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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Journal of Translational Medicine

Transcriptomic profiling of lineage transformation and actionable therapy opportunities in EGFR-mutant non-small cell lung cancer evolving to small cell lung cancer

Hui Yu, Meichen Li, Xiaodie Li, Mingjie Yu, Yin Pan, Jingping Yun, Likun Chen

Abstract Background Neuroendocrine transformation of epidermal growth factor receptor-mutant lung adenocarcinoma (EGFR m LUAD) represents a significant mechanism underlying acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). This histological transformation lacks effective treatments. We comprehensively discussed the treatments of transformed small cell lung cancer (T-SCLC) and analyzed the transcriptomic profile of EGFR m LUAD and paired T-SCLC, aiming to understand the immune landscape of this T-SCLC s …

28.08.2026journal-article

International Journal of Quantum Chemistry

Fault‐Tolerant Quantum Simulation of the Pauli‐Breit Hamiltonian for Ab Initio Hybrid Quantum‐Classical Molecular Design With Applications to Photodynamic Therapy

Emil Zak

ABSTRACT Relativistic spin effects are driving subtle molecular processes ranging from intersystem crossing in photodynamic therapy to spin‐mediated catalysis and high‐resolution spectroscopy. These effects can be described by the Pauli‐Breit Hamiltonian, which extends the nonrelativistic electronic Hamiltonian by including explicit one‐ and two‐electron spin‐orbit and spin‐spin interactions. However, first‐principles simulations of the full Pauli‐Breit Hamiltonian quickly become intractable on classical computers …

28.08.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

Not Just Faster Horses: Telerehabilitation as a Necessary Evolution in Physical Therapy

Miguel Farraj, Julien Lebleu, Bruno Bonnechère, Joachim Van Cant

This editorial draws an analogy between the transition from “faster horses” to automobiles, and the digital transition facing musculoskeletal physical therapy. Musculoskeletal rehabilitation has long emphasized face-to-face sessions; digital solutions such as telerehabilitation have often been perceived as alternatives to conventional care. However, increasing rehabilitation demands, persistent gaps between sessions, and the need for long-term patient support highlight the importance of rethinking how physical ther …

28.08.2026journal-article

Chinese Medical Journal

Novel targeted therapy and cellular immunotherapy enabling allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute myeloid leukemia

Liqin Cao, Daihong Hu, Lijuan Cui, Xiaohui Zhang

Abstract Patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) are characterized by a disastrous prognosis. For most patients with R/R AML, allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative option. It is important to conduct mutational analysis again when the disease relapses to identify any new genetic abnormalities that can be targeted with novel treatments. As part of a conditioning regimen or post-transplant maintenance therapy, new targeted agents support HSCT in …

28.08.2026journal-article

International Journal of Biology and Life Sciences

Controversial Focus and International Consensus Interpretation of Medical and Interventional Therapy for Type B IMH

Yucheng Gao, Hongwei Lei

Type B Intramural Aortic Hematoma (IMH) is an important subtype of acute aortic syndrome, and its clinical management has long been debated between conservative medical therapy and interventional therapy via Thoracic Endovascular Aortic Repair (TEVAR). Medical therapy mainly relies on strict blood pressure and heart rate control, advocating conservative management and long-term follow-up observation for uncomplicated cases. By contrast, interventional therapy features minimal trauma, which can effectively prevent d …

28.08.2026journal-article

Journal of Mechanics in Medicine and Biology

A CLOSED-LOOP SOMATOSENSORY MUSIC THERAPY SYSTEM BASED ON CHANNEL-ATTENTION LSTM FOR PHYSIOLOGICAL STATE REGULATION IN ALZHEIMER‘S DISEASE

FUPING XU, GUIMEI YU, QING SANG

Traditional somatosensory music therapy predominantly employs fixed-parameter protocols, which lack the capacity for dynamic adjustment based on the real-time physiological and emotional states of patients. This limitation results in significant individual variability in therapeutic outcomes, making personalized and precise interventions difficult to achieve. This study aims to develop a Channel Attention Multi-modal Long Short-Term Memory (CA-Multi-LSTM) model, as well as an Intelligent Vibroacoustic Music Therapy …

28.08.2026journal-article

JAMA Network Open

Discontinuation of Semaglutide Therapy for Obesity Management

Aurélie Mailhac, Lars Pedersen, Irene Petersen, Anton Pottegård, Henrik T. Sørensen, Reimar W. Thomsen

This cohort study examines the risk of and baseline variables associated with discontinuation of semaglutide treatment for obesity management among individuals in Denmark.

