Physiology
mRNA Translation and Proteasomal Degradation in Health and Neurological Disease
The homeostasis of cellular proteins, i.e., proteostasis, is critical for neuronal function and brain processes. Proteostasis comprises a set of cellular mechanisms that control protein synthesis, folding, posttranslational modification, and degradation. Mounting evidence indicates that disruptions in such mechanisms may underlie several neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric diseases. In this review, we discuss molecular pathways involved in protein synthesis and de …