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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Public Health

Lung cancer screening in occupational settings: a scoping review

Edelqueen Ijeoma Okoro, Helena Keller, Felix Greiner, Jan Heidrich, Volker Harth

Background Lung cancer is the leading cause of cancer-related mortality worldwide. It is often asymptomatic until advanced stages, resulting in delayed diagnosis and poor survival. Screening enables early detection and reduces mortality. Multiple occupational and environmental exposures have been linked to lung cancer, and some guidelines recommend their inclusion in risk assessment. This review aims to map the existing evidence on lung cancer screening (LCS) in occupational settings. Methods This review followed J …

27.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of psychological interventions on competitive anxiety and athletic performance in golfers: a systematic review and meta-analysis

Longhui Li, Zilong Zhao, Xuewen Li, Yang Yi

Abstract Background Competitive anxiety is common in golf and can negatively affect athletic performance. Psychological interventions are widely used to manage competitive anxiety and enhance performance; however, evidence specific to golfers has not yet been systematically synthesized. This study aims to evaluate the effects of psychological interventions on competitive anxiety and athletic performance in golfers. In addition, subgroup analyses were conducted to explore potential sources of variation in interventi …

27.08.2026journal-article

ACS Biomaterials Science & Engineering

Folic-Acid-Modified Fe-TCPP Metal-Organic Frameworks as Sonosensitive Agents and siATAD3A Carriers for Sonodynamic Co-Gene-Ferroptosis Therapy in Triple-Negative Breast Cancer

Yang Du, Jiangnan Yang, Shuai Chen, Xiaoxin Yang, Yian Wang, Yiyuan Yang, Deyuan Fu

Abstract Triple-negative breast cancer (TNBC) represents the most aggressive form of breast cancer and is associated with the worst prognosis. Ferroptosis holds great promise as an emerging therapeutic strategy; however, TNBC cells demonstrate reduced sensitivity to ferroptosis as a result of elevated mitochondrial membrane potential (MMP), inadequate production of reactive oxygen species (ROS), and the presence of activated antioxidant defencses, making it difficult for lipid peroxidation to accumulate to a lethal …

27.08.2026journal-article

Cancer Immunology Research

CD4+ T Cells Play Distinct Roles during the Priming versus Effector Phases of Immune Checkpoint Therapy–Dependent Tumor Elimination by CD8+ T Cells

Samuel Ameh, Derek J. Theisen, Mahima Thapa, Jackson S. Turner, Abhinav Rangarajan, Christopher A. Nelson, Aaron J. Schmitz, Yuang Song, Ruan F. Vieira Medrano, Cora D. Arthur, J. Michael White, Kathleen C.F. Sheehan, Daved H. Fremont, Ali H. Ellebedy, Hussein Sultan, Robert D. Schreiber

Abstract It is well established that CD4+ T cells play a critical role in facilitating immune checkpoint therapy (ICT). Although CD4+ T-cell function in lymph nodes during CD8+ T-cell priming has been well investigated, their requirement at the effector phase in the tumor is only now beginning to be appreciated. Herein, we used our major histocompatibility complex class II–negative (MHC-II−) sarcoma models to confirm that CD4+ T cells are essential not only during T-cell priming but also to maintain T-cell effector …

27.08.2026journal-article

PLOS Digital Health

Extracting adverse event nature, severity, timelines and resulting interventions from clinical notes of patients receiving CAR-T cell therapy using large language models

Jordan Guillot, Brenda Miao, Arvind Suresh, Madhumita Sushil, Christopher Y. K. Williams, Rohit Vashisht, Tomiko T. Oskotsky, Marina Sirota, Atul J. Butte

Chimeric Antigen Receptor T-cell (CAR‑T) therapy, genetically engineered patient T cells targeting tumor antigens, has transformed care for hematologic malignancies but requires careful tracking of adverse events (AEs) often documented only in unstructured electronic health record (EHR) notes. We evaluated a Large Language Model (LLM)–based approach in UCSF’s secure environment to extract AEs, dates, grades, and interventions within 30 days post‑infusion for six commercial CAR‑T products (2012–2023), benchmarking a …

27.08.2026journal-article

Micromachines

From Signal Stacking to Dynamic Coupling: A Critical Review of Wearable EEG–EMG Fusion Brain–Computer Interfaces for Stroke Rehabilitation

