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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Frontiers in Education

Comprehensively understanding K-12 teachers’ occupational health: a convergent mixed-methods exploration of stress and wellbeing

Cynthia A. Wiltshire, Christopher J. McCarthy, Caroline Weppner, Richard G. Lambert, Yijie Tian

Stress has detrimental impacts on K-12 teachers’ occupational health, yet there is no consensus on how best to define and measure it. As such, the present study implemented quantitative and qualitative methodologies, including a physiological measure of stress, to comprehensively assess and understand teacher stress in one independent school district in the southern United States. Forty-four public school teachers participated by completing self-reported measures of stress and occupational health, providing a hair …

28.08.2026journal-article

Surgical Neurology International

Case of salvage en bloc vertebrectomy for locally progressive T12 breast cancer metastasis after failed radiotherapy and systemic therapy

Isamu Miura, Takayoshi Shimizu, Takahiro Hori, Hanako Morisawa, Suguru Nakamura, Kaname Ito, Naohisa Miura, Kotaro Kohara

Background: Isolated local progression of breast cancer spinal metastases may occur despite adjunctive radiotherapy and systemic therapy. Here, a 71-year-old female underwent a salvage en bloc vertebrectomy for a locally progressive T12 breast cancer spinal metastasis that newly developed due to failure of prior adjunctive radiotherapy and systemic therapy. Case Description: A 71-year-old female developed a T12 spinal metastasis 10 years after surgery for breast cancer; she exhibited no other metastatic lesions. De …

28.08.2026journal-article

Turkish Journal of Internal Medicine

Targeting Inflammation in CKD-Related Anemia: The Emerging Role of Lactoferrin as an Adjunctive Therapy

Harsh J Shah, Jacky K Pariyani, Kalyani V Shinde, Dharmil P Pandya, Bhakti A Dave, Megha M Lokhande

Objective: Chronic kidney disease (CKD)-associated anemia is substantially driven by chronic inflammation, which promotes hepcidin upregulation, restricts iron availability, and impairs erythropoiesis. Conventional therapies, including erythropoiesis-stimulating agents and iron supplementation, primarily address erythropoietin deficiency and iron depletion but do not directly target the underlying inflammatory pathways. This narrative review evaluates the role of inflammation in CKD-associated anemia and examines t …

28.08.2026journal-article

Current Medicinal Chemistry

Ginsenosides in Ovarian Cancer Therapy: Mechanistic Insights with an Emphasis on microRNA Regulation and Translational Prospects

Sobhan Jalali, Mohammadreza Besharatloo, Mojtaba Zehtabi, Dorrin Alipour Amini, Amir Hossein Barjasteh, Mohammad Hossein Pourhanifeh

Abstract: Ovarian cancer remains one of the most lethal gynecological malignancies due to late diagnosis, high recurrence rates, and resistance to conventional therapies. Emerging evidence underscores the therapeutic potential of natural compounds, among which ginsenosides, the principal bioactive components of ginseng, exhibit remarkable anticancer properties. This review summarizes current insights into the anti-ovarian cancer activities of ginsenosides, with particular focus on their regulatory effects on non-- …

28.08.2026journal-article

Medicina

Rehabilitation and Physiotherapy for Functional Sequelae in Adults with Head and Neck Cancer: A Systematic Review and Meta-Analysis

Miriam Linero-Bocanegra, Carlos Fernández-Morales, Daniel Torres-Lagares, Elena Oliva-Ferrusola, Cristo Jesús Barrios-Quinta, Ángel Rufino Yáñez-Álvarez

Background and Objectives: Functional sequelae following head and neck cancer (HNC) treatment frequently impair swallowing, mouth opening, speech, cervical and shoulder mobility, and overall quality of life. Although rehabilitation is increasingly recognized as an essential component of multidisciplinary care, evidence has largely focused on isolated functional impairments rather than providing a comprehensive evaluation across rehabilitation domains. To systematically evaluate the effectiveness of rehabilitation a …

28.08.2026journal-article

Healthcare

Prospects for Physical Therapy in Rheumatoid Arthritis: Literature Review

Dana Taizhanova, Olga Pokrashenko, Anna Shalygina

Background: The incidence of rheumatoid arthritis is steadily increasing worldwide, resulting in a growing number of individuals who may lose the ability to perform self-care activities and professional duties, thereby reducing their quality of life. Rheumatoid arthritis represents a significant social problem, limiting the ability of the working population to lead a full life. A comprehensive approach to the treatment of patients with rheumatoid arthritis, including both pharmacological therapy and an individualiz …

28.08.2026journal-article

Current Drug Therapy

Monoclonal Antibodies Against EGFR, HER2, and VEGF: Mechanistic Insights and Emerging Strategies in Targeted Cancer Therapy

