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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
23.08.2026journal-article

Pharmacoepidemiology and Drug Safety

The Veterans Aging Cohort Study ( VACS )‐National: A Real‐World Data Source Profile

Christopher T. Rentsch, Vincent Lo Re, Melissa Skanderson, Kathleen A. McGinnis, Farah Kidwai‐Khan, Charles Alcorn, Anne C. Black, Kristina Crothers, Vincent C. Marconi, Matthew J. Freiberg, Jessie Torgersen, Amy C. Justice, William C. Becker, Lesley S. Park

ABSTRACT The Veterans Aging Cohort Study (VACS)‐National is a large, longitudinal real‐world data resource derived from electronic health records within the Department of Veterans Affairs (VA), the largest integrated healthcare system in the United States. As of December 2025, VACS‐National includes > 14.9 million Veterans who have received care in the VA since 2000. It captures information on VA‐related outpatient and inpatient care and includes structured (e.g., diagnostic codes, laboratory results, vital signs, …

23.08.2026journal-article

Angewandte Chemie

100‐Fold Reductivity Enhancement of Nanoscale Zero‐Valent Iron After 1‐Year Aging in Water via Regulating Corrosion Reactions

Yirong Wang, Yi Luan, Zhaowei Huang, Jiang Xu, Daohui Lin, Kun Yang, Wenhao Wu

ABSTRACT Nanoscale zero‐valent iron (nZVI) is the most promising reductant for in situ groundwater remediation, but its field application around the world is quite limited for decades, due to significant reductivity loss by water oxidation during long‐term (e.g., years) application. Herein, we report a polysiloxane(Fe)‐modified nZVI (PSO(Fe)‐nZVI, 269.0 ± 23.5 nm) featuring loosened hydrophobic C16 chains and Si─O groups on the surface and interior. Remarkably, after 420‐day aging in water, PSO(Fe)‐nZVI exhibits 10 …

23.08.2026journal-article

Bioengineering

Long-Term Air Pollution Exposure, Cardiovascular Disease, and Cardiometabolic Risk Factors in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study

Xuehua Wang, Zhaohui Wang, Yan Wang

The substantial burden of cardiovascular disease (CVD) attributable to air pollution remains a critical public health challenge, yet its combined effect with cardiometabolic factors is not fully understood. This study leveraged data from the Global Burden of Disease Study (GBD) and the China High Air Pollutants (CHAP) database to evaluate the CVD burden attributable to air pollution, which was found to increase progressively with age. We conducted a cross-sectional analysis using baseline (2011) data from 7420 part …

23.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

The Feasibility and Acceptability of a Collaborative Deprescribing Intervention to Reduce Anticholinergic Burden Among Hospitalised Older Patients

Kinda Ibrahim, Eloise Radcliffe, Edward Hewertson, Andrew Bates, Andy Fox, Emily Smith, Cathrine Mckenzie, Liam Jones, Sara Mckelvie, Ngianga Ii Kandala, Sara McCloskey, Tracey Sach, Stephen Lim

ABSTRACT Introduction 37%–48% of older patients receive anticholinergic medicines, increasing the risk for falls, delirium, dementia and death. Hospital admission may provide an opportunity for deprescribing to improve outcomes. This study evaluated the feasibility and acceptability of a digital tool to identify anticholinergic medicines and support deprescribing. Methods A pre‐post feasibility study was conducted (May–September 2025). Patients aged ≥ 75 with an ACB score of ≥ 3, screened using a digital tool, were …

23.08.2026journal-article

Advances in Communication and Swallowing

Swallowing Rehabilitation in People With Spinal Muscular Atrophy: A Scoping Review

Sofia Gandolfi, Chiara Andriani, Éadaoin Flynn, Margaret Walshe

Spinal muscular atrophy (SMA) is a neuromuscular disorder associated with motor, respiratory, and swallowing impairment. This scoping review aimed to explore how swallowing rehabilitation programmes and outcomes have been reported and measured in people with SMA. The Preferred Reporting Items for Systematic reviews and Meta-Analysis extension for Scoping Reviews guidelines and the Joanna Briggs Institute three-step search strategy were followed. Five electronic databases (Embase, CINAHL Complete, PubMed, Web of Sci …

23.08.2026journal-article

Social Science Review

Perceived Effect of the Old Age Allowance on the Well-being of Older Persons in Bangladesh

