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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
04.09.2026journal-article

Obstetrical & Gynecological Survey

Comment on “Frozen Versus Fresh Embryo Transfer in Women With Low Prognosis for In Vitro Fertilization Treatment: Pragmatic, Multicentre, Randomized Controlled Trial”

David L. Keefe

Clinical management of patients with a low prognosis for success in in vitro fertilization (IVF) remains a challenge despite advances in technology over the last several decades. Current criteria defining low prognosis include patients with 9 or fewer oocytes retrieved or poor ovarian reserve, and the prevalence of patients who meet these criteria is nearly 40% in IVF patients. Low prognosis is associated with a 50% lower cumulative live birth rate on average compared with patients with a normal prognosis. A new st …

01.09.2026journal-article

Stroke

Medical Treatment or Intervention for Asymptomatic Carotid Stenosis?: Interpreting CREST-2

Peter Kelly, John McCabe, Gert Jan De Borst

Older randomized trials have shown modest benefit for carotid endarterectomy for selected patients with asymptomatic carotid stenosis compared with medical treatment. However, improvements in contemporary medical therapy may have negated the benefit of carotid endarterectomy, and no large randomized trials comparing stenting with modern medical treatment have been completed. The recently reported CREST-2 trial (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trials) addressed thes …

01.09.2026journal-article

Industrial Lubrication and Tribology

Synergistic effects of surface heat treatment and friction modifiers on the wear resistance of QT tribo-pairs under boundary lubrication conditions

Ran Li, Pengpeng Bai, Wenshu Wei, Jianfeng Li, Mengyu Wu, Jian Ye, Wei Xu, Rongming Chen, Weihua Cao, Hao Liu, Hui Cao

Purpose Plunger pairs in emulsion pumps typically operate under extreme boundary lubrication conditions, resulting in severe wear issues. Existing studies have often examined material selection, heat treatment and lubrication independently, without adequately addressing their synergistic interactions. To bridge this gap, this work aims to systematically investigate the combined influence of these factors on tribological performance. Design/methodology/approach Using QT600 and QT400 ductile irons, specimens with var …

01.09.2026journal-article

Cell Death Discovery

The insulin-like growth factor 2 mRNA-binding protein 2 affects tumor cell metabolism via mitochondrial transporter activity and lipid alterations

Sandra Kendzia, Susanne Franke, Marcello Pirritano, Eva Grafahrend-Belau, Nikolai Köhler, Theresa Bauchspiess, Sören Franzenburg, Marcus Höring, Elia Raab, Linus Schmeier, Sinem Sürmeli, Frank Erdmann, Johannes Klose, Jörg Kleeff, Michael Boettcher, Gerhard Liebisch, Josch K. Pauling, Martin Simon, Björn H. Junker, Sonja M. Kessler

Abstract The insulin-like growth factor 2 mRNA-binding protein (IGF2BP) family is overexpressed in cancer and associated with poor prognosis. IGF2BP2 has been linked to single metabolic alterations by acting on its RNA targets. Here, we used a comprehensive approach to elucidate the effects of IGF2BP2 on primary and lipid metabolism. 13 C-metabolic flux analysis (MFA) combined with RNA-Seq data revealed that IGF2BP2 affects mitochondrial fluxes by regulating the expression of several mitochondrial transporters, suc …

01.09.2026journal-article

MedComm – Oncology

Immune Checkpoint Inhibitors in Cancer Therapy: Clinical Landscape, Resistance Mechanisms, and Therapeutic Innovations

Qiongyu Zhang, Zhi Qin, Caijuan Guo

ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of solid tumors, yet only a limited subset of patients achieves durable disease control. While China has emerged as a major contributor to global ICI development, a comprehensive synthesis of recent trial data and resistance mechanisms is urgently needed to guide clinical practice. This review examines the evolving landscape of ICI‐based combination therapies, including regimens that combine ICI with chemotherapy, targeted therapy, antib …

01.09.2026journal-article

Frontiers in Aging Neuroscience

Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions

Le Mao, Sijie Ma, Kun Zhu, Chao Feng, Xinyu Chen, Fangli Yang, Maoli Duan, Xiaowan Chen

Age-related hearing loss (ARHL) is the most common sensory disorder in older adults. Current hearing interventions, including hearing aids and cochlear implants, face limitations in accessibility and adherence. Therefore, efforts have been devoted to elucidating the molecular mechanisms underlying cochlear aging and identifying effective therapeutic targets for ARHL. This review summarizes several molecular mechanisms implicated in cochlear aging and ARHL, including autophagy dysregulation, oxidative stress, stereo …

01.09.2026journal-article

Journal of Comparative Effectiveness Research

Real-world treatment patterns and clinical outcomes of patients with primary biliary cholangitis in the United States

