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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
03.09.2026journal-article

Journal of Experimental & Clinical Cancer Research

Inflammatory macrophages promote metastatic potential in Triple-negative Breast Cancer through Integrated Stress Response signaling

Martina Crippa, Vincenzo Salemme, Jagat Chauhan, Emanuele Colombo, Alessia Loffreda, Alessia Lamolinara, Clara Cardella, Martina Leone, Eugenia Licari, Marco Gaviraghi, Francesca Genova, Achille Anselmo, Davide Mazza, Manuela Iezzi, Colin R Goding, Paola Defilippi, Carlo Tacchetti, Paola Falletta

Abstract Triple-negative Breast Cancer (TNBC) is characterized by inflammatory myeloid infiltration and a high metastatic potential, however, the mechanisms by which macrophage-derived signals govern tumor cell plasticity remain poorly understood. Here, through patient transcriptomic analyses, in vitro functional studies, and in vivo metastasis models, we identify the Integrated Stress Response (ISR) as a critical tumor cell-intrinsic pathway that translates inflammatory macrophage-derived cues into metastatic comp …

03.09.2026journal-article

Texto Digital

Ler no século XXI: a literatura digital como experiência educativa no ensino secundário

Nuno Pessoa, Carla Curado, Adriana Moreira

Este artigo apresenta e analisa três experiências didático-pedagógicas de introdução da literatura digital no Ensino Secundário, realizadas no âmbito do projeto “Introdução à Literatura Digital nos Ensinos Básico e Secundário” (ILDEBS). Dois mestrandos em estágio e uma professora já profissionalizada desenvolveram atividades com turmas do 11.º e 12.º anos, em escolas de Coimbra, explorando obras digitais em articulação com textos do programa de Português. As didatizações incidiram sobre a remediação digital do poem …

03.09.2026journal-article

Community Mental Health Journal

Sexual Health in Psychiatry: Bridging the Communication Gap and Training Needs between Patients and Clinicians – A Cross-Sectional Exploratory Pilot Study

Teresa Schweitzer, Peter Martl, Douglas Dubrovin Leão, Lena Hammerl, Theresa Halms, Katharina Domani, Sophia vom Baur, Anna-Sophia Eder, Andrea Rabenstein, Tobias Rüther, Alkomiet Hasan, Marcus Gertzen

Abstract Sexual health is integral to mental well-being, yet it remains under-addressed in psychiatric care. Mental disorders and psychotropic medications can cause sexual dysfunctions. Despite its clinical relevance, sexual health is often not routinely assessed or discussed in psychiatric assessment and treatment, possibly due to insufficient training, stigma, and clinicians’ uncertainty. This pilot study examined how sexuality is addressed in psychiatric treatment and how relevant the topic is perceived, integra …

03.09.2026journal-article

Frontiers in Medicine

Case Report: Soft endoscopic treatment of Herlyn–Werner–Wunderlich syndrome: an innovative clinical procedure for hymen preservation

Yonghua Tian, Wei Fu, Yan Geng

Background Herlyn–Werner–Wunderlich syndrome (HWWS) management typically requires hymenotomy. We describe the fully endoscopic, hymen-sparing septotomy in a patient with no history of sexual intercourse. Case presentation A 20-year-old patient with no prior sexual intercourse and progressive dysmenorrhea was diagnosed by MRI with HWWS, presenting as uterus didelphys, obstructed right hemivagina, and left renal agenesis. A 9-mm flexible gastroscope and endoscopic submucosal dissection (ESD) knives were introduced th …

03.09.2026journal-article

Frontiers in Neurology

Pediatric stroke in inborn errors of metabolism: clinical characteristics, neuroimaging features, and short-term outcomes

Javeria Raza Alvi, Areeba Wasim, Saher Gul Ahdi, Tipu Sultan, Muhammad Zia-ur-Rehman, Khalid Al-Thihli, Fathiya Al Murshedi, Amna Al Futaisi

Introduction Pediatric stroke has a broad etiological spectrum, with inborn errors of metabolism (IEM) increasingly recognized as an important and potentially treatable cause. This study aimed to characterize the clinical, radiological, and electroencephalographic features of IEM-related pediatric stroke and to evaluate short-term functional outcomes. Methods This prospective cohort study was conducted at The Children’s Hospital Lahore, Pakistan, and Sultan Qaboos University Hospital, Muscat, Oman (January 2024–Dec …

