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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Evidence-Based Chinese Medicine and Technology Assessment

How can traditional Chinese medicine trials achieve global credibility

Ying Wang, Gordon Guyatt

Abstract Traditional Chinese medicine (TCM) needs credible evidence that meets international evidence-based medicine standards to achieve global credibility and acceptance. A fundamental and crucial task is to conduct high-quality randomized controlled trials (RCTs). To achieve global credibility, TCM RCTs should meet universal standards of scientific rigor, such as addressing clinically important questions, achieving sufficient sample size and minimizing risk of bias, and enhance generalizability through appropria …

02.09.2026journal-article

Transfusion Medicine

Not all anti‐ CD38 antibodies are created equal: The epitope of felzartamab is partially DTT ‐resistant

Anja Zeretzke, Philipp Trummer, Cora P. Habicht, Clemens Schneeweiss

Abstract Objectives To evaluate anti‐CD38 antibody candidates for their ability to bind to DTT‐treated CD38 and red blood cells (RBCs). Background Dithiothreitol (DTT) treatment of RBCs is routinely used to denature CD38 and mitigate interference from anti‐CD38 antibodies, such as daratumumab and isatuximab, in immunohematology testing. However, new anti‐CD38 antibodies are in development, some of which may be directed against linear or otherwise DTT‐resistant epitopes. Methods/Materials Anti‐CD38 antibody candidat …

02.09.2026journal-article

Healthcare

Knowledge and Self-Reported Clinical Approaches Regarding Medication-Related Osteonecrosis of the Jaw Among Final-Year Dental Students, General Dentists, and Specialist Dentists: An Exploratory Cross-Sectional Study

İsmail Çapar, Çiğdem Şeker

Background/Objectives: Medication-related osteonecrosis of the jaw (MRONJ) must be recognized promptly by dental professionals at every career stage, yet whether this recognition differs across professional levels remains unclear. This study compared final-year dental students, general dentists, and specialist dentists in terms of their awareness, pharmacological knowledge, and self-reported clinical approaches to MRONJ. Methods: This cross-sectional, exploratory study used a 25-item online questionnaire administer …

02.09.2026journal-article

European Journal of Nutrition & Food Safety

Next-generation Probiotics for Human Health: A Critical Narrative Review of Mechanisms, Clinical Translation, Safety and Precision Microbiome Therapeutics

Sandhya Dhyani, Himani Belwal, Neetu Dobhal

The term next-generation probiotic (NGP) is increasingly used for health-associated gut commensals and rationally engineered microorganisms developed from microbiome science rather than from the historical food-fermentation route that produced most conventional probiotics. This expansion has created a translational opportunity, but also a recurrent evidential problem: taxonomic association, mechanistic plausibility, preclinical efficacy, human safety and clinical benefit are often treated as if they formed a single …

02.09.2026journal-article

BMC Medical Imaging

Automated whole-brain MRI segmentation combined with clinical scores for the diagnosis of sepsis-associated encephalopathy: a case-control study

Shasha Shao, Yanyan Liu, Jiale Yang, Daixing Zhou, Chengdong Peng, Dong Liu, Junshuai Wang, Jun Feng

Abstract Background Sepsis-associated encephalopathy (SAE) is a serious complication of sepsis that can lead to high mortality and poor neurological outcomes. Current diagnostic methods, whether based on clinical scores or brain images, remain inaccurate. We aimed to formulate a multimodal model that incorporated three-dimensional (3D) magnetic resonance imaging (MRI) neuroanatomical characteristics with clinical scores to improve SAE detection. Methods In this retrospective case-control study, 35 healthy controls …

02.09.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Arthroscopic Suprapectoral Biceps Tenodesis Using a Standard Suture Anchor Is Safe and Effective

Xavier A. Duralde, Caroline A. Heramb, Jennifer N. Blanda

Purpose To evaluate the safety and efficacy of an arthroscopic technique of suprapectoral biceps tenodesis using a standard absorbable double‐loaded suture anchor. Methods This retrospective study includes all patients who underwent arthroscopic biceps tenodesis by the senior author between December 2017 and June 2020. Biceps tenodesis was performed in patients who had failed conservative management and exhibited evidence of biceps pathology at the time of surgery that appeared to be contributing to the patient's p …

02.09.2026journal-article

American Journal of Lifestyle Medicine

Paving the Path to Wellness for Okinawan Descendants in Brazil: A Culturally Adapted Lifestyle Medicine Program in Group

