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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Computational Design, Molecular Docking, SAR, and ADMET Analysis of Novel JAK1 Inhibitors as a Possible Treatment for Rheumatoid Arthritis

Sarah Ahmed Waheed

Rheumatoid arthritis is an inflammatory autoimmune disease affecting the joints which eventually leads to systemic comorbidities. Its pathogenesis was attributed to disturbances in the Janus Kinase/Signal Transducer and Activator of Transcription signaling pathway. In this research, an innovative lead compound C6 was created and docked toward Janus Kinase1 (JAK1). The docking process was confirmed by re-docking of the co-crystallized ligand MI1 (Tofacitinib). C6 showed a predicted docking score of -9.17 kcal/mol, w …

03.09.2026journal-article

Journal of Hand Surgery (European Volume)

Targeted tenosynovial biopsy during carpal tunnel release for detection of transthyretin amyloid deposits

Nicolas Bigorre, Alexandre Petit, Jérome Brunet, Fabrice Rabarin, Julien Jeanneteau

Introduction: Carpal tunnel syndrome is increasingly recognized as an early musculoskeletal manifestation of transthyretin amyloidosis. Tenosynovial biopsy during carpal tunnel release may detect transthyretin amyloid deposits, but the yield of a targeted strategy remains uncertain. Methods: We conducted a single-centre comparative before-after study of 347 patients undergoing carpal tunnel release with tenosynovial biopsy. The non-targeted cohort was recruited between October 2021 and July 2023 and the targeted co …

03.09.2026journal-article

Clinical Research in Cardiology

Gaps in lipid management among high-risk patients without prior MI or stroke: the VESALIUS-REAL global study

Queenie Chan, Jaimini Cegla, Ulrich Laufs, Jan H. Cornel, Gaetano M. De Ferrari, Emil Hagström, Huei-Kai Huang, José Lopez-Miranda, Suna Avcil, Corinne Brooks, Thomas Cars, Adrienne Y. L. Chan, Celine S. L. Chui, Michael Duxbury, Edward Chia-Cheng Lai, David Neasham, Andreas Ochs, James O’Kelly, Gabriel Paiva da Silva Lima, Naomi Reimes, Swati Sakhuja, Shih-Chieh Shao, Ju-Young Shin, Mahendra Sibartie, Ilona Verburg, Matthew J. Budoff, Kyung Woo Park, Kenichi Tsujita, Kai Hang Yiu, Nafeesa Dhalwani, Ian C. K. Wong

Abstract Background Real-world evidence on lipid-lowering therapy (LLT) use and low-density lipoprotein cholesterol (LDL-C) control in patients at high cardiovascular (CV) risk without prior myocardial infarction (MI) or stroke remains limited. We evaluated LLT use, treatment intensification, LDL-C monitoring, and LDL-C goal attainment across North America, Europe, and Asia-Pacific. Methods VESALIUS-REAL is a retrospective observational study using a common protocol across 11 databases between 2017 and 2022. Eligib …

03.09.2026journal-article

Clinical Microbiology Reviews

Human vascular pythiosis: pathogenesis, diagnosis, and evidence-informed management

Nitipong Permpalung, Sadeep Medhasi, Pattama Torvorapanit, Rongpong Plongla, Navaporn Worasilchai

SUMMARY Human vascular pythiosis is a rare, life-threatening angioinvasive infection caused predominantly by the oomycete Pythium insidiosum . Unlike ocular or cutaneous pythiosis, the vascular form is defined by arterial wall invasion, long-segment thrombosis, limb ischemia, aneurysmal complications, and high risks of amputation and death. Although P. insidiosum is broadly distributed in freshwater environments, reported human vascular disease remains concentrated in Thailand, indicating that exposure alone is ins …

03.09.2026journal-article

European Journal of Clinical Microbiology & Infectious Diseases

Diagnosis of pneumococcal pneumonia using quantitative PCR targeting lytA and piaB in adult patients with community-acquired pneumonia

Nienke Paternotte, Willem R. Miellet, Tessa Nieuwenhuijsen, Rob Mariman, Wil A. van der Reijden, Wouter Rozemeijer, Elisabeth A.M. Sanders, Dominic Snijders, Cornelis H. van Werkhoven, Marc J.M. Bonten, Krzysztof Trzciński, Wim G. Boersma

Abstract Purpose Accurate diagnosis of pneumococcal pneumonia remains challenging due to suboptimal sensitivity of conventional microbiological methods. Molecular techniques may improve Streptococcus pneumoniae detection, but their clinical utility remains uncertain. Methods In this prospective observational study, we compared conventional diagnostics with qPCR-based detection of lytA and piaB genes in nasopharyngeal, oropharyngeal, saliva, and sputum samples collected from adults with community-acquired pneumonia …

