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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Eurasian Clinical and Analytical Medicine

Assessment of erectile function before and after treatment in male patients with newly diagnosed chronic obstructive pulmonary disease

Merve Yumrukuz Senel, Cagdas Senel

Aim Chronic obstructive pulmonary disease (COPD) is a prevalent condition with significant systemic consequences. Erectile dysfunction (ED) is common among patients with COPD; however, the impact of COPD treatment on erectile function has not been adequately investigated. This study aimed to evaluate the effect of COPD treatment on erectile function in newly diagnosed male patients. Methods This single-center prospective study included 51 newly diagnosed male patients with COPD, in accordance with predefined inclus …

03.09.2026journal-article

BMJ Paediatrics Open

Growth and nutritional outcomes in children during the first year of cancer treatment: a scoping review with implications for child health care in low- and middle-income countries (LMICs)

Sashiha Manimohan, Padmasani Venkat Ramanan, Prathyusha Gopalakrishnan

Background Improved survival among children with cancer has shifted attention towards quality of care and holistic child health outcomes during treatment. Growth faltering and undernutrition are common during cancer therapy, particularly in low- and middle-income countries (LMICs), where pre-existing nutritional vulnerability and health system constraints may exacerbate this effect. Evidence on growth patterns during the early phase of treatment remains fragmented. Objectives To map available evidence on growth and …

01.09.2026journal-article

Journal of Palliative Medicine

A Pilot Feasibility Study of PAL-CHW-PDAC, a Digitally Enhanced Community Health Worker-Led Intervention to Facilitate Stepped Palliative Care in Patients with Pancreatic Cancer

Nikhil R. Thiruvengadam, Maud Celestin-Joachim, Lizbeth Rivas, Nishita Matangi, Arman Bahmani, Matthew Oroso, Joel Brothers, Kendrick Che, Andrew Chang, Emmanuel Eguia, Paul Leonor, Gina Mohr, Raja Narayan, Sagar Pathak, Susanne Montgomery, Betty Ferrell

Background: Pancreatic Ductal Adenocarcinoma (PDAC) is associated with substantial morbidity and poor quality of life (QOL). Early palliative care (EPC) has been shown to improve QoL and reduce symptom burden in PDAC, but only a minority of PDAC patients receive it. Using three conceptual models, we developed a community health worker (CHW)-led intervention to help facilitate stepped PC. Objectives: To evaluate the feasibility, acceptability, and preliminary effectiveness of PAL-CHW-PDAC. Design: A single-center pr …

04.09.2026journal-article

Cancer Medicine

Performance of Machine Learning Models Based on Medical Imaging in Predicting Pathological Grade of Clear Cell Renal Cell Carcinoma

Yuchao Wang, Zhuwei Song, Zhaonan Hou, Yihao Chen, Shouyuan Liu, Chunyu Chen, Haoyun Guan, Zhengyang Pang, Songchen Yan, Zhiyu Zhang, Ruijia Tu, Gang Zhu, Xiantao Zeng, Bo Fan

ABSTRACT Background Predicting clear cell renal cell carcinoma (ccRCC) pathological grade preoperatively is critical for clinical management. This study aims to evaluate the diagnostic accuracy and clinical utility of machine learning (ML)‐based imaging models. Methods The Cochrane Library, PubMed, Embase, and Scopus databases were searched systematically for studies published before January 2026. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 and the Radiomics Quality Scor …

04.09.2026journal-article

Airway

Utility of Video Laryngoscopes in Head and Neck Cancer Surgeries Performed in Adult Patients – A Systematic Review

Sargam Kant, Anjana Sagar Wajekar

Abstract Airway management in adult head and neck cancer surgeries is often compromised by tumour distortion, trismus and radiation fibrosis. While awake flexible bronchoscopy remains the gold standard, video laryngoscopy (VL) increasingly serves as a first-line modality under general anaesthesia. This systematic review evaluates the utility, efficacy and safety of VL compared to direct laryngoscopy (DL) during nasotracheal intubation (NTI) in adult head and neck oncology surgeries. A systematic literature search ( …

