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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Cancers

Identification of Factors That Determine Adherence for Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer

Cynthia Araradian, Emmett Hunnicutt, Siting Chen, Shawna Rivedal, Shelby Willis, Maura Walsh, Vassiliki Liana Tsikitis, Sandy Hwang Fang

Background: Locally advanced rectal cancer (LARC) treatment has shifted from the utilization of neoadjuvant chemoradiation (NACRT), followed by total mesorectal excision (TME) and adjuvant chemotherapy (AC) to the implementation of total neoadjuvant therapy (TNT). This transition was influenced by data from multiple studies reporting suboptimal compliance rates to adjuvant chemotherapy. As a result, a paradigm shift to TNT occurred, consisting of chemoradiation with chemotherapy, based on the RAPIDO and PRODIGE-23 …

03.09.2026journal-article

Ege Tıp Dergisi

Real-world outcomes of first-line carboplatin–etoposide–atezolizumab in extensive-stage small-cell lung cancer

Abdülkadir Koçanoğlu, Oktay Ünsal, İbrahim Karadağ, Fırat Şirvan, Serdar Karakaya

Aim: The addition of atezolizumab to platinum-etoposide chemotherapy has become the standard first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC). However, real-world data regarding treatment outcomes and prognostic factors remain limited. This study evaluated the effectiveness of first-line carboplatin-etoposide-atezolizumab and investigated clinical and PET/CT-derived prognostic factors in patients with ES-SCLC.Materials and Methods: We retrospectively analyzed 59 consecutive patients with ES …

03.09.2026journal-article

Frontiers in Pharmacology

Lipid-dependent regulation of Kv10.1 in cancer: implications of membrane remodeling for channel function and pharmacology

Nguyen Van Phuong, Anna Stary-Weinzinger

The voltage-gated potassium channel Kv10.1 (Eag1), which is abnormally overexpressed across a wide range of tumor types, is a promising therapeutic target for cancer treatment. However, the clinical development of Kv10.1 inhibitors is currently constrained by severe off-target cardiotoxicity resulting from unintended inhibition of the structurally homologous Kv11.1 (hERG) channel. In this review, we examined cancer-associated membrane lipid remodelling and its implications for the lipid-dependent regulation of both …

03.09.2026journal-article

Interactions

Predictive analysis of wear rate in SUP9 spring steel under controlled heat treatment cooling rates

Mamookho Elizabeth Makhatha, Sergei Sherbakov, Daria Podgayskaya, Pawan Kumar

Abstract In the present work, SUP9 spring steel specimens were reheated to 1000 °C in a controlled muffle furnace to obtain a homogeneous austenitic structure. The specimens were then cooled at different rates (0.1, 5, 100, 375, and 650 °C) to generate varied microstructures. Increasing the cooling rate refined the pearlitic microstructure, resulting in a finer and more uniform grain structure. These heat-treated specimens were then subjected to the wear test to study the influence of cooling rate ( dT/dt ), load ( …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Radical nephroureterectomy after toripalimab plus disitamab vedotin in biomarker-non-enriched upper tract urothelial carcinoma

Guohui Cheng, Quan Zhang, Rundong Li, Zhongze Zhou, Xiangbin Kong, Zhilong Dong

Upper tract urothelial carcinoma (UTUC) is uncommon and aggressive, and evidence for perioperative antibody-drug conjugate or immunotherapy remains limited. We report a 59-year-old man with biomarker-non-enriched high-risk ureteral UTUC treated with four cycles of toripalimab plus disitamab vedotin before planned surgery. Magnetic resonance urography, urine cytology, and ureteroscopic biopsy supported high-grade UTUC with glandular differentiation; CDX-2, villin, and β-catenin positivity prompted exclusion of a gas …

03.09.2026journal-article

Frontiers in Medicine

Prevalence of financial toxicity and construction of a risk prediction model for lung cancer patients at 6 months after discharge

Ningning Liu, Xiaoyan Wang, Xiaofeng Pan, Caifang Tang, Ximiao Li, Yiting Zhang, Yaru Zhao

Objective To investigate the prevalence of 6-month post-discharge financial toxicity in lung cancer patients, identify its independent predictors, and establish a valid risk prediction model integrating socioeconomic, clinical, and patient-reported outcome variables as baseline predictors, so as to support early financial toxicity screening, targeted financial counseling and standardized nurse-led stratified transitional nursing interventions. Methods A single-center prospective cohort study enrolled 682 hospitaliz …