03.09.2026journal-article

Journal of Clinical Medicine

Association Between DLCO and Echocardiographic Right Ventricular–Pulmonary Arterial Coupling in Idiopathic Pulmonary Fibrosis

Francesca Coppi, Susan Darroudi, Giulia Renda, Alessandra Lodeserto, Arianna Maini, Damiano De Cesare, Youssef Othman, Martina Mercati, Dalia Caleffi, Filippo Gozzi, Francesco Marangi, Dario Andrisani, Federica Andolfi, Alessio Baccarani, Daniela Aschieri, Anna Vittoria Mattioli, Francesco Fedele, Enrico Clini, Stefania Cerri, Gianluca Pagnoni

Background: Idiopathic pulmonary fibrosis (IPF) is frequently complicated by pulmonary vascular involvement and right ventricular (RV) dysfunction, both of which adversely affect prognosis. The relationship between impaired gas exchange and echocardiographic indices of RV function, particularly the TAPSE/PAPs (tricuspid annular plane systolic excursion/systolic pulmonary artery pressure) ratio as a marker of RV–pulmonary arterial (RV–PA) coupling, has not been fully characterized. Methods: We retrospectively evalua …

03.09.2026journal-article

Journal of Clinical Medicine

The Association of SARIFA with Poor Prognosis and Aggressive Tumor Phenotypes in Cancers: A Meta-Analysis

Jiaqi Lao, Guangwei Tian, Lin Guan

Background: SARIFA (Stroma Areactive Invasion Front Areas) is an emerging histopathological biomarker defined by direct tumor–adipocyte contact at the invasive front. Preliminary studies suggest its association with poor prognosis, but evidence remains fragmented across cancer types. This meta-analysis aims to systematically evaluate the prognostic value of SARIFA for overall survival (OS) and its correlation with aggressive tumor phenotypes. Methods: Following PRISMA guidelines, we searched PubMed, Embase, Web of …

03.09.2026journal-article

Physics in Medicine & Biology

S2V-DREME: a time-resolved slice-to-volume MR image reconstruction framework with dynamic reconstruction and motion estimation

Xiaoxue Qian, Hua-Chieh Shao, Jie Deng, Yan Dai, You Zhang

Abstract Objective. Existing volumetric magnetic resonance imaging (MRI) techniques are constrained by the trade-off between acquisition time and image quality, limiting accuracy in motion-impacted sites such as the liver. To enable fast, better-quality volumetric imaging with sufficient spatiotemporal resolution, we developed a time-resolved volumetric MRI technique that recovers 3D volumes from acquired 2D MR slices for real-time 3D anatomy and motion tracking. Approach. 2D MR slices dynamically acquired in time …

03.09.2026journal-article

Indian Journal of Radiology and Imaging

Digital Twins in Oncology: From Multimodal Data Integration to Precision Clinical Practice

Annamalai Vairavan, Rupsa Bhattacharjee, Bagyam Raghavan

Oncology digital twins are patient-specific computational models that are built by combining electronic health records, multiomics genomic data, and diagnostic imaging to simulate individual tumor biology and predict multiple treatment-related outcomes. Conceptually originated from aerospace engineering, it has matured clinically through convergent advances in radiomics, mechanistic tumor modeling, pharmacokinetic- pharmacodynamic systems, federated machine learning, and, most recently, large language model (LLM)-b …

03.09.2026journal-article

Cancer

Long‐term outcomes and patterns of failure in patients with thymic malignancies treated with surgery and radiation therapy

Oded Icht, Inbar Nardi‐Agmon, Paaladinesh Thavendiranathan, Shaf Keshavjee, Amiya Agrawal, John‐Michael Miro, Omar Badran, Geoffrey Liu, Xiang Y. Ye, B. C. John Cho, Andrea Bezjak, Andrew Hope

Abstract Background The role of peri‐operative radiation therapy in thymic epithelial tumors remains controversial, and randomized data are lacking. The authors evaluated recurrence patterns, pathologic predictors of recurrence, and long‐term survival among patients who underwent surgery and received peri‐operative radiation at a high‐volume tertiary center. Methods The authors conducted a retrospective cohort study of patients who had thymic malignancies treated surgically between 2004 and 2021. Clinical, patholog …

03.09.2026journal-article

Anesthesia & Analgesia

Remote Ischemic Preconditioning and Survival in Noncardiac Surgery: An Updated Meta-analysis of Randomized Trials

Rosa Labanca, Federico Mattia Oliva, Stefano Fresilli, Maurizio Carravetta, Simone Vietri, Gaetano Lombardi, Marilena Marmiere, Luigi Beretta, Alberto Zangrillo, Domenico Pontillo, Stefano Turi, RIPC Study Group