Nisreen Shamseddine, Hongbo Yang, Su Zhang, Dongni Ye, Shravanthi Seshasayee, Jingyi Chen, Sonal Kumar, Kris V Kowdley

Background & aim: Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease that can lead to increased morbidity and mortality. This study described real-world treatment patterns and clinical outcomes by line of treatment among patients with PBC in the US. Materials & methods: Adults (≥18 years) diagnosed with PBC on or after 1 January 17 were identified in the IQVIA PharMetrics ® Plus database and grouped into newly diagnosed, first-line (1L) and second-line or more (2L+) cohorts. Index date was ini …

01.09.2026journal-article

FEBS Open Bio

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao

The Warburg effect has long suggested that oxidative phosphorylation (OXPHOS) is dispensable for tumor growth. However, recent studies have shown that the mitochondrial RNA polymerase inhibitors IMT1 and IMT1b, which impair OXPHOS, are potent anticancer agents. Here, we demonstrate that ionomycin, a selective ionophore known to modulate mitochondrial homeostasis, similarly inhibits mitochondrial gene expression across cancer cell lines. Specifically, gene expression and nascent RNA profiling revealed a global downr …

01.09.2026journal-article

Annual Review of Genetics

Stemness as a Systems-Level State: From Ancestral Plasticity to Systemic Control in Regeneration, Aging, and Cancer

Jagriti Arora, Sakshi Tiwari, Dasaradhi Palakodeti, Tina Mukherjee

Multicellularity necessitated the evolution of cellular diversity and specialization, yet across organisms, the retention of cellular plasticity within defined physiological contexts is a recurring principle. Here, we examine early-diverging metazoans to reevaluate the evolutionary logic of stemness. Rather than viewing stem cells as exceptional, we argue that cellular plasticity represents a deeply conserved attribute of early life. The ability of cells to remain responsive, multipotent, and regenerative under eco …

01.09.2026journal-article

Cancers

Preserving Continuity of Cancer Therapy in Patients with Hematologic Malignancies and Chronic Subdural Hematomas: Comparative Outcomes of Middle Meningeal Artery Embolization and Surgery

Esteban Ramirez-Ferrer, Juan P. Zuluaga-Garcia, Maria A. Sierra, Danielle Hammond, Hagop M. Kantarjian, Jeffrey S. Weinberg, Chibawanye I. Ene, Shaan M. Raza, Frederick F. Lang, Peter T. Kan, Stephen R. Chen, Christopher C. Young

Background/Objective: Hematologic cancer patients are at high risk of developing chronic subdural hematomas (cSDH), and traditional treatment with surgery is potentially risky in this patient population, with associated coagulopathy and thrombocytopenia. Neurointerventional endovascular middle meningeal artery embolization (MMAE) is emerging as a novel minimally invasive treatment method for cSDH, and its efficacy and complication profile has not been evaluated in patients with hematologic cancers. Methods: We cond …

01.09.2026journal-article

Frontiers in Microbiology

Interplay of gut microbiota, immune cells and natural products in reshaping cancer immunotherapy

Xiaomei Wu, Lingeng Lu, Tingdun Li, Liangyu Zhao, Linlin Wang, Yi Yao, Jian Chen, Tingting Liu, Xiangqian Li, Xiaokang Zhu, Quhuan Ma, Xiaoqin Li, Gongjian Zhu

Recent advances have underscored the gut microbiota as an essential orchestrator of host responses to cancer immunotherapy. Gut microbiota and their metabolites play a vital role in modulating host immune responses. They regulate the development, differentiation, and function of a variety of immune cells, including granulocytes, monocytes, macrophages, dendritic cells (DCs), natural killer (NK) cells, innate lymphoid cells (ILCs), cytotoxic T cells (CTLs), helper T (Th) cells, regulatory T cells (Tregs), and B cell …

01.09.2026journal-article

Nanotechnology

Hyaluronic acid-based nanocarriers for cancer therapy: molecular design, biointerface mechanisms, and translational challenges

Hao Wu, Petr P Snetkov, Jingran Zhang, Xinyu Zhang, Zuobin Wang, Svetlana N Morozkina

Abstract Hyaluronic acid (HA) has emerged as a versatile structural material and targeting ligand within cancer drug delivery systems and nanomedicine applications, owing to its biodegradability, tunable chemistry, and strong affinity for CD44 and related receptors. This review examines studies published from 2019 to 2026, with emphasis on high-quality research in leading journals, and connects the structural parameters of HA with quantitative drug delivery efficiency and therapeutic performance. The major HA-based …

01.09.2026journal-article

Cancer Medicine

Agreement in Staging and Treatment Recommendations Among Clinicians, Text‐Only Clinicians, DeepSeek‐V3 , and ChatGPT‐4o for Nasopharyngeal Carcinoma Patients

