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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

Otology & Neurotology

Semiautomatic Quantification of Cochlear Nerve Cross-sectional Area Predicts Speech Intelligibility in Cochlear Implant Users

Florian Herrmann Schmidt, Tammo Siemers, Daniel Cantré, Karsten Ehrt, Wilma Großmann, Robert Mlynski, Lichun Zhang

Objective: To apply a semiautomatic method for quantifying cochlear nerve cross-sectional area (CSA) based on 3D models from MRI picture and to evaluate the association between CSA at different nerve locations and postoperative speech perception in cochlear implant (CI) users. Study design: Retrospective cohort study. Setting: University Medical Center, tertiary academic referral center. Patients: Twenty adult patients with asymmetric hearing loss undergoing a MED-EL cochlear implant (Synchrony 2, FLEX electrode se …

28.08.2026journal-article

BJOG: An International Journal of Obstetrics & Gynaecology

Vaginal Oestrogen Therapy for Postmenopausal Women Undergoing Prolapse Surgery: A Multicentre Double‐Blind Randomised Placebo‐Controlled Clinical Trial

Eva V. Vodegel, Krista van Rest, Leonie Speksnijder, Astrid Vollebregt, Albert Adriaanse, Eveline J. Roos, Franca Gerards, Wilbert Spaans, Marko Sikkema, Joggem Veen, Flora Vernooij, Marinus van der Ploeg, Jan‐Paul W. R. Roovers, the EVA Study Group

ABSTRACT Objective To determine whether vaginal oestrogen therapy improves outcomes after prolapse surgery in postmenopausal women. Design Double‐blind, randomised, placebo‐controlled trial with 12 month follow‐up. Setting Multicentre, 22 hospitals in the Netherlands. Population Postmenopausal women with POP‐Q stage ≥ 2 scheduled for primary native‐tissue prolapse repair. Methods Women were randomised (1:1) to vaginal oestriol cream (1 mg/g) or identical placebo, started 4–6 weeks preoperatively and continued to 12 …

28.08.2026journal-article

PLOS One

Long-term effects of cognitive behavioural therapy on the quality of life in adult ADHD

Ravian Wettstein, Valentina Navarro-Ovando, Viktoria Janke, Ron Mathôt, Glenn Dumont

This study examined the long-term effects (4–8 years) of Cognitive Behavioural Therapy (CBT), added to pharmacotherapy and psychoeducation (PE), on quality of life (QoL) in adults with Attention-Deficit/Hyperactivity Disorder (ADHD). Although previous findings showed no added QoL benefit of CBT immediately post-treatment, CBT provides skill-building and coping strategies that may yield delayed benefits in terms of ADHD-related functional impairments. We hypothesize that CBT will provide delayed treatment gains and …

28.08.2026journal-article

Journal of Clinical Medicine

Therapeutic Plasma Exchange in Immune-Mediated Thrombotic Thrombocytopenic Purpura: From Cornerstone to Contextualized Therapy

Fedai Özcan, Alexandra Brinkhoff, Ralph Wendt

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening thrombotic microangiopathy caused by severe ADAMTS13 deficiency due to anti-ADAMTS13 autoantibodies. The resulting persistence of ultra-large von Willebrand factor (VWF) multimers promotes uncontrolled platelet adhesion and aggregation in the microcirculation, leading to thrombocytopenia, microangiopathic hemolytic anemia, and ischemic organ injury. Therapeutic plasma exchange (TPE) has transformed the prognosis of iTTP by removi …

28.08.2026journal-article

Frontiers in Neurology

Effects of music-based interventions on rehabilitation outcomes after stroke: a systematic review and meta-analysis of randomized controlled trials

Delin Liu, Tengteng Kang, Yakun Liang, Cunzhe Tong, Yufen Xue

Objective To systematically evaluate the effects of music-based interventions on rehabilitation outcomes in patients with stroke and provide evidence for clinical practice. Methods Web of Science, PubMed, Embase, Cochrane Library, Scopus, ProQuest, CINAHL, SinoMed (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Database, and Technology Journal Database (VIP) were searched from inception to April 7, 2026. Randomized controlled trials comparing music-based interventions plus conventional rehabilitation …

28.08.2026journal-article

Egyptian Rheumatology and Rehabilitation

Clinical integration of trabecular bone score in precision osteoporosis care: a position statement by the Egyptian academy of bone and muscle health

Yasser El Miedany, Mathias Toth, Susan Plummer, Safaa Mahran, Walaa Elwakil, Ali El Miedany, Ahmed El Yassaki

Abstract Background Dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) has long been the gold standard for osteoporosis diagnosis, yet its inability to account for bone quality leads to a significant “sensitivity gap” in fracture risk prediction. This position paper presents an up-to-date review of the evidence base, which informs the implementation of Trabecular Bone Score (TBS) in clinical practice. 2. This review explores the paradigm shift toward a dual Quantity + Quality model in bone he …

