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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Clinical Pharmacology & Therapeutics

Multiscale Modeling of an 8‐Week Combination Regimen of Bemnifosbuvir and Ruzasvir in Patients with Chronic Hepatitis C Virus Infection

Carolin Zitzmann, Ruy M. Ribeiro, Aurelien Marc, Xiao‐Jian Zhou, Alan S. Perelson

Bemnifosbuvir (BEM) and ruzasvir (RZR) are pan‐genotypic HCV polymerase (NS5B) and NS5A inhibitors, respectively. In a single‐arm study (NCT05904470), 215 treatment‐naïve, adherent participants with chronic HCV (with or without cirrhosis) received BEM 550 mg QD plus RZR 180 mg QD for 8 weeks. We employed a multiscale mathematical model fitted to the HCV RNA and ALT dynamics to quantify the antiviral activity and evaluate the modes of action of BEM and RZR. We found that after treatment initiation, the viral load (V …

03.09.2026journal-article

Translational Psychiatry

Longitudinal changes in endocannabinoids and clinical course of adolescent non-suicidal self-injury

Marc D. Ferger, Susanne Brodesser, Michael Kaess, Julian Koenig

Abstract Non-suicidal self-injury (NSSI) in adolescents has previously been linked to alterations in the endocannabinoid system. While increasing evidence supports endocannabinoid levels as potential biomarker in psychiatric care, little is known about their longitudinal trajectories over the course of treatment or in predicting clinical symptoms. This is the first study to investigate endocannabinoids in a longitudinal cohort of patients with NSSI, exploring associations with the development of symptoms over time. …

03.09.2026journal-article

Frontiers in Oncology

Early postoperative morbidity and short-term outcomes after cytoreductive surgery and HIPEC for peritoneal surface malignancies: initial single-center experience from Palestine

Marwan Abufara, Qais M. Alnjoom, Amanda Siniora, Elias Yacoub, Tareq Jarrar, Ibraheem AbuAlrub

Background Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is an established treatment option for selected patients with peritoneal surface malignancies. However, data from newly introduced programs in resource-constrained settings are limited. We report our initial experience in Palestine, a single center, in evaluating the feasibility, perioperative safety and short-term oncologic outcomes of CRS-HIPEC. Methods We conducted a retrospective descriptive study of all consecutive pa …

03.09.2026journal-article

Frontiers in Medicine

Current landscape and research gaps in artificial intelligence for ophthalmic nursing: a scoping review

Qiong Song, Xiaofang Huang, Yamin Hu, Kaiqin She

Introduction Artificial intelligence (AI) is advancing rapidly across clinical medicine, yet its application within ophthalmic nursing, spanning emergency triage, perioperative care, day surgery, and patient education, remains poorly characterized. The growing burden of eye disease and the demand for community-based ophthalmic screening create an urgent context for understanding where AI can augment nursing capacity in this field and what barriers may be limiting evidence generation. This review aimed to systematic …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Tea consumption and cardiovascular risk and outcomes: mechanistic insights, epidemiological evidence, and clinical implications

Rong Liu, Jialin Li, Yanchun Liang

Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide. Tea contains bioactive compounds with plausible antioxidant, anti-inflammatory, endothelial, metabolic, antithrombotic, and gut microbiota-mediated effects. Observational studies generally associate habitual tea consumption with lower risks of atherosclerotic CVD and mortality, but causal inference remains uncertain because secondary-prevention data are limited, randomized trials focus mainly on surrogate outcomes, and Mendel …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Paralytic ileus as an early manifestation of evolving neuroleptic malignant syndrome in a patient receiving anti-psychotics

Balakrishnan Arivalagan, Pragathi Munnangi, Yashkumar Girdharlal Kamani, Jyoti Guglani, Angel Barrera, Krishna Singh, Makker Jasbir, Harish Patel, Misbahuddin Khaja

Neuroleptic malignant syndrome (NMS) is an uncommon, but potentially life- threatening complication of antipsychotic therapy, primarily resulting from central dopaminergic blockade. NMS is a clinical diagnosis and occurs rarely in patients receiving atypical antipsychotics agents. Gastrointestinal manifestations, including severe hypomotility and paralytic ileus, are recognized adverse effects of antipsychotic medications. However, paralytic ileus preceding the characteristic neuromuscular and autonomic features of …

03.09.2026journal-article

European Journal of Dental Education

Evaluating the Accuracy of Large Language Models in Dentistry: A Multi‐Model Study Using Clinical Questions From Turkey's Dental Specialty Exams