BACKGROUND: Remote ischemic preconditioning (RIPC) demonstrated potential benefits in terms of organ protection in preclinical and several clinical settings. This systematic review of randomized controlled trials (RCTs) evaluates the association of RIPC with mortality and other relevant clinical outcomes in patients undergoing noncardiac surgery. METHODS: We conducted a systematic review and meta-analysis of RCTs assessing the effects of RIPC in adult patients undergoing noncardiac surgery. A comprehensive search w …

03.09.2026journal-article

Clinical Spine Surgery

Comparative Study of Sagittal Spinopelvic Parameters and Clinical Outcomes After Minimally Invasive Versus Open Fusion in Mild Isthmic Lumbar Spondylolisthesis

Zhongzheng Sun, Qiquan Hao, Kai Sun, Janlei Hou

Study Design: Retrospective comparative study. Objective: This study evaluated the radiologic and clinical outcomes of minimally invasive versus open fusion surgery using a computer-assisted image analysis tool. Background: Lumbar spondylolisthesis, isthmic in nature, tends to interfere with sagittal balance and results in chronic back pain and disability. Operationally, the primary aim is to correct sagittal imbalance and restore functional stability. Methods: Patients with single-level mild isthmic lumbar spondyl …

03.09.2026journal-article

Journal of Clinical Medicine

Recorded Early Imaging Responses After Transarterial Chemoembolization Plus Lenvatinib Versus Transarterial Chemoembolization Without Documented Lenvatinib for Unresectable Hepatocellular Carcinoma: A Vietnamese Cohort Study

Vu Le Minh, Nguyen Van Hung, Pham The Anh, Pham Tuan Anh, Pham Minh Thong

Background/Objectives: Vietnamese evidence on transarterial chemoembolization (TACE) plus lenvatinib for unresectable hepatocellular carcinoma (HCC) remains limited. We examined recorded early imaging responses and uncertainty from missing outcomes, exposure classification, and confounding. Methods: This single-center secondary cohort included all eligible available records during a shared post-approval period (21 February 2024–19 August 2025). The endpoint was a documented complete or partial response according to …

03.09.2026journal-article

Frontiers in Medicine

Comparative analysis using machine learning methods for determination of pharmaceutical solubility in supercritical CO2 considering physical properties of drugs

Saad M. Alshahrani

Background Reliable prediction of pharmaceutical solubility in supercritical carbon dioxide (SC-CO 2 ) can support particle engineering and formulation design. However, record-wise validation may overestimate generalization when measurements for the same compound occur in both the training and test sets. Methods A leakage-aware machine-learning workflow was evaluated using molecular weight, melting point, temperature, and pressure as predictors of drug solubility in SC-CO 2 . Experimental records compiled from publ …

03.09.2026journal-article

Experimental & Molecular Medicine

Generation of the functionally enhanced proximal tubular cells from human iPSC-derived kidney organoids

Sua Kim, Sun Ah Nam, Jin Won Kim, Jawoon Yi, Jin Ju Woo, Minji Lee, Jeongeun Lee, Tae-Hyung Kim, Hyunglae Kim, Hyung Wook Kim, Jiwhan Park, Yong Kyun Kim

Abstract Human renal proximal tubular epithelial cells (RPPTCs) are crucial for exploring the molecular and cellular mechanisms underlying the pathophysiology of kidney injuries. In this study, we generated the functionally enhanced kidney organoid-derived proximal tubule cells (FEKOPTCs) from human induced pluripotent stem cells. Heparan sulfate proteoglycans and transforming growth factor-β receptor inhibitor enhanced the functionality of PTCs isolated from the kidney organoids of which the vascularization and ma …

03.09.2026journal-article

Experimental & Molecular Medicine

Antiviral innate immunity in myocarditis: mechanisms and emerging therapeutics

Caleb Hammons, Athul Mohanram, Preston Nguyen, Wenting Lu, Betty Jacobs, Xian Chang Li, Zhiqiang Zhang, Junji Xing

Abstract Antiviral innate immunity is a decisive determinant of whether cardiotropic viral infection resolves or progresses to myocarditis and deadly heart failure. Viral myocarditis (VM) remains a leading cause of sudden death in children and young adults, yet its human pathophysiological mechanisms remain incompletely understood and effective therapies are limited. In this Review, we map the cellular and molecular logic of cardiac antiviral innate immunity from first sensing to therapeutic opportunity and synthes …

03.09.2026journal-article

Frontiers in Medicine

Clinical trial awareness and participation attitudes among patients with epidermolysis bullosa and their caregivers: a nationwide cross-sectional study from Saudi Arabia

Ashjan Alheggi, Saifaleslam A. Mahmoud, Danah Alali, Abrar Bukhari, Salma Albargawi, Rayan Alkhodair, Christine Wagger, Sophie Kitzmueller

