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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Mechanistic modeling of tumor immune microenvironment reveals strategies to enhance antibody-drug conjugates’ efficacy

Constantinos Harkos, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain

Background Antibody-drug conjugates (ADCs) and bispecific antibodies represent a rapidly advancing frontier in oncology, yet the abnormal tumor microenvironment (TME) hinders their delivery and reduces efficacy. Emerging immunomodulatory ADCs (IM-ADCs) demand mechanistic mathematical models that couple drug transport with immune dynamics. Methods Here, we present a mechanistic framework for the delivery of HE-S2 ADC, an anti-programmed cell death ligand 1 (PD-L1) antibody bearing the bifunctional immunomodulator D1 …

01.09.2026journal-article

Frontiers in Immunology

Statins use and prognosis in lung cancer patients treated with immune checkpoint inhibitors: evidence from a meta-analysis

Dandan Liang, Qinghua Liu, Min Liu, Yi Li

Background Lung cancer remains one of the most common and lethal malignancies worldwide. The advent of immune checkpoint inhibitors (ICIs) has substantially improved survival outcomes in patients with advanced disease; nevertheless, a considerable proportion of patients exhibit suboptimal responses to ICI monotherapy. In recent years, statins have garnered attention for their potential immunomodulatory and anti-inflammatory properties. Preclinical evidence suggests that statins may enhance antitumor immune response …

01.09.2026journal-article

Sport Sciences for Health

Understanding non-participation in a remote exercise trial among breast cancer survivors undergoing adjuvant endocrine therapy: a cross-sectional survey

Henrique Ims Bortolozo, Miguel Soares Conceição, Valeria L. G. Panissa, Marina L. V. Ferreira, Olivia M. Ruberti, Luis Otávio Sarian, Guilherme D. Telles, Felipe C. Vechin, Sophie Derchain

Abstract Purpose Despite wider access to remote/home-based exercise, many breast cancer survivors still decline structured programs. We analyzed the sociodemographic/clinical profile of women on adjuvant endocrine therapy who declined an online exercise intervention and explored their reasons for non-participation. Methods This ancillary cross-sectional survey was nested within a registered parent randomized trial (ReBEC RBR-3tqb39m). Ninety-eight women on adjuvant endocrine therapy were contacted; 25 were not reac …

01.09.2026journal-article

Journal of Evidence-Based Medical Research

Legal and Policy Barriers to Telemedicine Prescribing of Controlled Analgesics for Chronic Non-cancer Pain: A Systematic Review

Srija Yerram

Background: Telemedicine can reduce travel, geographic, mobility and specialist-access barriers in chronic non-cancer pain (CNCP), but prescribing controlled analgesics remotely is conditioned by overlapping controlled-substance law, patient-location licensure, prescribing standards, monitoring requirements, reimbursement and digital infrastructure. The evidence base is predominantly opioid-focused and has evolved rapidly since the COVID-19 public health emergency. Methods: We conducted a systematic evidence review …

01.09.2026journal-article

Medicine & Science in Sports & Exercise

Exercise Timing Influences Autonomic and Psychological Adaptations but not Functional Capacity in Cancer Patients Undergoing Treatment

Buck W. Covington II, Brooke Mattocks, Luke Krynski, Lea Haverbeck Simon, Jesse Hayward, Melissa Villafana, Mike Lazio, Reid Hayward

Purpose: To examine the effects of exercise timing (morning [AX] vs evening [PX]) on functional capacity, psychological outcomes, and sleep-related measures in cancer patients undergoing treatment. Methods: Forty-four cancer patients undergoing treatment participated in a supervised exercise intervention at the University of Northern Colorado Cancer Rehabilitation Institute (UNCCRI). Participants self-selected exercise timing as AX (0700–0900) or PX (1600–1800) and completed a range of pre- and post-intervention ph …

01.09.2026journal-article

Blood Journal

CAR transgenic T-cell lymphoproliferative neoplasm (CTTLN): malignant transformation of cellular immunotherapy

Francis Baumgartner, Michael J. Dickinson, Piers Blombery

Engineered T-cells have transformed hematooncology, but CAR transgene-bearing T-cell malignancies have emerged as a rare and serious genomic safety signal after CAR-T therapy. Available data support a multistep model in which pre-existing clonal fitness, CAR-T manufacture, vector integration, construct biology and post-infusion selection may contribute to different degrees. We review reported cases of CAR-transgenic T-cell lymphoproliferative neoplasms (CTTLN) and propose practical diagnostic criteria with a propor …

01.09.2026journal-article

Frontiers in Oncology

Feeding and swallowing function and dysphagia risk in children with posterior fossa tumors: a preliminary Italian cohort study