28.08.2026journal-article

ACS Omega

Fabrication and Characterization of Green-Synthesized Zinc Oxide Nanoparticles Loaded into Dissolving Microneedles: A Potential Delivery Platform for Breast Cancer Therapy

Haneen Faris Al-Shawabkeh, Rafa Aburayya, Haneen A. Basheer, Ahlam Zaid Alkilani, Maram A. Alhusban, Rania Hamed

Abstract Green-synthesized zinc oxide nanoparticles (ZnO NPs) can be used to explore their anticancer applications. Therefore, this study aimed to synthesize ZnO NPs using an eco-friendly method by combining Phoenix dactylifera (P. dactylifera) root hair extract with 0.8 M zinc acetate dihydrate at a volume ratio of 4:1. The ZnO NPs had an average size of 24.01 ± 1.70 nm, a polydispersity index (PDI) of 0.25 ± 0.02, and a zeta potential of −18.45 ± 1.80 mV. The X-ray diffraction analysis revealed the crystalline st …

28.08.2026journal-article

Journal of Head Trauma Rehabilitation

Multidimensional Preinjury Health and 6-month Outcome After Traumatic Brain Injury in Older Adults Presenting With Mainly GCS 13–15

Roy Tzemah-Shahar, Yael Rosen Lang, Ava M. Puccio, Esther L. Yuh, Domenico Lombardi, Michele Diaz Nelson, John Boscardin, J. Russell Huie, Kristine Yaffe, David O. Okonkwo, Ramon Diaz Arrastia, Geoffrey T. Manley, Raquel C. Gardner, the TRACK-TBI Investigators

Objective: To test the accuracy of existing traumatic brain injury (TBI) outcome prediction models in older adults with TBI (oaTBI), to determine the independent association of 5 different measures of preinjury health with 6-month outcome, and to investigate whether these preinjury health measures improve outcome prediction. Setting: Two level 1 trauma centers. Participants: A total of 112 adults aged ≥65 years who underwent head computed tomography after acute TBI (95% with Glasgow Coma Scale (GCS) score 13–15, 66 …

28.08.2026journal-article

Journal of Acute Care Physical Therapy

Impact of Intense Physical Therapy on Mobility Outcomes in Acute Stroke Stratified by Cortical and Subcortical Stroke Location

Sinead Farrelly, Andrea D. Boan, Emily Monsch, Mark Bowden, Ramish Ramakrishnan, Steve Kautz, Christine Holmstedt

ABSTRACT Purpose: Poststroke rehabilitation is critical for functional recovery, yet the impact of stroke location on therapy response remains underexplored. Cortical and subcortical strokes differ in motor learning mechanisms, raising questions about the role of therapy frequency and the use of error augmentation training in early recovery. This post hoc analysis builds on previously published pilot data ( JACPT , July 2024) and aims to explore whether frequent error augmentation therapy (twice-daily sessions) imp …

28.08.2026journal-article

Frontiers in Oncology

Uncharted phytochemical frontiers: a systematic review of novel bioactive compounds from underexplored aromatic plants for cancer therapy

Biswabhusan Dash, Himadri Tanaya Behera, N.G. Unnoottee, Swagat Mohanty, Divaker Shukla, Sudipta Jena, Asit Ray, Pratap Chandra Panda, Sanghamitra Nayak, Ambika Sahoo

Introduction Cancer continues to cause a high degree of morbidity and mortality worldwide, making it essential for new, safer, and more effective therapies to be developed. Aromatic plants provide researchers with diverse secondary metabolites that may have useful pharmacological effects. This systematic review examines several aromatic plants that were used medicinally in the past but have not been examined recently for their potential to produce new bioactive molecules with anticancer activity. Methods The protoc …

28.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Comprehension of Restrictive Focus With Zing6hai6 (“Only”) in School-Age Cantonese-Speaking Autistic and Neurotypical Children

Haoyan Ge, Peppina Po-lun Lee, Stephen Matthews

Purpose: This study investigated the comprehension of restrictive focus with the focus particle zing6hai6 (“only”) in school-age Cantonese-speaking autistic and neurotypical children. Specifically, it examined whether autistic children differed from neurotypical children in the comprehension of focus with zing6hai6 and explored the effects of age on their performance. Method: A total of 75 Cantonese-speaking children (42 autistic and 33 neurotypical) between 5 and 10 years old completed a picture verification task …