Background Epidermolysis bullosa (EB) is a rare, inherited skin fragility disorder with significant disease burden and rapidly evolving therapeutic options. Clinical trial recruitment in rare diseases remains challenging; understanding patient perspectives is essential to designing patient-centred protocols. The objective of this study was to explore clinical trial awareness, motivators, and barriers among patients with EB and their caregivers in Saudi Arabia. Materials and methods This cross-sectional study recrui …

03.09.2026journal-article

Frontiers in Surgery

Complete subserosal embedding of the appendix-cecal complex presenting as a non-visualized appendix during pediatric laparoscopic appendectomy: a case report

Guanghua Zhang, Ming Sun, Tao You, Hongqiang Bian, Jun Yang

Background Failure to identify the appendix during laparoscopic appendectomy is uncommon but challenging. Complete subserosal embedding of the appendix-cecal complex is an exceptionally rare variant that may obscure all conventional laparoscopic landmarks. We describe this anomaly in a pediatric patient and describe a practical exploration strategy derived from this case. Case presentation A 7-year-old boy presented with acute right lower quadrant pain suggestive of appendicitis. Computed tomography showed appendic …

03.09.2026journal-article

Frontiers in Medicine

Analytical validation of capillary blood Krebs von den Lungen-6 measurement using a high- sensitivity chemiluminescent immunoassay in pediatric patients

Chengyuan Zhao, Lingyun Shi, Dan Cao, Xianwei Zhang, Tong Cao

Objective This study evaluates the analytical validity of capillary blood for Krebs von den Lungen-6 (KL-6) detection using a high-sensitivity chemiluminescent immunoassay (CLIA) on the C5000 analyser and assesses agreement between capillary plasma and venous plasma measurements, with emphasis on methodological feasibility rather than clinical diagnostic performance. Methods Analytical performance was assessed in terms of repeatability, accuracy and method comparison. Precision was evaluated using pediatric venous …

03.09.2026journal-article

Proceedings of the Human Factors and Ergonomics Society Annual Meeting

Iterative Design of a Prototype Patient Tray for Unstable Spines

Yifan Li, Eve Shikanov, Loryn Hovelson, Darcy R. Erickson, Petrine Cerri, M. Susan Hallbeck, Gerald Malagrino

Hospital practitioners have a high prevalence of work-related musculoskeletal disorders due to manual patient transfers. Reducing patient transfers can improve safety for staff and patients, especially those with unstable spines. A study at our academic hospital with the Safe TrAnsfer Tray prototype (STAT Tray V1) found transfers could be reduced to the two unavoidable transfers at the beginning and end of care. Surveys from 37 practitioners identified clinical challenges. User feedback informed design requirements …

03.09.2026journal-article

Clinical Anatomy

Accuracy of Freehand Versus Navigated External Ventricular Drainage and Comparison of Insertion Trajectories: A Systematic Review and Meta Analysis

Adam Sedlák, Martin Černý, Adam Koza, David Kachlík, David Netuka, Lea Mladá, Miroslav Žáček, Martin Májovský

ABSTRACT The external ventricular drainage is a routine neurosurgical procedure, most often performed by cannulating the frontal horn of the lateral ventricle. Various entry points and insertion trajectory definitions have been proposed; nevertheless, it remains unclear which approach yields the highest success rate. Furthermore, in contemporary clinical practice, generally more efficient navigated ventriculostomies are available. This study aims to compare success rates between freehand and navigated procedures an …

03.09.2026journal-article

Bulletin of Pirogov National Medical & Surgical Center

PREDICTORS OF OCCURRENCE, DIAGNOSIS AND TREATMENT OF DIVERSION COLITIS IN STOMA PATIENTS AFTER GUNSHOT ABDOMINAL TRAUMA

A. L. Levchuk, N. A. Grin

The treatment of colitis of the “switched-off” colon is becoming increasingly important, both medically and socially and economically, in patients with abdominal gunshot trauma, significantly delaying the possibility of performing reconstructive surgeries aimed at eliminating the stoma and restoring colonic continuity with fecal passage. Materials and Methods: to determine the predictors of the development of diversion colitis and its severity in 42 patients with stomas following abdominal gunshot trauma, a retrosp …

03.09.2026journal-article

Intelligent Data Analysis: An International Journal

A two-step feature selection using permutation based feature importance and wrapper-based bio-inspired algorithms for classifying clinical dataset

Kochukrishnan Sivendran Navin, Khanna Harichandran Nehemiah, Nancy Jane Yesudhas, Kannan Arputharaj

Abstract The proposed framework aims to address the challenge of high-dimensional, noisy, irrelevant, and redundant features in clinical datasets by using a two-step feature selection approach. The first step involves a wrapper-based method for calculating the Permutation Based Feature Importance (PBFI) score using the Support Vector Machine (SVM) classifier. The second step employs three wrapper-based bio-inspired optimization algorithms, namely Harris Hawk Optimization (HHO), Binary Grasshopper Optimization (BGOA …