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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Patient-Reported Outcomes

The SISAQOL-IMI glossary: harmonising terminology for patient-reported outcomes in cancer clinical trials

Kenth Louis Joseph, Francesca Martinelli, Lisa M. Wintner, Silène ten Seldam, Vincent Claus, Andrej Belančić, Ragnhild S. Falk, Cecilie D. Amdal, Micha J. Pilz, Corneel Coens, Martin Taphoorn, Johannes M. Giesinger, Joseph C. Cappelleri, Vivek Pawar, Kristin Bjordal

Abstract Background This study presents the development of a glossary designed to harmonize terminology, foster consensus and support the successful implementation of the Setting International Standards in Analysing Patient-Reported Outcomes and Quality of Life Endpoints in Cancer Clinical Trials-Innovative Medicines Initiative (SISAQOL-IMI) guidelines. Methodology SISAQOL-IMI consortium representatives from 41 international organisations were invited to participate in the development of the glossary. From 2021 to …

03.09.2026journal-article

Clinical Genetics

Biallelic ABCA13 Loss‐of‐Function Variants in a Child With Neurodevelopmental Delay: A Case Report

Maya Atanasoska, Lubomir Balabanski, Daniela Avdjieva‐Tzavella, Tsvetina Veleva, Slavyana Yaneva Staykova, Irena Bradinova, Draga Toncheva, Radoslava Vazharova

ABSTRACT ABCA13 encodes ATP‐binding cassette subfamily A member 13, one of the largest members of the ABC transporter family. Rare ABCA13 variants have been reported in neuropsychiatric and neurodevelopmental phenotypes, including schizophrenia, bipolar disorder, autism spectrum disorder, intellectual disability, and developmental delay; however, the mode of inheritance remains uncertain, and most published cases have focused on heterozygous variants in the context of a possible dominant or susceptibility model. We …

03.09.2026journal-article

International VAT Monitor

VAT in the Digital Economy: Practical Challenges to Implementing the Destination Principle and VAT Collection Mechanisms in Africa

AishaAize Isa, YvetteNakibuule Wakabi

VAT has become the most significant source of tax revenue in many African jurisdictions, rising to an average of 4.5% of gross domestic product in 2022. However, the practical application of the destination principle, which requires taxing final consumption in the jurisdiction of the consumer, and VAT collection mechanisms to support the destination principle, especially on supplies of cross-border services and intangibles, remains technically and administratively challenging. While some countries in Africa have in …

03.09.2026journal-article

Journal of Universal Science Research

THE IMPACT OF PRE-MARITAL MEDICAL EXAMINATION ON YOUTH REPRODUCTIVE HEALTH

Mahmudova E’zoza

The article analyzes the essence, purpose, and practice of the pre-marital (preconception) medical examination system established by law in the Republic of Uzbekistan. The role of pre-marital medical screening in preventing hereditary and congenital diseases, as well as in assessing the reproductive health of prospective spouses, is examined. At the same time, the strengths and weaknesses of the existing system, the attitude of young people toward this process, and proposals for its improvement are presented

03.09.2026journal-article

Brazilian Journal of Implantology and Health Sciences

Endocardite: Desvendando a Microbiologia

Natalia Chilinque Zambão Da Silva, Evandro Tinoco Mesquita

O artigo aborda a atualização recente dos Critérios de Duke para o diagnóstico de endocardite infecciosa, refletindo avanços significativos na compreensão dos patógenos envolvidos e nas técnicas laboratoriais. Tradicionalmente, os Critérios de Duke classificam os microrganismos responsáveis pela endocardite infecciosa como típicos ou atípicos, baseando-se principalmente no número de frascos de hemocultura positivos. No entanto, novas descobertas microbiológicas, combinadas com melhorias em ferramentas diagnósticas …

03.09.2026journal-article

MicrobiologyOpen

Genetic Diversity and Epidemiological Overlap of Staphylococcus aureus at the Animal–Food–Environment–Human Interface Within a One Health Framework

Pinar Sagiroglu, Dursun Alp Gundog, Candan Gungor, Kursat Koskeroglu, Mustafa Altay Atalay, Adalet Dishan, Yeliz Ucar, Aytac Akcay, Huseyin Burak Disli, Harun Hizlisoy, Mukaddes Barel, Tekin Kececi, Nurhan Ertas Onmaz

