24.08.2026journal-article
Archives of Disease in Childhood
Gill Norman, Ross Fairbairn, Emma Dobson, Chizoba Oparah, Ayomikun Ogunyemi, Niina Kolehmainen
Objective To provide intelligence and foresight about persistent evidence gaps in medicines for children and young people experiencing gender incongruence or dysphoria. Design A horizon scan, with foresight analysis, of clinical trial registries. Setting Global. Patients Children and young people (aged 0–17 years) experiencing gender incongruence or dysphoria. Interventions Any medicine under evaluation in an ongoing study registered on a clinical trial registry. Main outcome measures Any. Results We identified 15 …
24.08.2026journal-article
JMIR Rehabilitation and Assistive Technologies
Makoto Nagasawa, Sho Nakamura, Yoshinobu Saito, Yuko Oguma, Takashi Kasukawa, Kaname Watanabe, Hiroto Narimatsu
Abstract Background Improving exercise self-efficacy (ESE) is a key strategy for promoting sustained physical activity among older adults with frailty. The lumbar-type Hybrid Assistive Limb (HAL), a wearable device that supports voluntary movement through bioelectric signals, may facilitate mastery experiences in individuals with low baseline self-efficacy via adjustable assistance. However, its effects on ESE remain unclear. Objective This study evaluated the effects of lumbar-type HAL exercise on ESE in older adu …
24.08.2026journal-article
Environmental Research Letters
Florent Bédécarrats
Abstract Impact evaluations of protected areas (PAs) routinely define ‘local populations’ through spatial proximity, yet the demographic scale implied by these definitions is almost never quantified. We estimate population counts inside PAs and within 10 km of their boundaries for 75 low- and lower-middle-income countries (LMICs) in 2000 and 2020, using the World Database on PAs and globally harmonized gridded population data (GHSL, with WorldPop as robustness check). India, which represents about 36% of the LMIC p …
24.08.2026journal-article
Journal of Gerontological Nursing
Eunice Oladepe Ojo, Victoria Loerzel, Boon Peng Ng, Rui Xie, Ladda Thiamwong
Purpose: To explore the experiences of low-income community-dwelling older adults with the physical, cognitive, sociocultural, and behavioral effects of physical activity measured with an activity tracker. Method: The current qualitative descriptive study was conducted among participants in the Physio-Feedback Exercise Program, who were aged ≥60 years and from low-income settings in Central Florida ( n = 19). A semi-structured interview guide was used to obtain participants' experiences, and the responses were tran …
24.08.2026journal-article
Behavioral Sciences
Ortal Cohen Elimelech, Naor Demeter, Sara Rosenblum
Loneliness is a growing public health concern among older adults, underscoring the need to better understand the complex interplay of factors associated with it. Although technology can enhance social connectedness, limited attention has been given to discrepancies between desired and actual technology use in daily life. This study examined loneliness, focusing on perceived technology-use gaps alongside health-related factors, including depressive symptoms, sleep quality, functional cognition, and sensorimotor abil …
24.08.2026journal-article
Journal of Gerontological Nursing
Sarah Romanelli, Veronica Rivera, Carolina Cuervo, Leah V. Estrada
Purpose: To evaluate whether nurse-led follow-up calls after emergency department (ED) discharge were associated with decreased 30-day ED revisits and hospital admissions among older adults in two geriatric practices. Method: The current retrospective quality improvement evaluation was conducted from April 2023 to March 2025. RNs called individuals aged ≥65 years within 5 business days of ED discharge to review instructions, assess symptoms, and support primary care provider (PCP) follow up. Outcomes were 30-day ED …
24.08.2026journal-article
Journal of Health and Human Services Administration
Harish Gupta
Adults aged 75 and older recorded the highest suicide rate in the United States in 2023. Yet late-life suicide has received limited treatment in public administration as a problem of design, interagency accountability, and statutory responsibility. Drawing on the disarticulated state condition in public administration theory, this analysis, this analysis finds that authority without accountability leaves predictable handoff points unassigned across the older-adult crisis trajectory. Four federal actors contact olde …
24.08.2026journal-article
The American Surgeon™
Gabriella Cote, Kalli Devecki, Keelin Roche, Sarah King, Hannah Collins, J. Bracken Burns
Agriculture remains one of the most hazardous industries in the United States, and livestock-related trauma represents an important source of injury in rural communities. As the agricultural workforce ages, understanding age-related differences in farm animal-related trauma has become increasingly important. Methods: We performed a retrospective multicenter cohort study of patients presenting with farm animal-related injuries to three regional trauma centers in Southern Appalachia between 2015 and 2024. Patients we …