03.09.2026journal-article

Frontiers in Public Health

Exposure to cement industry emissions and respiratory health outcomes: a global systematic review and meta-analysis from 2000 to 2025

Zahid Ali Khan, AliSalman Sheikh, Łukasz Afeltowicz, Jacek Gądecki

Introduction Cement manufacturing is a major contributor to industrial air pollution and releases particulate matter and toxic emissions, adversely affecting the respiratory health. Previous studies have reported respiratory impairment and its associated symptoms among exposed populations, yet the evidence remains inconsistent across occupational and residential settings. This systematic review and meta-analysis is aimed to quantify the association between exposure to cement factory emissions and respiratory health …

03.09.2026journal-article

Nutrition and Health

Breaking the link: The moderating role of mindful eating behaviour in the relationship between binge eating and body mass index

Cerasela Oana Gavril, Alexandra Iuliana Negoita, Kyriaki Giannou, Michail Mantzios

Background There is growing recognition of the positive role of mindful eating in improving eating behaviours and weight management. Aim However, there is limited research that explored how mindful eating behaviour (i.e., regulated attention while eating) may moderate the association between binge eating (BE) and body mass index (BMI), which was the primary aim of the present research. Methods In a cross-sectional study, 146 participants were recruited through online opportunity sampling to complete an online surve …

03.09.2026journal-article

International Journal of Cyber Threat Intelligence and Secure Networking

A Review of Machine Learning Techniques for Network Intrusion Detection Systems

Mr. Madhav Sharma

Security researchers rely heavily on Network Intrusion Detection Systems (NIDS) to keep an eye on network traffic and notify administrators of any suspicious activities. The purpose of this paper is to offer a comprehensive overview of intrusion detection systems (IDS), including the following topics: fundamentals, kinds of IDS, methods for detecting intrusions in NIDS, the architecture of IDS, data pre-processing, and examples of ML techniques used in NIDS. This covers several detection methods, including signatur …

03.09.2026journal-article

Journal on Innovation and Sustainability RISUS

Central bank digital currency as a tool of financial system transformation

Ekaterina Bochkareva, Petr Kurdyuk, Arina Chueva, Elena Voronenko

The development of central bank digital currencies represents a significant stage in the transformation of modern monetary systems and financial governance. The relevance of this study is determined by the growing role of central bank digital currency as an instrument of state regulation, financial transparency, and control within the digital economy. The purpose of the article is to analyze aspects of the introduction of the digital ruble in the Russian Federation and to assess its impact on monetary functions, pu …

03.09.2026journal-article

Frontiers in Neurology

Post-stroke sarcopenia as a neuromuscular disorder: a mini review of neural mechanisms and clinical implications

Lin Yang, Sen-Jun Deng

Background Post-stroke sarcopenia represents a distinct neuromuscular disorder characterized by progressive muscle loss and functional decline. Unlike age-related sarcopenia, stroke-induced muscle wasting involves specific neural mechanisms originating from central nervous system injury. Objective To systematically review the neural mechanisms underlying post-stroke sarcopenia and synthesize evidence on its clinical implications, diagnostic approaches, and therapeutic interventions. Methods A mini review of the lit …

03.09.2026journal-article

JMIR Formative Research

Evaluation of a Digital Clinician-Training Module for Treatment of Transgender and Gender Diverse Patients With Eating Disorders: Pre-Post Study

Nora Yanyi Sun, Alex S Keuroghlian

Abstract A digital clinician training module significantly improved attitudes, beliefs, and self-perceived competence in a cohort of medical students (n=87) toward working with transgender and gender diverse (TGD) people with eating disorders. Future clinician training resources can adopt this cost-effective and accessible learning model and build upon existing introductory attitude- and awareness-based programs by focusing on addressing a specific health disparity among TGD people.