Marco Tofani, Lavinia Savarese, Bianca Andreozzi, Antonella Cerchiari, Andrea Carai, Carolina Giordani, Giorgia Biondo, Gessica Della Bella, Francesca Pizza, Angela Mastronuzzi

Introduction Dysphagia is a frequent postoperative complication in children undergoing surgery for posterior fossa tumors (PFTs), yet early swallowing trajectories remain insufficiently characterized despite the growing focus on functional outcomes in pediatric neuro-oncology. Methods In this prospective cohort study conducted at a tertiary referral center, feeding and swallowing function were assessed at three standardized time points: preoperatively, one week postoperatively, and four weeks postoperatively using …

03.09.2026journal-article

BMJ Open

EQUITY-MS: evaluating the quality of investigation and treatment of multiple sclerosis using data from five specialist neurology centres in the UK—study protocol

Elizabeth O’Nions, Dan Lewer, Rachael W Cheung, Ellen Da Silva, Joyutpal Das, Ruth Dobson, Radoš Keravica, Faith Moyo, David Rog, Melanie Russell, Cord Spilker, Emma Tallantyre, Helen L Ford

Introduction The social determinants of health are the conditions in which people live and the systems around them that shape these conditions. Social determinants of health may affect diagnosis and treatment for people with multiple sclerosis (MS) even in countries with universal healthcare systems. This study will investigate whether a person’s age, sex and/or gender, living in a more socioeconomically deprived area and being of a minoritised ethnicity impact access to a diagnosis of MS and disease-modifying trea …

04.09.2026journal-article

ChemNanoMat

Fabrication of Boron Nitride@Polydopamine/Polyvinyl Alcohol/Polyvinylidene Fluoride Composite Film With Good Thermal Stability and Thermal Conductivity via Electrospinning and Hot Pressing Treatment

Zengxi Wang, Haorui Jin, Huidi Liu, Xiang Cai, Shaozao Tan, Shaoyuan Zhou, Jinglin Zhang

The field of thermal conductivity is one of the important applications of polymers. However, polymer material generally possesses low thermal conductivity due to its internal characteristic, which cannot meet the heat dissipation requirement of device. Therefore, the preparation of polymer material with high thermal conductivity has broad application prospect and important significance. To achieve this goal, a new‐type composite film was fabricated via electrospinning and hot pressing treatment. Utilizing the self‐ …

04.09.2026journal-article

Journal of the Renin-Angiotensin-Aldosterone System

Renin-angiotensin system imbalance is associated with immunometabolic reprogramming and tissue repair in COPD-lung cancer comorbidity

Yonghua Zheng, Dongli Song, Ding Zhang, Jingjing Hou, Hao Fang, Lihua Dai

Background Chronic obstructive pulmonary disease (COPD) and lung cancer frequently co-occur with shared inflammatory and metabolic drivers, while the systemic role of the renin-angiotensin system (RAS) in this comorbidity remains poorly understood. Methods We integrated Global Burden of Disease, Mendelian randomization, pan-cancer/single-cell transcriptomics, NHANES population data, and functional experiments to dissect this comorbidity, with mechanistic modeling to evaluate lifestyle factors and osteopontin's role …

01.09.2026journal-article

Stroke

Application of the AHA-Proposed Cancer-Related Ischemic Stroke Classification: Reclassification and Prognostic Impact

Yasufumi Gon, Tomohiro Kawano, Hiroshi Yamagami, Tsutomu Sasaki, Manabu Sakaguchi

BACKGROUND: Ischemic stroke in patients with active cancer is heterogeneous and frequently classified as cryptogenic under the TOAST classification (Trial of ORG 10172 in Acute Stroke Treatment). The American Heart Association recently proposed an etiological classification for cancer-related ischemic stroke (CRIS). This study aimed to evaluate its clinical and prognostic implications. METHODS: We analyzed data from the prospective SCAN study (Ischemic Stroke in Patients With Cancer and Neoplasia), which enrolled p …

1 Zitationen
01.09.2026journal-article

AI in Medicine

Deep Learning Methods for Breast Cancer Detection, Classification, and Segmentation Using MRI Scans: A Systematic Review

Qais Al-Azzam, Wamadeva Balachandran, Ziad Hunaiti

Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide, underscoring the importance of early and accurate diagnosis to improve patient outcomes. Magnetic resonance imaging (MRI) is a highly sensitive imaging modality for detecting breast malignancies, particularly in patients with dense breast tissue or those at high risk, where conventional imaging techniques may have limited sensitivity. Recent advances in deep learning (DL) have demonstrated considerable potential for i …

01.09.2026journal-article

Emergency Radiology

Clinical and radiographic findings that impact treatment: a study of 418 proximal humerus fractures

