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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Frontiers in Immunology

Traditional Chinese medicine remodels the immune microenvironment of colorectal cancer: mechanisms and therapeutic perspectives

Zeanbang Shi, Jie Mei, Qinchang Zhang, Liu Li, Haibo Cheng

Colorectal cancer (CRC) is a common malignancy of the digestive tract, and its initiation and progression are closely associated with dysregulation of the tumor immune microenvironment. The CRC immune microenvironment consists of effector immune cells, immunosuppressive cells, inflammatory mediators, immune checkpoint pathways, stromal cells, the extracellular matrix, the gut microbiota, and microbial metabolites. Its pathological features include impaired immune recognition and effector immunity, enhanced immunosu …

03.09.2026journal-article

International Journal of Legal Medicine

A technical note on the preparation and staining of unfixed, undecalcified and unembedded fresh and taphonomically altered human bone with five common stains and dyes

Simona A. Dinu, Iris Sluis, Wilma Duijst, Tristan Krap

Abstract Anthropological and forensic investigations often rely on skeletonized human remains as the only piece of evidence for lifestyle, age and post-mortem interval predictions. Recent studies have demonstrated that histological staining has the potential to extend or improve the knowledge that can be extracted from the microstructure of bone. However, histological staining has only been scarcely applied and investigated on (taphonomically altered) human bones, leading to a lack of available methodology. In this …

03.09.2026journal-article

Frontiers in Immunology

Complete and durable remission in a patient with brain metastasis from gastric cancer treated with SRS followed by RC48 plus camrelizumab after progression on chemo-immunotherapy: a case report and literature review

Xiao Liu, Baozhen Ma, Mengjiao Yang, Lingdi Zhao

Background Brain metastasis from gastric cancer carries a dismal prognosis, with median overall survival of only 3–6 months. Patients who progress on immune checkpoint inhibitor (ICI)-containing regimens have limited salvage options. HER2-low expression (IHC 1+ or IHC 2+/FISH-negative), historically excluded from anti-HER2 therapy, has now emerged as a novel therapeutic target for antibody-drug conjugates (ADCs) such as RC48 (disitamab vedotin). Case summary A 52-year-old male with HER2-low (IHC 2+/FISH-negative), …

03.09.2026journal-article

Measurement Science and Technology

Tacholess order tracking based on surrogate data test for bearing diagnosis under varying speed conditions

Tao Zhang, Jiahang Li, Cheng Li, Mengjie Luo, Yi Wang

Abstract For bearing fault diagnosis, vibration analysis is one of the most primary methods in engineering practice. Many traditional methods are ineffective in engineering applications with variable operating conditions. Tacholess envelope order analysis (TLEOA) technology shows promising application prospects for bearing fault diagnosis in conditions where speed varies, since it does not require additional speed measurement equipment to obtain phase information. Nevertheless, the widespread application of this me …

03.09.2026journal-article

Frontiers in Surgery

Comparison of ACDF with stand-alone PEEK cage versus zero-p implant for the treatment of cervical degenerative disease: a systematic review and meta-analysis

Yiheng Zhao, Juan Xie, Ling Zhu, Jianna Zhang, Junhui Zhang

Introduction In recent years, stand-alone polyetheretherketone (PEEK) cages (SA) and Zero-P implants (ZP) have been widely adopted clinically in anterior cervical discectomy and fusion (ACDF) for cervical degenerative disease (CDD). However, which is superior between SA and ZP remains highly controversial. This meta-analysis was designed to conduct a head-to-head comparison of the safety, clinical efficacy, and radiological effectiveness of ACDF with ZP and SA. Methods This research was carried out in accordance wi …

03.09.2026journal-article

Nutrients

Unmetabolized Folic Acid: Biology, Epidemiology, and Clinical Consequences: A Systematic Review

Richard E. Frye, Daniel A. Rossignol

Background: Mandatory folic acid (FA) fortification prevents neural tube defects but generates unmetabolized folic acid (UMFA) in blood, because hepatic dihydrofolate reductase (DHFR) reduces FA only slowly. Whether UMFA itself, as distinct from high total folate, carries biological consequences is unresolved. Methods: We systematically searched six databases (January 1995–May 2026; PROSPERO CRD420261407616) and included 65 publications describing 61 unique primary studies, yielding 71 analytic contributions (15 me …

03.09.2026journal-article

Journal of Palliative Medicine

Palliative Surgery to Restore Function and Dignity: A Case of Massive Breast Tumor Debulking in Rural Uganda

