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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Engineering Research Express

A deep residual complex learning framework with long-range temporal context for phase-aware speech enhancement

Debabrata Gogoi, Sushanta Kabir Dutta

Abstract In this paper, we propose an advanced speech enhancement model capable of effectively separating clean speech from noisy audio signals. The primary objective here is to improve speech intelligibility and quality in noisy environments while preserving critical speech components. We propose a GAN based novel residual learning architecture with long range temporal context using complex spectrograms. This is achieved by combining residual neural networks with dilated temporal processing. The model processes bo …

28.08.2026journal-article

Frontiers in Immunology

Increased reporting of interstitial pneumonitis with combined EGFR-TKI and PD-1/PD-L1 inhibitor therapy in NSCLC: a pharmacovigilance analysis of 67,818 reports

Jinyi Tao, Zhiwen Fu

Importance Both epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and PD-1/PD-L1 inhibitors are widely used in non–small cell lung cancer (NSCLC). The safety of their combination, particularly the risk of interstitial pneumonitis (IP), remains unclear but has critical implications for treatment strategies. Objective To evaluate reporting patterns of IP associated with EGFR-TKI monotherapy, PD-1/PD-L1 inhibitor monotherapy, and their combination among NSCLC cases. Design Retrospective, observat …

28.08.2026journal-article

International Journal of Molecular Sciences

Combination of 5-Aminolevulinic Acid and Indocyanine Green in Photodynamic Therapy for Squamous Cell Carcinoma: An In Vivo Study

Aisha Mahmood, Jeongwung Seo, Michelle Barreto Requena, Vanderlei Salvador Bagnato

Photodynamic therapy (PDT) is a promising minimally invasive treatment for non-melanoma skin cancer (NMSC). Still, its clinical efficacy is limited by light attenuation and drug distribution within tumor tissue, which restricts photosensitizer activation in deeper tumor regions. PDT with 5-aminolevulinic acid (ALA) is widely used as a precursor to induce accumulation of protoporphyrin IX (PpIX), followed by red light irradiation; it is effective for superficial lesions but often fails to achieve complete tumor cont …

28.08.2026journal-article

Clinical Medicine and Pharmacology

CHEMORADIATION AND ANTI-PD-1 THERAPY FOR RECTAL CANCER IN A PATIENT WITH MULTIPLE PRIMARY TUMORS: A RARE CLINICAL CASE

M. Bobkov

The article presents a rare clinical case of a 69-year-old patient with three multi-ple primary malignant tumors: cutaneous melanoma (pT4aN2bM0, stage IIIb), synchronous left renal cell carcinoma (cT2N0M0, stage II), and low-ampullary rectal cancer (cT2N0M0, stage I, pMMR/MSS). Treatment with the PD-1 inhibi-tor prolgolimab resulted in complete regression of metastatic melanoma lesions and stabilization of renal cancer. Upon development of rectal cancer, neoadjuvant chemoradiotherapy with capecitabine was initiated …

28.08.2026journal-article

Majalah Obstetri & Ginekologi

The role of synbiotics as adjunctive therapy in prolonging latency period in Preterm Premature Rupture of Membranes

Donel S, Amiruddin Hidayatullah, Maya Savira

HIGHLIGHTS Synbiotics significantly prolonged the latency period in women with preterm premature rupture of membranes (PPROM). The intervention group receiving synbiotics showed a longer latency period (>7 days) compared to the control group (OR = 9.53, p = 0.0126). The study supports the potential use of synbiotics as an adjunctive therapy to improve perinatal outcomes in PPROM cases. ABSTRACT Objective: Preterm Premature Rupture of Membranes (PPROM) is one of the main causes of preterm birth, significantly contri …

28.08.2026journal-article

Clinical Cancer Research

Neoadjuvant Olaparib and Pembrolizumab Combination Therapy in the Treatment of Patients with HRD-Positive Advanced Ovarian Cancer: A Pilot Study

Kenichi Harano, Takehiro Nakao, Shin Nishio, Takahiro Katsuda, Kazuto Tasaki, Kazuhiro Takehara, Takanori Yokoyama, Hideki Furuya, Kyoko Hongo, Masatoshi Asano, Takashi Ikeno, Masashi Wakabayashi, Akihiro Sato, Hitoshi Saito, Chiaki Mashima, Ryo Kamata, Akihiro Ohashi, Suguru Odajima, Hiroshi Tanabe, Tetsuro Taki, Yasuto Fujimoto, Hirohiko Miyake, Reiko Watanabe, Genichiro Ishii, Toru Mukohara