01.09.2026journal-article

Retina

INFLAMMATORY AND IMAGING BIOMARKERS IN TREATMENT-NAÏVE DIABETIC MACULAR EDEMA

Sibel Demirel, Özge Yanık, Figen Batıoğlu, Klara Dalva, Mehmet Ali Şekeroğlu, Tuna Çelik Büyüktepe, Beyza Doğanay Erdoğan, Emin Özmert

Purpose: To determine whether aqueous flare reflects intraocular inflammation in treatment-naïve diabetic macular edema (DME) and to examine associations between aqueous cytokines and optical coherence tomography (OCT) biomarkers, using Irvine–Gass syndrome (IGS) and cataract eyes as controls. Methods: Seventy-six eyes were included (40 DME, 19 IGS, 17 cataract controls). All eyes underwent OCT imaging and laser flare photometry. Aqueous levels of interleukin-6, monocyte chemoattractant protein-1, interferon-γ–indu …

01.09.2026journal-article

Journal of Clinical Oncology

Total Neoadjuvant Therapy With Long-Course Radiotherapy Versus Chemoradiotherapy in High-Risk Locally Advanced Rectal Cancer (TNTCRT): A Multicenter, Randomized, Phase III Trial

Xin Wang, Yuanling Tang, Junyang Lu, Wenjian Meng, Ping Liu, Jitao Zhou, Feng Wen, Peirong Ding, Jun Li, Biao Wang, Qing Guo, Jian Qiu, Hao Sun, Xiangbing Deng, Yali Shen, Hanjiang Zeng, Dan Jiang, Di Wang, Yunfeng Li, Yi Xiao, Ziqiang Wang

PURPOSE High-risk locally advanced rectal cancer (LARC) carries a substantial risk of distant recurrence, which limits disease-free survival (DFS). We compared total neoadjuvant therapy (TNT) integrating long-course radiotherapy (LCRT) with uninterrupted doublet chemotherapy (doublet-LC TNT) versus conventional neoadjuvant chemoradiotherapy (nCRT). METHODS In this multicenter, randomized, phase III trial, patients with stage II/III LARC and at least 1 high-risk feature (cT4a-b, cN2, mesorectal fascia involvement, o …

01.09.2026journal-article

Inventions

Improving Water Treatment Efficiency at Thermal Power Plants Through the Implementation of Resource-Efficient Technologies

Al-Saraireh Majd Ali, Iryna Chub, Tamara Airapetian, Natalia Smetankina, Andrii Kondratiev

Water treatment systems based on sodium–cation exchange are widely used at thermal power plants. However, their operation is associated with high consumption of water and sodium chloride during regeneration and the generation of highly mineralized wastewater. This study proposes an integrated approach to improving the performance of sodium–cation exchange water treatment systems by combining regeneration wastewater recycling with optimization of filter operating conditions. Experimental investigations were carried …

01.09.2026journal-article

Frontiers in Health Services

Integrating mental and behavioral health providers into VHA pain management teams and oncology clinics: assessment of early implementation from site visits

Molly Goodrich, Benjamin R. Szymanski, Brittany L. Cornwell, Kristen Perry, Katherine M. Dollar, Jennifer Patterson, John F. McCarthy

Introduction To enhance mental health access and suicide prevention services for Veteran patients in Pain Management Teams and Oncology Clinics, the Veterans Health Administration (VHA) initiated the Mental and Behavioral Health Integration (MBHI) Demonstration Projects at 53 facilities in 2022. MBHI integrates colocated mental health providers into these settings to deliver brief mental/behavioral healthcare. Findings describe site visits assessing early implementation. Methods Evaluators visited nine VHA faciliti …

01.09.2026journal-article

Annals of Biomedical Engineering

Characterizing Tumor Cell Movement in Partial Differential Equation Models of Triple-Negative Breast Cancer Receiving Neoadjuvant Therapy