03.09.2026journal-article

Journal of Medical Internet Research

Patient-Centered Summarization Framework for AI Clinical Summarization: Mixed Methods Study

Maria Lizarazo Jimenez, Ana Gabriela Claros, Kieran Green, David Toro-Tobon, Felipe Larios, Sheena Asthana, Camila Wenczenovicz, Kerly Guevara Maldonado, Luis Vilatuna-Andrango, Ana Cristina Proano, Satya Sai Sri Bandi, Shubhangi Bagewadi, Megan E Branda, Misk Al Zahidy, Saturnino Luz, Mirella Lapata, Juan P Brito, Oscar J Ponce-Ponte

Abstract Background Large language models (LLMs) are increasingly demonstrating the potential to reach human-level performance in generating clinical summaries from patient-clinician conversations. LLMs are usually evaluated against clinical summaries that focus mainly on patients’ biology and not on their biography (eg, preferences, values, wishes, and concerns). To achieve patient-centered care, artificial intelligence clinical summarization must incorporate patient-centered domains, implemented through patient-c …

03.09.2026journal-article

Historical Thinking, Culture, and Education

Healthy histories

Tim Huijgen, Rina Knoeff, Karen Hollewand, Koos Sikkema

There are rising concerns about adolescent (mental) health in the Netherlands. This article explores how history education can contribute to students’ Critical Health Literacy (CHL). We identify five interrelated ways in which historical thinking is connected to CHL. Additionally, we present three pedagogical approaches for implementation: The use of diachronic health themes, the application of a well-being framework, and the Strange Past contextualization framework. These approaches offer practical entry points fo …

03.09.2026journal-article

Jurnal Kesehatan Budi Luhur: Jurnal Ilmu-Ilmu Kesehatan Masyarakat, Keperawatan, dan Kebidanan

Changes in Pregnancy-Related Anxiety Following EX-HN 3 and CV 17 Acupressure Among Third-Trimester Pregnant Women at Siliwangi Health Center

Sheli Riani, Della Miranda, Lina Herlina

The third trimester of pregnancy is accompanied by physical and psychological changes, and pregnancy-related anxiety may increase as childbirth approaches. Acupressure has been used as a non-pharmacological approach to support relaxation during pregnancy. This study aimed to examine changes in anxiety following seven consecutive days of EX-HN3 and CV17 acupressure among third-trimester pregnant women at Siliwangi Public Health Center, Garut. A pre-experimental one-group pretest-posttest design included 28 pregnant …

03.09.2026journal-article

LAW AND BUSINESS

Legal Regime of the Circulation of Digital Financial Assets: A Comparative Legal Analysis

Danil R. Bogachev, Aleksandr S. Kiselev

The introduction of digital technologies into many economic processes is changing the functioning principles of many government institutions. This process requires regulatory regulation of newly emerged economic relations and their proper registration and legal protection. The issues of developing information relations in the sphere of turnover of the Central Federal District are related to economic, political, social and other factors that are taken into account in strategic planning, including the national securi …

03.09.2026journal-article

Energies

Hydro–Wind–Photovoltaic Multi-Energy Centralized Control Systems and Digital Twin-Based Simulation Training Platforms: A Review

Yan Ren, Wenjing Huang, Linmao Ren, Kang Luo, Jiangtao Chen, Peng Zhang

With the rapid development of clean energy, hydro–wind–photovoltaic multi-energy systems require centralized control centers with stronger operational support, coordinated dispatch, and emergency response capabilities. However, safety constraints in real control systems limit their use for operator training, fault handling, and emergency drills. In addition, existing simulation-training systems are still largely oriented toward individual plants or single-energy systems, with limited support for coordinated trainin …

03.09.2026journal-article

International Journal of Sports Science & Coaching

Artificial intelligence in football talent identification: A systematic review

Hongta Wang, Lechuan Shen, Jiarui Xing, Chao Xie, Yang Qin

Objectives To synthesize current evidence on the use of artificial intelligence (AI) in football talent identification. Design Systematic review. Method This review followed PRISMA 2020 guidelines and was registered in PROSPERO. PubMed, Scopus, Web of Science, IEEE Xplore, and ACM Digital Library were searched for studies published between 2016 and 2025. Eligible studies applied AI-related methods to football talent identification or player evaluation. After duplicate removal and screening, 24 studies were included …

03.09.2026journal-article

REVISTA CIENTÍFICA ACERTTE - ISSN 2763-8928

TDAH E DUPLA EXCEPCIONALIDADE NO SÉCULO XXI: DA DISFUNÇÃO NEUROBIOLÓGICA À EFETIVAÇÃO DOS DIREITOS À SAÚDE, INCLUSÃO LABORAL E ACESSIBILIDADE PROCESSUAL

Thereza Christiane Alves Varella

O presente artigo analisa os mecanismos jurídicos necessários para assegurar a efetiva inclusão e a qualidade de vida da pessoa com Transtorno do Déficit de Atenção com Hiperatividade (TDAH) e com Dupla Excepcionalidade (coexistência de TDAH e Altas Habilidades/Superdotação) no Brasil. Numa perspectiva que concilia a ciência jurídica à análise clínica das barreiras biológicas, examina-se o contraste entre a alta performance intelectual e o colapso funcional das funções executivas, os impactos psicossociais devastad …