24.08.2026journal-article
International Journal of Basic & Clinical Pharmacology
Janvi A. Gandani, Snigdha Misra, Amrit Kejriwal
Background: Cardiovascular disorders are a major cause of morbidity and mortality among older patients. Drug utilization studies are useful in assessment of prescribing behaviour and rational use of drugs. To study the drug utilization pattern of cardiovascular drugs and to evaluate the prescribing practices by WHO-INRUD prescribing indicators in geriatric patients of cardiovascular illnesses admitted in tertiary care hospital. Methods: A hospital based observational cross-sectional study was carried out in Medicin …
24.08.2026journal-article
J
Oluwatoyin Kode, Michin Hong, Long Nguyen, Soo-Yeon Ji
Dementia-related disorders, particularly Alzheimer’s disease (AD), represent a growing global health challenge, increasing the need for early and reliable detection. Electroencephalography (EEG), a non-invasive and cost-effective neurophysiological modality, has emerged as a promising tool for identifying neural signatures associated with cognitive decline. Recent advances in machine learning (ML) and deep learning (DL) have enabled more effective analysis of complex EEG signals for automated dementia prediction. T …
24.08.2026journal-article
SDÜ SAĞLIK BİLİMLERİ DERGİSİ
Kübra Erdoğan, Ayşenur Çelik
Objectives: Older adults are particularly vulnerable to ocular diseases that impair vision, quality of life, and functional independence. Understanding ophthalmology outpatient visit patterns in this population is essential for planning age-sensitive eye care services. This study aimed to analyze the primary reasons for ophthalmology outpatient visits among older adults in Turkey. Materials and Methods: Medical records of patients aged ≥65 years attending an outpatient ophthalmology clinic between January and Decem …
24.08.2026journal-article
American Journal of Physiology-Heart and Circulatory Physiology
Elena MV de Cavanagh, Felipe Inserra, León Ferder
In the present article, we aimed to determine whether the beneficial effects of renin-angiotensin system (RAS) blockade on aging involve epigenetic changes and the participation of any of the cell-rejuvenating Yamanaka factors. To this end, we have reviewed published work that investigated aging and its relation to epigenetic modifications, the effects of RAS blockade on aging and epigenetics, RAS’s influence on stem cell function, and RAS interactions with the Yamanaka factors KLF4, Oct4, c-Myc, and Sox2. The revi …
24.08.2026journal-article
Revista ft
Adriana Karollayne Silva Pedroso, Andréia Gomes Moreira
Introduction: Tirzepatide represents an important therapeutic advance in the treatment of obesity and type 2 diabetes mellitus, promoting significant weight loss. However, this weight reduction can cause changes in facial aesthetics, popularly known as Ozempic face, characterized by volume loss, skin laxity, and accentuation of facial wrinkles, making the role of Orofacial Harmonization (OF) relevant in managing these changes. Objective: To analyze, through an integrative literature review, the main facial aestheti …
24.08.2026journal-article
Frontiers in Dementia
Manpreet K. Gill, Shareefa Thekkan, Danine Irwin
Introduction Nature-based interventions are increasingly recognised as a promising non-pharmacological approach to support people living with dementia and their carers. Although a growing body of research has explored the relationship between nature engagement and dementia, the evidence remains dispersed across a wide range of intervention types, settings and outcome measures. This review aimed to identify and map the available evidence relating to nature-based interventions for people living with dementia and thei …
24.08.2026journal-article
Transactions of the Institute of British Geographers
Gauthier Dulout, Nissa Finney, David McCollum
ABSTRACT The housing crisis in England and Wales is commonly explained as a national shortage of housing supply, leading to a policy focus on aggregate production targets. This paper challenges that narrative, arguing that this framing has obscured a parallel dimension: a growing spatial mismatch between where homes are and where they are needed, compounded by deepening inequalities in how the existing stock is occupied. Using Local Authority District (LA) data from four decennial censuses (1991 to 2021), this stud …
24.08.2026journal-article
Frontiers in Aging Neuroscience
Mingyu Mao, Yan Wang, Qing Deng, Jun Xiang, Wentao Li
Parkinson’s disease (PD) is characterized by progressive nigrostriatal degeneration, yet the contribution of modification-rich small RNAs to PD pathology remains unclear. Here, we used PANDORA-seq to profile the striatal small RNA landscape in a subacute MPTP-induced mouse model of PD. MPTP-treated mice exhibited significant motor deficits together with reduced striatal tyrosine hydroxylase and dopamine transporter expression, confirming successful model establishment. Small RNA profiling revealed that transfer RNA …
24.08.2026journal-article
Multilingua
