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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

ARACÊ

EFEITOS DA MUSICOTERAPIA COMO INTERVENÇÃO COMPLEMENTAR NO TRATAMENTO DE PACIENTES COM DEPRESSÃO: UMA ABORDAGEM CLÍNICA

Janete Maria de Oliveira Praxedes Lira Costa

Contexto: A depressão é um transtorno mental de alta prevalência associado a comprometimentos significativos na qualidade de vida. Perante as limitações dos tratamentos convencionais, a busca por abordagens complementares e não farmacológicas vem se tornado essencial. Objetivo: Analisar os efeitos da musicoterapia como intervenção complementar no tratamento de pacientes com depressão, a partir de uma perspectiva clínica. Metodologia: Trata-se de uma revisão de escopo (scoping review), de abordagem qualitativa e car …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

The impact of combination therapy for vulvar lichen sclerosus et atrophicus on the quality of life, psychoemotional profile and sexual function of women

N.I. Chernova, M.I. Proskurina, O.V. Dolya, I.S. Zadorozhnaya

Increasing incidence of vulvar lichen sclerosus et atrophicus (VLSA), chronic nature of the disease, severity of itching, and late complications with changes in the anatomy of the external genital organs lead to the development of a number of disorders, including psychoemotional and sexual dysfunctions, and significantly deteriorate the quality of life of patients. Long-term use of topical glucocorticosteroids (tGCSs) has a number of side effects, requires patient compliance, and does not ensure long-lasting diseas …

28.08.2026journal-article

Malignant tumours

The mDCF combination as first-line therapy in patients with locally advanced or metastatic esophageal squamous cell carcinoma

V. V. Sokolovskiy, E. A. Dinaeva, A. A. Margusheva, A. A. Tryakin

Introduction. There is no consensus regarding the optimal first-line chemotherapy regimen for locally advanced or metastatic esophageal squamous cell carcinoma. The efficacy of standard chemotherapy combinations is limited and therefore has to be improved. Due to the limited accessibility of modern immunotherapy, chemotherapy remains a valuable commonly used option. We conducted a non-randomized prospective study to evaluate the efficacy and tolerability of the triple combination mDCF. Materials and Methods. The ma …

28.08.2026journal-article

Frontiers in Medicine

Mechanisms of and mitigating strategies for cellular immune responses to CRISPR-associated nucleases in genome editing therapy

Bryan Hu, Venkata Sumanth Reddy Gutty, Roland W. Herzog, Dongsheng Duan

Immunogenicity of CRISPR-associated nucleases (Cas) is a critical barrier to the development of safe and effective genome editing therapies. These proteins inherently pose a risk of immune recognition due to their prokaryotic origins. A multitude of factors, such as the delivery vehicle, the route of administration, components of the therapeutics, tissue microenvironment, and pre-existing immunity, also contribute to the complexity of the host immune response to Cas proteins. As CRISPR-based therapies advance into …

28.08.2026journal-article

Journal of Orthopaedic & Sports Physical Therapy

Rehabilitation of Athletes With Hamstring Strain Injury: SONAFE-Brazil Clinical Practice Guideline

Bruno Manfredini Baroni, Rodrigo Ribeiro de Oliveira, Albino Luciano Abreu Pereira, Felipe Coimbra Meira, Filipe Abdalla dos Reis, Flavio Fernandes Bryk, Luiz Hespanhol, Katherinne Ferro Moura Franco, Larissa Santos Pinto Pinheiro, Natalia Franco Neto Bittencourt, Aline Carla Araújo Carvalho, Daniel Ferreira Moreira Lobato, Fábio Carlos Lucas de Oliveira, Rodolfo Borges Parreira, Verônica Colpani, Cynthia Gobbi Alves Araújo

The National Society of Sports Physical Therapy (SONAFE-Brazil), the official organization representing sports physical therapists in Brazil, developed this Clinical Practice Guideline to support clinicians and athletes in managing hamstring strain injury. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was employed to address the clinical question: “Which interventions provided by physical therapists improve rehabilitation outcomes in athletes with hamstring strain injury?” …

28.08.2026journal-article

Nordic Wittgenstein Review

Two Types of Philosophical Therapy: Wittgenstein’s Late Discovery of Freud

Thomas J. Spiegel

A variety of influential readers of Wittgenstein endorse the view that Wittgenstein consistently held onto one conception philosophical therapy (the ‘singularity assumption’). This article argues against the singularity assumption such that there are two fundamentally different types of philosophical therapy present in the early and later Wittgenstein. This change is elicited by Wittgenstein ‘discovering’ the idea of psychoanalysis after the Tractatus, this discovery’s impact being more fundamentally than is usuall …