Simran Kripalani, Howard Eison, Goretti Nassali, Prossy Nafula, Benjamin Schwarz, Randi Diamond

Background: Palliative surgery plays a critical role in alleviating symptom burden and thus improving quality of life in patients with advanced disease. Case Presentation: This is a case of a 23-year-old female in rural Uganda with an untreated, massive right breast mass present since infancy and progressive abdominal distention of unclear etiology. Over time, the breast mass impaired her mobility, rendering her largely homebound and dependent on others for basic movement. Despite evidence of profound malnutrition, …

03.09.2026journal-article

Frontiers in Endocrinology

Longitudinal clinical trajectories and vascular–inflammatory–neurophysiological associations in diabetic peripheral neuropathy: an exploratory analysis of a TENS-treated cohort

Qian Gao, Liwan Yang, Bin Wang, Lijuan Gao, Qing Yao, Jiangwei Hu

Background Transcutaneous electrical nerve stimulation (TENS) is used as an adjunctive treatment for diabetic peripheral neuropathy (DPN), but long-term clinical trajectories vary among patients. The biological characteristics associated with these different trajectories remain incompletely characterized. This study aimed to identify longitudinal clinical trajectory patterns and examine their associations with vascular, inflammatory, and neurophysiological measures. Methods Prospective 24-month data from 685 patien …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Connective tissue disorders and cardiac arrhythmias: genetic pathways, mechanistic bridges, and clinical implications

Luke Dreher, Hussein Abdul Nabi, Ramzi Ibrahim, Mahmoud Abdelnabi, Omar Baqal, Christopher N. Kanaan, Min Choon Tan, Linnea M. Baudhuin, Fadi E. Shamoun, Hicham Z. El Masry

Background Connective tissue disorders (CTDs) such as Marfan syndrome, Loeys-Dietz syndrome, and Ehlers-Danlos syndromes are traditionally defined by vascular fragility and aortic complications. Increasing evidence, however, demonstrates that CTDs also predispose to atrial and ventricular arrhythmias, often independent of overt cardiomyopathy or severe valvular disease. Content This review integrates emerging data on the arrhythmogenic substrates of CTDs. Four mechanistic bridges are emphasized: (1) diffuse myocard …

03.09.2026journal-article

Frontiers in Pharmacology

The clinical trial landscape of bispecific antibodies in non-small cell lung cancer: mechanistic trends and developmental strategies

Zunyuan Li, Xiyu Wang, Qin Shi, Yuhong Guo, Guirong Dong, Zhidan Liu

Background Non-small cell lung cancer (NSCLC) management remains constrained by acquired resistance to targeted therapies and refractoriness to immune checkpoint inhibitors (ICIs), the latter driven largely by the immunosuppressive tumor microenvironment (TME). Bispecific antibodies (bsAbs) represent a promising modality capable of circumventing these therapeutic hurdles through proximity-driven dual-targeting mechanisms that co-block bypass signaling pathways and reverse immunosuppression. This study systematicall …

03.09.2026journal-article

Ege Tıp Dergisi

Changes in public interest in plastic surgery over time: A comprehensive global perspective using google trends. No job, Yes Aesthetics?

Ecem Esma Yeğin, Mehmet Emre Yeğin

Aim: Google Trends has become an essential resource in health research, providing valuable insights into evolving public interest patterns. Social media platforms significantly influence public interest in cosmetic surgery, with effects observed across age groups. Research shows a clear connection between social media exposure and heightened public interest, serving as a means for surgeons to educate patients and market their services.Material and Methods: This study uses Google Trends data to analyze changes in in …

03.09.2026journal-article

Frontiers in Surgery

Application of “parenchyma-first” approach in laparoscopic living donor left lateral sectionectomy

Hui Tang, Dongwei Wu, Kaining Zeng, Xiao Feng, Binsheng Fu, Qing Yang, Jia Yao, Yang Yang, Shuhong Yi

Objective This study aimed to evaluate the safety and feasibility of a “Parenchyma-First” approach for laparoscopic left lateral sectionectomy (LLS) in living donor hepatectomy, with the primary goal of minimizing vascular injury. Methods To avoid premature and excessive dissection of the portal vein and hepatic artery at the first hepatic hilum—which increases the risk of vascular injury—and to prevent torsion or occlusion of these mobilized vessels during parenchymal transection, we adopted a technique that prior …