Casey E. Stowers, Chengyue Wu, Guillermo Lorenzo, David A. Hormuth, Clinton Yam, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov

Abstract Purpose Approximately half of triple-negative breast cancer (TNBC) patients attain a complete response to neoadjuvant therapy (NAT). Thus, methods to predict and optimize NAT response are essential to improving patient outcomes. Methods Previously, mathematical models with a reaction term describing cell growth and death and a diffusion term describing cell invasion have accurately forecasted NAT response but have had limited flexibly in capturing cell movement. We investigate the relative contributions of …

01.09.2026journal-article

International Journal of Health Management Review

TREATMENT OF GINGIVAL FIBROMATOSIS IN PEDIATRIC PATIENTS

Giacomo Gobbo Trojan, Julia Yanes Moia Vivan, Katiane Vieira Menezes Leite, Alice Jacques de Borba, Larissa Caroline Bruchez Pereira

Gingival fibromatosis is a rare condition characterized by the excessive and progressive enlargement of gingival tissue, which may occur in isolation or in association with genetic syndromes. In pediatric patients, this hyperplasia can interfere with tooth eruption, mastication, speech, oral hygiene, and aesthetics. The aim of this review was to synthesize available evidence regarding the diagnosis and treatment of gingival fibromatosis in pediatric patients, emphasizing associated genetic conditions, therapeutic m …

02.09.2026journal-article

Breast Cancer Research and Treatment

Oestrogen receptor testing and initiation of adjuvant endocrine therapy in women with ductal carcinoma in situ: a population-based study

Qian Chen, Ian Campbell, Mark Elwood, Alana Cavadino, Phyu Sin Aye, Sandar Tin Tin

Abstract Introduction Use of adjuvant endocrine therapy (ET) for ductal carcinoma in situ (DCIS) varies widely in clinical practice. We investigated oestrogen receptor (ER) testing, the initiation of ET, and the effect of ET on outcomes for DCIS in New Zealand. Methods Women with DCIS (2000–2022) were identified from the New Zealand Breast Cancer Foundation National Register and linked to the national pharmaceutical data. Logistic regression identified factors associated with ER testing, and cumulative incidence of …

01.09.2026journal-article

Journal of Gastroenterology and Hepatology

METTL3–m6A–IGF2BP2 Axis‐Mediated Stabilization of MTFR1 Promotes Glycolytic Reprogramming in Colorectal Cancer

Liqiang Wei, Denghe Liu, Chunyu Lin, Yibei Song, Dong Lan, Xiaojv Chi

ABSTRACT Background Metabolic reprogramming fuels colorectal cancer (CRC), yet upstream regulators that lock cells into a glycolytic state remain incompletely defined. Methods We integrated single‐cell and spatial transcriptomics with GWAS–eQTL–Mendelian randomization to nominate CRC‐associated candidate genes, and profiled their expression, spatial localization, and prognostic value in patient cohorts. The function of MTFR1 was tested by proliferation, migration/invasion, EMT marker analysis, and Seahorse extracel …

01.09.2026journal-article

Frontiers in Genetics

DNA damage repair gene defects combined predict the efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: a retrospective cohort study

Kesong Qin, Gangqiang Hu, Erli Song

Background Immune checkpoint inhibitors (ICIs) yield heterogeneous benefit in metastatic castration-resistant prostate cancer (mCRPC), underscoring the unmet need for robust predictive biomarkers. DNA damage repair (DDR) gene defects encompass mechanistically distinct subtypes—homologous recombination repair (HRR) deficiency, mismatch repair deficiency/microsatellite instability-high (MMRd/MSI-H), and CDK12 inactivation—that may differentially modulate anti-tumor immunity. This study evaluated the combined predicti …

01.09.2026journal-article

Rehabilitation Oncology

Predicting Adherence to Physical Activity in Individuals With Cancer Using Machine Learning and National Health and Nutrition Examination Survey Data