Shuvashis Kumar Rimon, Md. Mahir Faysal

The Old Age Allowance Program (OAAP) provides cash aid to support impoverished older persons, which is important for ensuring their well-being. The present study examined the positive effect of the Old Age Allowance (OAA) on the well-being of older persons in Bangladesh, as perceived by both beneficiaries and non-beneficiaries. The study also explored the factors that contribute to a perceived positive effect among allowance beneficiaries. A cross-sectional study was conducted among 309 older individuals, comprisin …

23.08.2026journal-article

People and Nature

Exploring more‐than‐human ethics and the digital dimensions of nature recovery through an interactive fiction game

Leah Govia, Roberta Hawkins, Eric Nost, Jennifer J. Silver

Abstract This perspective piece considers how a more‐than‐human approach to ethics can foster nuanced, critical understandings of the digital dimensions of nature recovery. A more‐than‐human approach expands on who or what is included as ethical actors while focusing on the interconnectedness of human and nonhuman experiences. First, we discuss what more‐than‐human ethics involve, the opportunities they provide for analysis and practice, as well as what limitations in dominant approaches to nature recovery they can …

23.08.2026journal-article

ACS Omega

Understanding and Managing Phase Instability and Aging Reactions of Coalgae Pyrolysis Oils

Olwethu Poswayo, Tendai Dembaremba, Adeniyi Ogunlaja, Gary Dugmore, Zenixole Tshentu

Abstract South Africa greatly suffers from the accumulation of waste coal fines due to its heavy reliance on coal mining. The processing of pyrolysis oil ensures the beneficiation of waste coal fines to provide alternative sustainable fuels. However, phase separation and aging reactions affect the stability of the pyrolysis oils negatively, affecting their processing and the product yields and quality. Understanding and managing the stability of Coalgae pyrolysis oil remain gaps to resolving this issue, and as such …

23.08.2026journal-article

Journal of Esthetic and Restorative Dentistry

Translucency Changes of Ceramic Veneers After Aging When Cemented on Substrates With Different Saturation: Effect of Ceramic Translucency and Resin Cement Shade

Samara Franco da Silva, Camila Pontes Custódio, Paulo Francisco Cesar, Carlos Eduardo Francci

ABSTRACT Objective To evaluate the effect of ceramic translucency and resin cement shade on the translucency alteration after aging over different substrates. Methods Sixty specimens were divided into 12 groups ( n = 5) composed of lithium disilicate (IPS e.max CAD, Ivoclar Vivadent) in three translucencies (HT, MT, LT). The 0.5 mm thick specimens were cemented with Variolink Esthetic LC (Ivoclar Vivadent) Light+ (L+) and Neutral (N) over resin substrates A1 and A4. Samples were subjected to 20,000 aging thermocycl …

23.08.2026journal-article

British Journal of Occupational Therapy

An exploration into how people living in secure hospitals experience work

Joshua Ige, Jacqueline Parkes, Tracey Redwood

Introduction: This study examines how people living in secure hospitals experience work. Work is widely recognised as a vital element in mental health rehabilitation, providing structure, purpose, and opportunities for personal growth. However, engaging in work within secure hospital settings is often more complex due to environmental restrictions and their diverse needs. Methodology: Using a descriptive phenomenological approach, the study explored the lived experiences of seven individuals in secure hospitals who …

23.08.2026journal-article

Journal of Evidence-Based Community Health

Hypertension Self-Management Knowledge Before and Immediately After a Community Education Program Among Older Adults Attending a Posyandu

Novita Leony Ruhukael, Abdul Thalib, Nadira Pattimura, Lintje Sintje Corputty, Nova Bugis, Siti Nurhidayati

Hypertension requires sustained day-to-day management, but a brief community education program can directly evaluate only the outcomes it measures. This community service program described the immediate change in hypertension self-management knowledge among older adults in Suli Village, Central Maluku. Fifteen older adults were recruited through invitations at the Posyandu Lansia and participated voluntarily. The intervention consisted of one face-to-face education session delivered through an oral presentation sup …