Ananda Kumar Chettupalli, Paramvir Singh Tomar, Shikha Yadav, Chandan Mondal

Introduction: Monoclonal antibodies (mAbs) that target receptor-mediated oncogenic pathways have revolutionized oncology research. Better therapeutic indices are possible with these mAbs for targeted tumor treatment. This review covers receptor-targeted monoclonal antibodies targeting the EGFR, HER2, and VEGF pathways in solid tumors, as well as their therapeutic use and development. Methods: The study searched the scientific literature to identify key FDA-authorized studies on the EGFR, HER2, and VEGF/VEGFR pathwa …

28.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Optimizing exercise for breast cancer survivors: a randomized controlled trial of daily individualization of high-intensity online concurrent training guided by autonomic modulation

Ana Myriam Lavín-Pérez, Daniel Collado-Mateo, Inés Nieto, Xián Mayo, Carmen Hinojo González, Ana de Juan Ferré, Gary Liguori, Alfonso Jiménez

Abstract Background Breast cancer and its treatments cause physical and physiological side effects that exercise can mitigate. However, there is little evidence on the effects and feasibility of high-intensity remote supervised training. In addition, there is no evidence of the effect of individualizing intensity prescription based on autonomic control in this population. Thus, this study aimed to compare the effects of two concurrent online exercise programs, pre-planned intensity prescription (PPI) and intensity …

28.08.2026journal-article

Esophagus

Treatment-dependent and independent prognostic value of inflammation-based nutritional indices in immune checkpoint inhibitor-based therapy for esophageal cancer

Hiroki Matsuda, Tomoki Makino, Shuichiro Hara, Shigeto Nakai, Takaomi Hagi, Kota Momose, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Atsushi Takeno, Tsuyoshi Takahashi, Masaaki Motoori, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki

Abstract Background Phase III trials have established the efficacy of immune-based therapies for unresectable advanced or recurrent esophageal squamous cell carcinoma (ESCC). However, real-world evidence comparing regimens and clinically applicable prognostic biomarkers remains limited. Methods We retrospectively evaluated 245 patients with unresectable advanced/recurrent ESCC treated with first-line 5-fluorouracil plus cisplatin combined with nivolumab or pembrolizumab (CF + ICI; n = 114), first-line ipilimumab pl …

28.08.2026journal-article

African Journal of Health Nursing and Midwifery

Prevalence and Socio-Demographic Correlates (Age and Parity) of HBV Infection Among Pregnant Women in Oyo State

Aina, M. A.

Hepatitis B virus (HBV) is still a major public health problem in sub-Saharan Africa, especially because of the risk of transmission of the infection from mothers to their babies at birth. This study set out to establish the level of sero-prevalence of HBV, maternal perception and THE relationship between maternal age, parity, and sero-status in Oyo State. A Descriptive cross-sectional design was used and consisted of 100 respondents for the questionnaire and 622 respondents for the laboratory. The HBV sero-prevale …

28.08.2026journal-article

American Journal of Hospice and Palliative Medicine®

Oncology Providers’ Perspectives on Psychedelic-Assisted Therapy

Krishna S. Hanubal, Akul N. Munjal, Jino Park, Rufus Banks, Esther Choi, Michael A. Hoyt, Jessica N. Humphreys, Mona Mojtahedzadeh, Jeremy P. Harris

Purpose Despite most psychedelic substances remaining Schedule I, clinical research exploring psychedelic-assisted therapy (PAT) in oncology is expanding. We sought to assess oncology providers’ attitudes toward and understanding of PAT. Methods We conducted a cross-sectional survey of healthcare professionals involved in oncology across five academic institutions in California, South Carolina, and Florida, and one nonacademic institution in Georgia. The survey was also distributed to 4500 members of the American A …

28.08.2026journal-article

British Journal of Occupational Therapy

Children’s perspectives on occupational participation in UK primary schools

Jamie Liddell, Tara Sims, Clare Sugarman-Clarke

Introduction: Occupational participation is a fundamental right for all children, yet little is known about how UK primary-aged children experience it in school. This study explored their views on meaningful occupations, school demands, and factors influencing participation. Method: Eleven children aged 7–11 from three UK mainstream primary schools participated in the first phase of a Critical Participatory Action Research study. Data were collected through photo tours and discussion groups and analysed using refle …

28.08.2026journal-article

Internal and Emergency Medicine

Nano-enabled natriuretic peptide therapy in post-myocardial infarction heart failure: from functional NP deficiency to dual-axis (cGMP-dependent and -independent) cardioprotection