28.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Reliability and Validity of the Mandarin Articulation and Phonological Test: Scale Development and Psychometric Properties for Preschool Children

Chih-Chen Liang, Pao-Chuan Torng

Purpose: This study aimed to (a) develop preliminary reference data for the Mandarin Articulation and Phonological Test (MAPT) and (b) examine its reliability and validity for assessing speech abilities in Mandarin-speaking preschool children aged 3–6 years. The study responded to the need for speech assessment tools with systematic psychometric documentation in Mandarin, where standardized instruments with comprehensive scoring systems remain limited. Method: Participants included 148 typically developing children …

28.08.2026journal-article

Current Neuropharmacology

Statin Therapy for Primary Prevention in Adults Aged 80 Years and Older: A Systematic Review Conducted in Accordance with PRISMA 2020

Francisco Epelde

Introduction: Statins are well established for the primary prevention of cardiovascular disease (CVD) up to approximately 75 years of age; however, direct evidence in adults aged 80 years and older remains limited. Extrapolation from younger populations is uncertain because advanced age is associated with greater competing mortality, frailty, multimorbidity, polypharmacy, and a shorter remaining time in which benefit can accrue. Methods: We conducted a systematic review in accordance with PRISMA 2020. A prespecifie …

28.08.2026journal-article

Advanced International Journal for Research

Deep view of Polyethylenimine polymer as a non-viral vector for gene therapy

Senthil Prabhu R, Swetha R, Varshini K, Yogashruthi S

Polyethylenimine (PEI) is a general-purpose polycationic polymer which has received much attention as a non-viral vector for therapeutic nucleic acid delivery in medicine. The high level of amine groups enables electrostatic complexation with negatively charged genetic material, leading to the formation of polyplex and higher cellular uptake. Once internalized, PEI can facilitate endosomal escape because of its buffering capacity and or its ability to destabilize cellular membranes, which promotes efficient deliver …

28.08.2026journal-article

Critical Care & Emergency Medicine

Reacción de hipersensibilidad inmediata aguda durante la terapia con antiveneno F(ab’)2 por envenenamiento grado II por serpiente de cascabel: reporte de caso en México

Georgina Flores Martini, Juan Carlos Borrego Moreno, Ana Elizabeth de la Cruz Reyes, Blanca Idalia Cardiel Méndez, Ernesto Deloya Tómas, Elizabeth Guadalupe Haro Cruz, Maria Julieta Cárdenas de Luna

Rattlesnake envenomation remains a relevant cause of morbidity in Mexico, and antivenom is still the specific treatment of choice. We report the case of a 35-year-old man with grade II rattlesnake envenomation affecting the left hand, initially managed with six vials of equine polyvalent F(ab’)2 antivenom, analgesia, local supportive care, and serial clinical and laboratory monitoring. Approximately 30 minutes after antivenom administration, he developed fever, generalized pruritus, urticaria, and mild dyspnea, wit …

28.08.2026journal-article

American Journal of Therapeutics

Comparing the Safety and Efficacy of Outpatient Parenteral Antibiotic Therapy Versus Hospital-Based Antibiotic Therapy in Patients with Infective Endocarditis: A Systematic Review and Meta-Analysis

Mohanad A. Alkuwaiti, Faisal A. Al-Harbi, Feras A. Alkuwaiti, Ahmed K. Alsaif, Hamza Ashraf

Introduction: Infective endocarditis (IE) requires 4 to 6 weeks of intravenous antibiotics. Outpatient parenteral antibiotic therapy (OPAT) is increasingly used and guideline endorsed, but IE-specific comparative evidence is limited, as prior meta-analyses pooled single-arm data without an inpatient comparator. We compared the safety and efficacy of OPAT versus continued hospital-based antibiotic therapy. Methods: This systematic review and meta-analysis followed Preferred Reporting Items for Systematic Reviews and …

28.08.2026journal-article

Annals of the American Thoracic Society

Fall-related injuries in long-term oxygen therapy: Incidence and predictive factors

