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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
02.09.2026journal-article

Transgender Health

Alterations in Breast Tissue Morphology and Androgen Receptor Expression Following Masculinizing Gender-Affirming Hormone Therapy in Transgender Men

Poonpissamai Suwajo, Thawin Techapongsatorn, Adiluck Pisutpunya, Kasama Nilprapha, Jiraroch Meevassana, Apichai Angspatt, Kroonpong Iampenkhae, Saranpong Pornsinsirirak

Purpose: This study aimed to evaluate histological alterations and androgen receptor (AR) expression within breast tissue associated with masculinizing gender-affirming hormone therapy (GAHT) exposure of different duration in transgender men. Methods: A retrospective review of breast histopathological specimens obtained from 81 transgender men following gender-affirming mastectomy between 2017 and 2023 was conducted. Histological features and AR expression were compared between individuals with and without prior GA …

02.09.2026journal-article

Journal of Language Teaching and Research

Linguistic Foundations for Constructing Speech Synthesis in the Kazakh Language

Fazylzhan A.M., Bazarbayeva Z.M., Amanbayeva A.Zh., Zhumabayeva Zh.T., Ospangaziyeva N.B., Karshigayeva A.А.

The article is devoted to the problem of correctly recognizing and pronouncing, in accordance with orthoepic norms, shortened words and abbreviations, numerical symbols, mathematical operations, formulas, and conventional signs within the Kazakh-language text-to-speech system. The main objective of the study is to identify the linguistic features of fully expanding shortened words and abbreviations in texts processed by the speech synthesis system, as well as of representing mathematical expressions in written form …

02.09.2026journal-article

International Journal of Sports Physical Therapy

Utilization of the Functional Lower Extremity Evaluation (FLEE) in Return-to-Sport Rehabilitation Protocol Following Hip Arthroscopy in Collegiate Athletes: A Case Series

Yazdan Raji, Rebecca E. Luft, Kinsley J. Pierre, Floyd VitoCruz, Marc R. Safran

Background The Functional Lower Extremity Evaluation (FLEE) is a validated assessment tool designed to assess lower limb function and symmetry. There is a gap in knowledge in return to sport (RTS) regarding the application of the FLEE in RTS rehabilitation protocols following hip arthroscopy. The purpose of this case series was to assess the utility of the FLEE in guiding RTS rehabilitation protocols for collegiate athletes after hip arthroscopy and to evaluate lower limb symmetry using FLEE components. Hypothesis …

02.09.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Arthroscopic Suprapectoral Biceps Tenodesis Using a Standard Suture Anchor Is Safe and Effective

Xavier A. Duralde, Caroline A. Heramb, Jennifer N. Blanda

Purpose To evaluate the safety and efficacy of an arthroscopic technique of suprapectoral biceps tenodesis using a standard absorbable double‐loaded suture anchor. Methods This retrospective study includes all patients who underwent arthroscopic biceps tenodesis by the senior author between December 2017 and June 2020. Biceps tenodesis was performed in patients who had failed conservative management and exhibited evidence of biceps pathology at the time of surgery that appeared to be contributing to the patient's p …

02.09.2026journal-article

Epilepsy Currents

The Odd Couple: Replacement Therapy for Citrate Transporter Deficiency in the Brain and the Liver

Sara Eyal

AAV-mediated gene therapy in a model of SLC13A5 citrate transporter disorder rescues epileptic and metabolic phenotypes Bailey LE, Adams RM, Schackmuth MK, Garza IT, Knight K, Holmes SK, Eller MM, Lee M, and Bailey RM. J Clin Invest . 2026 Feb 19;136(8):e197503. doi: 10.1172/JCI197503. PMID: 41712282; PMCID: PMC13078891. SLC13A5 citrate transporter disorder is a rare epileptic encephalopathy caused by loss-of-function pathogenic variants in the SLC13A5 gene. Loss of sodium/citrate cotransporter function causes a se …

02.09.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Categorizing race profiles in professional men’s and women’s road cycling races using clustering

Annemiek J. Roete, Marije T. Elferink-Gemser, Robert P. Lamberts, Matthias Kempe

Abstract Background Professional road cycling races differ in physiological demands because race profiles vary. Yet no standardized method exists to categorize race profiles across professional road cycling races. Organizer labels are inconsistent or missing. Systematic categorization would enable large-scale analysis of race demands. This study develops a categorization of race profiles in men’s and women’s professional road cycling. Methods The dataset comprised international men’s and women’s races from 2024 sup …

02.09.2026journal-article

BMC Musculoskeletal Disorders

Effectiveness of dynamic neuromuscular stabilization exercises on clinical variables in postoperative rehabilitation of patients with lumbar disc herniation: a randomized controlled trial

