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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Vasa

Advancements in imaging for endovascular treatment of peripheral artery disease

Daniel Raskin, Mia Zivkovic, Levester Kirksey, Sean P. Lyden, Abraham Levitin, Vera Sorin, Patrick Ghibes, Eyal Klang, Sasan Partovi

Summary: Peripheral Artery Disease (PAD) is a significant global health concern, leading to morbidity through progressive stenosis and eventually occlusion of the lower extremity arterial vasculature. Advanced imaging modalities play a major role in diagnosing PAD, in planning endovascular as well as surgical interventions, and in monitoring post-treatment outcomes. This review highlights the current major imaging techniques, including duplex ultrasound, computed tomography angiography (CTA) and magnetic resonance …

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02.09.2026journal-article

Journal for ImmunoTherapy of Cancer

LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics

Teming Zhang, Yingying Sun, Chao Chen, Jingwei Zheng, Liyun Chang, Yizhen Xiang, Qiongying Zhang, Haoliang Li, Wangkai Xie, Qiaoyi Xu, Chenchen Mao, Mingdong Lu, Zhenzhai Cai, Xian Shen, Xiangyang Xue, Zheng Han

Background A substantial amount of research has been dedicated to the mechanisms by which tumor cells evade immune system recognition and manipulate the immune microenvironment to facilitate immune escape. Recent studies have shown that viruses and tumors can protect themselves from immune cytotoxicity by remodeling the actin cytoskeleton. However, cytoskeleton-mediated immune resistance and the specific cytoskeleton-related proteins involved require further research. Methods Single-cell RNA sequencing was used to …

01.09.2026journal-article

International Journal of Molecular Sciences

The hsa_circ_0084050/miR-373-3p Axis Controls Bone Sialoprotein-Induced ADAM9 Upregulation to Drive Lung Cancer Progression and Metastasis

Le Huynh Hoai Thuong, Chang-Lun Huang, Chun-Lin Liu, Jeng-Hung Guo, Po-I Liu, Chih-Hsin Tang

Lung cancer carries a high mortality burden, with metastatic dissemination accounting for much of its poor prognosis. Bone sialoprotein (BSP), a matricellular protein belonging to the SIBLING family, has been associated with tumor invasion; nonetheless, its role in lung cancer remains inadequately characterized. Clinical database analysis indicates that BSP is the most critical SIBLING protein associated with lung cancer proliferation and metastasis. Our clinical data also confirmed that BSP levels are higher in me …

01.09.2026journal-article

Healthcare

Association of Stroke and Myocardial Infarction Symptom Knowledge with Cancer Screening Participation Among Patients with Hypertension and Diabetes: A Cross-Sectional Study in Korea

Min Soo Kim, Mina Suh, Hye-Sun Lee, Jae Kwan Jun, Hyeon Ji Lee

Background/Objectives: Patients with hypertension or diabetes often share common risk factors for both cardiovascular diseases and cancer. Although health knowledge is associated with preventive health behaviors, the association between knowledge of stroke and myocardial infarction (MI) symptoms and cancer screening participation remains poorly understood. Methods: This cross-sectional study analyzed data from the 2023 Community Health Survey, including 45,949 adults with hypertension and 20,357 with diabetes aged …

01.09.2026journal-article

Cancers

Health-Related Quality of Life, Comorbidities, and Lifestyle Behaviors Among Survivors of Obesity-Related and Non-Obesity-Related Cancer Types

William Hernández, Génesis Rodríguez-Ortiz, Lorena González-Sepúlveda, Cynthia M. Pérez, Marievelisse Soto-Salgado, Carola T. Sánchez-Díaz

Background/Objectives: Obesity is a well-established risk factor for several cancers, yet few studies have explored survivorship outcomes among obesity-related cancer (ORC) survivors—a growing public health concern. Beyond cancer risk, obesity is associated with poorer health-related quality of life (HRQoL), greater comorbidity burden, and adverse lifestyle behaviors during survivorship. This study examined differences in these outcomes between ORC and non-ORC survivors living in Puerto Rico. Methods: We analyzed 5 …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Transcriptomic Association Between Poliovirus Receptor (PVR/CD155) and Claudin Signaling Pathways in Colorectal Cancer

STEVEN LEHRER, PETER H. RHEINSTEIN

Background/Aim: Enterotoxigenic Bacteroides fragilis promotes colorectal carcinogenesis through toxin-mediated cleavage of E-cadherin, a process facilitated by membrane-associated Claudin-4 (CLDN4). Separately, the poliovirus receptor (PVR/CD155) modulates tumor epithelial and immune dynamics. This study explored potential transcriptomic interactions and co-expression frameworks between PVR and claudin signaling pathways in colorectal cancer. Materials and Methods: Transcriptomic and proteomic data from the The Can …