28.08.2026journal-article

Frontiers in Pharmacology

Sinus bradycardia after intravenous methylprednisolone pulse therapy in patients with thyroid-associated ophthalmopathy

Yaning Zhang, Tiantian Gao, Yahui Zhang, Wen Zhang, Hengcai Yu

Background Intravenous methylprednisolone pulse (IVMP) therapy is the first-line treatment for active moderate-to-severe and very severe thyroid-associated ophthalmopathy (TAO). IVMP-induced sinus bradycardia has not been previously reported in patients with TAO in the published English-language literature. This study aimed to determine the prevalence and characteristics of IVMP-induced bradycardia in patients with TAO and to analyze the associated factors. Methods This retrospective cohort study was conducted on 1 …

28.08.2026journal-article

Journal of Clinical Medicine

Comparative Effectiveness of Focused Versus Radial Extracorporeal Shockwave Therapy and Leukocyte-Poor Versus Leukocyte-Rich Platelet-Rich Plasma for Lateral Epicondylitis: A Network Meta-Analysis

Jun Min Cha, Seo Yeon Yoon, Yong Wook Kim, Jong Mi Park, Sang Chul Lee

Background/Objectives: Lateral elbow tendinopathy (LET) causes chronic pain and functional limitation, and the evidence base is confounded by the “lumping” of biologically and physically distinct interventions. We conducted a systematic review and network meta-analysis (NMA) distinguishing focused (fESWT) from radial (rESWT) extracorporeal shockwave therapy (ESWT) and leukocyte-rich (LrPRP) from leukocyte-poor (LpPRP) platelet-rich plasma (PRP) to establish a precise hierarchy of treatment efficacy. Methods: We sea …

28.08.2026journal-article

Journal of Neuro-Oncology

CAR-T cell therapy: potential for paediatric brain tumours—an update

Alexandra Zehner, Benjamin Draper, Darren Hargrave, Laura K. Donovan, John Anderson

Abstract Central nervous system (CNS) tumours are the deadliest cancer for children and currently present limited treatment options. Chimeric antigen receptor (CAR)-T cell therapies have emerged as an innovative approach supported by encouraging clinical results. Current clinical trials using CAR-T cells in the treatment of paediatric CNS cancers differ in a number of variables, including the CAR-T cell route of delivery, presence of lymphodepletion, identified target antigen, and CAR engineering features. Consider …

28.08.2026journal-article

Memory & Cognition

Intentional encoding does not alter the trade-off between speech-in-noise perception and memory

Morgan Robertson, Kaitlin L. Lansford, Lotte Eijk, Stephanie A. Borrie

Abstract Degraded speech increases listening effort at the expense of memory encoding, but the flexibility of this resource trade-off under varying motivational conditions remains poorly understood. The present study investigated how encoding intention influences cognitive resource allocation during a speech-in-noise task. Participants’ sentence comprehension was tested using a sentence verification task (SVT) under varying signal-to-noise ratios (SNRs). Memory of the sentences was then assessed by a recognition ta …

28.08.2026journal-article

European Journal of Haematology

InflaMix Predicts Severe CRS , ICU Admission, and Progression‐Free Survival After CAR ‐T Therapy in LBCL

Eugenio Galli, Daniele Mannina, Alessandro Corrente, Chiara De Philippis, Ilaria Pansini, Marcello Viscovo, Stefan Hohaus, Patrizia Chiusolo, Federica Sorà, Stefania Bramanti, Simona Sica

ABSTRACT Objectives Baseline systemic inflammation has emerged as a determinant of outcome after CD19‐directed CAR‐T therapy. We evaluated the prognostic performance of the recently developed INFLAmmation MIXture Model (InflaMix) in an independent bicentric cohort of patients with large B‐cell lymphoma (LBCL) receiving commercial CAR‐T cells, focusing on treatment‐related toxicities. Methods We retrospectively analyzed 212 consecutive patients with relapsed/refractory LBCL treated with axi‐cel, tisa‐cel, or liso‐ce …

28.08.2026journal-article

Journal of Clinical Psychology in Medical Settings

Treating Multiple Chemical Sensitivity as a Specific Phobia Using Cognitive Behavioural Therapy: A Case Study in an Older Adult