Burak Buğday, Büşra Arısüt, Elif Esma Bayraktar, Ömer Şevgi̇n

Abstract Purpose This study evaluates the effects of an 8-week Dynamic Neuromuscular Stabilization (DNS) program on disability, physical activity, and fear-avoidance behaviors in postoperative lumbar disc herniation (LDH) patients. Method The study was designed as a randomized controlled trial. Participants of both sexes, aged 35–50 years, were recruited from a single-center postoperative outpatient physiotherapy setting and randomized into DNS (intervention) and standard care (control) groups. The DNS program emph …

02.09.2026journal-article

Stem Cell Research & Therapy

Extracellular vesicles from specific muscle progenitor cells as a novel therapeutic strategy for sarcopenia

Bi Zhao, Yao Yao, Hong Shi, Srinivas M. Tipparaju, Muhammad Ashraf, Wanling Xuan

Abstract Background Sarcopenia, characterized by age-related loss of skeletal muscle mass and function, poses a significant challenge to lifelong health and wellbeing. Currently, no effective therapeutic interventions exist. In previous work, we developed specialized muscle progenitor cells (MPCs), termed Givi-MPC, from human induced pluripotent stem cells (hiPSCs). These cells demonstrated robust regenerative capacity in both sarcopenic and dystrophic muscle models. However, the potential of extracellular vesicles …

02.09.2026journal-article

Australian Occupational Therapy Journal

Exploring successful implementation of occupational therapy led home fall‐hazard reduction interventions

Susan Melchert, Richard Franklin, Daniel Lowrie

Abstract Introduction Falls among older adults are a major cause of death, injury, and loss of independence. High‐certainty evidence demonstrates that comprehensive, occupational therapy–led home fall‐hazard reduction interventions can reduce the number of falls among older adults at high risk. Despite this evidence, these interventions are not routinely implemented in practice. Current literature provides limited insight into the factors that influence successful implementation of home fall‐hazard reduction interv …

02.09.2026journal-article

American Journal of Biopharmacy and Pharmaceutical Sciences

Evaluation of natural and synthetic photosensitizers in visible light-mediated antimicrobial photodynamic therapy against pathogenic bacteria

Seemi Tasnim Alam, Ferdousi Akhter, Esrat Jahan Toma, Most Farhana Khatun, Sadika Tasnim, Abdullah Bin Hossain Rayhan, Sadi Mahmud Sakib, Mehjabin Ferdous, Md. Aftab Uddin

Objectives: Alternative effective treatment solutions to antibiotic resistance are long overdue. Antibiotic overuse and unfinished antibiotic courses have become globally life threatening, especially in Bangladesh. An alternative way to inactivate pathogenic microorganisms is antimicrobial photodynamic treatment (APDT). This study aims to explore the antimicrobial photodynamic activity of hypericin (a naturally occurring non-toxic photosensitizer [PS]) and methylene blue (a chemical PS), which in combination with l …

02.09.2026journal-article

International Journal of Advanced Research in Science Communication and Technology

Light Activated Drug Delivery System: A Novel Approach for Controlled and Targeted Therapy

Amol S. Rone, Mrs. Rupali G. Chaudhari, Dr. P. N. Sable

Light-Activated Drug Delivery Systems (LADDS) are advanced drug delivery systems that release drugs only when exposed to a specific wavelength of light. Unlike conventional drug delivery, which often causes uncontrolled drug release and systemic side effects, LADDS provide targeted and controlled drug release at the desired site and time. These systems use photoresponsive carriers such as liposomes, nanoparticles, hydrogels, and micelles, which respond to ultraviolet (UV), visible, or near-infrared (NIR) light. Lig …

02.09.2026journal-article

physioscience

Exploration of Patients’ Perspective on Telerehabilitation in Physiotherapy: What are Potential Facilitators and Barriers?

Marco Stahn, Anne-Kathrin Rausch

Abstract Telerehabilitation (TR) has emerged as a significant development in physiotherapy care. While research has examined physiotherapists’ perspectives on TR in Germany, patients’ experiences and views remain understudied. Previous research has primarily examined physiotherapists’ perspectives on TR; this study complements it by exploring the patients’ perspective, including satisfaction, barriers and facilitators. A qualitative study was conducted using individual and focus group interviews in 10 purposefully …

02.09.2026journal-article

Clinical Otolaryngology

Azelastine‐Fluticasone Intranasal Combination Therapy in Otorhinolaryngology: Clinical Evidence, Current Practice Patterns and Future Perspectives

