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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
01.09.2026journal-article

Water and Environment Journal

Role of Earthworms in Mitigating Antimicrobial Resistance During Wastewater Treatment by Vermifiltration Technology

Rishita Parihar, Sarita Vatwani, Sakshi Upadhyay, Amanpreet Kaur, Saniya Chawla, Harshita Jonwal, Tamanna Pamnani, Komal Sharma, Aakanksha Kalra, Sandeep K. Shrivastava, Sonia Sethi, Niha Mohan Kulshreshtha, Nimisha Singh, Sudipti Arora

ABSTRACT Antibiotic‐resistant microorganisms in wastewater pose significant threats to public health and the environment due to the limited effectiveness of conventional treatment systems. This study investigates the potential of vermifiltration technology, utilising Eisenia fetida earthworms, to reduce antibiotic‐resistant bacteria (ARB) and pollutant load in institutional wastewater by comparing a vermifilter (VF) against a biofilter (BF) lacking earthworms at pilot scale. Treatment performance was evaluated base …

01.09.2026journal-article

Die Ophthalmologie

Das oregis-IVOM-Register – Einführung eines Registers für die systematische Erhebung repräsentativer IVOM-Versorgungsdaten aus dem Behandlungsalltag bei Makulaerkrankungen in Deutschland

Ildikó Piszár, Anais Buhl, Argyrios Chronopoulos, Lukas Schloesser, Christopher Dicke, Nicole Eter, Julian Alexander Zimmermann, oregis, Robert P. Finger

Zusammenfassung Hintergrund Intravitreale operative Medikamenteneingaben (IVOMs) im Versorgungsalltag erreichen häufig nicht die in klinischen Studien gezeigten Behandlungsergebnisse. In Deutschland fehlen bislang flächendeckende, repräsentative Real-World-Daten zur IVOM-Versorgung bei Makulaerkrankungen. Ziel der Arbeit Vor diesem Hintergrund wurde das oregis-IVOM-Register als Subregister des nationalen oregis-Registers etabliert. Ziel ist die standardisierte Erhebung und Analyse von IVOM-Therapieverläufen im klin …

01.09.2026journal-article

Gels

In Situ Gelling of TPZ-Loaded Nanogel for Sustained Intratumoral Delivery and Enhanced Cancer Immunotherapy

Ling Li, Kexin Wang, Zhe Song, Hongan Tian, Cai Wang, Ling Zhang, Houqiang Yu

TPZ is a hypoxia-activated anticancer agent that exerts selective cytotoxicity within hypoxic tumor microenvironments. Although intratumoral injection of TPZ can achieve localized antitumor activity, the drug is prone to rapid diffusion and clearance from the injection site, limiting its long-term retention and thereby reducing therapeutic durability and overall efficacy. To achieve sustained release and prolonged retention of TPZ in subcutaneous tumors, a thermosensitive nanogel loaded with TPZ (TPZ@PNA-TNG) was d …

01.09.2026journal-article

Nature Communications

Efficacy of everolimus and letrozole with or without ribociclib in recurrent endometrial cancer: a phase 2 randomized clinical trial

Jeffrey A. How, Shannon N. Westin, Melissa Pham, Barrett Lawson, Minxing Chen, Nidhi Tandon, Ying Yuan, Rugang Zhang, Amir A. Jazaeri, Anil K. Sood, Michaela Onstad Grinsfelder, Kathleen M. Schmeler, David J. Vining, Samantha M. Fix, Yibo Dai, Mikayla B. Bowen, Karen H. Lu, Melinda S. Yates, Russell Broaddus, Pamela T. Soliman

Abstract In this phase II trial, patients with endometrial cancer (EC) were randomized to everolimus/letrozole with (experimental arm) or without ribociclib (control arm) (ClinicalTrials.gov Identifier: NCT03008408). The primary endpoint was progression-free survival (PFS). Secondary endpoints included toxicity, overall survival (OS), objective response rate (ORR), and clinical benefit rate (CBR). For all-comers, there was no difference in PFS (HR 0.78, 95% CI 0.4-1.4, p = 0.38), OS (HR 0.8, 95% CI 0.4-1.5, p = 0.4 …