Shenglan Lin, Cai Zhang, Feifei Zhong, Xiyi Liao, Liuyun Gong, Dunhuang Wang

ABSTRACT Purpose With AI tools being increasingly utilized for medical inquiries, this study evaluated the agreement between clinicians, text‐only clinicians, DeepSeek‐V3, and ChatGPT‐4o in TNM staging and preferred treatment recommendations for newly diagnosed nasopharyngeal carcinoma (NPC) patients. Methods A retrospective study analyzed 322 consecutive NPC patients treated at our institution from January 2023 to February 2025. TNM staging (AJCC 8th edition) and preferred treatment recommendations were independen …

02.09.2026journal-article

Supportive Care in Cancer

Navigating nutritional information while living with metastatic cancer: a qualitative study of patient experiences and needs

Barbara S van der Meij, Manon GA van den Berg, Iris EC Nagtegaal, Floortje K Ploos van Amstel, Petronella B Ottevanger, Anja JThCM de Kruif

Abstract Purpose Nutrition often becomes a prominent concern for patients living with metastatic cancer. While patients frequently seek nutritional information to support their health and manage treatment-related challenges, they may encounter inconsistent advice from different sources. This study aimed to explore how patients with metastatic cancer perceive and navigate nutritional information, and to identify their experiences and needs regarding nutritional support during systemic therapy. Methods A qualitative …

01.09.2026journal-article

Analytical Chemistry

CHAI-sEV: A Programmable Hairpin-Driven Cas9 Platform with AI Integration for Dual-Protein Profiling and Intelligent Classification of Tumor-Derived Small Extracellular Vesicles

Haoyu Shen, Xinyu Pan, Yan Wu, Bing Chen, Xiaolei Zhou, Linbo Qiao, Clement Yaw Effah, Jing Zhou, Junying Yu, Zhenzhong Zhang, Xiaonan Yang, Yongjun Wu, Lihua Ding

Abstract Multiplexed protein profiling of tumor-derived small extracellular vesicles (TsEVs) requires signal-conversion strategies that are sensitive, low-background, and orthogonal. Collateral-cleavage CRISPR assays based on Cas12a or Cas13a provide efficient amplification but can compromise single-pot multitarget detection, whereas the sequence-specific cleavage of Cas9 remains underexplored for converting vesicle-surface protein recognition into orthogonal amplified outputs. Here, we report CHAI-sEV, a programma …

01.09.2026journal-article

Healthcare

An Integrated Prevention, Treatment, and Rehabilitation Program for Toileting-Related Falls in Older Adults and People with Disabilities: The Protocol for a Multicenter Prospective Single-Arm Implementation Study

Zexuan Lv, Yin Lu, Hongyu Zhang, Rentang Li, Chengsong Mi, Kefeng Li, Fan Gao, Qiang Hu, Yi Wang, Qing Yuan

Background/Objectives: Toileting-related falls may arise from interacting urinary symptoms, impaired mobility and balance, cognitive or psychological factors, environmental hazards, and caregiver limitations that are often managed separately. This study aims to evaluate the implementation, safety, and 6-month clinical outcomes of an integrated multidisciplinary prevention, treatment, and rehabilitation pathway for older adults and people with disabilities at risk of toileting-related falls. Methods: This multicente …

03.09.2026journal-article

Journal of Indian Association of Pediatric Surgeons

Laparoscopic Wilms Tumor Nephrectomy and Lymph Node Sampling: Oncotechnical Considerations

Nitin James Peters, B Sashikiran, Ravi Prakash Kanojia, Muneer Abas Malik, Indu Mohini Sen, Shailesh Solanki, Monika Bawa, Jai Kumar Mahajan, Deepak Bansal

A BSTRACT Wilms tumor (WT) is the most prevalent pediatric renal malignancy, with surgical intervention being a cornerstone of multimodal management. This report evaluates the surgical feasibility, oncotechnical considerations, and short-term outcomes of laparoscopic WT nephrectomy (LWTN) in 17 children following neoadjuvant chemotherapy (NACT). LWTN was successfully completed in 47.1% (8/17) of cases, with conversions primarily necessitated by intraoperative bleeding, efforts to prevent tumor rupture, and strict a …

01.09.2026journal-article

Cancer Diagnosis & Prognosis

Real-world Outcomes of First-line Platinum-based Chemotherapy in Patients Aged 80 Years or Older With Metastatic Urothelial Carcinoma

AKINORI MINATO, KAZUMASA JOJIMA, YUTO TSUBONUMA, YUI MIZUSHIMA, YOSHIHIRO SUGITA, TAKUO MATSUKAWA, IKKO TOMISAKI, EIJI KASHIWAGI