Nihan Kaya Acar, Fatih Sengul, Peris Celikel, Aziz Sahin Erdogan

ABSTRACT Aim Artificial intelligence ( AI ) has become an integral part of dental education and clinical practice. While several studies have assessed the performance of ChatGPT in medical exams, comparative analyses of various large language models ( LLMs ) in dentistry remain scarce. This study aimed to evaluate and compare the performance of five prominent AI models in answering clinical questions from Turkey's dental specialty examination ( DUS ). Materials and Methods A total of 1026 clinical science questions …

03.09.2026journal-article

Bulletin of Pirogov National Medical & Surgical Center

PIGMENTARY GLAUCOMA. CURRENT CONCEPTS OF DEVELOPMENT AND RESULTS OF PATHOGENETICALLY TARGETED TREATMENT

T. V. Sokolovskaya, A. S. Pleshakova, I. D. Arsyutov

Rationale : Pigmentary glaucoma (PG), which develops against the background of pigment dispersion syndrome (PDS), is a significant medical and social problem in ophthalmology. A key feature of PG is that it affects young people of working age (20 to 40 years old). The social significance of PG is exacerbated by the high risk (35% to 50%) of asymptomatic PDS transforming into clinically significant glaucomatous optic neuropathy within 4 to 10 years. Without timely treatment, this leads to irreversible vision loss du …

03.09.2026journal-article

Diabetes Technology & Therapeutics

Optimizing Continuous Glucose Monitoring for Older Adults with Diabetes: From Clinical Evidence to a Practical Implementation Pathway

Tong Yang, Jinghao Cai, Jiaying Ni, Jingyi Lu, Jian Zhou

Older adults represent a growing proportion of people with diabetes and often experience hypoglycemia, glycemic variability (GV), multimorbidity, frailty, and treatment-related vulnerabilities that are not fully captured by glycated hemoglobin A1c (HbA1c) alone. Continuous glucose monitoring (CGM) provides time-resolved glucose profiles, trend information, alerts, and remote data sharing, making it well suited to safety-focused geriatric diabetes care. In this narrative review, we synthesize evidence on CGM feature …

03.09.2026journal-article

Journal of Minimal Access Surgery

Subcutaneous emphysema beyond conventional grading following uncomplicated totally extraperitoneal inguinal hernia repair: A case report

Abdullah Gürhan Duyan, Muhammed Nezih Koç

Abstract Subcutaneous emphysema (SE) is a rare and usually self-limiting complication of laparoscopic totally extraperitoneal (TEP) inguinal hernia repair. We report a 74-year-old man who developed massive SE after a short, technically uncomplicated 32-min TEP repair, despite the absence of major modifiable technical risk factors – working pressure ≤12 mmHg, open (Hasson) entry, single absorbable tack and no peritoneal breach. An abrupt rise in end-tidal carbon dioxide (EtCO 2 ) from a stable baseline (34–36 mmHg) …

02.09.2026journal-article

International Journal of Analysis and Applications

A Study on Medical Diagnosis Using Neutrosophic Over Complex Sets and Artificial Neural Networks Under Uncertain Environments

Prabakaran Raghavendran, Nidal Anakira, Yamini Parthiban, Abed Al-Rahman M. Malkawi, Tala Sasa

The present article introduces the idea of Neutrosophic Over Complex Sets, and in a way it kind of explores how they can be used for medical diagnosis tasks that live in uncertain and inconsistent environments. The proposed framework mixes the benefits of neutrosophic sets, over sets, and also complex-valued information into one single mathematical structure, so it can manage indeterminate, contradictory and over-valued complex data without too much fuss. In the proposed setup, the truth-membership, indeterminacy-m …

02.09.2026journal-article

Journal of Clinical Medicine

Hepatic Steatosis in Pulsed Field Ablation for Atrial Fibrillation: Prevalence, Liver Marker Concordance and Acute Procedural Characteristics

Maria Boszko, Bartosz Krzowski, Michał Gawlik, Alicja Skrobucha, Julia Szydlik, Mateusz Wawrzeńczyk, Karolina Mitrzak, Kacper Rutkowski, Karolina Ignaczak, Monika Gawałko, Cezary Maciejewski, Jakub Rokicki, Michał Peller, Michał Marchel, Piotr Lodziński, Grzegorz Styczyński, Marcin Grabowski, Paweł Balsam