23.08.2026journal-article

Aging Cell

Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats

Qian Qian Yang, Zhanghao Huang, Yan Xue, Jia Yu Shi, You Lang Zhou

ABSTRACT Aging increases tendon injury incidence and poor repair outcomes, but age‐related differences in tendon mechanical properties and underlying mechanisms remain unclear. We first analyzed data from the Global Burden of Disease (GBD) database to characterize the associations between aging and population‐level changes in tendon injury burden. We found the age‐standardized incidence rate (ASIR) of tendon injuries caused by mechanical force decreased with advancing age, whereas the age‐standardized prevalence ra …

23.08.2026journal-article

American Journal of Hematology

Older Age, STAG2 , and DNMT3A Mutations Predict Superior Posttransplant Survival in Newly Diagnosed Acute Myeloid Leukemia Treated With Venetoclax Plus Hypomethylating Agents

Momna Warraich, Sudhesh Kumar, Mahnoor Fatima, Kristen McCullough, Aref Al‐Kali, Hassan B. Alkhateeb, Kebede H. Begna, Abhishek Mangaonkar, Antoine N. Saliba, Aasiya Matin, Mark R. Litzow, William Hogan, Mithun V. Shah, Mrinal M. Patnaik, Animesh Pardanani, James Foran, Lisa Sproat, Nandita Khera, Ayalew Tefferi, Naseema Gangat

ABSTRACT Venetoclax (Ven) plus hypomethylating agents (HMA) is standard frontline therapy for newly diagnosed AML (ND‐AML) patients unfit for intensive chemotherapy and is also considered in younger, fit patients. However, consolidation with allogeneic stem cell transplant (ASCT) is often required to secure durable remission. The current study examines posttransplant outcomes in patients with ND‐AML treated with frontline Ven‐HMA who subsequently underwent ASCT. A total of 111 ND‐AML patients (58% male, 60% seconda …

23.08.2026journal-article

Diabetes, Obesity and Metabolism

Variation in Treatment Patterns of Type 2 Diabetes in Older Patients

Phuc Le, Ning Guo, Anita Misra‐Hebert, Christopher B. Boyer, Kevin M. Pantalone, Hamlet Gasoyan, Nicholas J. Casacchia, Michael B. Rothberg

ABSTRACT Aims To estimate the proportion of older patients with type 2 diabetes (T2D) and HbA1c above or below goal at provider level and explore factors associated with patients being above or below goal. Materials and Methods We used 2023 Cleveland Clinic electronic health records, including patients ≥ 65 years old with T2D, ≥ 1 diabetes medication and ≥ 1 HbA1c measurement. Patients were assigned to their listed primary care provider or the one they saw most frequently and stratified into good, intermediate, or …

22.08.2026journal-article

Scientific Reports

Carotid plaque burden and hemodynamic alterations are associated with domain-specific cognitive impairment in community-dwelling older adults

Ahmed Elhfnawy, Mohamed Saud Kishk, Hany El Deeb, Jaidaa Mekky

Abstract Carotid atherosclerosis has been linked to cognitive decline, but evidence regarding its association with domain-specific cognitive performance in understudied non-Western populations remains limited. We investigated the associations of carotid plaque burden and hemodynamic markers with cognitive impairment in 100 community-dwelling Egyptian adults aged ≥ 60 years without prior neurological disease. Carotid plaque burden was quantified by duplex ultrasound using plaque score, and cognition was assessed usi …

22.08.2026journal-article

The Gerontologist

Adverse Childhood Experiences, Cognitive Outcomes, and Frailty in Older Adults: A Systematic Review and Meta-analysis

Fengxue Yang, Hongli Miao, Bing Cao, Li Zeng, Yin Zhou, Zhongqing Yuan, Yi Tian, Yuanting Li

Abstract Background and Objectives Adverse childhood experiences (ACEs) are important life-course determinants of health and may contribute to vulnerability in later life. Frailty and cognitive outcomes are important concerns in older adults, yet evidence linking ACEs to these outcomes has not been systematically synthesized. This review evaluated the associations between ACEs and frailty or cognitive outcomes in middle-aged and older adults. Research Design and Methods Following PRISMA guidelines, we searched seve …

22.08.2026journal-article

Research Involvement and Engagement

Patient and public involvement and engagement in co-designing guidance for mental health professionals supporting neurodivergent children and young people in child and adolescent mental health services

Naomi Williams, Helene Torr, Julie Taylor, Helena Tuomainen

Abstract Background Neurodivergent children and young people, including those with autism, attention-deficit/hyperactivity disorder and intellectual disability, experience higher rates of mental health difficulties than their neurotypical peers. Despite this increased need, many families encounter barriers when accessing child and adolescent mental health services (CAMHS). These barriers may occur across the service pathway, including referral, triage, assessment, treatment, and discharge. Patient and Public Involv …