Matthew Wilcock, Alice Loyal, David Hitt

Abstract Multiple Chemical Sensitivity (MCS) is a poorly understood condition characterised by physical symptoms triggered by minimal exposure to odorous or chemical agents, often without identifiable organic pathology. This case study describes cognitive behavioural therapy (CBT) for MCS in an older adult referred to a respiratory team after developing persistent, generalised reactions to odours following an acute toxic inhalation. Symptoms led to severe avoidance, functional impairment and suicidal ideation. Foll …

28.08.2026journal-article

Molecular Pharmaceutics

A Diazaborine-Based ROS Switch Enables Copper Transfer for Tumor-Specific Prodrug Activation and Therapy

Zeqian Huang, Yaqing Ding, Shengzhi Wang, Zijun Lin, Conghan Wang, Dong Zheng, Tao Zhang, Chunshun Zhao

Abstract Reactive oxygen species (ROS) are significantly elevated in tumor cells, providing an intrinsic trigger for selective drug activation and tumor-specific therapy. However, commonly used ROS-responsive linkers, such as thioketals and boronates, often suffer from limited sensitivity or poor physiological stability, and the development of new ROS-responsive motifs remains scarce. Herein, we develop a hydrazide-derived diazaborine (DAB) scaffold and establish it as a general ROS-responsive linker for small-mole …

28.08.2026journal-article

Frontiers in Medicine

Comparative efficacy of different durations and dosages of vonoprazan and amoxicillin dual therapy: a network meta-analysis of randomized controlled trials

Feng-yi Wei, Zhen-peng Huang, Sha Nie, Ru-jie Gao

Background The combination of vonoprazan and amoxicillin (VA) has been shown to be effective in eradicating Helicobacter pylori infection; however, the optimal treatment duration and dosage are yet to be determined. Methods A systematic literature search of PubMed, Embase, and China National Knowledge Infrastructure was performed to identify randomized controlled trials (RCTs) comparing different durations of VA dual therapy or comparing this dual therapy with bismuth-containing quadruple therapy (BQT). All trials …

28.08.2026journal-article

Japanese Journal of Clinical Oncology

Darolutamide-based triplet therapy versus androgen receptor pathway inhibitor-based doublet therapy for metastatic castration-sensitive prostate cancer: a real-world analysis using the TriNetX database

Yoichiro Tohi, Yuri Kitadani, Takuma Kato, Shunsuke Nakamura, Naoya Kani, Iori Matsuda, Kana Kohashiguchi, Yohei Abe, Hirohito Naito, Homare Okazoe, Rikiya Taoka, Fumiaki Mikami, Mikio Sugimoto

Abstract Background Currently, there are no large cohort studies comparing the clinical outcomes of triplet therapy with those of androgen receptor pathway inhibitor (ARPI)-based doublet therapy for patients with metastatic castration-sensitive prostate cancer (mCSPC) representing real-world practice. Therefore, the present study aimed to compare whether triplet or doublet therapy is more effective in patients with mCSPC. Methods This large-scale retrospective cohort study used TriNetX electronic medical record dat …

28.08.2026journal-article

Electronics

The MRP Corpus: A Speech Dataset of Modern Received Pronunciation

Daniel Tweddle, Eugenio Donati, Julie Wall

Suitable speech data is crucial for the development of Mispronunciation Detection and Diagnosis (MDD) systems, which rely on examples of correct pronunciations and mispronunciations. This paper describes the creation of a novel dataset for British English MDD systems, with a focus on developing an accent-specific approach using deep learning methods. The dataset consists of over 7000 utterances from 29 speakers who were identified as using the ‘Modern Received Pronunciation’ (MRP) accent, and includes orthographic …

28.08.2026journal-article

Frontiers in Child and Adolescent Psychiatry

Co-designing and piloting adolescent-adapted social rhythm therapy for young people with unipolar and bipolar depression: a mixed-methods feasibility case series

Gonzalo Salazar de Pablo, Claudia Aymerich, Zahra Kamran, Cecilia Sanjuan-Ortiz, Nuria Laherran-Cantera, Shantal Zeb, Eleonora Armyra, Allan H. Young, Aditya Sharma, Cornelius Ani, Manasi Kumar, Holly A. Swartz

Objective Depressive and bipolar disorders commonly emerge during adolescence and are associated with disturbances in sleep, daily routines and social rhythms, as well as functional impairment. Social Rhythm Therapy (SRT) targets these processes. However, adult-derived rhythm protocols do not adequately reflect adolescents’ school and family schedules, developmental autonomy, social and digital routines, or preferences regarding monitoring. Direct youth co-design is therefore needed to improve developmental fit, en …