Background/Objectives: Hepatic steatosis and metabolic dysfunction-associated steatotic liver disease (MASLD) are cardiometabolic phenotypes relevant to atrial fibrillation (AF), but their prevalence and acute procedural relevance in pulsed field ablation (PFA) are poorly defined. We estimated the prevalence of hepato-renal index (HRI)-detected hepatic steatosis, assessed liver marker concordance, and explored acute procedural characteristics. Methods: In this single-centre prospective study, 99 consecutive eligibl …

02.09.2026journal-article

Allergy

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

S. Dramburg, C. J. Hernandez Toro, U. Grittner, E. Potapova, A. Travaglini, S. Tripodi, S. Arasi, S. Pelosi, F. Monnati, A. Acar Şahin, X. Aggelidis, A. Barbalace, A. Bourgoin, B. Bregu, M. A. Brighetti, E. Caeiro, S. Caglayan Sozmen, L. Caminiti, D. Charpin, M. Couto, L. Delgado, A. Di Rienzo Businco, C. Dimier, M. V. Dimou, J. A. Fonseca, O. Goksel, D. Hernandez, T. M. Hoffmann, D. T. Jang, F. Kalpaklioglu, B. Lame, R. Llusar, M. Makris, A. Mazon, E. Mesonjesi, A. Nieto, A. B. Öztürk, L. Pahus, G. Pajno, I. Panasiti

ABSTRACT Background Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e‐Diaries) are feasible tools to collect prospective patient‐reported data. Objective To test the consistency between prospectively recorded symptoms and retrospective ARIA classification and to generate a new SAR classification based on prospective e‐Diary data. Meth …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Impact of Diabetes Mellitus on Drug-Induced Liver Injury during Antituberculosis Therapy: A Prospective Cohort Study

Ruina Chen, Yu Wu, Xiaoyan Xu, Jingru Cheng, Yan Jiang, Xiaomin He, Hongqiu Pan, Meiling Zhang, Lihuan Lu, Honggang Yi, Shaowen Tang

ABSTRACT. Drug-induced liver injury (DILI) is a significant concern during antituberculosis (anti-TB) treatment, and its association with diabetes mellitus (DM) remains inconsistent. This study investigated whether DM influences anti-TB DILI occurrence in Chinese patients. A prospective cohort study enrolled patients receiving anti-TB treatment at four hospitals. Patients were grouped by DM status and followed up until treatment completion. Propensity score matching (PSM) was performed at a 1:1 ratio to ensure comp …

02.09.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Paracapillaria philippinensis Infection in India: A Report of Four Cases

Ashis Kumar Choudhury, John Titus George, Nicholas Vijay Rao, Amit Kumar Dutta, Dipti Masih, Samuel George Hansdak, Ravikar Ralph, Sitara Swarna Rao Ajjampur

ABSTRACT. Capillaria philippinensis (recently renamed Paracapillaria philippinensis [ P. philippinensis ]) is a nematode infection endemic to Southeast Asia and Egypt and is rarely reported in India. This disease can be fatal if it is not diagnosed early and treated appropriately. Four cases of P. philippinensis infection identified over a decade from a single center in India are reported. All patients presented with diarrhea and reported symptoms such as abdominal pain, vomiting, and pedal edema, suggesting malabs …

02.09.2026journal-article

JAMA Surgery

Blood or Crystalloids for Hemorrhagic Shock—Response to the Agency for Healthcare Research and Quality

Julia R. Coleman, Reynold Henry, Nakul Raykar, John B. Holcomb

This Viewpoint evaluates the Agency for Healthcare Research and Quality report on prehospital blood transfusion and fluid interventions for hemorrhagic shock and argues that its claims of scientific equipoise stem from methodologic challenges instead of clinical equivalence of blood transfusion and crystalloid therapy.