03.09.2026journal-article

Drug Development Research

Mitochondrial Quality Regulation Genes as Prognostic Markers in Hepatocellular Carcinoma: Tumor Microenvironment, Therapeutic Response, and Drug Sensitivity Analysis

Binbin Li, Lijun Zeng, Zhilong He, Lunqi Luo, Yongmei Luo, Xinyu Yi, Zhimin Li, Hongbo Zhu, Yuehua Li

ABSTRACT Aberrant expression of mitochondrial quality regulation genes (MQRGs) is intricately linked to mitochondrial dysfunction and the progression of hepatocellular carcinoma (HCC), highlighting the urgent need for reliable prognostic biomarkers. In this study, we aimed to identify differentially expressed MQRGs from 20 candidate genes by analyzing transcriptomic profiles and clinical records from the TCGA ( n = 371) and GEO ( n = 167) datasets. The identified prognostic MQRGs, along with associated subtype diff …

04.09.2026journal-article

Considerations in Medicine

Mendelian randomisation studies of lipid traits and risk of colorectal cancer: a systematic review

Uchechukwu Chibuzo Ogbodo, Ashita Jawali, Pauline Wangeci King’ori, Emmanuel Israel Nsedu, Olaitan Igbagbo Awe

Background Colorectal cancer (CRC) is a leading cause of global cancer morbidity and mortality. Lipid metabolism dysregulation has been implicated in CRC development, yet evidence for the causal role of specific lipid traits remains largely inconsistent. Mendelian randomisation (MR) studies provide a means to strengthen causal inference by using genetic variants as proxies for lipid levels and limiting reverse causation. This study aimed to systematically review MR studies assessing the causal association between l …

01.09.2026journal-article

Current Bioactive Compounds

Boswellic Acid and Cisplatin Synergy: A Promising Approach to Enhance Chemosensitivity in Lung Cancer Therapy

Mohammed Abdalla Hussein, Reham Mahmoud Abdel Moneim, Amira Emad Hamdy, Elarya Armanuoos Fawzy, Alaa Mohamed Ismail, Eman Abdelrahman Mohamed, Nawal Ibrahim El-Adl

Introduction: Lung cancer maintains its devastating position as the most fatal malignancy globally, responsible for nearly 1 in 5 cancer deaths according to recent WHO reports. The search for innovative solutions has led our research team to investigate boswellic acid, a bioactive component isolated from the resin of Boswellia serrata trees that has demonstrated remarkable cytotoxic properties in our preliminary laboratory tests. Our investigation had two primary goals: first, to examine how boswellic acid influenc …

01.09.2026journal-article

Journal of Public Health Management & Practice

A Mixed-Methods Analysis of the National Program of Cancer Registries Program Evaluation and Technical Assistance

Sofia A. Huster, Paran Pordell, Melissa Alvarado, Emily Nethercott

ABSTRACT Context: The Centers for Disease Control and Prevention's (CDC) National Program of Cancer Registries (NPCR) supports the management and operations of central cancer registries (registries) across the United States through funding and technical assistance (TA). Objective: To examine barriers and facilitators to program evaluation among NPCR-funded cancer registries, assess registries' TA needs related to evaluation and implementation, and evaluate satisfaction with CDC-provided TA. Design and setting: We u …

01.09.2026journal-article

Frontiers in Public Health

Determinants of self-care practices in patients with breast cancer-related upper limb lymphedema: a cross-sectional analysis

Zhongru Cao, Hongbo Huo

Objective To assess the level of self-care practices among patients with BCRL and explore factors associated with these practices. Methods A total of 137 patients with BCRL who received treatment at our hospital between April 2022 and 2023 were included in this study. All participants met the predefined inclusion and exclusion criteria. Data were collected using a general information questionnaire, the Self-Care Behavior Scale for BCRL Patients, the Lymphedema Limb Function-Disability-Health Scale, and the Lymphede …

01.09.2026journal-article

Cancer Discovery

Following the Genetic Breadcrumbs of MPNs

Gaurav Agarwal, Vijay G. Sankaran

Summary: We provide an overview of a recent study in Cancer Discovery by Leongamornlert and colleagues involving genomic profiling of 30 patients with myeloproliferative neoplasms using available blood or bone marrow samples to assess what factors underlie disease evolution or predict stability. See related article by Leongamornlert et al., p. 1843

01.09.2026journal-article

Scientific Reports

Targeting hormone treatment for the brain in menopause

Noriko Itoh, Yuichiro Itoh, Rajita Patil, Christi Till, Marissa Smith, Jaclyn Schwartz, Brittany Davis, Erica Oberman, Brianne D. Romeroso, Rhonda R. Voskuhl