03.09.2026journal-article

Frontiers in Oncology

Brain metastasis secondary to primary vaginal clear cell adenocarcinoma not associated with diethylstilbestrol: a case report and a review of the literature

Esther Anyimadu Buckson, Obi Emereole, John Richard Ouma

Background Cases of primary clear cell adenocarcinoma of the vagina (PCCAV) are infrequently encountered and account for only 5%–10% of all primary vaginal cancers 1. The most common associated risk factor for developing PCCAV is in utero exposure to diethylstilbestrol (DES). Patients with non-DES-related PCCAV are even scarcer and usually have a worse prognosis. PCCAV has been reported to metastasize to the lungs, supraclavicular lymph nodes, and the pelvis, while metastases to the liver, brain, and peritoneum are …

03.09.2026journal-article

Petroleum Engineering

ANALYSIS OF THE EFFECTIVENESS OF STEAM TREATMENT DURING CYCLIC STEAM SIMULATED

Yu.E. Mikhailova, D.Yu. Savrey, V.V. Durkin

Cyclic steam simulated (CSS) is the most common technology of thermal impacton the formation of high-viscosity oil. The CSS technology is the injection of steam into a well, followed by the soaking stage (stopping the injection of steam to condense), followed by switching to the operating mode of the producing well. After the production wells are put into operation, production is carried out to a certain level of water cut floating oil or a cost-effective flow rate. The duration of the effect of the CSS can be both …

03.09.2026journal-article

Frontiers in Cellular and Infection Microbiology

Global trends and emerging frontiers in cancer immunotherapy and gut microbiota-derived metabolites: a bibliometric analysis

Yingying Hu, Chenhuai Teng, Dian Zhang

Objectives Cancer immunotherapy has achieved remarkable clinical success; however, therapeutic resistance remains a major challenge. Increasing evidence suggests that gut microbiota-derived metabolites play a critical role in modulating host immune responses and influencing treatment outcomes. This study aimed to systematically characterize the global research landscape and identify emerging trends in this field using bibliometric approaches. Methods Publications were retrieved from the Web of Science Core Collecti …

03.09.2026journal-article

Frontiers in Oncology

Oncologic safety of sentinel lymph node–based nodal de-escalation in apparent uterine-confined endometrial cancer: a multicenter international cohort study

Alessandro Buda, Ilaria Capasso, Jessica Mauro, Emanuele Perrone, Michael Mueller, Robert Fruscio, Valentina Bruno, Sara Imboden, Tommaso Grassi, Virginia Garcia-Pineda, Elisa Tripodi, Salih Taskin, Stefano Restaino, Diego Raimondo, Vito Andrea Capozzi, Andrea Papadia, Franziska Siegenthaler, Jvan Casarin, Giuseppe Cucinella, Enrico Vizza, Ignacio Zapardiel, Giuseppe Vizzielli, Cagatay Taskiran, Francesco Fanfani

Background Sentinel lymph node (SLN) mapping has increasingly replaced systematic lymphadenectomy in apparent uterine-confined endometrial cancer (EC). However, concerns persist regarding the risk of recurrence following nodal surgical de-escalation, particularly in patients with aggressive histologic subtypes. We aimed to evaluate the oncologic safety of SLN-based nodal de-escalation by analyzing recurrence patterns and recurrence-free survival in patients with apparent early-stage EC. Methods We conducted a retro …

03.09.2026journal-article

Frontiers in Oncology

Short-term mortality after intensive care admission in acute lymphoblastic versus predominantly acute myeloid leukemia: a retrospective cohort study using MIMIC-IV with eICU external replication

Zhe Li, Jianglin Yu

Background Adults with acute leukemia admitted to intensive care have high early mortality. Whether acute lymphoblastic leukemia (ALL) adds prognostic information beyond baseline severity remains clinically important. Methods We performed a retrospective MIMIC-IV cohort study of 486 first ICU stays from 372 adults with acute leukemia. Primary outcomes were hospital and ICU mortality. ALL was compared with a predominantly acute myeloid leukemia comparator using complementary confounder-only and severity-adjusted mod …

03.09.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

CEA-targeted fluorescence endoscopy for the detection of high-grade dysplasia and early invasive rectal cancer: A proof-of-concept trial