ABSTRACT This study aimed to assess the genetic diversity and potential epidemiological overlap of Staphylococcus aureus using molecular (spa and SCCmec typing) and phenotypic characterization of 108 isolates obtained along the farm‐to‐fork continuum (dairy and meat chains) and 50 human clinical isolates. Forty‐four spa types, including 17 novel patterns, were identified, with t11284 and t127 predominating among animal‐related MRSA and clinical MRSA, respectively. Six SCCmec types (I–VI) were detected in the majori …

03.09.2026journal-article

Indoor and Built Environment

Causes of PM 2.5 pollution in the atmospheric environment, health risks and economic losses in different geographical administrative regions

Yongbo Cui, Huihui He, Xiaoqing Zhou, Chengliang Fan

PM 2.5 has become a major pollutant in the atmospheric environment, posing a serious threat to people's health and seriously hindering the sustainable development of urban environments. However, there is still limited assessment of the health risks and economic losses associated with PM 2.5 pollution in megacities. Therefore, this study systematically analysed the spatiotemporal distribution characteristics, health risks and economic losses associated with PM 2.5 concentrations in seven typical Chinese cities. The …

03.09.2026journal-article

Nutrition and Health

Potential effects of kombucha on endoplasmic reticulum stress and weight regulation in a high-fat diet-induced obesity model

Didem Korkmaz, Ayşe Gül Mutlu

Background Obesity is increasingly recognized as a global metabolic disease, often accompanied by endoplasmic reticulum (ER) stress, which contributes to the development of metabolic disorders such as insulin resistance and type 2 diabetes. Kombucha, a fermented tea known for its health-promoting effects, has been associated with weight loss and lipid-lowering properties. Aim This study aimed to evaluate the potential effects of kombucha on ER stress in obese rats induced by a high-fat diet (HFD). Methods Fifty mal …

03.09.2026journal-article

Journal of Community Health Provision

Association of Lipid Profile, Glycated Hemoglobin (HbA1c), and Hypertension History with Coronary Artery Disease among Adult Patients: A Cross-Sectional Study

Witi Karwiti, Nasrazuhdy Nasrazuhdy, Wuni Sri Lestari, Nurhayati Nurhayati, Yusneli Yusneli, Asrori Asrori

Coronary artery disease (CAD) remains a major cause of cardiovascular morbidity and mortality worldwide. This study aimed to examine the association of lipid profile, glycated hemoglobin (HbA1c), and hypertension history with CAD among adult patients. A cross-sectional analytical study was conducted among 40 adult patients undergoing cardiovascular evaluation at Abdul Manap Regional General Hospital, Jambi, Indonesia, including 20 patients with CAD and 20 participants without CAD. Demographic characteristics, lipid …

03.09.2026journal-article

F1000Research

Artificial Intelligence-Assisted Community Eye Screening in Primary Healthcare: A Prospective Multicentre Diagnostic Accuracy and Implementation Study

Debapriya Mukhopadhyay, Ankit Varshney, Rajib Mandal, Shoubhik Chakraborty, SK Jahir, Anik Dingal, Apurbayan Biswas, Vishakh Nair, Hlabje Carel Masemola, Swati Mukhopadhyay, Shreyasi Mukherjee, Harinath Mukherjee

Background Artificial intelligence (AI)-assisted retinal screening may extend access to eye care in primary healthcare, but prospective evidence on diagnostic performance and implementation under routine community conditions remains limited. Methods We conducted a prospective multicentre diagnostic accuracy and implementation study across 12 urban and rural community eye-screening centres in India from 1 January to 30 June 2025. Adults aged ≥18 years underwent AI-assisted retinal-image analysis followed by masked c …

03.09.2026journal-article

Frontiers in Political Science

Fear goes viral: the digital securitization of immigration in the 2024 elections

Anastasios Stavropoulos

Introduction Immigration was among the defining issues of the 2024 electoral cycle on both sides of the Atlantic. This study examines how the securitization framing of immigration in campaign discourse — its construction as an existential threat — relates to electoral mobilization, and whether the affordances of social-media platforms amplify that frame. It compares two dissimilar democratic contexts: the 2024 U.S. presidential election and the 2024 European Parliament elections. Methods Combining framing theory an …

03.09.2026journal-article

Frontiers in Neuroscience

Multimodal neuroimaging fusion in presurgical evaluation of drug-resistant epilepsy: current evidence, clinical integration, and future directions