Mengna Dai, Mingke Jiao, Yuheng Wang

This structured critical review examines wearable brain–computer interface (BCI) systems that integrate electroencephalographic (EEG) and electromyographic (EMG) signals for post-stroke motor rehabilitation. The central engineering problem is the spatio-temporal heterogeneity between cortical and muscular signals, which limits the reliability and generalizability of conventional EEG–EMG fusion. We review acquisition and synchronization methods, data-, feature-, and decision-level fusion, deep-learning architectures …

27.08.2026journal-article

Scientific and Technical Journal of Information Technologies, Mechanics and Optics

Deep learning for speech enhancement: architectures, paradigms, and emerging trends

D. V. Ivanko

A systematic review of modern neural network methods for Speech Enhancement is presented, aimed at improving speech intelligibility and quality under acoustic distortions. The reviewed methods can be applied in voice control systems, telecommunications, hearing aids, and human–machine interaction interfaces. Key architectural approaches are considered, including classical recurrent and convolutional networks as well as modern hybrid architectures with attention mechanisms (Transformer, Conformer), state-space model …

27.08.2026journal-article

Applied Sciences

Voice-Controlled Intralogistics on an Open Cyber–Physical Middleware: Deep Learning-Based Speech Processing and Validation in an Industrial Noisy Environment

Predrag Pecev, Marinko Maslarić, Vladimir Todorović, Saša Sudar, Svetlana Nikoličić

The rapid development of Industry 4.0 brings significant benefits to intralogistics through increased flexibility, interoperability, and real-time responsiveness. However, the growing complexity of industrial environments creates challenges for logistics process adaptation and the integration of emerging technologies such as voice-driven control of heterogeneous robotic and IoT systems. Open-source solutions offer a promising approach by enabling vendor independence and cost-effective deployment. This paper investi …

27.08.2026journal-article

Frontiers in Nuclear Medicine

Artificial intelligence across oncologic theranostics: evidence for patient stratification, dosimetry, and adaptive radiopharmaceutical therapy

Mallareddy Banala, Shabbir Ezuddin, Mark Foley, Russ Kuker

Artificial intelligence (AI) has been studied across radiopharmaceutical therapy (RPT); however, evidence for treatment-changing use remains limited. We conducted a structured narrative review with descriptive mapping of learned models for patient stratification, segmentation, tumor-burden quantification, quantitative preprocessing, dosimetry, toxicity prediction, response assessment, and radiation-safety/logistics support. The mapped set contained 73 direct full journal reports and eight direct conference abstract …

27.08.2026journal-article

Neuro-Oncology

15 Promoting the need for a dedicated Neuro‑Oncology Occupational Therapy Service at QEHB: A Quality Improvement Project

Megan Jones

Abstract Introduction This project highlights the role of Occupational Therapists (OTs) in supporting the neuro‑oncology patient population at the Queen Elizabeth Hospital Birmingham (QEHB). Although the OT service is well established, there is currently no structured pathway to ensure that patients with brain cancer receive optimal pre‑ and post‑operative management. This patient group is also at risk of inadequate follow‑up after discharge, re-affirming the need for service development and targeted investment. Me …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Investigating Microglia Phenotype at the Chronic Stage of Ischemic Stroke After Gene Therapy with AAV-NeuroD1

Naomi Hawreluk

Ischemic stroke remains a leading contributor to mortality and long-term neurological disability worldwide. While improvements in emergency care have increased survival rates, most effective clinical interventions are largely restricted to the acute phase of injury. As a result, increasing attention has shifted toward understanding cellular processes that influence tissue remodelling and recovery during the chronic stage. Microglia, the resident immune cells of the central nervous system, play a critical role in sh …

27.08.2026journal-article

Advances in Physiology Education

Physiology of menopause and the role of hormone therapy

Sabyasachi Moulik

Natural menopause, a biological transition in women, is often underrepresented in medical education, leading to knowledge gaps among healthcare professionals. This Staying Current article aims to provide physiology educators with an updated, comprehensive overview of menopause, including its physiological basis, symptomatic manifestations, systemic effects, and the current controversies and benefits surrounding menopausal hormone therapy (MHT). This article details the hormonal regulation of reproductive aging, the …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Combined Strategy of Targeted Therapy and Immunotherapy for Bladder Cancer