01.09.2026journal-article

BMC Gastroenterology

Development and internal evaluation of a nomogram for identifying current sleep disturbance in patients with colorectal cancer undergoing chemotherapy: a cross-sectional study

Ao Tang, Tian Xiao, Zhenrong Yin, Qing Li, Ruihan Xiao, Fangyi Li, Linyu Zhou, Biao He, Xiaoju Chen

Abstract Objectives This study aimed to identify factors associated with current sleep disturbance (SD) in patients with colorectal cancer (CRC) undergoing chemotherapy and to develop and internally evaluate a nomogram for estimating the probability of current SD. Methods A total of 630 patients with CRC undergoing chemotherapy were recruited from five hospitals in China. Participants were assessed using the Demographic Information Questionnaire, Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depre …

01.09.2026journal-article

Journal of Clinical Medicine

Real-World Clinical Outcomes of Manual Versus Powered Endoscopic Staplers in Minimally Invasive Lung Cancer Surgery

Cosimo Lequaglie, Gabriella Giudice, Annalisa Carlucci, Roberto Cascone

Objectives: Manual surgical staplers remain widely used in minimally invasive lung surgery, while powered devices have been introduced to improve tissue compression, staple formation, and device handling. This study compared clinical outcomes associated with manual and powered endoscopic staplers in patients undergoing minimally invasive lung cancer surgery, with postoperative air leak as the main outcome of interest. Methods: We retrospectively reviewed 400 consecutive patients who underwent VATS segmentectomy or …

01.09.2026journal-article

Equine Veterinary Education

Tracheal duplication cyst in a horse: Computed tomographic findings, surgical treatment and long‐term follow‐up

I. Claeys, M. Meulyzer, S. Hauspie, Z. Joostens, D. Kadic

Summary A tracheal duplication cyst (TDC) is a rare congenital anomaly. It is most commonly diagnosed in early life due to its mass effect, resulting in respiratory compromise and dysphagia. This case report describes a 3‐year‐old stallion presented with a chronic right ventrolateral cervical swelling. Clinical evaluation, ultrasonography and computed tomography identified a well‐defined multiloculated cystic lesion associated with the trachea and adjacent vascular structures. Surgical excision was performed. Histo …

02.09.2026journal-article

Statistics in Medicine

Multilevel Network Meta‐Regression With a Survival Outcome and an Application to Non‐Small Cell Lung Cancer

Ruofan Jia, Huangdi Yi, Zhaoyang Teng, Sammi Tang, Jiping Wang, Shuangge Ma

ABSTRACT In biopharmaceutical studies, it is often of interest to compare the effects of two treatments (say, A and B), but data that contain a direct comparison are not available. However, there may be studies that compare them against another competitor (say, C). In this case, an indirect comparison of A versus B through C needs to be conducted. In this article, we consider the scenario where individual participant data (IPD) is available for the comparison of A versus C, but only aggregate‐level data (AgD), for …

02.09.2026journal-article

The Oncologist

59 GPNMB:CD44 Signaling Drives Tumor Progression in Translocation Renal Cell Carcinoma

Kaushal Asrani, Juhyung Woo, Thiago Vidotto, Kewen Feng, Adrianna Amaral, Vikrant Palande, Jayaprakash Mandal, Eddie Imada, Christopher Thoburn, Sangeeta Ray, Huili Li, Pornima Phatak, James Donahue, Yasser Ged, Nirmish Singla, John Copland, Laura Schmidt, Marston Linehan, Pedram Argani, Tamara Lotan

Abstract Background MiT/TFE-rearranged, translocation renal cell carcinoma (tRCC) is characterized by gene fusions involving TFE3 or TFEB, and is a rare, aggressive non-ccRCC, often occurring in children and with few biomarkers or targeted therapy options. TFE3 is the most commonly translocated gene with ASPSCR1, PRCC and SFPQ as fusion partners. GPNMB (Glycoprotein non-metastatic melanoma protein B) is a canonical transcriptional target of MiT/TFE proteins expressed at low levels in normal tissues but upregulated …

03.09.2026journal-article

Breast Cancer: Basic and Clinical Research

Circulating Tumor DNA in Breast Cancer: A Liquid Biopsy Revolution for Non-Invasive Genomic Profiling and Clinical Decision-Making

