Background Health-related quality of life (HRQoL) is an important outcome measure for evaluating community health interventions. Exploring effective community-based health self-management strategies is of practical significance in the context of population aging. This study compared the associations of different activity delivery modes (hybrid online-offline, offline-dominant, and online-dominant) implemented within community health self-management groups on residents’ HRQoL, and explored associations with activity …

03.09.2026journal-article

Discover Public Health

A scoping review protocol on knowledge, perceptions and attitudes toward cervical cancer among Ghanaians

Isaac Aidoo Erzuah, Christiana Asiedu, Amidu Alhassan, Ernest Addae

Abstract Introduction Cervical malignancy remains a major public health challenge in low- and middle-income countries, with sub-Saharan Africa bearing a disproportionate burden of disease. In Ghana, cervical cancer incidence and mortality remain high despite the availability of effective preventive measures, including human papillomavirus (HPV) vaccination and screening. Knowledge, perceptions, and attitudes influence uptake of cervical cancer prevention services, yet evidence from Ghana remains limited. This scopi …

03.09.2026journal-article

The Indonesian Journal of International Clinical Legal Education

Legal Education and Child-Responsive Digital Reporting Systems for School Bullying Victims

Anis Widyawati, Diyah Satya Retnani

School bullying remains a significant challenge in educational institutions, affecting children's psychological well-being, academic performance, and access to justice. Despite the existence of legal protection frameworks and anti-bullying policies, many cases remain unreported due to fear of retaliation, limited legal awareness, social stigma, and the absence of child-friendly reporting mechanisms. This study aims to examine the role of legal education as the foundation for developing child-responsive digital repo …

03.09.2026journal-article

Frontiers in Public Health

Mortality trends and influencing factors of mental disorders among urban and rural residents in China between 2009 and 2021: a longitudinal study with projections to 2030

Kaiyao Shen, Chenghao Wu, Wenhui Kong, Xu Wang, Yujie Zhao, Xueying Wang, Shan Hong, Hui Li

Introduction Mental disorders pose a major public health challenge in China, with marked urban–rural disparities in resources and outcomes. However, long-term mortality trends, their influencing factors, and future projections across urban and rural areas remain underexplored. This study aimed to analyze these mortality trends, identify relevant factors, and project mortality to 2030 using national data from 2009 to 2021. Methods Data were extracted from the China Health Statistical Yearbook , the China Health and …

03.09.2026journal-article

BMC Pediatrics

Ring chromosome 7 syndrome with severe hypertriglyceridemia and mild echocardiographic abnormalities: a case report

Ruiting Ma, Yan Liu, Feng Wei

Abstract Background Ring chromosome 7 [r(7)] is an extremely rare constitutional chromosomal abnormality. The most frequently reported features include growth retardation, pigmented skin lesions, and microcephaly. However, the full phenotypic spectrum remains incompletely defined, particularly with regard to metabolic abnormalities and mild cardiovascular findings. Case presentation We report a 14-year-old Chinese girl referred for severe short stature. She had microcephaly, mild-to-moderate intellectual disability …

03.09.2026journal-article

BMC Public Health

Socio-economic factors associated with online health information seeking in the European Union: a panel data analysis (2016–2024)

Hasan Fehmi Demirci

Abstract Objective This study aims to investigate socio-economic factors associated with online health information seeking in the digital health environment across 27 European Union countries between 2016 and 2024. Method The analysis used a balanced panel dataset comprising 27 European Union countries for the period 2016 through 2024. The independent variables used include tertiary education attainment, income inequality (Gini coefficient), GDP per capita, internet access, age dependency ratio, and government and …

03.09.2026journal-article

Medical Technology and Public Health Journal

Effectiveness of Specific Interventions to Address Stunting in East Java Province in 2023: An Ecological Analysis

Nurul Jannatul Firdausi, Cicik Swi Antika, Agung Dwi Laksono, Waritsah Sukarjiyah

The Indonesian Health Survey in 2023 indicates that the prevalence of stunting in Indonesia remains high, at approximately 21.5%. The objective of the present study is to evaluate the efficacy of specific strategies designed to mitigate stunting in East Java Province. The research utilised secondary data, which was gathered ecologically. The study utilised a cross-sectional design, with the prevalence of stunting serving as the dependent variable and eleven distinct interventions as independent variables. The analy …

03.09.2026journal-article

The Economic and Labour Relations Review

When work hurts: The health consequences of job stress and part-time work among a longitudinal sample of older European workers

Sabela Siaba, Berta Rivera, Luis Currais

Abstract In the context of population ageing and extended working lives, understanding how employment quality affects older workers’ health is of growing policy relevance. Although previous research has linked working conditions to health, significant gaps remain in panel designs, unobserved heterogeneity, measurement validity, and sample representativeness. Using longitudinal microdata from the Survey of Health, Ageing, and Retirement in Europe (SHARE), we estimate individual fixed-effects models over a 12-year pe …

03.09.2026journal-article

Frontiers in Public Health

Explainable ensemble transfer learning for skin lesion classification with multi-method explainability validation

Nemili Sravani, Srinivas Koppu

Introduction Skin cancer is among the most prevalent and life-threatening malignancies worldwide. Early and accurate detection significantly improves therapeutic outcomes. Automated classification of dermoscopic skin lesions remains challenging due to class imbalance, inter-class visual similarity, and lack of interpretable predictions. This study proposes an accurate and interpretable weighted soft voting ensemble for multi-class skin lesion classification. Methods A weighted soft voting ensemble of three heteroge …

03.09.2026journal-article

Frontiers in Medicine

Fulminant group A streptococcal necrotizing fasciitis presenting as severe calf pain after pharyngitis in an adolescent: a case report

Lisa Roncoroni, Jan Kühle, Lampros Kousoulas, Katharina Müller-Peltzer, Dawid L. Staudacher

Background Invasive Group A Streptococcus (GAS) infection can rapidly progress to life-threatening conditions, including necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS). While typically associated with cutaneous breaches or underlying comorbidities, hematogenous seeding following primary pharyngeal infection is a rare but documented phenomenon. Early diagnosis is often complicated by subtle skin changes and the rarity of the disease. Case A previously healthy 17-year-old female presented wi …