22.08.2026journal-article

Community Mental Health Journal

Exploring the Role of Lived Experience Advocacy in Enhancing Civic Participation among Young People with Mental Ill-Health

Christopher Wainwright, Neil Harris, Rob O’Leary, Tom Riley, Ernesta Sofija

Abstract Civic disengagement among young adults is a significant societal challenge, exacerbated in those experiencing mental ill-health where stigma and social isolation can create a debilitating cycle of withdrawal. This exploratory study investigated how advocacy training for young people with mental ill-health cultivates self-determination through efficacy and increases civic participation. We conducted semi-structured interviews with 18 lived experience advocates (LEAs) participating in advocacy opportunities …

22.08.2026journal-article

Diseases of the Esophagus

P1.236. Surgical Decision Model for Elderly Patients With Esophageal Cancer: Development and Validation of a Geriatric Stage (gStage) System

Yasue Kimura, Naomichi Koga, Rena Yokomizo, Munehide Terashi, Ayako Iwanaga, Masahiko Sugiyama, Masaru Morita

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background The increasing age of patients with esophageal cancer poses significant challenges in surgical decision-making. Elderly individuals frequently present with multimorbidity, impaired physiological reserve, and nutritional vulnerability, all of which increase postoperative risk. Chronological age and performance status alone are insufficient to determine surgical eligibility. A structured approach incorporating mu …

22.08.2026journal-article

Nature Communications

Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables

Jinjoo Shim, Jukka-Pekka Onnela

Abstract Disrupted rest-activity rhythms have been associated with aging and chronic disease, yet longitudinal evidence from free-living populations has been lacking. Here we integrate multi-year Fitbit activity data from the All of Us Research Program with clinical biomarker-derived PhenoAge from 2,222 participants (8,447 person-years). Through high-dimensional digital phenotyping, we show that circadian rest-activity rhythm intensity, timing, and stability are associated with biological aging trajectories. Higher …

22.08.2026journal-article

Healthcare

Preliminary Psychometric Evaluation of the Economic Living Standards Index Short Form (ELSI-SF) Among Spanish Older Adults

Celia Álvarez-Bueno, María Eugenia Visier-Alfonso, Mar de Miguel-Brox, Blanca Zuheros-Lara, María Frontelo-García, Beatriz Rodríguez-Martín

Objective: To examine the reliability, construct validity, and discriminative capacity of the Spanish version of the Economic Living Standards Index Short Form (ELSISF) in a sample of older adults in Spain. Methods: This analysis was conducted using baseline data from 133 participants (mean age = 66.2 years, SD = 5.6; 53.8% women) recruited from community health and social centers in the provinces of Cuenca, Albacete, and Toledo within the PEPE cohort. Participants completed the ELSISF (25 items), sociodemographic …

22.08.2026journal-article

American Journal of Aging Science and Research

Social isolation and loneliness in older adults: A growing public health challenge with evidence from Nepal

Hom Nath Chalise

Social isolation and loneliness are increasingly recognized as major public health concerns in ageing populations, yet they remain under-addressed in low- and middle-income countries. This article examines the definitions, epidemiology, health consequences, and evidence-based responses related to social isolation and loneliness among older adults, with focused attention to Nepal. Nepal faces a dual challenge: a rapidly growing older adult population—exceeding 10% of the national total in 2021 —and large-scale youth …

22.08.2026journal-article

Diseases of the Esophagus

OA10.5. Laparoscopic Repair of Paraesophageal Hernia in Patients Older Than Seventyyears: A High-Volume Center Experience

Arianna Vittori, Andrés R Latorre-Rodriguez, Sai Padithala, Hideyuki Takeuchi, Sumeet K Mittal

Abstract Topic Benign Disease: Esophageal Surgery Background With increasing life expectancy, more elderly patients are diagnosed with large paraesophageal hernias (PEHs). However, the optimal management of PEHs in patients aged ≥70 years remains debated because of concerns regarding operative risk, frailty, and postoperative recovery. While elective minimally invasive repair is commonly performed in younger populations, evidence describing perioperative safety, short-term outcomes, and patient-reported satisfactio …