Qing Zhang, Suril Gohel

Background: Physical activity (PA) is a core component of cancer survivorship care, yet adherence to PA guidelines remains low. Correlates of PA adherence reflect a complex interplay of multiple factors, many aligning with domains addressed in physical therapy (PT) but not integrated within a PT-informed analytic framework. Machine learning (ML) approaches may support modeling of complex relationships by accommodating nonlinear interactions. This study aimed to develop and compare ML models to classify PA adherence …

01.09.2026journal-article

Frontiers in Oncology

The role of glutamine metabolism in the pathogenesis of idiopathic pulmonary fibrosis and its therapeutic potential

Junzi Li

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal interstitial lung disease characterized by usual interstitial pneumonia, relentless decline in lung function and incomplete disease modification by available antifibrotic therapies. Beyond canonical profibrotic pathways, accumulating evidence identifies aberrant glutamine metabolism as a convergent metabolic feature of IPF pathogenesis. In structural cells, glutaminolysis fuels myofibroblast activation, de novo glycine and proline synthesis for collagen, w …

01.09.2026journal-article

Journal of Clinical Investigation

γδ T cells and cancer

Lukas Bolini, Seth B. Coffelt, Bruno Silva-Santos, David L. Wiest, Lorenzo Galluzzi

γδ T cells are a subset of lymphoid cells that, unlike their αβ lineage counterparts, express a heterodimeric TCR that mostly operates in an MHC-independent manner. γδ T cells are abundant in barrier tissues, where they continuously monitor epithelial cells for signs of stress or damage. Thus, γδ T cells are among the first responders to pathophysiological conditions, including viral infection and oncogenesis. Human γδ T cells can be classified based on TCR γ and δ chain usage into three main subsets: (a) Vγ9 + Vδ2 …

01.09.2026journal-article

BMC Women's Health

Factors associated with the acceptability of HPV Self-sampling for cervical cancer screening among Thai ethnic women in Pai, Mae Hong Son

Phuttipol Chaiprom, Patumrat Sripan, Linda Aurpibul, Woottichai Khamduang, Sayamon Hongjaisee, Amaraporn Rerkasem, Arunrat Tangmunkongvorakul, Kriengkrai Srithanaviboonchai

Abstract Background Cervical cancer remains a major public health problem worldwide particularly in low- and middle-income countries. Human Papillomavirus (HPV) self-sampling is a promising strategy to increase screening participation. However, evidence regarding its acceptability among Thai ethnic communities is limited. This study aimed to estimate the proportion of acceptability of HPV self-sampling for cervical cancer screening among the ethnic women living in border areas of Thailand and determine its associat …

03.09.2026journal-article

Journal of International Medical Research

Value of shear wave elastography in evaluating response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis

Bin Lian, Chuanxin Ye, Fengjie Li, Huotang Qin, Lifang Zhou, Changyuan Wei, Huihui Yang

Objective To determine how well shear wave elastography performs as a diagnostic tool for determining the pathological response to neoadjuvant chemotherapy in breast cancer. Methods Through April 2025, a systematic search of PubMed, MEDLINE, Cochrane Library, China National Knowledge Infrastructure, and SinoMed was used to perform a diagnostic meta-analysis. Included were studies of individuals with breast cancer receiving neoadjuvant chemotherapy with shear wave elastography evaluation. The diagnostic performance …

01.09.2026journal-article

Journal of Laparoendoscopic & Advanced Surgical Techniques

Stage IV Esophageal Cancer: Room for Improvement?

