24.08.2026journal-article
Theoretical and Natural Science
Spatially Organized Immune Remodeling in Menopause: Single-Cell and Spatial Transcriptomic Evidence from Ovarian Aging and Atherosclerosis
As the proportion of people in their mid-to-late years increases around the world, so too does the prevalence of multiple long-term illnesses associated with menopause, many of which involve changes in the immune system. Bulk RNA sequencing averages expression in heterogeneous cell populations and thus cannot identify which cells are changing or where those changes occur. Collectively, single-cell RNA sequencing and spatial transcriptomics have provided two major examples of menopausal changes, ovarian aging and at …