Abstract Estrogens are neuroprotective, and menopause may contribute to neurodegeneration. Estriol preferentially binds estrogen receptor beta (ERβ) in brain to induce neuroprotection. Previously, oral estriol improved cognitive processing speed and reduced cerebral cortex atrophy at treatment month twelve in women with multiple sclerosis (MS). Here, treatment with a blisterpack designed for healthy menopausal women which contains estriol and progesterone (Pearlpak) was assessed for its effect on cognitive domain-s …

01.09.2026journal-article

Nature Communications

CRACD loss drives hypoxia-induced immune escape in gastric cancer

Yoojeong Seo, Jinho Jang, Kyung-Pil Ko, Gengyi Zou, Sang-Min Kim, Yuanjian Huang, Shengzhe Zhang, Jie Zhang, Sohee Jun, Wonhong Chu, Vishwa Venkatesan, Sanjana Dhakshinamoorthy, Hyunki Kim, Jae-Il Park

Abstract Mucinous gastric adenocarcinoma (MGC) is a distinct histologic subtype characterized by poor prognosis and limited responsiveness to chemotherapy and immunotherapy. CRACD, an actin polymerization regulator, is frequently inactivated in gastric cancer (GC), with enrichment in mucinous subtypes. We found that genetic engineering of murine gastric organoids with Cracd ablation combined with Kras mutation and Trp53 loss induced mucinous cell plasticity, disrupted epithelial integrity, and promoted immune evasi …

01.09.2026journal-article

Current Oncology

Case of MYB-Rearranged Prostatic Adenoid Cystic Carcinoma

Sha Liu, Yuhan Liu, Ziyu Zhang, Shuiping Yin, Xinyi Wu, Ying Dai, Yingying Du

Background: Prostatic adenoid cystic carcinoma/basal cell carcinoma (ACC/BCC) has been reclassified under the fifth edition of the World Health Organization’s classification of tumors, distinguishing it from basal cell cancer of the skin. This malignant neoplasm exhibits distinct biological characteristics that differ from those of typical prostatic adenocarcinoma. However, optimal clinical management of prostatic ACC/BCC remains uncertain because of its rarity and the limited evidence available. Methods: This stud …

01.09.2026journal-article

Trends in Immunotherapy

Natural and Synthetic Coumarins as Tumor Microenvironment-Oriented Immunotherapeutic Agents: A Review

Yasser Fakri Mustafa

The tumor microenvironment (TME) plays a major role in cancer progression, immune evasion, and resistance to immunotherapy. Coumarins, a structurally diverse class of natural and synthetic compounds, have attracted increasing attention because of their anticancer, anti-inflammatory, antioxidant, and immunomodulatory properties, suggesting potential applications in TME-oriented cancer immunotherapy. This review aimed to summarize the immunotherapeutic potential of natural and synthetic coumarin derivatives in modula …

01.09.2026journal-article

Biomass

From Hydrothermal Treatment to Pyrolysis: Kinetics, Thermodynamics, Evolved Gas Behavior, and Reaction Mechanism During Coupled Thermal Conversion of Chicken Manure

Akash Kumar, Lata Kumari, Moses Akintayo Aborisade, Belay Tafa Oba, Qiuxia Meng, Qiang Zhang

Chicken manure represents a major agricultural waste stream with significant environmental risks if left unmanaged, yet its hydrothermally treated hydrochar (HCCM) holds promise as a renewable solid fuel. This study investigates the pyrolysis behavior, kinetics, thermodynamics, and gas evolution mechanism of HCCM using thermogravimetric analysis coupled with FTIR and mass spectrometry (TG-FTIR/TG-MS) at five heating rates (5–25 °C/min). TG-DTG results revealed a characteristic three-stage decomposition, with the ma …

03.09.2026journal-article

Starch - Stärke

The Impact of Microwave Treatment on Quality Characteristics of Starch From Sweet Potato ( Ipomoea batatas )

Soniya S. Patil, Devayani M. Sabnis, Sunidhi V. Kulkarni, Snehal P. Khandekar, Iranna S. Udachan, Shital A. Patil

ABSTRACT This study aimed to investigate the effects of microwave treatment on the functional, structural, thermal, and color properties of sweet potato starch to enhance its industrial applicability. Sweet potato starch was extracted using an alkali method and modified at microwave powers of 100, 300, 450, 600, and 900 W for 3 min at 50% moisture content, with native starch (T0) as the control. The modified starches were analyzed for color (L, a, b*), bulk density, tapped density, Hausner ratio, Carr's index, wate …

01.09.2026journal-article

Eurasian Clinical and Analytical Medicine

Assessment of erectile function before and after treatment in male patients with newly diagnosed chronic obstructive pulmonary disease