28.08.2026journal-article

Messenger of ANESTHESIOLOGY AND RESUSCITATION

Intermittent hypoxia-hyperoxia therapy in patients with chronic disorders of consciousness after severe acquired brain injury: interim study results

A. A. Ilina, M. M. Kanarskii, M. V. Petrova, D. V. Ilin, V. E. Zakharchenko

Introduction . Chronic disorders of consciousness (DoC) after severe brain injury are observed in patients requiring prolonged intensive care treatment and rehabilitation. Given the high medication burden, safe non-pharmacological approaches to consciousness recovery remain clinically relevant. One such approach is intermittent hypoxia–hyperoxia therapy (IHHT). The objective was to assess the effect of IHHT on the dynamics of consciousness recovery in patients with DoC after severe acquired brain injury. Materials …

28.08.2026journal-article

Journal of Applied Clinical Medical Physics

Clinical in‐vivo dosimetry for total skin electron therapy using gafchromic™ EBT4 film

Zhexuan Zhang, Lan Lu, Gregory M. M Videtic, Cherian Sheen, Ping Xia, Peng Qi

Abstract Background Total skin electron therapy (TSET) is a standard treatment for cutaneous T‐cell lymphoma. Due to the complex patient positioning and irregular body contours, robust in‐vivo dosimetry (IVD) is essential to verify dose uniformity. While thermoluminescent dosimeters (TLDs) are traditional standard, their utility is hindered by labor‐intensive, manual processing. Purposes This study evaluates the clinical implementation of a Gafchromic™ EBT4 film‐based IVD system integrated with a bespoke, open‐sour …

28.08.2026journal-article

Journal of Clinical Medicine

Balance and Mobility Impairment in Older Adults with Cardiovascular Disease Before and After Rehabilitation: A Narrative Review

Zhengyang Song, Sasha Douglas, Imran Khan Niazi, Yanxin Zhang, Jocelyne Benatar, Paul W. Marshall

Balance impairment threatens mobility and independence in older adults with cardiovascular disease, yet cardiac rehabilitation (CR) has traditionally prioritised aerobic capacity and cardiovascular outcomes. This narrative review examines the mechanisms and assessment of balance impairment, balance recovery within CR, and implications for clinical practice. Balance impairment reflects interactions among musculoskeletal, sensory, cognitive–motor, and cardiovascular constraints that affect different domains of postur …

28.08.2026journal-article

ACS Applied Electronic Materials

High-Sensitivity, Long-Lifetime Flexible Piezoresistive Sensor Based on a Ternary PI/CB/MWCNTs/MXene Conductive Network for Health Monitoring and Speech Recognition

Xuyan Liu, Yitong Gao, Can Yang, Wenqing Bao, Yijie Xia, Qiang Li

Abstract Flexible piezoresistive sensors hold promising application prospects in wearable health monitoring and human−machine interaction. However, existing devices struggle to achieve a favorable balance among high sensitivity, wide detection range, long cycle life, and low cost simultaneously. In this work, an N/A/CB/MWCNTs/MXene (PCMM) flexible piezoresistive sensor with a ternary conductive network was proposed based on a polyimide (N/A) sponge. The low-cost and high-resilience N/A sponge substrate was prepared …

28.08.2026journal-article

Middle East Current Psychiatry

Impact of Menopausal Hormone Therapy on cognitive function and dementia Risk: A systematic review and meta-analysis focusing on the timing hypothesis and administration route

Shih-Shuan Fang, Sheng-Han Chen

Abstract Background The relationship between menopausal hormone therapy (MHT) and the trajectory of cognitive function in midlife and later life remains one of the most consequential and contested questions in women’s health. The “critical window” or timing hypothesis posits that the cognitive consequences of exogenous estrogen depend on when therapy is initiated relative to the menopausal transition, and on which formulation, route, dose, and duration are used. After two decades of randomised trials and large phar …

28.08.2026journal-article

Pharmaceuticals

Artificial Intelligence-Guided Prioritization and Experimental Evaluation of Synergistic Target Combinations for Breast Cancer Therapy

Chunlai Feng, Qiuqi Feng, Shengnan She, Ruojing Yang, Mengru Li, Lu Gong, Mengjie Rui

Background/Objectives: Breast cancer exhibits substantial molecular heterogeneity, resulting in diverse therapeutic vulnerabilities and limiting the efficacy of single-agent therapies. Although multi-target strategies may offer improved therapeutic benefit, the systematic identification of synergistic higher-order target combinations remains challenging. This study aimed to identify and validate effective higher-order target combinations for heterogeneous breast cancer. Methods: DeepMDS, a previously developed deep …