Abstract Purpose: Preclinical studies suggest that poly (ADP-ribose) polymerase inhibition enhances tumor immunogenicity through stimulation of IFN genes pathway activation, providing rationale for combination with immune checkpoint inhibitors. However, clinical evidence supporting this synergy remains limited. We conducted a neoadjuvant pilot study evaluating olaparib with or without pembrolizumab in homologous recombination deficiency (HRD)–positive advanced ovarian cancer. Patients and Methods: Patients with new …

28.08.2026journal-article

Nutrients

Pectin and Kaolin as Adjunctive Metabolic Therapy for Maintaining Remission in Ulcerative Colitis: Biological Rationale, Current Evidence and Future Clinical Perspectives

John K. Triantafillidis, Andreas Panayiotou, Apostolos E. Papalois

Background: Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease in which long-term maintenance of remission remains a major therapeutic challenge. Increasing evidence indicates that disruption of host–microbiome metabolic interactions, impaired production of short-chain fatty acids (SCFAs), defective epithelial energy metabolism, and intestinal barrier dysfunction contribute to disease relapse. These observations have generated interest in adjunctive metabolic strategies aimed at restoring lum …

28.08.2026journal-article

American Journal of Occupational Therapy

Longitudinal Associations of Driving Status and Occupational Dysfunction With Health Outcomes After Acquired Brain Injury

Shuto Takehara, Tasuku Sotokawa, Yuta Tauchi, Rie Sakamoto, Yoshihiro Kanata, Kazuhisa Domen

Importance Driving facilitates community involvement after acquired brain injury (ABI). While driving cessation can lower quality of life, the long-term health impacts of driving resumption, and how baseline occupational dysfunction (OD) affects them remain unclear. Objective To investigate the longitudinal associations between driving status (resumption vs. cessation) and health outcomes following ABI and determine whether baseline OD influences these associations. Design Retrospective longitudinal cohort study us …

28.08.2026journal-article

JAMA Network Open

Prediction of Treatment Benefit With Internet-Based Cognitive Behavioral Therapy for Depression

Cora Schefft, Heiner Stuke, Selin Demir, Maximilian Preiß, Lukas Pezawas, Jakob Kaminski, Björn Meyer, Steffen Moritz, Thomas Berger, Johanne Schröder, Jan Philipp Klein, Stephan Köhler

Importance Treatment benefit prediction models may help identify which patients will benefit most from internet-based cognitive behavioral therapy (iCBT) for depression; it is unclear whether such models can support useful treatment allocation across programs. Objective To develop a model predicting individual treatment benefit from iCBT for depression across programs and to externally validate it in independent samples. Design, Setting, and Participants This prognostic study used individual participant data from 5 …

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28.08.2026journal-article

Current Drug Therapy

Anti-Colitic Properties of Linum usitatissimum Alkaloid in Ulcerative Colitis Induced by Dextran Sodium Sulphate in BALB/c Mice

Riad Ferhat, Meriem Aziez, Mohamed Sofiane Merakeb, Rashed N. Herqash, Abdeltif Amrane, Noureddine Bribi

Introduction: Inflammatory bowel disease, encompassing ulcerative colitis and Crohn's disease, represents a growing global health burden, characterised by chronic intestinal inflammation, oxidative stress, and progressive mucosal barrier dysfunction. This study investigated the anti-colitic potential of the whole alkaloid extract of Linum usitatissimum (ALU) in a murine model of dextran sodium sulphate (DSS)-induced colitis, evaluating its antioxidant, anti-inflammatory, and mucosal-protective properties. Methods: …

28.08.2026journal-article

Children

Speech Characteristics of Childhood Apraxia of Speech in Hebrew-Speaking Children

Natalie Watter, Edwin Maas, Osnat Segal

Purpose: Childhood apraxia of speech (CAS) is a motor speech disorder characterized by deficits in speech planning and programming. However, current diagnostic frameworks have been developed primarily from studies of English-speaking children, raising questions regarding their applicability to other languages. This study examined the common and diagnostic speech characteristics of Hebrew-speaking children with CAS as perceived by Israeli speech–language pathologists (SLPs). Method: Two hundred Israeli SLPs with exp …

28.08.2026journal-article

Academia Drug Development and Pharmacotherapy

Micelles in cancer nanomedicine: targeted delivery, imaging, and therapy

Amirhossein Rashnoodi, Zaynab Seraj, Niyoosha Zamani, Bahareh Khalili Najafabad

Despite advancements in oncology, conventional cancer therapies remain limited by poor specificity, systemic toxicity, and suboptimal therapeutic indices. Micellar nanostructures have emerged as a transformative platform to overcome these hurdles, leveraging their amphiphilic nature to encapsulate hydrophobic agents within aqueous biological environments. This review evaluates the current landscape of micelle-based technologies in cancer management, focusing on their integration into medical physics through diagnos …