Giulia Cevoli, Ivan Isaia, Reza Parvan, Horng H. Chen, Lorenzo Malatino, John C. Burnett, Alessandro Cataliotti

Abstract Myocardial infarction (MI) remains a major driver of incident heart failure (HF) despite timely reperfusion and guideline-directed medical therapy. Current treatments, largely centered on neurohormonal blockades, attenuate maladaptive pathways but do not restore endogenous cardioprotective systems. Among these, the natriuretic peptide (NP) network plays a central role in counteracting fibrosis, hypertrophy, sodium retention, and microvascular dysfunction. In advanced HF, impaired prohormone processing, cor …

28.08.2026journal-article

International Journal of Research and Review

Factors Associated with Medication Adherence to Tuberculosis Preventive Therapy (TPT) Among Household Contacts in the Service Area of Paninggahan Primary Health Center, Solok Regency

Indrawadi ., Mustofa ., Asrul Fahmi

Background: Tuberculosis (TB) remains a major public health problem in Indonesia. Household contacts of TB patients are at high risk of acquiring TB infection and therefore require Tuberculosis Preventive Therapy (TPT). The success of the TPT program is highly dependent on medication adherence. Several factors, including knowledge, social support, treatment-related factors, and socioeconomic status, are presumed to influence adherence to TPT medication. Objective: To identify factors associated with adherence to TP …

28.08.2026journal-article

Frontiers in Physiology

Effects of aquatic exercise therapy on lung function in patients with asthma: a systematic review and meta-analysis

Xiaofeng Cheng, Jinsong Luo, Xianhui Liao

Background Exercise is recommended as an adjunctive therapy for asthma, yet the effects of aquatic exercise on pulmonary function remain uncertain because findings from randomized controlled trials (RCTs) have been inconsistent. This systematic review and meta-analysis aimed to synthesize the current evidence regarding the effects of aquatic exercise on pulmonary function in patients with asthma. Methods This systematic review was conducted in accordance with the PRISMA 2020 statement. PubMed, Embase, Web of Scienc …

28.08.2026journal-article

British Journal of Dermatology

Low-dose methotrexate in therapy-resistant lichen sclerosus: first clinical experience with recurrence-free interval extension in HPV-independent vulvar intraepithelial neoplasia (HPVi VIN)

Dune Wouters, Lotte M Voeten, Renee Ebisch, Peggy J de Vos van Steenwijk, Johanna W M Aarts, Edith M G van Esch

Low-dose methotrexate (MTX) has been used for corticosteroid-refractory lichen sclerosus, but its effect on differentiated vulvar intraepithelial neoplasia (dVIN) recurrence has never been reported. In this first multicenter within-patient observational study, all six continuing patients exceeded their shortest pre-MTX recurrence-free interval, and three achieved sustained reduction in topical corticosteroid use. These findings support prospective evaluation in the MERCURE trial and provide a rationale for MTX as a …

28.08.2026journal-article

Mammalian Genome

Assessment of auditory and vestibular function and gene therapy in the Snell’s waltzer mouse model of human deafness and balance dysfunction

Eyal Marton, Roni Hahn, Lior Bikovski, Gwenaëlle S. G. Géléoc, Jeffrey R. Holt, Matti Mintz, Karen B. Avraham

Abstract The Snell’s waltzer mouse ( Myo6 sv/sv ) serves as a model for human deafness and vestibular behavioral impairment, caused by a spontaneous 130 bp recessive deletion in the Myo6 gene. In this study, we characterized the auditory and vestibular phenotypes of Myo6 sv/sv mice. These mice exhibit profound hearing loss, with cochlear hair cell stereocilia beginning to fuse soon after birth, ultimately leading to disorganization of hair bundles and degeneration of hair cells. Mice also exhibit behavioral phenoty …

28.08.2026journal-article

Journal of Medical Internet Research

Comparative Effectiveness of Noninvasive Brain-Computer Interface–Based Interventions for Upper Limb Rehabilitation in Poststroke Hemiplegia: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Jiabin Xu, Yitian Gao, Siqi Xie, Weikang Jiang, Huiqing Zhang, Lin Qiu, Mengxue Jiang, Lanshu Zhou

Abstract Background Noninvasive brain-computer interface (BCI)–based interventions show promise for poststroke motor recovery. However, the intrinsic complexity of BCI-based interventions limits the determination of their comparative efficacy. Objective Guided by the International Classification of Functioning, Disability and Health framework, this review evaluated the effectiveness of BCI-based interventions in poststroke upper limb rehabilitation and identify the optimal intervention. Methods We searched PubMed, …