Pamela Milito, Stefano Siboni, Serena Grimaldi, Pietro Masseria, Daniele Bernardi, Matteo Melloni, Valentina Milani, Emanuele Asti

Objective: This study aimed to assess short- and long-term outcomes in patients undergoing surgery for pathological stage IV esophageal cancer. Background Data: Esophageal cancer has a very poor prognosis in advanced stages, with 5-year survival rates below 6% in stage IV disease. Although current guidelines generally discourage surgery in metastatic patients, selected cases with oligometastatic disease may benefit from esophagectomy within a multimodal treatment framework. Methods: We retrospectively reviewed a pr …

02.09.2026journal-article

The Oncologist

28 Real-World Treatment Patterns, Healthcare Resource Utilization (HCRU) And Costs in First-Line (1L) Advanced Renal Cell Carcinoma (aRCC) in the US

Neil Shah, Ching-Yu Wang, Pratik Rane, Wei Gao, Esteban Lemus Wirtz, Tina Long, Julia Koloskova, Robert Motzer

Abstract Background Advances in tyrosine kinase inhibitor (TKI) and immuno-oncology (IO) therapies have reshaped the aRCC treatment landscape, necessitating an updated understanding of real-world treatment patterns, HCRU, and costs. Methods We conducted a retrospective cohort study using Optum’s deidentified Clinformatics® Data Mart Database (2019-2024). Adults with ≥2 claims with an RCC diagnosis, evidence of secondary metastasis, and who initiated first line (1L) systemic therapy (IO + IO, IO + TKI or TKI monothe …

03.09.2026journal-article

ACR Open Rheumatology

Spondyloarthritis Research and Treatment Network Recommendations for the Referral of Adults With Chronic Back Pain and Suspected Axial Spondyloarthritis to a Rheumatologist

Maureen Dubreuil, Abhijeet Danve, Jean W. Liew, Swetha Ann Alexander, Yuliya Afinogenova, Mohamad Bittar, Liana Fraenkel, Alyssa Grimshaw, Anand Kumthekar, Michael P. LaValley, Marina Nighat Magrey, Vikas Majithia, Sali Merjanah, Hillary Norton, Jessica A Walsh, Atul Deodhar

Objective In the United States, axial spondyloarthritis (axSpA) diagnosis is delayed up to 14 years preventing effective management. We convened a multidisciplinary clinician and patient group to develop recommendations for rheumatology referral of adults with chronic back pain. Methods Systematic review (SR) and meta‐analysis determined predictive values of clinical, laboratory, and imaging axSpA features for diagnosis. In a Delphi exercise, experts reviewed these test characteristics and voted to gain consensus f …

02.09.2026journal-article

Journal for ImmunoTherapy of Cancer

GTPase RAB31 supports ANXA1-driven macrophage education through clathrin-mediated endocytosis to suppress antitumor immunity

Jingjing Liu, Shanshan Wang, Dengyi Bao, Ge Dong, Yunxi Ma, Guorong Zhang, Xin Liu, Dongli Zhang, Lulu Wang, Shuqian Xu, Zhigang Cai

Background Tumor-associated macrophages (TAMs) play pivotal roles in shaping the tumor-microenvironment (TME) through functional plasticity, which is regulated by extrinsic and intrinsic signals. However, the role of vesicular trafficking in TAMs remains poorly understood. RAB31, a small GTPase enriched in myeloid cells, was proposed as a potential regulator of TAM polarization through clathrin-mediated endocytosis (CME). We hypothesized that RAB31 modulates TAM education by tumor-derived signals and thereby shapes …

01.09.2026journal-article

Nano Research

Dental curing light-triggered on-target CO release from NHC-Fe complex for cancer immunotherapy

Wu-Yin Wang, Haozhe Dong, En-Li Yang, Xiaoqian He, Zhiqiang Zhang, Qing Wang, Nian Chen, Hong Yi, Aiwen Lei, Zhi-Jun Sun

Abstract Malignant tumors remain a leading cause of premature death worldwide, with disproportionately increasing burdens in resource-limited regions. Although immune checkpoint blockade (ICB) has emerged as a transformative cancer therapy, its efficacy is often limited by the immunosuppressive tumor microenvironment (TME). Leveraging iron as the most abundant bioactive transition metal in Earth's crust, we report F-Fe, a complex IV-targeted carbon monoxide-releasing molecule (CORM) that is activated by a clinicall …