M. I. Warmerdam, T. H. Dijkhuis, D. J. G. Linders, C. M. W. Pesch, A. S. L. P. Crobach, A. Matoshi, K. Basiliya, S. H. van den Berg, F. Cailler, K. C. M. J. Peeters, F. A. Holman, J. S. D. Mieog, A. L. Vahrmeijer, D. E. Hilling, J. J. Boonstra

Abstract Purpose Accurate recognition of high-grade dysplasia (HGD) and early invasive carcinoma (IC) within colorectal polyps is essential for selecting the preferred local resection technique. However, optical endoscopic diagnosis can be challenging, particularly in large and advanced polyps. This study investigates whether carcinoembryonic antigen (CEA)-targeted near-infrared fluorescence (NIRF) imaging can distinguish polyps containing HGD/IC from polyps solely containing low-grade dysplasia (LGD), given prior …

03.09.2026journal-article

Frontiers in Psychology

Parenting concerns among patients with cancer: a qualitative meta-synthesis

Yuchen Jiao, Ping Zhu, Liuliu Zhang, Bing Wu

Objectives This qualitative meta-synthesis aimed to interpret how cancer patients experience and manage parenting concerns, and to identify implications for family-centered psychosocial care. Design A qualitative meta-synthesis was conducted. Methods PubMed, Embase, Web of Science, Cochrane Library, CINAHL, EBSCO, ProQuest, China Science and Technology Journal Database, China National Knowledge Infrastructure, and Wanfang Database were searched from inception to April 2025. Qualitative studies published in Chinese …

03.09.2026journal-article

Frontiers in Oncology

Risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis in elderly patients with lung cancer

Ying Hu, Shuhua Chen, Yingying Lu, Lingjuan Yang

Objective This study aimed to investigate the clinical characteristics, risk factors, severity-related factors, and clinical outcomes of immune checkpoint inhibitor-associated pneumonitis (CIP) after immune checkpoint inhibitor (ICI) treatment in elderly patients with lung cancer, providing evidence for risk identification and nursing management during ICI therapy. Methods Clinical data from 206 elderly patients with lung cancer who received ICI therapy at the Second Affiliated Hospital of Naval Medical University …

03.09.2026journal-article

Frontiers in Oncology

Case Report: Gastric glomus tumor with long-term dynamic multimodal imaging findings

Yujun Jiang, Wenli Lian, Xiaochen Dong, Xueyan Jia, Qingxia Xu, Min Wang, Zhongcheng Hang, Xuan Yang

Gastric glomus tumor (GGT) is a rare mesenchymal neoplasm with nonspecific clinical and imaging features, often leading to preoperative misdiagnosis. Its longitudinal imaging evolution remains poorly characterized. Herein, we report a 51-year-old man with a GGT in the gastric antrum who underwent 6-year multimodal imaging follow-up, including CT, MRI, and serial endoscopic ultrasonography (EUS). The lesion presented as a well-circumscribed subepithelial nodule with marked and persistent enhancement on CT. It showed …

03.09.2026journal-article

Discover Public Health

A scoping review protocol on knowledge, perceptions and attitudes toward cervical cancer among Ghanaians

Isaac Aidoo Erzuah, Christiana Asiedu, Amidu Alhassan, Ernest Addae

Abstract Introduction Cervical malignancy remains a major public health challenge in low- and middle-income countries, with sub-Saharan Africa bearing a disproportionate burden of disease. In Ghana, cervical cancer incidence and mortality remain high despite the availability of effective preventive measures, including human papillomavirus (HPV) vaccination and screening. Knowledge, perceptions, and attitudes influence uptake of cervical cancer prevention services, yet evidence from Ghana remains limited. This scopi …

03.09.2026journal-article

Frontiers in Oncology

Factors associated with clinical research participation among Medicare beneficiaries with prostate cancer in the United States

Ryan A. Hankins, Alysha M. McGovern, Abimbola O. Williams, Virgil H. Simons, Sean P. Collins, Deepak Kumar

Introduction Clinical research participation among patients with prostate cancer remains limited, and demographic, clinical, and contextual factors may influence opportunities for participation. Although disparities in prostate cancer diagnosis and treatment are well documented, less is known about the factors associated with clinical research participation in this population. This study examined patient-level and contextual factors associated with clinical research participation among older Medicare beneficiaries …

03.09.2026journal-article

Phytotherapy Research

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka

ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as valerolactones and glucuronides, which support the growth of several beneficial bacterial species including Bifidobacterium and Lactobacillus while inhibiting harmfu …