02.09.2026journal-article

Journal of Functional Biomaterials

Data-Driven Development of Biomedical Hydrogels for Controlled Drug Delivery: Clinical Applications and Emerging Machine-Learning Approaches

Elham Eskandarnia, Ayah Binrajab, Adnan Alsaei, Fatema Rahimi, Nasser Alahmed, Ahmad Zarwi, G. Roshan Deen

Hydrogels are hydrated three-dimensional polymeric networks with biomedical potential because they can encapsulate therapeutic agents and provide localised, sustained, or stimulus-responsive drug delivery. Their performance is determined by interacting variables, including polymer composition, synthesis route, crosslinking chemistry, drug loading, swelling, degradation, and the biological microenvironment. This multidimensional design space often makes hydrogel development slow and dependent on trial-and-error expe …

02.09.2026journal-article

Current Opinion in Clinical Nutrition & Metabolic Care

Iron deficiency during pregnancy and lactation

Laura Wasserfallen, Diego Moretti

Purpose of review Iron deficiency persists as the most common nutritional deficiency worldwide and is highly prevalent among women of reproductive age. Pregnancy substantially raises iron requirements, increasing the risk of complications for mother and newborn particularly in low-income and middle-income countries. We summarize current evidence on the determinants, physiological adaptations, diagnostic thresholds, and management of iron deficiency during pregnancy and lactation, focusing on recent developments. Re …

02.09.2026journal-article

Diagnostics

Diagnosis of Extensive DCIS with Progressive Microcalcifications over a Period of 11 Years

Menelaos Zafrakas, Theodoros Argyriou, Panayiota Papasozomenou, Christos Emmanouilides

A 53-year-old woman presented complaining of enlargement of her right breast; 12 years earlier she was treated elsewhere for an invasive ductal carcinoma of the right breast with breast-conserving surgery, adjuvant chemotherapy, anti-HER2 therapy, radiotherapy and endocrine therapy. One year postoperatively, a group of microcalcifications was seen in the ipsilateral breast on mammography. In the following years, the area of microcalcifications progressively increased, but instead of vacuum-assisted biopsy, the trea …

02.09.2026journal-article

The Clinical Teacher

Professional Identity Formation in the Transition From Undergraduate to Postgraduate Medical Education: A Scoping Review

Juliana Sá, Ana L. Da Silva, Pia Strand, Simon Kitto

ABSTRACT Background The transition from undergraduate to postgraduate medical education is a crucial phase of professional development, requiring trainees to assume greater clinical responsibility and adapt to new social norms. This transition influences professional identity formation (PIF), which is important for safe practice, well‐being and resilience. We conducted a scoping review to map studies of PIF during this transition and synthesise the key findings of this body of literature. Methods We searched five d …

02.09.2026journal-article

Journal of Laparoendoscopic & Advanced Surgical Techniques

Clinical Outcomes of Magnesium-Based Balloon-Expandable Biodegradable Stenting for Benign Biliary Strictures: A Single-Center Retrospective Cohort Study

Mariano Eduardo Giménez, Chiara Innocenzi, Ignacio Corteggiano, Juliana Maria Racedo, Lucas Fehlauer, Samantha Robert, Pablo Acquafresca, Eduardo Houghton, Mariano Palermo

Background: Benign biliary strictures, most commonly anastomotic after hepaticojejunostomy or related to bile duct injury, are conventionally managed with balloon dilation, multiple plastic stents, or covered metal stents, all of which typically require repeated procedures. Magnesium-based balloon-expandable biodegradable stents (UNITY-B) have been proposed as a single-step alternative, but dedicated cohort data are limited. Methods: We retrospectively reviewed 22 consecutive UNITY-B stent-placement procedures perf …

02.09.2026journal-article

Siberian Journal of Clinical and Experimental Medicine

The impact of intraoperative epiaortic scanning of the ascending aorta on the tactics and outcomes of coronary artery bypass grafting (literature review)

S. L. Andreev, Yu. Yu. Vechersky, V. V. Zatolokin, B. N. Kozlov

This review evaluates the use of intraoperative epiaortic scanning (IES) of the ascending aorta in coronary artery bypass grafting. The diagnostic advantages of IES 3 over traditional palpation and transesophageal echocardiography are discussed, allowing for the detection of atherosclerotic plaques, including mobile and ulcerated ones. Clinical trial data are presented, demonstrating that the use of IES leads to a change in surgical tactics in 5–15% of cases (avoidance of aortic manipulation, use of contactless dev …

02.09.2026journal-article

Evidence-Based Chinese Medicine and Technology Assessment

How can traditional Chinese medicine trials achieve global credibility

Ying Wang, Gordon Guyatt

Abstract Traditional Chinese medicine (TCM) needs credible evidence that meets international evidence-based medicine standards to achieve global credibility and acceptance. A fundamental and crucial task is to conduct high-quality randomized controlled trials (RCTs). To achieve global credibility, TCM RCTs should meet universal standards of scientific rigor, such as addressing clinically important questions, achieving sufficient sample size and minimizing risk of bias, and enhance generalizability through appropria …