Sley Tanigawa Guimaraes, Elizabeth Frates, Julia Pangalangan, Bruna Morais, Fernanda Santos

Noncommunicable chronic diseases (NCDs) are the leading cause of premature death and disability worldwide. Lifestyle medicine group interventions are effective in promoting behavior change and improving health outcomes. This study evaluated the impact of the PAVING THE PATH TO WELLNESS program among Okinawan descendants in São Paulo, Brazil. A longitudinal mixed-methods pilot study was conducted with 16 adults (≥18 years) from the Okinawa Vila Carrão Association. The 8-week group program included weekly sessions ad …

02.09.2026journal-article

The International Journal of Artificial Organs

Intravascular hemolysis and clinical outcomes in continuous-flow LVAD patients: A single-center retrospective analysis

Ali Onder Kilic, Cagatay Engin, Tahir Yagdi, Mustafa Ozbaran

Objective: To determine the incidence of intravascular hemolysis in patients implanted with continuous-flow left ventricular assist devices (LVADs), to describe longitudinal changes in hemolysis-related laboratory markers (LDH, total/direct bilirubin, INR), and to assess their diagnostic value for pump thrombosis and cerebrovascular events. Methods: We retrospectively analyzed 100 end-stage heart failure patients (2014–2015). To ensure consistent longitudinal analysis, 59 long-term survivors (42 HeartWare HVAD, 17 …

02.09.2026journal-article

Apollo Medicine

A Novel Multimodal Approach in AAU Resistant to Conventional Therapies and Tofacitinib: A Case Report

Sumit Kumar Bose

Introduction: Alopecia areata universalis (AAU) is a long-lasting, chronic, recurrent immune-mediated disease characterised by non-scarring hair loss of the scalp and other hair-bearing body areas. Even when treated with various treatments such as oral and topical steroids, anthralin, phototherapy and tofacitinib, recurrence is common after 6 months to 1 year. AAU presents with well-delineated, circumscribed patches of hair loss of the scalp. Remission is observed in 50% of cases within 1 year. Relapse may occur in …

02.09.2026journal-article

Aging Clinical and Experimental Research

Screening of sarcopenia in long-term care facilities using wireless surface electromyography and deep transfer learning: a proof-of-concept study

Andrea Manni, Giacomo Scotti, Gabriele Rescio, Andrea Caroppo, Giulia Pasolini, Alessia Ghidini, Eleonora Macchia, Zaira Romeo, Alvise Bobbo, Marianna Noale, Stefania Maggi, Alessandro Leone, Alessandro Morandi, for the I-COUNT study group

Abstract Background Sarcopenia is prevalent in long-term care facilities (LTCFs) and is associated with falls, functional decline, and mortality. Aims This proof-of-concept study, within the I-COUNT pilot randomized controlled trial, evaluated the feasibility and diagnostic performance of a non-invasive sarcopenia screening approach based on wearable surface electromyography (sEMG) combined with artificial intelligence. Results Eighteen older adults residing in two Italian LTCFs (6 sarcopenic, 12 controls; 33.3% me …

02.09.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Approach to the Patient: Theranostics as precision medicine for neuroendocrine tumors

Regina Koch, Guillaume Pegna, Nadine Mallak, Celeste Winters, Jaydi Del Rivero, Hallbera Gudmundsdottir, Thor Halfdanarson, Erik Mittra

Abstract Context Theranostics has emerged as a precision medicine paradigm in neuroendocrine tumors (NETs), integrating receptor-based imaging with targeted radionuclide therapy to individualize treatment. This approach is particularly valuable in functional and biologically heterogeneous NETs, where hormonal control and variable clinical behavior dominate therapeutic priorities. Case Description We present a three-case series illustrating the application of theranostics across diverse NET contexts. Case 1 describe …

02.09.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Categorizing race profiles in professional men’s and women’s road cycling races using clustering

Annemiek J. Roete, Marije T. Elferink-Gemser, Robert P. Lamberts, Matthias Kempe

Abstract Background Professional road cycling races differ in physiological demands because race profiles vary. Yet no standardized method exists to categorize race profiles across professional road cycling races. Organizer labels are inconsistent or missing. Systematic categorization would enable large-scale analysis of race demands. This study develops a categorization of race profiles in men’s and women’s professional road cycling. Methods The dataset comprised international men’s and women’s races from 2024 sup …

02.09.2026journal-article

Frontiers in Cell and Developmental Biology

Gut microbiota dysbiosis and the gut–lung axis in COPD: mechanisms, clinical relevance, and microbiota-targeted interventions