28.08.2026journal-article

APIK Journal of Internal Medicine

Acute Myocardial Infarction Following Intravenous Immunoglobulin Therapy in a Young Patient with Guillain–Barré Syndrome

M. Yashwanth, Samarth V. Shetty, Anagha Rao, H. S. Vijay Mahantesh Aradhya, M. Harsha

Abstract Intravenous immunoglobulin (IVIG) is widely used for the treatment of autoimmune disorders such as Guillain–Barré syndrome (GBS) and is generally considered safe. However, rare but severe complications such as thromboembolic events, including myocardial infarction (MI), have been reported secondary to IVIG therapy. We describe a 16-year-old previously healthy female diagnosed with GBS who developed acute chest pain 1 h after initiation of IVIG infusion. The electrocardiogram revealed ST-segment elevation i …

28.08.2026journal-article

Journal of Clinical Medicine

Animal-Assisted Therapy in Dementia: A Systematic Review and Meta-Analysis of Cognitive, Affective, and Behavioral Outcomes

Man Amanat, Mona Salehi, Mahdieh Saeidi, Larissa Villacres Mosquera, Mohsan Ali, Jai Ahuja, Nicole Theis-Mahon, Omar Fattal, Sasidhar Gunturu

Background/Objectives: Behavioral and psychological symptoms of dementia (BPSD) are common and represent major drivers of caregiver burden and healthcare utilization. Animal-assisted therapy (AAT) is used as a non-pharmacological intervention in dementia care, yet quantitative evidence of its efficacy remains inconsistent. We systematically evaluated the effects of AAT on cognitive, affective, and behavioral outcomes in individuals with dementia. Methods: Following PRISMA 2020 guidelines, we searched seven electron …

28.08.2026journal-article

Mini-Reviews in Organic Chemistry

From Structure to Therapy: A Comprehensive Review on the Pharmacological Applications of Tertiary Amides

Wiame Boumzour, Mohamed Merouane El Hammoumi, Mohamed Dakir, Oussama Maazouz, Mounir Belbahloul, Abdelhadi El Bachiri

Tertiary amides have attracted increasing interest from pharmaceutical researchers because of their particular structural characteristics, high chemical stability, and wide variety of biological activities. Tertiary amides are present in many bioactive molecules and represent an important motif for new drug development. This review systematically discusses recent advances in the therapeutic uses of tertiary amide derivatives. Recent studies indicate that tertiary amides have great potential as anticancer agents wit …

28.08.2026journal-article

Cardiology in Review

Adjunctive Corticosteroid Therapy in Kawasaki Disease: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

Abbas Khan, Syed Wajihullah Shah, Sundus Huma, Rimsha Adnan, Muhammad Yahya, Abuzar Khan, Wara Adnan, Usama Habib, Ilsa Khan, Moeen Ikram, Muhammad Awais, Ubaid Ullah, Muhammad Hasnain Mankani, Amal Mahmood, Fahd Niaz Shaikh, Taimor Mohammed Khan, Syed Musa Mufarrih, Farid Ullah, Muhammad Aneeque Ijaz, Kashif Ullah, Mohammed Shaban, Mesrop Aleksanyan, Ayesha Zahid, Jibran Ikram, Aizaz Ali

Kawasaki disease is the leading cause of acquired heart disease in children, with coronary artery lesions (CALs) as its most serious complication. Although intravenous immunoglobulin (IVIG) is the standard first-line treatment, some patients develop IVIG resistance or persistent inflammation, increasing the risk of adverse outcomes. This systematic review and meta-analysis evaluated the efficacy and safety of adjunctive corticosteroid therapy in children with Kawasaki disease. PubMed, Embase, and Cochrane CENTRAL w …

28.08.2026journal-article

Frontiers in Oral Health

Preliminary evidence of effectiveness of preparations from Nigella sativa and its leading compound thymoquinone in periodontal therapy

Sigrun Chrubasik-Hausmann, Julia Vlachojannis, Marietta Wolf, Fabian Cieplik, Ali Al-Ahmad

Background Preparations of Nigella sativa and its major bioactive compound thymoquinone (TQ) possess antioxidant, antimicrobial, anti-inflammatory, and wound-healing properties. These characteristics suggest potential utility as adjuncts in the management of gingivitis, mucositis, periodontitis, and peri-implantitis. Objective To critically evaluate the current clinical evidence regarding the use of Nigella sativa preparations and TQ in periodontal therapy. Methods A systematic literature search following PRISMA gu …

28.08.2026journal-article

Advanced Healthcare Materials

Targeted Lactic Acid Regulation via Engineered Exosomes for Synergistic Metabolic and Photodynamic Tumor Therapy