Emmanuel Ifeanyi Obeagu, Chukwuma J. Okafor

Breast cancer remains the most frequently diagnosed cancer and a leading cause of cancer-related mortality among women worldwide, underscoring the need for accurate, minimally invasive biomarkers to support precision oncology. Conventional tissue biopsy remains the standard for molecular characterization but is limited by its invasiveness, inability to capture spatial and temporal tumor heterogeneity, and challenges in serial monitoring. Circulating tumor DNA (ctDNA), a tumor-derived fraction of cell-free DNA, has …

01.09.2026journal-article

JCO Global Oncology

Clinical Relevance of Genomics Defined WHO5 Subtypes of Pediatric B-ALL in the Context of Measurable Residual Disease–Directed Risk-Based Therapy

Sweta Rajpal, Gaurav Chatterjee, Prasanna Bhanshe, Vishram Terse, Swapnali Joshi, Shruti Chaudhary, Dhanalaxmi Shetty, Purvi Mohanty, Chetan Dhamne, Prashant Ramesh Tembhare, Shyam Srinivasan, Akanksha Chichra, Nirmalya Roy Moulik, Shripad Banavali, Sumeet Gujral, Gaurav Narula, Papagudi G Subramanian, Nikhil Patkar

PURPOSE WHO5 (2022) classification of B-lymphoblastic leukemia (B-ALL) incorporates several novel entities requiring high-throughput sequencing for their accurate characterization. The clinical relevance of this classification in the context of contemporary measurable residual disease (MRD)–directed therapy is unclear. METHODS We analyzed 533 pediatric B-ALL uniformly treated with Indian Collaborative Childhood Leukaemia group (ICiCLe)-ALL-14 protocol as defined by WHO-2016 and reclassified them as per WHO5 using t …

01.09.2026journal-article

Journal of the American Veterinary Medical Association

Liquid biopsy technologies offer new insights and approaches for canine cancer detection and management

John Robertson, Amr Sayed Issa, Nikolas Dervisis, Kay McGuire, Joanne Tuohy, John Rossmeisl, Brycie Marine, Lori Jodar, Laura Marconato, Carlos Fonseca-Alves, Caitlin Feiock, Bobbi Conner, Erica B. Fesler, Lacey Ngo, Romina Seifollahi Asl, Megan Luczko, Courtney White, Ryan Senger

Abstract Liquid biopsy (LBx) is the analysis of fluids such as blood, urine, saliva, or secretions to detect cancer biomarkers and circulating tumor cells. It is becoming a common investigational tool in human oncology, but less so in veterinary medicine. Liquid biopsy is less invasive and has fewer complications than tissue biopsy, but it is not intended to replace tissue biopsy. In human oncology, LBx is primarily used as an investigational tool because of the cost and technology requirements. Liquid biopsy may e …

01.09.2026journal-article

Medicina Fluminensis

Rekonstrukcijska kirurgija u liječenju spinocelularnog karcinoma vlasišta

Ante Ključević, Jan Ljubičić, Jakov Ivan Bućan, Zvjezdana Milačak

Cilj: Prikaz ovog slučaja pokazat će važnost interdisciplinarnarnog pristupa liječenju spinocelularnog karcinoma (SCC) u kojem dermatologija te rekonstrukcijska kirurgija zajedničkom suradnjom osiguravaju optimalan terapijski ishod za pacijenta. Prikaz slučaja: Muškarac u dobi od 89 godina upućen je kod plastičnog kirurga zbog izraženog defekta nakon resekcije spinocelularnog karcinom lokaliziranog na skalpu, frontoparijetalno lijevo. Dermatolozi su proveli radikalnu resekciju, a potom je utvrđeno kako je bolest lo …

01.09.2026journal-article

Frontiers in Oncology

Direct comparison of serine restriction on the viability of normal and cancer cells demonstrates that methionine restriction is more cancer specific

Yuta Miyashi, Tomoyuki Ishiguro, Qinghong Han, Shukuan Li, Byung Mo Kang, Michael Bouvet, Yasunori Tome, Kotaro Nishida, Robert M. Hoffman