Yinghui Chai, Junya Lan, Kang Li, Xue Mei, Yanan Chen, Nannan Zhou, Xin Liu, Wenping Gong, Hong Lei

Chronic obstructive pulmonary disease (COPD), which is characterised by persistent inflammation and airflow limitation, has increasingly been linked to the gut-lung axis. Patients with COPD commonly exhibit reduced diversity of gut microbiota, decreased levels of bacteria that produce short-chain fatty acids (SCFAs), increased levels of opportunistic pathogens, and compromised intestinal barrier function. These alterations are driven by factors such as smoking, hypoxia, oxidative stress, medication use and ageing, …

02.09.2026journal-article

Journal of Orthopaedic Surgery and Research

Duloxetine for postoperative pain management in total hip and knee arthroplasty: a systematic review and meta-analysis

Abdelrahman Ibrahim, Mohamed Abdelnabi, Reda Ali Sheta

Abstract Background Postoperative pain following total hip arthroplasty (THA) and total knee arthroplasty (TKA) drives opioid dependence. Perioperative duloxetine is an option as a multimodal analgesic adjunct, yet its efficacy and safety in this population are not fully defined. Methods This systematic review and meta-analysis compared perioperative duloxetine to placebo in THA and TKA patients, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered with …

02.09.2026journal-article

Journal of Orthopaedic Science and Research

Using a Mathematical Model to Develop an Objective Outcome Measure for Lumbar Spine Surgery in Patients with Thoracolumbar Trauma in Nigeria

Kawu Ahidjo Abdulkadiri, Misbahu Haruna Ahmad, Ahmed Bola Abdulkadir, Oderinde Gbadebo Afeez, Aremu Abdurrahman Bolaji, Maruf Sherif Temitope, Buba Lukman Bello

Background: Outcomes following thoracolumbar spine trauma in resource-limited settings are typically reported using neurological scales such as the ASIA Impairment Scale (AIS). However, these scales do not capture the functional outcomes that matter most to patients-mobility, self-care, employment and independence. This study aimed to develop a measurable, objective outcome system for use in resource-constrained Nigerian settings. Methods: A retrospective cohort study of 237 patients who underwent surgery for thora …

02.09.2026journal-article

AGING MEDICINE

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

Qi Pan, Lixin Guo

ABSTRACT Obesity in older adults has become a prominent public health issue. Owing to age‐related physiological changes and multimorbidity, obesity in this population is associated with complex clinical manifestations and markedly increased difficulty in management. Based on this, a multidisciplinary panel of obesity experts from Beijing Hospital, National Center for Gerontology, formulated this consensus after rigorous evaluation and iterative revision. The consensus emphasizes that management of obesity in older …

02.09.2026journal-article

PLOS One

Retinopathy of prematurity as a clinical marker of developmental vulnerability in preschool children: A nationwide Korean Health Screening study

Tae-Eun Kim, Hye Won Park, Sanghyun Park, Hyun Jin Shin

Purpose To determine the Retinopathy of prematurity (ROP) and its association with developmental delay in Korean preschool children. Methods We conducted a nationwide cohort study using the Korean National Health Insurance Service and National Health Screening Program for Infants and Children (NHSPIC). The study included 808,536 children born 2014–2018 who completed the 7th NHSPIC screening at 54–60 months. Development assessed by the Korean Developmental Screening Test (K-DST) in six domains (self-care, cognition, …

02.09.2026journal-article

British Journal of Healthcare and Medical Research

Associations of Musculoskeletal Pain with Sociodemographic, Health Related, Reproductive Related, Pain Related, Treatment Seeking Pattern and Outcome Among Postmenopausal Women From Dhaka City

Rojina Akter, Abu Sayed Mohammad Giasuddin, Jasim Uddin, Md. Raisul Hassan

Background: The associations (correlations) of Musculoskeletal pain (MSP) with the presenting characteristics in postmenopausal women from Dhaka City are not known; Objectives: To determine the statistical significance of the associations of MSP with the presenting characteristics in postmenopausal women from Dhaka City; Materials & Methods: Statistically further analyses were done for associations of MSP with the presenting features reported in our descriptive cross-sectional study. The SPSS version 22.0 was used …

02.09.2026journal-article

BMJ

Secondary use and scholarly impact of a portfolio of clinical trials with shared individual participant level data: cross sectional study