Sisi Zhou, Yu Cao, Xianbiao Wang, Songqin Liu

ABSTRACT Tumor cells exhibit a hyper‐glycolytic phenotype, resulting in massive lactic acid (LA) production that acidifies the tumor microenvironment (TME) and fosters immunosuppression. Current lactate‐targeted therapies often lack synergistic dual‐directional regulation. Herein, we engineer an exosomal nanoplatform, PpIX/siRNA@EXO‐LOD, to simultaneously disrupt intra‐ and extracellular LA homeostasis, thereby enabling synergistic metabolic and photodynamic therapy (PDT). The system integrates three key components …

28.08.2026journal-article

Multimodal Technologies and Interaction

Immersive Virtual Reality for Occupational Track Safety Training: A Quasi-Experimental Field Study Comparing Six Training Formats

Oliver Christ, Aaron Ettlin, Pascal Valentin Meier, Pascal Duchêne, Paul Hügli, Stefan Adam, Stephan Gut

Conventional occupational safety training is often criticized for weak transfer of declarative knowledge into workplace behavior. Immersive virtual reality (iVR) has been proposed as a promising complement, yet comparisons of different iVR formats remain scarce in real occupational settings. This quasi-experimental field study (N = 127) compared six training formats—training-as-usual (control), desktop single-player, iVR single-player, iVR multi-player, iVR multi-player with retrospective perspective change (RPC), …

28.08.2026journal-article

International Journal of Nanoscience

Formulation and evaluation of fluconazole-loaded in situ gel nanoemulsion using polymeric systems for ocular antifungal therapy

Ardeshi Emrani, Seyedeh Negin Kassaee, Pegah Changavi, Adel Salahi, Shabnam Pourmoslemi, Mohammad Mehdi Mahboobian

The therapeutic efficiency of topical antifungal drops is limited due to rapid precorneal clearance and short residence time, which reduce drug bioavailability at the site of infection so this study aimed to develop and evaluate a thermosensitive in situ gelling nanoemulsion of fluconazole for enhanced ophthalmic delivery and prolonged ocular retention. Pseudo-ternary phase diagrams were constructed by using Triacetin as the oil, Propylene glycol as the co-surfactant, Cremophor ® RH 40 as the surfactant and water t …

28.08.2026journal-article

Scientific Reports

Musculoskeletal pain and associated occupational factors among emergency personnel in Nakhon Pathom Province Thailand

Chitkamon Srichomphoo, Santisith Khiewkhern, Chamnan Chinnasee, Yuparat Limmongkon

Abstract Musculoskeletal pain is a common occupational health problem among emergency medical service personnel due to the physically demanding nature of their work. This study aimed to determine the prevalence of musculoskeletal pain and identify associated factors among emergency personnel in Nakhon Pathom Province, Thailand. A cross-sectional study was conducted among 466 emergency personnel using a structured questionnaire. The seven-day prevalence of musculoskeletal pain was 70.80%, while the twelve-month prev …

28.08.2026journal-article

Occupational and Environmental Medicine

Drug utilisation across occupations among pregnant women working in the healthcare and social assistance sector in France: a nationwide population-based study

Mélanie Araujo, Justine Bénévent, Christine Damase-Michel, Yolande Esquirol, Anna-Belle Beau

Objectives Medication use during pregnancy is common, but patterns may differ across occupational subgroups, particularly in healthcare and social assistance where working conditions, education and health literacy vary. We aimed to compare medications dispensed to pregnant women across occupations within this sector. Methods We conducted a nationwide population-based study using the French EDP-Santé database, linking occupational and socioeconomic data with healthcare reimbursement records. Pregnancies from 2009 to …

28.08.2026journal-article

RSV

A influência da fisioterapia sensório-motora nas unidades de terapia intensiva neonatal: ensaio teórico

Cesario Rui Callou Filho, Elisamara Silva da Cunha, Mirnis Aparecida Vieira de Macedo

Os benefícios da fisioterapia sensório-motora em unidades de terapia intensiva contribuem para melhores desfechos clínicos e redução de complicações relacionadas à hospitalização prolongada, como a imaturidade do sistema nervoso e a dificuldade de integração sensorial. OBJETIVO: Evidenciar as perspectivas atuais da influência da estimulação sensório-motora em recém-nascidos em unidade de terapia intensiva neonatal. MÉTODOS: Trata-se de um ensaio teórico desenvolvido por meio de pesquisas em bases eletrônicas, tais …

28.08.2026journal-article

BMC Nursing

Determinants of gout therapy non-adherence in patients attending an Egyptian rheumatology outpatient clinic