Background/aim Many studies in the present century have stated that restriction of serine is a cancer-specific vulnerability. The present study aimed to determine whether restriction of serine, compared to restriction of methionine, distinguishes cancer and normal cells. Materials and methods 143B-RFP osteosarcoma cells, HT1080-RFP fibrosarcoma cells, HCT116-GFP colon-cancer cells, and Hs27 normal fibroblasts were used in the present study. All cells are of human origin. Cancer and normal cells were cultured in RPM …

01.09.2026journal-article

Journal for ImmunoTherapy of Cancer

Mechanistic modeling of tumor immune microenvironment reveals strategies to enhance antibody-drug conjugates’ efficacy

Constantinos Harkos, Lance L Munn, Triantafyllos Stylianopoulos, Rakesh K Jain

Background Antibody-drug conjugates (ADCs) and bispecific antibodies represent a rapidly advancing frontier in oncology, yet the abnormal tumor microenvironment (TME) hinders their delivery and reduces efficacy. Emerging immunomodulatory ADCs (IM-ADCs) demand mechanistic mathematical models that couple drug transport with immune dynamics. Methods Here, we present a mechanistic framework for the delivery of HE-S2 ADC, an anti-programmed cell death ligand 1 (PD-L1) antibody bearing the bifunctional immunomodulator D1 …

01.09.2026journal-article

Frontiers in Immunology

Statins use and prognosis in lung cancer patients treated with immune checkpoint inhibitors: evidence from a meta-analysis

Dandan Liang, Qinghua Liu, Min Liu, Yi Li

Background Lung cancer remains one of the most common and lethal malignancies worldwide. The advent of immune checkpoint inhibitors (ICIs) has substantially improved survival outcomes in patients with advanced disease; nevertheless, a considerable proportion of patients exhibit suboptimal responses to ICI monotherapy. In recent years, statins have garnered attention for their potential immunomodulatory and anti-inflammatory properties. Preclinical evidence suggests that statins may enhance antitumor immune response …

01.09.2026journal-article

Sport Sciences for Health

Understanding non-participation in a remote exercise trial among breast cancer survivors undergoing adjuvant endocrine therapy: a cross-sectional survey

Henrique Ims Bortolozo, Miguel Soares Conceição, Valeria L. G. Panissa, Marina L. V. Ferreira, Olivia M. Ruberti, Luis Otávio Sarian, Guilherme D. Telles, Felipe C. Vechin, Sophie Derchain

Abstract Purpose Despite wider access to remote/home-based exercise, many breast cancer survivors still decline structured programs. We analyzed the sociodemographic/clinical profile of women on adjuvant endocrine therapy who declined an online exercise intervention and explored their reasons for non-participation. Methods This ancillary cross-sectional survey was nested within a registered parent randomized trial (ReBEC RBR-3tqb39m). Ninety-eight women on adjuvant endocrine therapy were contacted; 25 were not reac …

01.09.2026journal-article

Journal of Evidence-Based Medical Research

Legal and Policy Barriers to Telemedicine Prescribing of Controlled Analgesics for Chronic Non-cancer Pain: A Systematic Review

Srija Yerram

Background: Telemedicine can reduce travel, geographic, mobility and specialist-access barriers in chronic non-cancer pain (CNCP), but prescribing controlled analgesics remotely is conditioned by overlapping controlled-substance law, patient-location licensure, prescribing standards, monitoring requirements, reimbursement and digital infrastructure. The evidence base is predominantly opioid-focused and has evolved rapidly since the COVID-19 public health emergency. Methods: We conducted a systematic evidence review …

01.09.2026journal-article

Medicine & Science in Sports & Exercise

Exercise Timing Influences Autonomic and Psychological Adaptations but not Functional Capacity in Cancer Patients Undergoing Treatment

Buck W. Covington II, Brooke Mattocks, Luke Krynski, Lea Haverbeck Simon, Jesse Hayward, Melissa Villafana, Mike Lazio, Reid Hayward

Purpose: To examine the effects of exercise timing (morning [AX] vs evening [PX]) on functional capacity, psychological outcomes, and sleep-related measures in cancer patients undergoing treatment. Methods: Forty-four cancer patients undergoing treatment participated in a supervised exercise intervention at the University of Northern Colorado Cancer Rehabilitation Institute (UNCCRI). Participants self-selected exercise timing as AX (0700–0900) or PX (1600–1800) and completed a range of pre- and post-intervention ph …