28.08.2026journal-article

Audiology Research

Longitudinal Listening Difficulties in Children Initially Presenting with Speech Sound Disorder: Two Case Reports

Yoriko Fujimoto, Hirokazu Sakamoto, Tomoe Sekido

Background and Clinical Significance: Children may experience substantial listening difficulty (LiD) despite clinically normal pure-tone thresholds. The longitudinal course of LiD in children initially referred for speech sound disorder (SSD) is not well documented. Case Presentation: We retrospectively reviewed two individuals first evaluated during the preschool years for SSD and followed through adolescence or adulthood. Available preschool records showed air-conduction thresholds no poorer than 20 dB HL. Tympan …

28.08.2026journal-article

Journal of Occupational & Environmental Medicine

Comparison of Fixed and Age-Sex-Adjusted NFPA Standards for Cardiopulmonary Fitness in Thai Wildland Firefighters

Jinjuta Panumasvivat, Pheerasak Assavanopakun, Kampanat Wangsan, Vithawat Surawattanasakul, Wachiranun Sirikul, Pannawich Chantaklang, Thitirat Vinsirivorakul

Objective: This study examined Thai wildland firefighters' cardiopulmonary fitness, comparing previous and updated NFPA criteria. Methods: Chiang Mai wildland firefighters' health was cross-sectionally examined. Chester Step cardiopulmonary fitness was assessed using the fixed 12-MET threshold and age- and sex-adjusted 50th percentile criterion. McNemar test indicated standard concordance, and multivariable linear regression found MET values. Statistical significance was assigned by p-values < 0.05. Results: Signif …

28.08.2026journal-article

ACS Applied Nano Materials

A Compositionally Tunable Micelle Platform for Integrated Photoacoustic Imaging, Direct Visual Guidance, and Photothermal Therapy of Solid Tumors

Jennifer Ferd, Ariane Rocha Bartolomeu, Nicole Carrillo-Malani, Qiushi Liang, Maryam Soleimani, Daniela Araiza-Olivera, Margie L. Clapper, Joann Miller, Theresa M. Busch, Zhiliang Cheng, Andrew Tsourkas, Ahmad Amirshaghaghi

Abstract Incomplete tumor resection remains a primary driver of cancer recurrence and would benefit from technologies that enable both accurate tumor delineation and localized ablation of residual disease. Here, we report a compositionally tunable nanotheranostic platform based on sub-50 nm (∼40–50 nm) poly(ethylene glycol)-block-poly(caprolactone) (PEG-PCL) nanoscale micelles coloaded with phthalocyanine (Pc) and naphthalocyanine (Nc) dyes, designed for integrated photoacoustic (PA) imaging, direct visual guidance …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Brain Network and Synaptic Plasticity Changes Associated with Electroconvulsive Therapy for Depression: A Multilevel Review

Yihan Jiang, Xinying Jiang, Yuting Huang, Xiaohui Yu

Electroconvulsive therapy (ECT) is an important treatment for severe, treatment-resistant, or high-risk depression, yet the relationship between its antidepressant effects, brain network changes, and cellular and molecular processes remains incompletely understood. Recent advances in multimodal magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), molecular biology, and animal electroconvulsive stimulation models have provided multilevel evidence for understanding the neurobiological mechanisms o …

28.08.2026journal-article

Frontiers in Neurology

Transcranial direct current stimulation combined with rehabilitation training for chronic spinal pain: a systematic review and Meta-analysis

Chenna Li, Lei Wu, Juan Chen, Qi Sun, Ping Cao

Objective To evaluate the incremental clinical effects and safety of active transcranial direct current stimulation (tDCS) added to rehabilitation in adults with chronic spinal pain. Methods PubMed, Web of Science Core Collection, CENTRAL, SPORTDiscus via EBSCOhost, and CNKI were searched from inception to 4 July 2026. Randomized trials evaluating active tDCS combined with rehabilitation were eligible. Primary meta-analyses were restricted to active versus sham tDCS delivered with the same or closely matched rehabi …

28.08.2026journal-article

NEW SOLUTIONS: A Journal of Environmental and Occupational Health Policy

Cycles of Change: Understanding Corporate Employees’ Perceptions of Menstrual Leave in Delhi NCR

Nisha, Sunaina Dua, Liza Attrey, Ruchi Kaushik

Menstrual health and hygiene management has emerged as a critical concern in workplace equity and occupational health discourse, yet policies such as menstrual leave remain contested in India. The study explores the perceptions of corporate employees in Delhi NCR on menstrual leave policy. A descriptive study was conducted with 50 corporate employees (40 women, 10 men) in Delhi NCR, selected through purposive and snowball sampling. Data were gathered using gender-specific semistructured interviews and analyzed thro …