03.09.2026journal-article

Addiction Science & Clinical Practice

Changing minds on MOUD: impact of messages to motivate expanded access to buprenorphine in primary care settings

Karen L. Roper, Melissa Zook, Kory Heier, Kristen McQuerry, Sarah Marks, Hannah K. Knudsen

Abstract Background Practitioners in primary care (PCPs) face significant barriers and lack of motivation for expansion of medications for opioid use disorder (MOUD) in their service. Educational videos specifically targeted at the primary care setting and utilizing key determinants of behavior change were assessed for impact on PCP viewer’s attitudes and intention to explore MOUD. Methods A rural-setting PCP scripted the videos, describing her extensive experience treating patients using buprenorphine. Content add …

03.09.2026journal-article

INTERNATIONAL JOURNAL OF HEALTH AND PHARMACEUTICAL RESEARCH

Determinants of Quality Family Planning Services in Sokoto State, Nigeria

Suleiman Aliyu

This study examines determinants of quality family planning services in Sokoto State, Nigeria. Using a descriptive cross-sectional design, data were collected from 519 respondents and analyzed using descriptive statistics. Findings show that provider competence, socio-cultural beliefs, informed choice, and financial barriers significantly influence service quality and utilization the results indicate that provider competence is the strongest determinant of service quality, highlighting the importance of skilled hea …

03.09.2026journal-article

Journal of Global Social Transformation

Dissemination of Health Content through social media and its Acceptability by the Viewers

Nisar Ahmad Anjum, Imran Muslim

Increasing exposure to the different social media applications has led towards more dependency on social media influencers in general and especially on health-related content creators. This survey study is an attempt to investigate the reasons for this blind following and outcome of this faith on health content creators. 384 respondents were approached by researchers to collect the data by using a survey questionnaire. Results of the study show that health content in the form of short videos, especially through Ins …

03.09.2026journal-article

An Idea Health Journal

Factors Associated the Perceived Effectiveness of Seven-Jumps Problem with Based Learning Tutorials among Nursing Students: A Mixed-Methods Study

Ika Purnamasari, Candra Dewi Rahayu, Anisa Ell Raharyani

Background: Seven-Jumps Problem-Based Learning (PBL) tutorials are commonly implemented in nursing education to foster active learning, critical reasoning, and collaborative problem-solving. However, evidence on factors influencing students’ perceptions of tutorial effectiveness remains limited in Indonesian nursing education. Methods: An explanatory sequential mixed-methods design was employed. The quantitative phase included 70 fourth-semester undergraduate nursing students and utilized the Tutorial Group Effecti …

03.09.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Macrophage FOXO1 Inhibition Protects Against Hyperglycaemia‐Associated Kidney Injury

Hejie Zhu, Qian Liu, Lunqiang Yang, Chenyu Zhang, Ying Zhang, Ruiqi Zhao, Zhongyuan Zheng, Xi Wang, Linlin Li, Long Zhang, Lu Tie

ABSTRACT Diabetic kidney disease (DKD) is one of the most significant microvascular complications of diabetes, characterized by high incidence and mortality; however, its pathogenesis remains unclear. Renal inflammation and macrophage infiltration play pivotal roles in driving DKD progression. The transcription factor forkhead box protein O1 (FOXO1) regulates the transcriptional expression of multiple pro‐inflammatory molecules and modulates macrophage polarization. Nevertheless, its specific role in DKD macrophage …

03.09.2026journal-article

American Journal of Audiology

Clinical and Demographic Characterization of Tinnitus and Factors Associated With Discomfort in a Large Sample of Patients Evaluated in Bogotá, Colombia

German Alejandro Pabón Ochoa, Miguel Humberto Parra Pinto

Purpose: The purpose of this study was to clinically and demographically characterize tinnitus in a large sample of patients evaluated in Bogotá, Colombia, and to analyze the factors associated with the level of discomfort. Method: A total of 763 medical histories of adults seen between 2018 and 2024 at a specialized tinnitus center were analyzed. Demographic, clinical, and audiological data were collected, in addition to scores from self-report instruments (Tinnitus Handicap Inventory, Tinnitus Reaction Questionna …