03.09.2026journal-article

Frontiers in Surgery

Latent class analysis–derived prediction model of shoulder function after arthroscopic repair for rotator cuff tear: a large retrospective cohort study

Tingting Ma, Yun Wu, Lujian Liang, Yumeng Tang, Yang Li, Rui Yin, Xia Ming, Liyan Bian

Objectives Considering the potential probabilities of shoulder function following arthroscopic rotator cuff repair (ARCR) was crucial for clinical decision-making and postoperative managements. This study aimed to identify distinct patterns of postoperative shoulder function and their prognostic factors. Methods Records of adult patients who underwent ARCR for the treatment of rotator cuff tear were reviewed from the electronic medical records. Constant–Murley scores were utilized to measure shoulder function at ba …

03.09.2026journal-article

Frontiers in Cardiovascular Medicine

Integrating conformal prediction with machine learning for uncertainty-aware risk stratification in coronary artery disease

Shengnan Lin, Xuyang Hu, Yang Zhang, Qi Zhang, Xiaoning Wang, Yang Yang, Fuzheng Song, Yutong Li, Yushan Liu, Yuanpeng Zhao, Dingjian Zhao, Minghua Nan, Changchuan Bai

Background Predictive models are increasingly used in clinical decision-making in coronary artery disease (CAD). However, most existing models focus on discriminative ability while ignoring individual prediction uncertainty, which is particularly prominent in small-sample contexts, limiting clinical applications. Methods We developed an uncertainty-aware model integrating machine learning and conformal prediction (CP) for CAD prediction in a small-sample setting cohort ( N = 297). Logistic regression (LR) and rando …

03.09.2026journal-article

Frontiers in Dental Medicine

Case Report: Dental treatment under general anesthesia for a child with Ullrich congenital muscular dystrophy

SokIok Cheang, WeiYun Chen, Shuang Wang, XinXin Wang, Kuo Wan, Lin Ma

Background Ullrich congenital muscular dystrophy (UCMD) is a rare inherited myopathy caused by mutations in the COL6 gene and is frequently associated with multisystem complications affecting the respiratory and skeletal systems, which may increase airway and anesthetic risks during dental treatment. Case report This report describes a 4-year-old girl with UCMD who presented with pain in the left lower molar. After a comprehensive multidisciplinary evaluation by the Department of Stomatology, Anesthesiology, and Pe …

03.09.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Moisturizer formulations for diabetic foot xerosis: a systematic review and meta-analysis of randomized controlled trials

Karin Borgström, Sebastian Björklund, Petri Gudmundsson, Anna Ericsson, Stefan Acosta

Background Foot xerosis in people with diabetes increases the risk of skin fissuring, ulceration and complications like amputation, sepsis and death. Preventive skin care is therefore important, yet evidence-based guidance on the most effective formulations remains limited. This systematic review aimed to identify effective ingredients and formulations to treat diabetic foot xerosis. Methods A literature search was conducted in Medline, Cinahl, Embase, CENTRAL and Scopus. Randomized controlled trials (RCTs) involvi …

03.09.2026journal-article

Petroleum Engineering

INVESTIGATION OF THE FRACTIONAL COMPOSITION OF RESIN COMPONENTS OF HEAVY OIL UNDER STEAM-THERMAL TREATMENT

I.I. Mukhamatdinov, G.Kh. Sitdikova

In recent decades, the extraction and processing of heavy high-viscosity oil has become an urgent task for the oil industry. Such raw materials require additional preparation, including destruction of high molecular weight components to increase the yield of light fractions. The main share in it is occupied by resins and asphaltenes, the study of the structure of which is important both for understanding the processes of oil formation and for optimizing production, transport and processing. The paper studied the fr …

03.09.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

Advances towards biological hearing restoration by genetic reprogramming

Melissa M. McGovern, Andrew K. Groves

Purpose of review Advances in genetic reprogramming and groundbreaking first-in-human gene therapy trials have generated significant momentum for treating sensorineural hearing loss. This review evaluates the expanding potential of biological approaches for hearing restoration. Recent findings The mammalian organ of Corti possesses limited natural regenerative capacity. Recent studies are attempting to restore hearing by genetically reprogramming supporting cells into hair cells. While merely modulating cell signal …

03.09.2026journal-article

Geriatrics

A Patient- and Function-Centric Model/Approach for Hypoglycemia Management in Older Adults