28.08.2026journal-article

Hypertension Research

Antihypertensive therapy tailored to the circadian blood pressure profile as precision medicine

Francesca Coccina, Chiara Cuccurullo, Rosa Scurti, Sante D. Pierdomenico

Abstract Circadian blood pressure (BP) values may be different from clinic BP values. Thus, antihypertensive therapy guided solely by clinic BP might not prove appropriate. Moreover, ambulatory BP parameters are superior to clinic BP in predicting outcomes, indicating they should receive more attention as therapeutic targets. Among all relevant 24-h BP parameters, in both untreated and treated patients, two clinically unpredictable windows with proven prognostic relevance deserve attention: the period after awakeni …

28.08.2026journal-article

Odovtos - International Journal of Dental Sciences

Primary Anterior Teeth Rehabilitation with 3D‑Printed Resin Crowns in a Digital Workflow: Case Report

Alejandra Porras Zúñiga, Francisco Porras Arancibia, María F. Rodríguez Callaci

Severe early childhood caries is among the most prevalent oral conditions in children and may significantly affect health, esthetics, and self-esteem. Finding restorative solutions that are both functional, esthetic, and well accepted by young patients can be a clinical challenge, especially in primary anterior teeth with extensive structural loss. This report presents the case of a 5-year-2-month-old boy with multiple carious lesions in the primary dentition, a high caries risk profile, and a strong esthetic conce …

28.08.2026journal-article

Journal of Radiological Protection

Angular distributions of secondary neutron and photon ambient dose equivalent in proton therapy: a systematic PHITS 3.35 study at 70–250 MeV

Thi Yen Hong Huynh, Huu Ngan Thy Truong, Hong Hai Vo, Hoa Lang Trinh

Abstract Monte Carlo simulation of secondary neutron and photon dosimetry — specifically the ambient dose equivalent H*(10) — is central to radiation protection in pencil-beam scanning (PBS) proton therapy. We report particle and heavy ion transport code system (PHITS) version 3.35 calculations of H*(10) for proton beams from 70 to 250MeV incident on a water phantom representative of the Ion Beam Applications Blue Phantom, scored at 11 emission angles at 80 cm using International Commission on Radiological Protecti …

28.08.2026journal-article

Borneo Engineering: Jurnal Teknik Sipil

Analysis of Occupational Accident Risks (Case Study: Phase 1 Construction Project of the Justice Tower Building, Faculty of Law, Hasanuddin University)

Istiawati Darwis, Muhammad Dwiyanto Agung Prakasa, Muh. Sucitra Amanasah, Ulfah Ulfah

The construction industry is one of the sectors with the highest occupational accident risk. This study was conducted at the Justice Tower Phase 1 Building Construction Project, Faculty of Law, Hasanuddin University, which involves working at height, heavy equipment operation, and activities within an active campus environment. The objectives are to identify potential occupational accident risks, determine dominant risks, and formulate control strategies. A quantitative approach supported by qualitative methods was …

28.08.2026journal-article

Medicine

Effect of perioperative thermal control on postoperative rehabilitation in patients undergoing laparoscopic resection for colorectal malignancy

Miao Wang, Yuanfu Zhang, Yumei Xiang

This study examines the association between receipt of a multicomponent enhanced perioperative warming strategy and short-term recovery after elective laparoscopic colorectal cancer resection. This single-center retrospective cohort study included adults treated from January 2024 through December 2025. The warming strategy was determined by the protocol documented in anesthesia and nursing records rather than by random allocation. Propensity scores were estimated using pre-exposure variables, and patients were matc …

28.08.2026journal-article

Occupational Medicine

Nutrition and hydration habits of German anaesthesiology residents

J Reuter, P Meybohm, J Menger

Abstract Background Adequate nutrition and hydration during clinical workdays are essential for physicians’ wellbeing, health, cognitive function, and performance. Anaesthesiology residents work in high-pressure environments that may hinder adherence to recommended dietary and fluid intake guidelines and impair their healthy eating and drinking habits. Aims To assess the dietary and hydration habits of anaesthesiology residents in Germany, identify workplace-related barriers, and evaluate their readiness for behavi …

28.08.2026journal-article

Buildings

A Regression-Based Machine Learning Approach for Rehabilitation of Corroded RC Culverts Strengthened with SMA