Lucia Aletto
Abstract Since 2015, Ventimiglia has become a “choke point” for “people on the move” traversing turbulent routes conditioned by restrictive European border policies. This article employs a participatory ethnography of graffiti to offer a singular perspective on undocumented movements. By treating graffiti as “participatory objects” rather than mere artifacts, the study documents approximately 250 units geolocated between the Roya river’s informal camp and Grimaldi shelters. The methodology emphasizes “spontaneous p …
24.08.2026journal-article
Brain
Amaryllis A Tsiknia, Victoria R Tennant, Marylan Davison, Rajesh Nandy, Matthew Borzage, Alexandra L Clark, Arthur W Toga, Kristine Yaffe, Sid O’Bryant, Meredith N Braskie
Abstract Type 2 diabetes mellitus is associated with cognitive impairment and greater Alzheimer’s disease risk, with cross-sectional studies suggesting that this is driven by neurodegeneration and vascular changes. Longitudinal studies, however, report similar rates of total brain atrophy over time in diabetic and non-diabetic adults. We recently showed that diabetes-related neurodegeneration in cognitively unimpaired adults is regional and may not be evident in longitudinal studies of global brain atrophy. The mec …
24.08.2026journal-article
Dementia
Anthony Scerri, Charles Scerri
Dance-based interventions are increasingly recognised as valuable psychosocial approaches to support the wellbeing and social participation of people living with dementia. However, existing research has largely focused on outcomes, with limited attention to how such programmes are facilitated and experienced in practice. This study explored how dance facilitators understand and navigate the multi-level influences shaping the organisation, delivery and perceived impact of dance sessions for people living with dement …
24.08.2026journal-article
Addiction
Patrick J. A. Kelly, Elizabeth Chen, Amelia Bailey, Katie Biello, Brandon D. L. Marshall, Josiah D. Rich, Jaclyn M. W. Hughto
Abstract Background and aims Artificial intelligence (AI) may improve addiction medicine workflows and health outcomes but raises questions about data privacy and unintended harms for people who use drugs (PWUD). This qualitative study aimed to understand the perspectives of clinicians and PWUD regarding perceived benefits and concerns about clinical AI in addiction medicine. Design A qualitative study with one‐on‐one semi‐structured interviews about AI. Setting Addiction medicine clinicians in Rhode Island ( n = 7 …
24.08.2026journal-article
Revista sanitaria de investigación
Lucía Cantón Ramos, Avelina Cachón Villadangos, Javier Francisco Merillas Alija
Las caídas intrahospitalarias constituyen un evento adverso especialmente relevante en las personas mayores, debido a su origen multifactorial y a las posibles consecuencias sobre la morbimortalidad, la autonomía funcional y la duración de la hospitalización. Se presenta el caso de una mujer de 82 años, ingresada en una unidad de Medicina Interna por descompensación de una enfermedad renal crónica, con antecedentes de enfermedad de Alzheimer y diabetes mellitus. La paciente presentaba riesgo alto de caídas, con una …
24.08.2026journal-article
Current Nutrition & Food Science
Rnad AbdelRahman, Mariam Iqbal, Stefanos Tyrovolas, Dimitrios Papandreou
Introduction: Older adults face multiple challenges in meeting their daily energy, protein, and fluid requirements. These challenges adversely affect metabolic function, gastrointestinal health, muscle mass, and sensory perception. Malnutrition and appetite loss remain highly prevalent despite increasing clinical recognition and are often underdiagnosed in clinical practice. This narrative review aims to understand the prevalence of appetite loss and malnutrition in older adults and their combined effects on dietar …
24.08.2026journal-article
International Journal of Molecular Sciences
Zulfiya Guvatova, Anastasiya Kobelyatskaya, Alexander Gorbunov, Elena Pudova, Alexey Moskalev
Aptamer-based multiplexed proteomic platforms, especially the SOMAmer-based SomaScan assay, are widely used for large-scale discovery of circulating biomarkers relevant to human aging. This review summarizes 42 original research articles published from 2020 through 2026 in which aptamers or aptamer-derived biosensors were used to characterize aging-related biomarkers in human samples or clinically relevant human-disease contexts. The eligible literature falls into several thematic areas: whole-plasma and organ-spec …
24.08.2026journal-article
eceee Summer Study proceedings
Michael Fell
Extended abstract 1-066-26 Large Language Model (LLM) agents are increasingly used to simulate human perspectives in domains such as research and design. There is evidence that at the population level, LLM agents can perform reasonably well in replicating general trends apparent in research with humans, including on the topic of energy. This approach is of interest because of the very significant time- and cost-efficiencies agents offer. However, substantial concerns also exist. Such models have demonstrated potent …