Background/Aim: As populations age, more patients aged ≥80 years with metastatic urothelial carcinoma (mUC) require systemic therapy. However, the efficacy and safety of first-line platinum-based chemotherapy (PBC) in octogenarians remain unclear. This study aimed to describe clinical outcomes in patients aged ≥80 years with mUC eligible for PBC. Patients and Methods: We retrospectively analyzed 30 patients with mUC who received first-line PBC between 2005 and 2022. Patient characteristics, tumour response, treatme …

01.09.2026journal-article

SVOA Medical Research

Overcoming Logistical Delays and Resource Constraints: Achieving Complete Response in High-Risk Medulloblastoma with Delayed Metastatic Progression at a Newly Established Secondary Cancer Center

Mymoona Alzouebi, Dahlawi Ismail Al, Majed Alawiat, Batool Alghadeer, Ahmed Albaqshi, Asmaa Elgayer, Salma Almohammed

Introduction: High-risk Medulloblastoma (MB) requires time-critical, multimodal therapy. This report details the management of a high-risk MB case where critical logistical barriers necessitated treatment adaptation in a newly established, resource-limited secondary center. Case Presentation: A 12-year-old female with Anaplastic/Large Cell MB suffered a critical two-month delay in initiating adjuvant therapy due to referral failures. This delay resulted in disease progression and confirmed M+ spinal drop metastases …

04.09.2026journal-article

Obstetrical & Gynecological Survey

Comment on “GLP-1 Receptor Agonists Plus Progestins and Endometrial Cancer Risk in Nonmalignant Uterine Diseases”

Linda Van Le

The most common gynecologic malignancy is endometrial cancer (EC), with an estimated annual case number of 69,120. Cancer and pre cancer (endometrial intraepithelial neoplasia, EIN) patients present with abnormal uterine bleeding (AUB)in 90% of cases but the risk of EC and EIN in patients with AUB is thought to be low (0.3% to 1.3%). Recent studies have shown that alterations in metabolic factors impact the risk of developing precursor diseases; obesity, insulin resistance, type 2 diabetes, and unopposed estrogen m …

01.09.2026journal-article

Breast Cancer Research and Treatment

Associations of neighborhood deprivation with breast cancer tumor genomics, targeted treatment use, and survival

Emily L. Podany, Lorenzo Foffano, Lorenzo Gerratana, Arielle J. Medford, Natalie K. Heater, Eleonora Nicolò, Shaili Tapiavala, Letizia Pontolillo, Annika Putur, Diana A. Jaber, Katherine Clifton, Nitin Katakam, Sarah Addison, Marla Lipsyc-Sharf, Carolina Reduzzi, Foluso O. Ademuyiwa, Fabio Puglisi, William J. Gradishar, Cynthia X. Ma, Aditya Bardia, Massimo Cristofanilli, Andrew A. Davis

Abstract Purpose Neighborhood environments appear to influence breast cancer biology and outcomes. This study evaluated somatic, treatment, and outcome differences by Area Deprivation Index in patients with metastatic breast cancer. Methods Retrospective, population-based cohort study using clinical and genomic data gathered between 2015 and 2024 at four academic institutions in the United States. The outcomes were differences in circulating tumor DNA mutation profiles, PI3K inhibitor use, and survival between pati …

01.09.2026journal-article

Lasers in Medical Science

The role of bipolar radiofrequency in the treatment of vaginal laxity: a single-center cohort study in premenopausal women

Pablo González Isaza, Diana Velez, Manuela Cerón, Mary Ríos, Diana Carolina Bermúdez, Jahir Alexander Soto-Mora

Abstract Vaginal laxity is a prevalent condition that can impair sexual function. Bipolar radiofrequency (RF) is a minimally invasive treatment; however, prospective evidence remains limited. This study aimed to evaluate changes in both subjective and objective measures of vaginal laxity following bipolar RF. This prospective observational study enrolled premenopausal women with symptomatic vaginal laxity who received four intravaginal bipolar RF sessions. The primary outcome was the change from baseline to 6 month …

01.09.2026journal-article

ASM Case Reports

Toxoplasmosis-associated hemophagocytic lymphohistiocytosis during tumor-infiltrating lymphocyte therapy

Tariq Odeh, Priscilla Quach, Amin Mostofizadeh, Julia D. Hankins, Robert Hamilton-Seth, Chelsea Gorsline

ABSTRACT Background Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome triggered by infections, malignancies, or autoimmune disorders. Tumor-infiltrating lymphocyte (TIL) therapy requires lymphodepleting chemotherapy and interleukin-2, producing profound immunosuppression. While HLH-like syndromes have been characterized after chimeric antigen receptor T-cell therapy, HLH has not been reported in the setting of TIL therapy. Toxoplasma gondii is a recognized but uncommon parasitic trigge …