Merve Yumrukuz Senel, Cagdas Senel

Aim Chronic obstructive pulmonary disease (COPD) is a prevalent condition with significant systemic consequences. Erectile dysfunction (ED) is common among patients with COPD; however, the impact of COPD treatment on erectile function has not been adequately investigated. This study aimed to evaluate the effect of COPD treatment on erectile function in newly diagnosed male patients. Methods This single-center prospective study included 51 newly diagnosed male patients with COPD, in accordance with predefined inclus …

03.09.2026journal-article

BMJ Paediatrics Open

Growth and nutritional outcomes in children during the first year of cancer treatment: a scoping review with implications for child health care in low- and middle-income countries (LMICs)

Sashiha Manimohan, Padmasani Venkat Ramanan, Prathyusha Gopalakrishnan

Background Improved survival among children with cancer has shifted attention towards quality of care and holistic child health outcomes during treatment. Growth faltering and undernutrition are common during cancer therapy, particularly in low- and middle-income countries (LMICs), where pre-existing nutritional vulnerability and health system constraints may exacerbate this effect. Evidence on growth patterns during the early phase of treatment remains fragmented. Objectives To map available evidence on growth and …

01.09.2026journal-article

Journal of Palliative Medicine

A Pilot Feasibility Study of PAL-CHW-PDAC, a Digitally Enhanced Community Health Worker-Led Intervention to Facilitate Stepped Palliative Care in Patients with Pancreatic Cancer

Nikhil R. Thiruvengadam, Maud Celestin-Joachim, Lizbeth Rivas, Nishita Matangi, Arman Bahmani, Matthew Oroso, Joel Brothers, Kendrick Che, Andrew Chang, Emmanuel Eguia, Paul Leonor, Gina Mohr, Raja Narayan, Sagar Pathak, Susanne Montgomery, Betty Ferrell

Background: Pancreatic Ductal Adenocarcinoma (PDAC) is associated with substantial morbidity and poor quality of life (QOL). Early palliative care (EPC) has been shown to improve QoL and reduce symptom burden in PDAC, but only a minority of PDAC patients receive it. Using three conceptual models, we developed a community health worker (CHW)-led intervention to help facilitate stepped PC. Objectives: To evaluate the feasibility, acceptability, and preliminary effectiveness of PAL-CHW-PDAC. Design: A single-center pr …

04.09.2026journal-article

Cancer Medicine

Performance of Machine Learning Models Based on Medical Imaging in Predicting Pathological Grade of Clear Cell Renal Cell Carcinoma

Yuchao Wang, Zhuwei Song, Zhaonan Hou, Yihao Chen, Shouyuan Liu, Chunyu Chen, Haoyun Guan, Zhengyang Pang, Songchen Yan, Zhiyu Zhang, Ruijia Tu, Gang Zhu, Xiantao Zeng, Bo Fan

ABSTRACT Background Predicting clear cell renal cell carcinoma (ccRCC) pathological grade preoperatively is critical for clinical management. This study aims to evaluate the diagnostic accuracy and clinical utility of machine learning (ML)‐based imaging models. Methods The Cochrane Library, PubMed, Embase, and Scopus databases were searched systematically for studies published before January 2026. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 and the Radiomics Quality Scor …

04.09.2026journal-article

Airway

Utility of Video Laryngoscopes in Head and Neck Cancer Surgeries Performed in Adult Patients – A Systematic Review

Sargam Kant, Anjana Sagar Wajekar

Abstract Airway management in adult head and neck cancer surgeries is often compromised by tumour distortion, trismus and radiation fibrosis. While awake flexible bronchoscopy remains the gold standard, video laryngoscopy (VL) increasingly serves as a first-line modality under general anaesthesia. This systematic review evaluates the utility, efficacy and safety of VL compared to direct laryngoscopy (DL) during nasotracheal intubation (NTI) in adult head and neck oncology surgeries. A systematic literature search ( …

01.09.2026journal-article

Retina

INFLAMMATORY AND IMAGING BIOMARKERS IN TREATMENT-NAÏVE DIABETIC MACULAR EDEMA

Sibel Demirel, Özge Yanık, Figen Batıoğlu, Klara Dalva, Mehmet Ali Şekeroğlu, Tuna Çelik Büyüktepe, Beyza Doğanay Erdoğan, Emin Özmert

Purpose: To determine whether aqueous flare reflects intraocular inflammation in treatment-naïve diabetic macular edema (DME) and to examine associations between aqueous cytokines and optical coherence tomography (OCT) biomarkers, using Irvine–Gass syndrome (IGS) and cataract eyes as controls. Methods: Seventy-six eyes were included (40 DME, 19 IGS, 17 cataract controls). All eyes underwent OCT imaging and laser flare photometry. Aqueous levels of interleukin-6, monocyte chemoattractant protein-1, interferon-γ–indu …