Julian Forero-Millan, Wondwossen T. Lerebo, Vandan S. Patel, Lewis Fanney, Alexandre Arkader, Jie C. Nguyen

Abstract Purpose Regional skeletal maturation can influence injury pattern and treatment selection. This study aimed to systematically characterize pediatric proximal humerus fractures to identify radiographic findings that impact treatment selection. Methods This IRB-approved retrospective comparative study included pediatric patients ( 42% and > 22°, respectively. In the adjusted multivariable logistic regression, independent predictors for surgery included fracture displacement > 42% (OR: 13.3, 95% CI: 4.2–41.7, …

01.09.2026journal-article

Dentistry Journal

Development and Validation of a Patient-Reported Outcome Questionnaire for Children Undergoing Removable Orthodontic Treatment

Panaite Tinela, Carmen Diana Nicoleta Savin, Ana Sîrghie, Teona Ana-Maria Tudorici, Irina Bamboi, Anca Rapis, Ana Nemțoi, Ciprian-Iulian Axinte, Carina Ana-Maria Balcos

Background/Objectives: Patient-reported outcome measures (PROMs) complement clinical indicators in orthodontics, yet validated instruments for children undergoing removable orthodontic treatment remain limited. This study aimed to develop and validate a questionnaire assessing compliance and physical discomfort, psychosocial impact, and perceived support. Methods: A cross-sectional validation study included 250 children and adolescents (

01.09.2026journal-article

Nano Research

Ultrasound responsive microneedles for sequential antibacterial and immune regulation in keratitis treatment

Bin Kong, Taige Chen, Qin Chen, Rui Liu, Tiantian Kong, Yuanjin Zhao

Abstract Bacterial keratitis is a leading cause of corneal blindness, yet current antibiotic therapies suffer from poor ocular bioavailability and rising drug resistance. Effective treatment requires not only bacterial eradication but also coordinated anti-inflammation and wound repair. In this paper, we present a "two birds with one stone" strategy for bacterial keratitis treatment based on an ultrasound-activated cascade responsive core-shell microneedle. Upon corneal insertion and ultrasound stimulation, piezoel …

01.09.2026journal-article

Journal of Iranian Medical Council

Appendicular Pathologies in Ovarian Mucinous Adenocarcinoma and Borderline Tumor: A Retrospective Analysis

Zeinab Hashem Aghaei, Atefeh Moridi

Background: The role of appendectomy in the control of mucinous adenocarcinoma of the ovary has become a controversial issue, and its effectiveness in increasing the 5-year survival rate of patients is not well known. Mucinous carcinoma account for 3-4% of primary ovarian cancer. Nearly all mucinous carcinoma of the ovary presents with early-stage disease stage 1. Therefore, in this study, the aim was to examine simultaneous appendectomy in ovarian mucinous adenocarcinoma surgery and its reported pathologies. Metho …

01.09.2026journal-article

TERRA ORTHOPAEDICA

Results of Surgical Treatment of Patients with Stage II Rotator Cuff Arthropathy According to Hamada

S.S. Strafun, S.V. Bohdan, I.V. Shyshka, R.O. Serhiienko, M.P. Hofman

Summary. Background. Surgical treatment of rotator cuff arthropathy (RCA) of the shoulder joint remains challenging and insufficiently studied because these patients develop biomechanical disorders in the shoulder joint associated with superior migration of the humeral head and fatty degeneration of the rotator cuff muscles. Objective. To compare the outcomes of different surgical treatment options in patients with Hamada stage II RCA. Materials and Methods. A total of 391 patients with RCA of varying severity were …

01.09.2026journal-article

Journal of Extracellular Vesicles

Bovine Colostrum‐Derived Extracellular Vesicles Impair Cancer Cell Proliferation Through Transcriptional Dysregulation

Claudia Betsabé Huesa‐Carballo, Bruno Puga, Susana Bravo, Manuel Rodríguez‐Pérez, Yessica Domínguez‐Novoa, Julio Iglesias‐García, Brígida Hermida, Isolina Raña, María Teresa Antelo, Rafael López‐López, Miguel Abal, Jorge Barbazán

ABSTRACT Milk‐derived extracellular vesicles (EVs) are a promising source of molecules with therapeutic potential. Bovine colostrum is particularly enriched in EVs, which carry cargo of proteins involved in immune regulation, development and cellular signalling. Some studies have explored their role as bioactive anti‐cancer agents, however, their mechanistic effects remain underexplored. Here, we show that colostrum‐derived EVs (Col‐EVs) exert anti‐proliferative effects in gastrointestinal cancer models, including …