Kannayiram Alagiakrishnan, Laurie Mereu, Gulelala Rahim, Mahua Ghosh, Albert Vu

Diabetes-related hypoglycemia contributes substantially to increased morbidity, mortality, health-care utilization, and reduced quality of life. Older adults with diabetes represent a heterogeneous group of patients who need individualized blood glucose targets to avoid hypoglycemia. Since the elderly present with varying degrees of functional and cognitive status and individualized health needs, their management varies among individuals. Complicating this, the hypoglycemia risk in older adults treated with insulin …

03.09.2026journal-article

El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam

The Effect of Service Quality, Trust, Hospital Image and Facilities on Patient Satisfaction in Outpatient Pharmacy Services

Jaka Arifin Budiyana, Istiatin Istiatin, Oong Ridhoi

This research aims to test and analyze the influence of service quality, trust, hospital image and facilities on patient satisfaction in outpatient pharmacy services at Dr. RM. Soedjarwadi Mental Hospital. The research method used is quantitative. The number of samples used was 100 respondents with instrument testing in the form of validity and reliability tests. Furthermore, the research data was analyzed using Multiple Linear Regression, F-Test, t-test, and Coefficient of Determination. The results of the study i …

03.09.2026journal-article

Humanities and Social Sciences Communications

Psychosocial predictors and justification patterns of traditional and alternative medicine in Peru

Angelo Fasce, Jose Rosales-Trabuco, Javier Rodriguez-Ferreiro, Itxaso Barberia, Elvis Pinedo-Yzaguirre, Juan Manuel Espinoza Nunez, Wilson Marcos Ortiz-Treviños, Christian David Pizarro-Moncada, Mario Reyes-Bossio, Carlos Carbajal-León, Ezequiel Lopez-Lopez

Abstract This mixed-methods study investigates the prevalence, attitudes, psychological predictors, and reasons for perceived effectiveness of traditional and alternative medicine in Peru. A representative national sample ( N = 805) reported their experiences with 16 unconventional medical techniques, alongside psychometric measures of pseudoscientific beliefs, ideological traditionalism, and trust in the medical profession. Traditional medicine was more widely used, while alternative medicine elicited more favorab …

03.09.2026journal-article

Frontiers in Medicine

Development and validation of an automatic machine learning-based myocardial contusion prediction model in rib fracture patients: a retrospective multicenter cohort study

Yan Yang, Ping Liu, Ni Jia, Yisha Xu, Peng Wu, Zhigang Zhang, Tingyong Han, Yan Jiang, Xianpeng Huang, Long Li

Objective This study aims to construct an automatic machine learning-based prediction model to accurately identify the risk of myocardial contusion in traumatic rib fracture patients, addressing the core limitations of insufficient sensitivity in traditional diagnostic methods and difficulties in clinical translation of existing prediction models. Methods A multicenter retrospective study design was adopted, including 1,038 rib fracture patients from 8 hospitals (training set: 808 cases; testing set: 230 cases) fro …

03.09.2026journal-article

Frontiers in Immunology

Hepatic immune microenvironment dynamics in severe obesity and post-bariatric surgery: insights from immunohistochemical analysis

Alina-Iuliana Onoiu, Sergio González-Serrano, Vicente Cambra-Cortés, Andrea Jiménez-Franco, Carmen Guilarte, Karla Beatriz Peña, Francesc Riu, Jordi Camps, Jorge Joven, David Parada

Severe obesity is linked to metabolic dysfunction-associated steatotic liver disease (MASLD), which can progress to metabolic dysfunction-associated steatohepatitis (MASH) and advanced fibrosis. Currently, there are no accurate tissue biomarkers for measuring immune-mediated liver injury or remission post-bariatric surgery. This study utilized digital pathology and immunohistochemistry to analyze liver biopsies from three patient groups: those with severe obesity and liver damage before bariatric surgery, their pai …

03.09.2026journal-article

Frontiers in Neuroscience

How physician relationships with neurotechnology companies impact clinical practice: interviews with physicians

Meredith V. Parsons, Judith M. Mwobobia, Erin D. Solomon, Michael Kudom-Agyemang, James M. DuBois, Tristan McIntosh

Introduction Physicians and neurotechnology companies each play a critical collaborative role when integrating neurotechnology into clinical practice. Physicians serve as gatekeepers and decision-makers in adopting neurotechnology, while companies often support the development, training, and maintenance of these devices. Relationships with industry require physicians to navigate complex clinical, ethical, and technological factors that affect their clinical roles. To understand physicians’ relationships with neurot …