Filip Björklund, Andreas Palm, Josefin Sundh, Magnus Ekström

Abstract Introduction Fall-related injuries are a common cause of morbidity and impaired quality of life among patients with severe respiratory disease. Use of long-term oxygen therapy (LTOT) may be associated with a further increased risk. Methods This was a longitudinal study of patients starting LTOT between 2006 and 2023 in the Swedish DISCOVERY cohort. Rates of healthcare contact due to three types of fall-related injuries (distal radius fracture, hip fracture, and skull trauma) were compared to those of age- …

28.08.2026journal-article

Bleeding, Thrombosis and Vascular Biology

Clinical characteristics, prescription patterns and clinical outcomes of patients with extended therapy with direct oral anticoagulants for unprovoked venous thromboembolism

Alicia Lorenzo, Carmine Siniscalchi, Silvia Natalia Morales, Teresa Sancho, Reina Valle, Aida Gil-Diaz, Parham Sadeghipour, Patricia Sigüenza, Manuel Monreal, The RIETE Investigators

Background: Extended therapy with direct oral anticoagulants (DOACs) is common for managing unprovoked venous thromboembolism (VTE), but real-world data on dosing decisions and their association with outcomes are limited. Methods: From April 2013 to September 2023, we identified patients with unprovoked VTE in the RIETE registry who survived the first 6 months without recurrent VTE or major bleeding. We examined predictors of reduced- vs. full-dose DOACs (rivaroxaban or apixaban) and the association between dosing …

28.08.2026journal-article

Revista Tópicos

HEAD SUPPORTS IN REHABILITATION AND CARE: A NARRATIVE REVIEW

Louise Bogéa Ribeiro, Nikolle Jamille das Mercês Figueiredo de Lima, Manoel da Silva Filho

O suporte de cabeça desempenha um papel central na reabilitação e nos cuidados de longa duração, contribuindo para a mobilidade, comunicação, alimentação, respiração e segurança de pessoas com condições neuromusculares, ortopédicas e neurológicas. Uma revisão narrativa estruturada analisou tecnologias de suporte de cabeça e suas aplicações clínicas, incluindo apoios de cabeça estáticos e dinâmicos acoplados a cadeiras de rodas, órteses cervicais, dispositivos inovadores e específicos para certas patologias, além do …

28.08.2026journal-article

The Cardiothoracic Surgeon

Optimizing hemostasis in thoracic surgery: a systematic review and meta-analysis of perioperative antifibrinolytic therapy

Muhammad Hamza, Zohad Shah, Hasnain Wajeeh Saqib, Syeda Rabiah Shahid, Muhammad Murad Khurshid, Sheza Irfan, Aizaz Anwar Khalid, Arshdeep Singh, Ikram Ul Haq Chaudhry, Asif Raza Shah

Abstract Background Excessive perioperative bleeding remains a major challenge in non-cardiac thoracic surgeries. Antifibrinolytic therapy can enhance hemostasis and reduce transfusion requirements, although its use carries a theoretical risk of postoperative thromboembolic complications that warrants evaluation alongside its hemostatic benefits. Main text Methods: For this systematic review and meta-analysis, we searched multiple databases for studies that compared antifibrinolytic therapy with placebo or no inter …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Examining the Relationship Between Occupational Balance, Spirituality, and Quality of Life in Older Adults

Yasin Tekeci, Mustafa Cemali, Berkan Torpil

Introduction: This study aimed to examine the relationships between occupational balance, spiritual well-being, and quality of life (QoL) in older adults, and to evaluate the effects of these variables on occupational balance.Methods: This cross-sectional study included 156 volunteers aged 65 years and older without cognitive impairment. Data were collected using the Occupational Balance Questionnaire, the Spiritual Well-Being Scale and the WHOQOL-BREF Quality of Life Scale. Pearson correlation and multiple linear …

28.08.2026journal-article

Cells

Cellular Recovery and Therapeutic Rechallenge After Cancer Therapy-Induced Kidney Injury: Mechanistic Insights and Clinical Implications

Yosuke Dotsu, Kazumasa Akagi, Noritaka Honda, Midori Matsuo, Hirokazu Taniguchi, Shinnosuke Takemoto, Tomoya Nishino, Hiroshi Mukae

Cancer therapy-related acute kidney injury has become an increasingly common challenge as modern treatments prolong survival and increase exposure to potentially nephrotoxic therapies. Decisions regarding therapeutic rechallenge have relied on normalizing serum creatinine and recovering estimated glomerular filtration rate, despite growing evidence that biochemical recovery does not necessarily indicate restoration of kidney integrity or resilience. In this review, we propose biological kidney recovery as a concept …