01.09.2026journal-article

Blood Journal

CAR transgenic T-cell lymphoproliferative neoplasm (CTTLN): malignant transformation of cellular immunotherapy

Francis Baumgartner, Michael J. Dickinson, Piers Blombery

Engineered T-cells have transformed hematooncology, but CAR transgene-bearing T-cell malignancies have emerged as a rare and serious genomic safety signal after CAR-T therapy. Available data support a multistep model in which pre-existing clonal fitness, CAR-T manufacture, vector integration, construct biology and post-infusion selection may contribute to different degrees. We review reported cases of CAR-transgenic T-cell lymphoproliferative neoplasms (CTTLN) and propose practical diagnostic criteria with a propor …

01.09.2026journal-article

Frontiers in Oncology

Feeding and swallowing function and dysphagia risk in children with posterior fossa tumors: a preliminary Italian cohort study

Marco Tofani, Lavinia Savarese, Bianca Andreozzi, Antonella Cerchiari, Andrea Carai, Carolina Giordani, Giorgia Biondo, Gessica Della Bella, Francesca Pizza, Angela Mastronuzzi

Introduction Dysphagia is a frequent postoperative complication in children undergoing surgery for posterior fossa tumors (PFTs), yet early swallowing trajectories remain insufficiently characterized despite the growing focus on functional outcomes in pediatric neuro-oncology. Methods In this prospective cohort study conducted at a tertiary referral center, feeding and swallowing function were assessed at three standardized time points: preoperatively, one week postoperatively, and four weeks postoperatively using …

03.09.2026journal-article

BMJ Open

EQUITY-MS: evaluating the quality of investigation and treatment of multiple sclerosis using data from five specialist neurology centres in the UK—study protocol

Elizabeth O’Nions, Dan Lewer, Rachael W Cheung, Ellen Da Silva, Joyutpal Das, Ruth Dobson, Radoš Keravica, Faith Moyo, David Rog, Melanie Russell, Cord Spilker, Emma Tallantyre, Helen L Ford

Introduction The social determinants of health are the conditions in which people live and the systems around them that shape these conditions. Social determinants of health may affect diagnosis and treatment for people with multiple sclerosis (MS) even in countries with universal healthcare systems. This study will investigate whether a person’s age, sex and/or gender, living in a more socioeconomically deprived area and being of a minoritised ethnicity impact access to a diagnosis of MS and disease-modifying trea …

04.09.2026journal-article

ChemNanoMat

Fabrication of Boron Nitride@Polydopamine/Polyvinyl Alcohol/Polyvinylidene Fluoride Composite Film With Good Thermal Stability and Thermal Conductivity via Electrospinning and Hot Pressing Treatment

Zengxi Wang, Haorui Jin, Huidi Liu, Xiang Cai, Shaozao Tan, Shaoyuan Zhou, Jinglin Zhang

The field of thermal conductivity is one of the important applications of polymers. However, polymer material generally possesses low thermal conductivity due to its internal characteristic, which cannot meet the heat dissipation requirement of device. Therefore, the preparation of polymer material with high thermal conductivity has broad application prospect and important significance. To achieve this goal, a new‐type composite film was fabricated via electrospinning and hot pressing treatment. Utilizing the self‐ …

04.09.2026journal-article

Journal of the Renin-Angiotensin-Aldosterone System

Renin-angiotensin system imbalance is associated with immunometabolic reprogramming and tissue repair in COPD-lung cancer comorbidity

Yonghua Zheng, Dongli Song, Ding Zhang, Jingjing Hou, Hao Fang, Lihua Dai

Background Chronic obstructive pulmonary disease (COPD) and lung cancer frequently co-occur with shared inflammatory and metabolic drivers, while the systemic role of the renin-angiotensin system (RAS) in this comorbidity remains poorly understood. Methods We integrated Global Burden of Disease, Mendelian randomization, pan-cancer/single-cell transcriptomics, NHANES population data, and functional experiments to dissect this comorbidity, with mechanistic modeling to evaluate lifestyle factors and osteopontin's role …