Samira Saad Ali, Samah Ramadan Shaheen Ibrahim, Manal Saeed Mohammed

Abstract Background Non-adherence to urate-lowering therapy (ULT) is a significant issue in the management of gout, a prevalent form of inflammatory arthritis that adversely affects patients’ quality of life and burdens healthcare systems. Although ULT is effective in reducing serum uric acid levels, many patients fail to adhere to their medication regimens. Factors contributing to this non-adherence include treatment complexity, medication costs, side effects, forgetfulness, and individual health beliefs, as well …

28.08.2026journal-article

Clinical Medicine (Russian Journal)

Mathematical modeling of the expected effectiveness of empirical antibiotic therapy for peri-prosthetic infection

L. V. Lyubimova, E. A. Mikishanina, S. I. Pavlova, E. A. Lyubimov

Periprosthetic infection (PJI) is a serious problem in orthopedic practice. In the case of an unknown pathogen, empirical antibiotic therapy is based on local epidemiological data. The aim of this study is to calculate the expected effectiveness of empirical antibiotic therapy based on microbiological monitoring of PJI pathogens using mathematical modeling. Material and methods. A retrospective analysis of 379 bacterial isolates isolated in the PJI of the hip, knee and shoulder joints (2018–2024) was carried out. M …

28.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Stakeholder Perspectives on Facilitators of and Barriers to the Implementation of Internet of Things–Equipped Powered Wheelchairs in Sweden: Qualitative Case Study

Johan Borg, Marie Elf, Anders Brantnell, Klas Palm

Abstract Background The implementation of Internet of Things (IoT) technologies to proactively monitor the functioning of assistive products remains underexplored, particularly in public assistive technology services. Objective This qualitative single-case study investigated how a public assistive technology provider in Sweden implemented IoT-equipped assistive products. Methods The implementation process was mapped, and a thematic analysis of interviews with 6 participants representing key organizational roles was …

28.08.2026journal-article

BioMedical Engineering OnLine

Feasibility and preliminary efficacy of a soft robotic glove for hand rehabilitation in early subacute stroke: a pilot investigation

Yingnan Lin, Chuankai Wang, Gavin Yin, Yansheng Lin, Jie Gu, Sujing Xu, Xueli Shan, Yanyan Huang, Jie Jia

Abstract Objectives This pilot study aimed to investigate the feasibility, safety, and preliminary efficacy of a rehabilitation program utilizing Syrebo ™ SY-HR03E soft robotic glove with pneumatic actuators for hand function recovery in patients with early subacute stroke. Methods A single-blind pilot randomized controlled trial was conducted in an inpatient clinical setting. The intervention was administered 5 days per week for 4 weeks (20 session’s total). During this period, the robotic therapy (RT) group ( n = …

28.08.2026journal-article

Journal of Oral Rehabilitation

Effects of Digital Health Interventions on Pain, Maximum Mouth Opening, and Jaw Function in Individuals With Temporomandibular Disorders: A Systematic Review

Kailing Xu, Lanqi Li, Yinuo He, Fangyuan Jing, Jingxia Kong, Minmin Jiang

ABSTRACT Background Temporomandibular disorders (TMD) encompass a group of musculoskeletal and neuromuscular conditions involving the temporomandibular joint (TMJ), masticatory muscles, and associated structures. As an emerging self‐management approach, digital health interventions (DHIs) have demonstrated potential clinical value. Objective To investigate the effects of DHIs on pain, maximum mouth opening, and jaw function in individuals with TMD. Methods A literature search was performed in five electronic databa …

28.08.2026journal-article

Journal of Occupational & Environmental Medicine

Occupational Air Pollutants and Early Kidney Injury: Insights from Oxidative Stress and KIM-1 Biomonitoring in Iron and Steel Industry Workers.

Mona Abdallah Ramadan, Hebatallah Saad Teleb, Marwa Mohammed Fouad

Objectives: The current study aimed to investigate the association between occupational exposure to air pollutants and renal function parameters, as well as oxidative stress. Methods: In a cross-sectional comparative study, 88 participants were grouped into exposed workers and controls. Occupational air pollutant levels, renal function parameters, and oxidative stress markers were evaluated in an iron and steel facility. Results: Although environmental pollutant concentrations were within recommended permissible li …

28.08.2026journal-article

International Journal of Public Health and Medical Research

Fluid Balance in the 24 Hours Before Continuous Renal Replacement Therapy and ICU Mortality Among Critically Ill Adult Patients: A Nursing Risk Assessment Study Using MIMIC-IV

Qiaozhen Pan, Lei Peng, Xue Ren

Objective: To investigate the predictive value of cumulative fluid balance measured within 24 hours before initiation of continuous renal replacement therapy (CRRT) for Intensive Care Unit (ICU) mortality among critically ill adult patients. Methods: A retrospective cohort study used the MIMIC-IV 3.1 database to include adult patients who received CRRT during their first ICU admission and whose CRRT initiation occurred between ICU admission and discharge. The index time point was defined as the start of the first C …