Giorgio Ciprandi, Ignazio La Mantia, Attilio Varricchio

ABSTRACT Background Allergic rhinitis (AR) represents a significant burden in Ear Nose Throat (ENT) practice and markedly affects quality‐of‐life and work productivity of AR patients. The fixed combination of intranasal azelastine and fluticasone propionate (AzeFlu) has emerged as a valuable therapeutic option for moderate‐to‐severe AR. Recent updates to international guidelines and real‐world evidence warrant a comprehensive review of its role in ENT practice, with particular attention to both seasonal and perenni …

02.09.2026journal-article

Physics in Medicine & Biology

Biologically optimized 3D range modulators for fast conformal carbon ion therapy: in vitro validation, treatment planning, and robustness analysis

Sae Hyun Hailey Ahn, Domenico Ivan Filosa, Peter Lysakovski, Stephan Brons, Amir Abdollahi, Jürgen Debus, Ivana Dokic, Thomas Tessonnier, Andrea Mairani

Abstract Objective. Patient-specific 3D range modulators (RMs) allow rapid and conformal particle therapy with monoenergetic beams and may support motion management and ultra-high dose rate (UHDR) studies. For carbon ions, however, relative biological effectiveness (RBE) varies strongly with depth, so RM geometry should be optimized for biological effect rather than physical dose alone. This work presents a translational pathway for biologically optimized 3D RMs (bio-RMs) for carbon ion therapy, evaluated through d …

02.09.2026journal-article

World Advances in Renal Medicine

Antibiotic catheter lock: An adjunct therapy for recurrent tunneled hemodialysis catheter infections

Ahmed Atris, Issa Al Salmi, ThaMr.een Al Zadjali, Adham Ahmed, Muhammed Elneel, Michael Mamdouh Soliaman, Hamed Ali Said Al Shahri

The objective of the study is to evaluate the use of antibiotic catheter locks in reducing recurrent catheter-related bloodstream infections (CRBSIs) in hemodialysis (HD) patients. This prospective case series was conducted at ASeeb Renal Dialysis Center, from September 2022 to August 2023, including four hemodialysis outpatients with recurrent catheter-related infections. All patients were unfit for an arteriovenous fistula (AVF) or graft (AVG) and were maintained on dialysis via their last access option, which wa …

02.09.2026journal-article

FRONTIERS OF LAW JOURNAL

Efeitos da fisioterapia respiratória em criança com paralisia cerebral: uma revisão integrativa da literatura

Poliana Karine Martins Eremita, Nicolle da Silva Costa, Lana Cristina Barreto Ramos Melo

A Paralisia Cerebral (PC) caracteriza-se por distúrbios motores crônicos decorrentes de lesões encefálicas não progressivas. Alterações posturais, fraqueza muscular e deformidades torácicas frequentemente comprometem a mecânica ventilatória desses indivíduos, elevando o risco de infecções respiratórias recorrentes. Nesse cenário, a fisioterapia respiratória é fundamental para otimizar a função pulmonar e prevenir complicações. Neste sentido o presente estudo tem como objetivo avaliar os efeitos da intervenção fisio …

02.09.2026journal-article

Frontiers in Psychology

Tracing narrative development in children with speech, language, and communication difficulties: a CiteSpace analysis

Ruijie Zhao, Yusong Gao, Yu Cui, Xiaochen Wang

Narrative development is central to children’s language, communication, and academic functioning, yet children with speech, language, and communication difficulties often experience challenges in organizing and expressing coherent stories. This study used CiteSpace to analyze 628 articles and reviews retrieved from the Web of Science Core Collection and published between 1985 and 2024. The publication trend was descriptively divided into three periods: the Emerging Stage, the Development Stage, and the Growth Stage …

02.09.2026journal-article

Journal of Cancer Research and Clinical Oncology

Time to subsequent therapy (TTST) as an endpoint in clinical studies: development of standardized documentation of subsequent therapy through systematic literature review, expert interviews, and Delphi survey

Bianca Biedenweg, Thorsten Ruppert, Thomas Kohlmann, Martin Danner, Anja Mehnert-Theuerkauf, Diana Lüftner, Ulrike Filippig, Janine Ziemann, Ulrike Osowski, Peter Kaskel

Abstract Background The endpoint Time to Subsequent Therapy (TTST) is an intermediate endpoint used in research and regulatory assessments. TTST denotes initiation of subsequent therapy and is a clearly definable, clinically relevant event for healthcare professionals. However, it has not been systematically established to which extent TTST is subjectively meaningful to patients. The objective of this study was to define TTST as a patient-relevant intermediate endpoint. Methods The study examined five oncological i …