Khan Abdul Majid, Faning Dang, Abdulmoez Al Ismaeel, Fayiz Amin, Ijaz Ali

Box culverts are critical components of transportation infrastructure, yet their load-carrying capacity is often compromised by reinforcement corrosion and geometric deterioration. This study proposes an integrated finite element (FEM) and machine learning (ML) framework to evaluate and predict the ultimate capacity of corroded reinforced concrete box culverts strengthened with shape memory alloy (SMA). Severe corrosion was simulated by reducing the slab thickness by 20 mm, and SMA was subsequently applied to the c …

28.08.2026journal-article

Journal of Medical Internet Research

Application of Digital Health Technologies in Scoliosis Rehabilitation: Systematic Review Based on the Technology Classification Framework

Yujie Guan, Jiaben Xu, Zelin Liu, Qi Qin, Xian Wang, Chengyuan An, Gege Wang, Zhiyuan Zhang, Maomao Gong, Bin Zhao

Abstract Background Digital health technologies are increasingly being used in scoliosis rehabilitation, but current evidence remains fragmented, and the effectiveness of these technologies across different categories, and their implementation in the real world remains unclear. Objective We systematically evaluated the efficacy, implementation factors, and potential mechanisms of action of digital health technologies across various categories for scoliosis rehabilitation. Methods We searched PubMed, IEEE Xplore, Em …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Genetically engineered biological therapy in dermatology: modern technologies and development prospects. Part 1

V.V. Petunina, V.Yu. Vasenova, E.I. Tsygankova, E.V. Fedorova, B.N. Ramazonov

Modern dermatology is experiencing a revolutionary period due to the implementation of genetically engineered biological therapy (GEBT) and targeted methods for the treatment of chronic skin diseases. The article presents a comprehensive analysis of modern technologies of genetically engineered biological therapy (GEBT) in dermatology. The main methods of GEBT are considered, including the CRISPR/Cas9 system, adenoviral vectors and RNA interference, as well as various classes of biological drugs: inhibitors of tumo …

28.08.2026journal-article

Micromachines

Artificial Versus Magneto-Aerotactic Bacterial Robots for Cancer Therapy

Sylvain Martel

The use of magnetotactic bacteria (MTB), proposed by the author about 25 years ago, allowed the implementation of embedded capabilities allowing the execution of specific complex tasks such as the target delivery of therapeutics in tumoral hypoxic zones that could not be implemented in artificial micro/nanorobots due to technological limitations at such a small scale. Since then, technology has evolved but the question remains about how long such superior advantage of using only certain types of live microorganisms …

28.08.2026journal-article

Публічне управління і право: історія, теорія, практика

ПУБЛІЧНЕ УПРАВЛІННЯ У СФЕРІ СОЦІАЛЬНО-ПСИХОЛОГІЧНОЇ РЕАБІЛІТАЦІЇ ВІЙСЬКОВОСЛУЖБОВЦІВ І ВЕТЕРАНІВ ВІЙНИ: НОРМАТИВНО-ПРАВОВЕ ЗАБЕЗПЕЧЕННЯ

Оксана Лазор, Олег Лазор, Ірина Юник

Досліджено нормативно-правове забезпечення публічного управління у сфері соціально-психологічної реабілітації військовослужбовців і ветеранів війни в умовах повномасштабної збройної агресії проти України. Обґрунтовано актуальність удосконалення системи публічного управління, зумовлену стрімким зростанням кількості військовослужбовців і ветеранів війни, які потребують комплексної соціальної, психологічної, медичної та професійної підтримки. Проаналізовано конституційні засади публічного управління у сфері соціально- …

28.08.2026journal-article

Odovtos - International Journal of Dental Sciences

Effects of Surgical and Non-surgical Periodontal Therapy on Renal Function and Inflammatory Biomarkers and Mortality in Patients with Chronic Kidney Disease: An Umbrella Review

Anny Marcela Vivares-Builes, María Teresa Pertúz-Rondón, German Márquez-Toro, Carlos Pizarro-Herrera, Andrés Alonso Agudelo-Suarez, Carlos M. Ardila

Periodontitis and chronic kidney disease (CKD) share common pathophysiological mechanisms, with periodontitis acting as a chronic inflammatory comorbidity that exacerbates systemic inflammation in CKD patients. This study aimed to analyze the effect of surgical and non-surgical periodontal therapy on renal function, inflammatory biomarkers, and mortality in patients with CKD according to the available evidence. An umbrella review was conducted, including systematic reviews and meta-analyses from databases such as P …