03.09.2026journal-article

Cancers

STK11/LKB1 Loss in Cancer: From Developmental Constraint to Stress-Adapted Malignancy

Yu Kang, Yanhong Gao, Xiao-Yan Zhang, Hai-Ou Liu, Cong-Jian Xu, Yanying Huo

Peutz–Jeghers syndrome (PJS) presents an apparent biological paradox: heterozygous germline pathogenic variants in STK11 predispose to predominantly benign hamartomatous growth while conferring a markedly elevated lifetime risk of cancer, whereas somatic STK11 inactivation in established tumors is frequently associated with aggressive progression and therapeutic resistance. STK11 encodes liver kinase B1 (LKB1), a serine/threonine kinase that integrates metabolic, oxidative, architectural, and immune stress response …

03.09.2026journal-article

Indian Journal of Nuclear Medicine

A Resource-Efficient End-to-End Multimodal AI Framework for Automated PET-CT Report Generation and TNM Staging in Breast Cancer

Dibya Prakash, Venkatesh Rangarajan, Manoj Kumar

Objectives: Positron Emission Tomography-Computed Tomography (PET-CT) is integral to breast cancer staging. However, manual interpretation is time-consuming and subject to inter-observer variability. While artificial intelligence has shown promise in lesion detection and standardised uptake value (SUVmax) quantification, existing approaches are fragmented and do not generate complete TNM-aligned structured reports. Consequently, there remains a need for an integrated framework capable of translating PET-CT data int …

03.09.2026journal-article

Frontiers in Oncology

Performance evaluation of large language models in bladder cancer patient education Q&A: a cross-sectional study

Dian Wan, Youwen Li, Zheng Dong, Chen Dai, Jinghe Ye, Song Li, Sunlu Jiang

Background Bladder cancer ranks among the most prevalent urological tumors worldwide, with its global incidence continuing to rise steadily. Although patient education materials (PEMs) play a crucial role in enhancing disease comprehension and supporting joint clinical decision-making, current online resources frequently surpass the readability thresholds recommended for the general public. Large language models (LLMs) hold promise for health communication, yet no systematic assessment has been conducted regarding …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

Antibacterial polyphenols for osteomyelitis treatment: from antibacterial mechanisms to biomaterial-based delivery

Xuemei Cao, Yuanmin He, Yamin Zhu, Ping Gu, Ting Dai, Yuyu Zheng

Osteomyelitis is a refractory infection caused by bacterial invasion of bone tissue. Biofilms, small-colony variants (SCVs), and intracellular persistence enable bacteria to evade immune clearance and antibiotic killing, while sequestra and implant surfaces may act as long-term infection reservoirs. Some pathogens can also invade the osteocyte lacuno-canalicular network, further hindering complete eradication. Meanwhile, persistent inflammation, oxidative stress, and impaired local blood supply aggravate bone destr …

03.09.2026journal-article

Pediatric Blood & Cancer

A Three‐Component Immune Framework Stratifies Treatment Response and Escalation in Pediatric Hemophagocytic Lymphohistiocytosis: A Prospective Single‐Center Cohort Study

Mai Anh Thi Nguyen, Truong Nhat Trinh, Duong Ngoc Mai, Phung Nguyen The Nguyen

ABSTRACT Background Pediatric hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome that can be classified into three principal etiologies (primary HLH [pHLH], Epstein–Barr‐virus‐driven HLH [EBV‐HLH], and secondary HLH [sHLH]) and is associated with disparate outcomes. Treatment escalation decisions remain largely empirical, guided by clinical presentation and conventional laboratory results rather than by an integrated biomarker framework. Procedure We prospectively enrolled 180 consecutive pedi …

03.09.2026journal-article

Frontiers in Cell and Developmental Biology

RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential

Qingmiao Shi, Yangni Li, Chaonan Guan

Ferroptosis, an iron-dependent form of regulated cell death, is increasingly recognized as a context-dependent therapeutic vulnerability in cancer, particularly as malignant cells adapt to oxidative, metabolic, and therapy-induced stresses. As a prevalent and reversible epitranscriptomic modification, RNA N6-methyladenosine (m6A) modification orchestrates RNA stability, translation, splicing and decay; consequently, its dysregulation contributes to cancer progression and therapeutic resistance. The intersection of …