02.09.2026journal-article

Physics in Medicine & Biology

Parameterizable salivary gland model for small-scale Monte Carlo radiopharmaceutical therapy dosimetry: evaluation of mouse and human models

David P Adam, Tahir Yusufaly, Ian Marsh, Remco Bastiaannet, Ana Kiess, Wesley E Bolch, Nouran Zaid, Anupriya Chhabra, Rebecca Krimins, Kathy Gabrielson, Cory Brayton, George Sgouros, Robert F Hobbs

Abstract Standard of care radiopharmaceutical therapy (RPT) may result in dose-limiting side effects of the salivary glands including sialadenitis and xerostomia that are inconsistent with outcomes from external beam for equivalent absorbed doses (ADs). This work develops a parameterizable ‘Macro-to-Micro’ (M2 μ ) model that demonstrates the consideration of small-scale dosimetry in comparison to conventional methods that typically assume uniform voxel or organ-level uptake. Anatomical features of the salivary glan …

02.09.2026journal-article

Journal of Occupational Rehabilitation

Antecedents of Long‑Term Work Disability After Mental Health-Related Sickness Absence: The Role of Occupational Health Care Pathways

Pekka Varje, Ilkka Kivimäki, Ari Väänänen, Simo Taimela, Olli Haavisto, Matti Joensuu, Tiina Kalliomäki-Levanto

Abstract Purpose The relationship between specific occupational health care (OHC) pathways and subsequent work disability following an initial mental health-related sickness absence (SA) is poorly understood. This study aimed to predict long-term SA outcomes by modeling the timing and composition of OHC pathways among employees absent due to mood disorders or anxiety. Methods We conducted a register‑based observational cohort study using structured occupational health records from a major Finnish OHC provider (2015 …

02.09.2026journal-article

Frontiers in Endocrinology

Weekly long-acting growth hormone versus daily growth hormone therapy on quality of life, efficacy, and safety in children with short stature: a systematic review and meta-analysis

Fan Liu, Linying Xiu, Wei Zhang, Chunhui Zang, Shuyu Wang

Background This meta-analysis aims to compare the QoL, efficacy, and safety of once-weekly LAGH versus daily GH in children with short stature. Methods We systematically searched PubMed, Embase, the Cochrane Library, and Web of Science from inception to June 30, 2026, for studies comparing LAGH with daily GH in children with short stature. Outcomes of interest encompassed QoL, efficacy, and safety. Pooled analyses were conducted using a random-effects model. Treatment effects for continuous and dichotomous variable …

02.09.2026journal-article

Journal of Language Teaching and Research

Sound-Meaning Correspondence and Child-Directed Speech in Early Language Development: Evidence From Kazakh Caregiver Speech

Zaure S. Sovetova, Anar Fazylzhan, Kuralay Kuderinova, Aiman Zhanabekova, Beisenkhan Samal, Yelimay Shynatay

This study examines the phonological, semantic, and communicative features of caregiver speech and children’s self-created words in early language development, based on data from Kazakh-speaking families. The research is based on a survey of 50 parents and explores two key aspects: (1) the use of terms of endearment in child-directed speech, and (2) children’s spontaneous formation of novel words associated with object properties. The results show that nearly half of the respondents use non-standard, phonologically …

02.09.2026journal-article

Australian Occupational Therapy Journal

Exploring the occupational therapy goal‐setting process with immigrant families of children with disabilities in the Australian context

Sarah Ninan Fenn, Natasha Jojo, Stephen Isbel, Claire Pearce

Abstract Introduction Collaborative relationship‐focussed practice centres on the relational aspects of co‐designing priorities and goals with individuals, collectives, and occupational therapists. To establish a relationship with immigrant families of children with disabilities, aligning the goals with their values and resources is essential. However, this is perceived as challenging, and there is a significant knowledge gap regarding how the goals are set in the occupational therapy process with immigrant familie …

02.09.2026journal-article

Pakistan Journal of Medical Sciences

FPN1–8C>G Polymorphism as a potential genetic modifier of iron overload in transfusion-dependent β-Thalassemia major patients receiving HbF augmentation therapy

Maeesa Wadood, Muhammad Younus Jamal Siddiqui, Iram Nazir, Muhammad Rizwan

Objectives: To assess the association of the FPN1–8C>G polymorphism with iron overload and iron-regulatory biomarkers in transfusion-dependent β-thalassemia major patients receiving fetal hemoglobin (HbF) augmentation therapy. Methodology: This cross-sectional study was conducted from January 2024 to May 2025 at Fatima Hospital, Baqai Medical University, and Muhammadi Thalassemia Centre, Karachi, Pakistan. A total of 120 transfusion-dependent β-thalassemia major patients receiving hydroxyurea-based HbF augmentation …