01.09.2026journal-article

Slovenian Journal of Public Health

Osteoporosis Treatment Gap — A Systematic Literature Review

Kaja Gril Rogina, Luka Petravič, Christos Oikonomidis

Abstract Introduction Osteoporosis is a common metabolic bone disease that increases fracture risk, particularly among older adults, and imposes a substantial global burden. Despite advances in risk assessment and treatment, a large treatment gap remains, with many high-risk individuals not receiving care. Methods We conducted a systematic review of English-language studies published up to April 2025, identified through searches in multiple databases (PubMed, Scopus, Web of Science, ScienceDirect, Europe PMC). 43 s …

01.09.2026journal-article

JAMA

Addition of High-Dose Vitamin D 3 to Standard Treatment in Patients With Metastatic Colorectal Cancer

Kimmie Ng, Fang-Shu Ou, Tyler Zemla, Nadine A. Jackson, Aparna Kalyan, Craig Devoe, Michael Shusterman, Namrata Vijayvergia, Christina S. Wu, Stacey A. Cohen, Sydney Pulsipher, Ardaman Shergill, Yasmeem Watson, Barbara Kleiber, Myounghee Lee, Christine G. Kohn, Jennifer S. Thalappillil, Lawrence H. Schwartz, Dan Zuckerman, Bruce W. Hollis, Eileen M. O’Reilly, Jeffrey A. Meyerhardt

Importance In a phase 2 randomized clinical trial, high-dose vitamin D 3 added to standard treatment improved progression-free survival (PFS) compared with standard-dose vitamin D 3 in patients with metastatic colorectal cancer (mCRC). Objective To determine if high-dose vitamin D 3 added to standard chemotherapy improves outcomes in patients with previously untreated mCRC. Design, Setting, and Participants Double-blind phase 3 randomized clinical trial enrolling 455 patients with previously untreated mCRC, conduct …

02.09.2026journal-article

The Oncologist

48 Metabolic Control of Tumor Immunity Through Lipid Remodeling in FH-Deficient Renal Cancer

Amrita (Nargund) Mangalvedhekar, Nicole Rittenhouse, Judith Murciano, Fengshen Kuo, Samir Zaidi, A Ari Hakimi

Abstract Background Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is an aggressive metabolic subtype of kidney cancer characterized by fumarate accumulation and profound rewiring of mitochondrial metabolism. While FH loss is known to promote reductive carboxylation and lipid synthesis, how these metabolic changes influence tumor immunity remains unclear. Methods To investigate the relationship between lipid metabolism and immune signaling in FH-deficient RCC, we performed lipidomic profiling of FH-de …

01.09.2026journal-article

Humanities

Blogs as Dialogical Reparatory Work: A Theoretically Informed Analysis of Online Cancer Narratives

Kaja Kvaale, Oddgeir Synnes, Hilde Bondevik

Globally, the World Health Organization (WHO) estimates that there are 20.6 million new cancer cases each year, and its incidence is expected to rise as the global population ages. At the same time, new technologies and advanced treatments are increasing survival rates, particularly in high-income countries. The need to understand cancer’s impact on psychosocial well-being and patients’ existential lifeworld is reflected in research, literature, pathographies, and other art forms. This article examines blogs as a d …

03.09.2026journal-article

BMJ Global Health

A new conceptual framework for evaluating healthcare quality: shifting from reactive treatment to proactive health preservation

Keisuke Kanda

Healthcare quality is commonly assessed using clinical outcomes and service-based metrics that begin after illness has occurred. While such measures are important, they often overlook healthcare’s fundamental purpose: to preserve health, prevent disease and minimise reliance on medical intervention. Drawing from global definitions of healthcare and quality—and philosophical insights from Sunzi’s Art of War—this paper proposes a new framework that shifts evaluation from reactive treatment to proactive health preserv …

04.09.2026journal-article

Biointerphases

Green-synthesized Mg-doped CuO nanoparticles targeting septicemia pathogens: Enhanced antibacterial and cancer cell cytotoxicity

Murugeswari Raju, M. Karunakaran, M. Divya Gnaneswari, P. Shunmuga Sundaram, D. Shanmugapriya, L. Bruno Chandrasekar

Copper oxide (CuO) and Mg-doped CuO (CuO-Mg) nanoparticles were synthesized using a green approach with Azadirachta indica leaf extract. The biosynthesized nanoparticles were characterized using multiple techniques including x-ray diffraction (XRD), energy-dispersive x-ray (EDX) analysis, scanning electron microscopy (SEM), and UV-Vis-NIR spectrometry. The XRD analysis verified the purity of the synthesized materials and confirmed a monoclinic crystal structure. Doping CuO with Mg decreased the average crystallite …