Yuying Zhao, Mingli Wang, Bo Shen, Wei Luo

Approximately 30% of patients with epilepsy are drug-resistant, and for many of them surgical resection of the epileptogenic zone (EZ) offers the best chance of seizure freedom. Because the EZ cannot be measured directly by any single test, it must be inferred from the convergence of complementary imaging markers, and multimodal neuroimaging fusion has therefore become central to modern presurgical evaluation. This critical narrative review examines what each modality—structural MRI, [18F]FDG-PET, ictal SPECT/SISCO …

03.09.2026journal-article

Frontiers in Public Health

Latent class analysis of sleep-related worry and its influencing factors among shift work nurses: a cross-sectional study

Shuangli Zhang, Zhilin Cheng, Jianhong Qiao

Objective To identify the distinct profiles of sleep-related worry among shift-work nurses and explore their influencing factors, thereby providing a basis for developing targeted interventions for nursing management. Methods A convenience sampling method was used to select 653 shift nurses from three tertiary grade A hospitals in Shandong Province from March to July 2025 as the study participants. Data were collected using a general information questionnaire, the Anxiety and Preoccupation about Sleep Questionnaire …

03.09.2026journal-article

Frontiers in Endocrinology

Artificial intelligence in obesity management: clinical evidence, translational gaps, and implementation priorities—a structured narrative review

Wenneng Liu, Jian Zhao, Dan Zhang, Chun Dang, Yaoheng Lu, Xiao Du

Obesity is a chronic, relapsing disease that requires long-term lifestyle treatment, pharmacotherapy, and metabolic and bariatric surgery. Artificial intelligence (AI) is increasingly being studied across these pathways, but its clinical readiness varies substantially. This Scale for the Assessment of Narrative Review Articles (SANRA)-informed structured narrative review searched PubMed/MEDLINE, Embase, Scopus, ScienceDirect, and Google Scholar through 1 June 2026, primarily for literature published since 2015, wit …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Diagnostic accuracy of recombinase polymerase amplification-based assays for mosquito-borne virus detection in clinical samples: a systematic review and meta-analysis

Yonghui Gao, Jihong Chen

Background Mosquito-borne viral diseases pose an important public health threat due to their frequent outbreaks, similar early clinical manifestations, and potential for rapid transmission. Conventional diagnostic methods, such as virus isolation, serological assays and RT-qPCR, are reliable but may be limited by long turnaround time, cross-reactivity, laboratory equipment requirements and trained operators. Recombinase polymerase amplification (RPA)-based methods have emerged as promising tools for rapid detection …

03.09.2026journal-article

Frontiers in Dental Medicine

Making periodontal risk visible: the role of artificial intelligence in recall adherence

Prajakta Karkare

Supportive periodontal care is essential for maintaining periodontal stability after active therapy, yet adherence to periodontal maintenance remains difficult. Once bleeding, halitosis or other presenting concerns improve, some patients may interpret the disease as resolved and the maintenance visit as “just a clean.” This Perspective uses the intention–behaviour gap to examine behavioural, financial and health-literacy barriers to continued supportive care. It then considers a narrower, testable hypothesis: artif …

03.09.2026journal-article

Frontiers in Political Science

Digital transformation of sanitary and epidemiological monitoring: the case of Kazakhstan

Zhanat Saduakassova, Ane Tynyshbayeva, Margarita Kadyrova, Svetlana Beglerova, Anastassiya Makovetskaya, Zhanar Aldashova, Ainagul Kuatbayeva

Introduction This study examines the digital transformation of sanitary and epidemiological monitoring in Kazakhstan and identifies managerial mechanisms supporting timely, coordinated, and data-driven public health responses. Methods The study combines a two-tier comparative analysis of benchmark countries and regional institutional comparators with regulatory review, institutional analysis, digital maturity assessment, national indicators for 2019–2023, and expert evaluation. Results The analysis identifies fragm …

03.09.2026journal-article

Frontiers in Public Health

Early interventions in mental health services: a rapid review of systematic review

Rosina Anna Adu, Medard Kofi Adu, Belinda Agyapong, Vincent I. O. Agyapong

Background Mental health disorders account for a substantial global burden of disease, with many individuals experiencing significant delays in receiving appropriate care. Early intervention has emerged as a key strategy to improve clinical, functional, and economic outcomes across the mental health continuum. Although evidence surrounding early intervention is well established, a broader synthesis of early intervention models across diagnoses, age groups, and service settings has been lacking. Objectives This Rapi …