Erfan Taherifard, Maryam Mooghali, Hollin R Hakimian, Sahil R Mane, Mengyuan Fu, Stephen Bamford, Jesse A Berlin, Karla Childers, Nihar R Desai, Cary P Gross, Debbie Hewens, Richard Lehman, Jessica D Ritchie, Tamsin Sargood, Joanne Waldstreicher, Joshua D Wallach, Molly K Willeford, Harlan M Krumholz, Joseph S Ross

Abstract Objective To assess the number, timing, characteristics, and scholarly impact of secondary publications generated using individual participant level data (IPD) from a portfolio of clinical trials shared with external investigators through a data sharing platform. Design Cross sectional study. Setting Yale University Open Data Access (YODA) Project platform. Participants Johnson & Johnson sponsored clinical trials listed on the YODA Project platform with IPD available for external sharing through 2021 and w …

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02.09.2026journal-article

Clinical Otolaryngology

Azelastine‐Fluticasone Intranasal Combination Therapy in Otorhinolaryngology: Clinical Evidence, Current Practice Patterns and Future Perspectives

Giorgio Ciprandi, Ignazio La Mantia, Attilio Varricchio

ABSTRACT Background Allergic rhinitis (AR) represents a significant burden in Ear Nose Throat (ENT) practice and markedly affects quality‐of‐life and work productivity of AR patients. The fixed combination of intranasal azelastine and fluticasone propionate (AzeFlu) has emerged as a valuable therapeutic option for moderate‐to‐severe AR. Recent updates to international guidelines and real‐world evidence warrant a comprehensive review of its role in ENT practice, with particular attention to both seasonal and perenni …

02.09.2026journal-article

Ibero Ciencias - Revista Científica y Académica - ISSN 3072-7197

Sulfato de Magnesio para Reducir la Respuesta Hemodinámica a la Laringoscopia Directa en Pacientes ASA I–II en Cirugía No Cardiaca

Fabricio Herrera Vargas, Omar Sotelo Pichardo

Direct laryngoscopy and endotracheal intubation elicit a sympathetic response that rapidly raises heart rate and blood pressure, changes that may become clinically relevant in vulnerable patients. This study examined whether magnesium sulfate, used as an adjuvant, reduced that hemodynamic response compared with a control group. An experimental, prospective, comparative and randomized study was conducted with 52 adult ASA I–II patients undergoing non-cardiac surgery under balanced general anesthesia, allocated to an …

02.09.2026journal-article

Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine

Angiography-Derived vs Wire-Based Physiological Assessment in Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Muhammad Mudasir, Abdul Rehman, Muhammad Ibrahim Rashid, Mohammad Salah, Muhammad Jawad, Ramesha Tahir, Raja Muhammad Umer, Prem Kumar, Rohin Kumar

This study aimed to determine whether angiography-based physiological assessment yields clinical outcomes comparable to those of conventional wire-based pressure measurements in patients with coronary artery disease (CAD) undergoing evaluation of intermediate coronary stenoses. A systematic literature search was conducted in PubMed, Embase, and the Cochrane Central Register of Controlled Trials through April 12, 2026. Randomized controlled trials comparing angiography-derived indices (such as QFR, vFFR, and angiogr …

02.09.2026journal-article

Annals of African Medicine

Neurobehavioral Evaluation of Renin-Angiotensin System Modulators in an MPTP-Induced Model of Parkinson’s Disease in Swiss Albino Mice

K.G. Prakash, K. Saniya, Shubham Jaju, Madhavrao Chavan, K. Mythili Bai, Aishwarya Mantri

Abstract Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor deficits. Emerging evidence suggests a role of the renin-angiotensin system (RAS) in neurodegeneration, making it a potential therapeutic target. Aim: To evaluate the neuroprotective effects of RAS-modulating drugs such as captopril, perindopril, and losartan in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of PD. Methods: An experimental in vivo study was conducted usi …

02.09.2026journal-article

Acta Odontologica Turcica

Evaluation of parents' knowledge and awareness of early orthodontic treatment for their children in Türkiye

Mehmed Taha Alpaydın, Merve Köklü, Tuğçe Alpaydin

ABSTRACT OBJECTIVE: The aim of this study is to evaluate the knowledge and awareness levels of parents in Turkish society regarding early orthodontic treatment and to explain how it is related to various factors. MATERIALS AND METHODS: The survey was distributed to voluntary participants across Türkiye via Google Forms. Sociodemographic data and data measuring the level of knowledge and awareness about early orthodontic treatment were obtained. Data analysis was performed using SPSS (Statistical Package for Social …