Zonghua Wang

Bladder cancer is a highly prevalent malignant tumor in the urinary system worldwide, and the treatment has been long facing significant challenges. Immunotherapy represented by PD-1 (programmed death receptor-1)/PD-L1 (programmed death ligand-1) inhibitors and targeted therapies such as antibody-drug conjugates have already changed the landscape. However, the efficacy of a single drug is limited, and the problem of drug resistance is quite prominent. The combined treatment strategy, through the deep synergy of pha …

27.08.2026journal-article

Alzheimer's Research & Therapy

Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP)

Claudia Schwarz, Stefan Frenzel, Till Ittermann, Ulrike Grittner, Silke M Wortha, Tina Brzoska, Hans J Grabe, Agnes Flöel, Friedrich Ihler

Abstract Background Hearing loss has been reported as a major, potentially modifiable risk factor for dementia and often co-occurs with tinnitus. Both conditions are prevalent and have been linked to brain health and cognitive decline. However, evidence from studies containing the whole age span of adults remains limited. Therefore, this study investigated associations of hearing loss and tinnitus with brain structure and cognitive performance in a large population-based cohort from northeastern Germany. Methods Da …

27.08.2026journal-article

Biomedicines

From Delivery to Design: Site-Specific Genome Engineering for Next-Generation CAR T-Cell Therapy

Hala Aldahshan, Abeer Al-Hubaysh, Dimah K. Alrabiah, Meshael Alturki, Reem R. Alkharji, Salwa Lin, Mohammed S. Aldughaim, Raef Albugami

Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of haematological malignancies, but conventional viral transduction results in semi-random genomic integration, contributing to heterogeneous CAR expression and potential insertional effects. Site-specific genome engineering offers an alternative by directing CAR insertion to defined genomic loci, allowing greater control over transgene expression and cellular function. This narrative review evaluates advances in site-specific CAR T-cell e …

27.08.2026journal-article

Genetics and Molecular Research

EFFECTIVENESS OF VIRTUAL AND AUGMENTED REALITY-BASED INTERVENTIONS COMPARED WITH CONVENTIONAL PHYSIOTHERAPY FOR IMPROVING SENSORIMOTOR SKILLS IN CHILDREN WITH AUTISM SPECTRUM DISORDER: A PILOT RANDOMIZED CONTROLLED TRIAL

Srilakshmi. J, Veenakirthika. S, Senthilkumar N, Selvaraj Sudhakar

Background: Autism Spectrum Disorder (ASD) is linked to deficiencies in motor coordination, sensory processing, and sensorimotor integration, all of which can have a detrimental impact on independence in day-to day activities Virtual reality (VR) and augmented reality (AR) are emerging tools to enhance rehabilitation outcomes in paediatric populations. Objective: To evaluate the efficacy of traditional physiotherapy with VR and AR-based training in enhancing sensorimotor and functional results in kids with ASD. Met …

27.08.2026journal-article

HRB Open Research

Pilot of a person-centred, interdisciplinary approach to goal setting in Ireland’s National Rehabilitation Hospital: a study protocol

Lauren Christophers, Zsofia Torok, Catherine Cornall, Aine Carroll

Background Research has emphasised the value of a person-centred, interdisciplinary team (IDT) approach to structured goal setting in rehabilitation; yet these approaches are not consistently implemented in clinical practice, limiting the effect that goal setting can have on rehabilitation. The introduction of a new IDT, person-centred goal-setting process to Ireland’s National Rehabilitation Hospital (NRH) offers an opportunity to gain insight into barriers to implementing and normalising IDT goal setting in compl …

27.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Early Organization of Simultaneous Multimodal Behaviors: Perception- and Production-Based Contingencies as a Scaffold for Language Development

Bonnie Levin-Asher, Liat Kishon-Rabin

Aim: This study investigated how infants' simultaneous multimodal behaviors (SMBs)—the concurrent coordination of vocal, gaze, facial, and manual signals—are organized during natural caregiver–infant interactions at 3 and 6 months. Within a contingency-based framework, we examined how perception-based and production-based SMBs reflect early multisensory and sensorimotor coordination and how these patterns relate to later language development with the aim of characterizing SMBs as functional units of early communica …