03.09.2026journal-article

Frontiers in Public Health

Psychosocial determinants of exercise behavior in Parkinson’s disease: a mini-review

Guanyu Zhang

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, characterized by progressive motor and non-motor symptoms that profoundly impact quality of life. Physical exercise has emerged as a promising non-pharmacological intervention with neuroprotective potential, yet adherence rates remain suboptimal. This mini-review synthesizes current evidence on psychosocial determinants influencing exercise behavior in PD patients. Accumulating evidence suggests that psychosocial factors play an importan …

03.09.2026journal-article

Frontiers in Public Health

Superior-head automated external defibrillator placement during single-rescuer cardiopulmonary resuscitation: a randomized crossover simulation study and retrospective multicenter cohort

Daojian Xu, Jingchen Zhang, Honghang Lin, Qiqi Cai, Sheng Zhang, Jueyue Yan

Background During single-rescuer cardiopulmonary resuscitation (CPR), one rescuer must sustain chest compressions while operating an automated external defibrillator (AED), yet the optimal physical position of the AED within the rescuer’s working area is uncertain. The study evaluated whether superior-head AED placement improves the single-rescuer defibrillation workflow. Methods The study combined a randomized four-sequence crossover manikin simulation (32 healthcare providers; 128 evaluable trials) comparing four …

03.09.2026journal-article

Frontiers in Public Health

The role of universities in enhancing interprofessional collaboration during COVID-19 in Lebanon: academia as neutral convener in a public-private twinning initiative—a qualitative case study

Kawthar Jaber Fadlallah, Michèle Kosremelli Asmar, Joumana Stephan Yeretzian

Background The Coronavirus Disease 2019 (COVID-19) pandemic underscored the importance of interprofessional collaboration, including partnerships between academic institutions and healthcare organizations. Such collaborations, however, are challenging to initiate and sustain during public health emergencies. This study examines the role and perceived effectiveness of academic involvement within a public–private twinning initiative designed to strengthen COVID-19 response capacities in Lebanon. Methods Using a quali …

03.09.2026journal-article

Texto Digital

A remediação da poesia para crianças e o “lugar vazio” do texto: uma reflexão a partir da antologia digital tear poético

Jaqueline Conte

A ideia de uma obra literária para crianças ser transposta do meio impresso para o digital, num processo que Bolter e Grusin denominam “remediação” (BOLTER E GRUSIN, 2000), não raro suscita críticas de agentes do próprio ecossistema educativo-literário. Isso porque, utilizando-se dos recursos próprios do meio digital, poderia, supostamente, reduzir a capacidade imaginativa daquele leitor, uma vez que preencheria, a priori, com imagens, sons e recursos interativos, por exemplo, as lacunas deixadas pelo texto escrito …

03.09.2026journal-article

Texto Digital

Contação de história e ensino remoto: desafios e possibilidades na formação de leitores durante a pandemia da covid-19

Aparecida Suiane Batista Estevam, Diana Maria Leite Lopes Saldanha

No presente artigo discutimos acerca dos impactos da pandemia da Covid-19 na formação de leitores por meio da contação de histórias durante o ensino remoto, com foco nos desafios e possibilidades encontrados por duas professoras do Ensino Fundamental – Anos Iniciais, de uma escola pública de Pau dos Ferros/RN. A pesquisa é de abordagem qualitativa, do tipo de campo e utiliza como técnica para a coleta de dados o questionário e a entrevista coletiva. Utiliza uma fundamentação teórica com base em autores como Alves ( …

03.09.2026journal-article

Journal of Technology and Humanities

Perceived Impact of Artificial Intelligence on Work-Related Stress Among Nigerian Radiographers: A Cross-Sectional Survey

Shakirah G. AbdulAzeez, Kudirat Lawal-Adesina, Musa Y. Dambele, Womi C. Iboh, Abdul Fatai K. Bakre

The rapid demand for utilisation of medical imaging has led to increased workload among radiographers. The integration of artificial intelligent system into imaging for seamless workflows, equipment operation, medical safety and image review processes has potential to assist radiographers with many of the demanding tasks. However, such advances in Artificial Intelligence (AI) may also introduce a new source of work-related stress, which has yet to be fully addressed. This study assessed Work-Related Stress (WRS), e …