27.08.2026journal-article

International Journal of Health and Pharmaceutical (IJHP)

Hypoglycemia Incidence Among Patients With Type 2 Diabetes Mellitus Receiving Antidiabetic Therapy: A Retrospective Hospital-Based Study in South Kalimantan, Indonesia

Nadiyah Wafa, Tyas Setia Nugraha, Herda Ariyani

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease with an increasing prevalence. Antidiabetic drugs (OAD) are necessary for glycemic control, but they carry the risk of causing hypoglycemia. Objective: This study aimed to assess patient characteristics, OAD usage patterns including drug type, dosage, and regimen, hypoglycemic complaints, and side effect categories using the Naranjo Algorithm. Method: A descriptive, observational quantitative study with a retrospective, non-experimental design was condu …

27.08.2026journal-article

Current Molecular Medicine

Revisiting Macrophage Plasticity: From M1/M2 Polarization to Immune Modulation in Cancer Therapy

Rasheka Mathur, Yasmin Bano, Anshika Gupta, Sakshi Chauhan, Prince Sharma, Dhananjay Dhar Dwivedi, Rohini Saha, Pramod Kumar, Dinesh Kumar Singhal

Macrophages play a key role in organizing the immune system's response to different types of infections. Their remarkable plasticity enables them to develop and polarize into M1 (tumor-suppressing) and M2 (tumor-promoting) macrophages, in addition to Tumor-Associated Macrophages (TAMs). This thorough review examines how distinct signaling inducers affect macrophage polarization and behavior across various cancer types, including breast, lung, hepatocellular, prostate, and cervical cancers. In colorectal cancer, how …

27.08.2026journal-article

Journal of Oral Rehabilitation

Tooth Wear Severity and Temporomandibular Joint Degenerative Findings on Cone‐Beam Computed Tomography: A Cross‐Sectional Study in Adults

Gizem Altundal, Ceyda Deniz Özdemir, Ece Zorlu, Fatma Yüce, Sibel Biren

ABSTRACT Background Tooth wear is commonly assumed to be a marker of parafunctional load and, by extension, of mechanical stress on the temporomandibular joint (TMJ); whether greater wear accompanies greater degeneration in the same joint has rarely been tested. Objective To determine whether tooth wear severity is associated with ipsilateral CBCT‐detected TMJ degeneration in adults with TMD symptoms. Methods In this cross‐sectional study, 80 adults (160 joints; mean age 27 years; 80% female) underwent standardised …

27.08.2026journal-article

Liver International

Impact of PD ‐1 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib‐Based Triple Therapy

Jian He, Jian Chen, Bohua Yu, Fuqun Wei, Weifu Liu, Peishu Huang, Songhui Wu, Xiang You, Zhisheng Chen, Ziqi Lin, Wuhua Guo, Shaowu Zhuang, Yiping Chen, Zhongwu Chen

ABSTRACT Background and Aims The optimal sequencing of programmed cell death protein 1 (PD‐1) inhibitors relative to locoregional therapy (LRT) in unresectable hepatocellular carcinoma (uHCC) remains undefined. This study evaluated the impact of PD‐1 inhibitor timing on outcomes in patients receiving hepatic arterial infusion chemotherapy (HAIC) or transarterial chemoembolisation (TACE) plus lenvatinib and PD‐1 inhibitors. Methods Patients with initially uHCC who received LRT in combination with lenvatinib and PD‐1 …

27.08.2026journal-article

Pediatric Transplantation

Subcutaneous Alemtuzumab as Salvage Therapy for Acute Kidney Transplant Rejection Following Thymoglobulin Anaphylaxis: A Pediatric Case Report

Kevin W. O'Connor, Serena Bagnasco, Cozumel Pruette, Elizabeth Goswami, Olga Charnaya

ABSTRACT Background Acute kidney allograft rejection is a significant cause of graft dysfunction in pediatric transplant recipients. Standard of care for moderate to severe acute T‐cell‐mediated rejection among pediatric transplant recipients includes lymphocyte‐depleting agents such as rabbit anti‐thymocyte globulin (rATG). However, intolerance to or contraindications to rATG may limit its use and necessitate alternative immunosuppressive strategies. Alemtuzumab, a humanized monoclonal antibody targeting CD52, ind …